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This book illustrates applications of mathematics to various processes (physiological or artificial) involving flowing blood, including hemorheology, microcirculation, coagulation, kidney filtration and dialysis, offering a historical overview of each topic. Mathematical models are used to simulate processes normally occurring in flowing blood and to predict the effects of dysfunctions (e.g. bleeding disorders, renal failure), as well as the effects of therapies with an eye to improving treatments. Most of the models have a completely new approach that makes patient-specific simulations possible. The book is mainly intended for mathematicians interested in medical applications, but it is also useful for clinicians such as hematologists, nephrologists, cardio-surgeons, and bioengineers. Some parts require no specific knowledge of mathematics. The book is a valuable addition to mathematics, medical, biology, and bioengineering libraries.
For more than 65 years, this best-selling text by Drs. Barbara J. Bain, Imelda Bates, and Mike A. Laffan has been the worldwide standard in laboratory haematology. The 12th Edition of Dacie and Lewis Practical Haematology continues the tradition of excellence with thorough coverage of all of the techniques used in the investigation of patients with blood disorders, including the latest technologies as well as traditional manual methods of measurement. You'll find expert discussions of the principles of each test, possible causes of error, and the interpretation and clinical significance of the findings. A unique section on haematology in under-resourced laboratories. Ideal as a laboratory reference or as a comprehensive exam study tool. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices. diagnosis, molecular testing, blood transfusion- and much more. Complete coverage of the latest advances in the field. An expanded section on coagulation now covers testing for new anticoagulants and includes clinical applications of the tests.
This issue of Hematology/Oncology Clinics of North America is devoted to Congenital and Acquired Disorders of Macrophages and Histiocytes. Guest Editors Nancy Berliner, MD and Barrett Rollins, MD have assembled a group of expert authors to review the following topics: Nosology of Langerhans Cell Histiocytosis (LCH); Cell of Origin of LCH; Genomic Changes in LCH; Clinical Treatment of LCH; Neurodegeneration in LCH; Pathogenesis of Hemophagocytic Lymphohistiocytosis (HLH); Familial HLH; HLH in Adults; Macrophage Activation Syndrome; and Stem Cell Transplant for HLH.
There are today five major proteins in plasma fractioning. In the near future, other fractions could also be used as therapeutic agents. But perhaps they could be used for alternative, non-therapeutic applications? For example, producing human culture media with specific ingredients for biotechnology research might also be of use. Whatever the future may hold, there is one essential question: in today's world of cellular and genetic engineering, are extracted therapeutic proteins still of any relevance? For a clear and up-to-date view of recent developments in blood-protein-separation technology, this book will prove an invaluable resource.
With its highly templated, easy-to-use format and new information throughout, the third edition of Hematopathology, a volume in the Foundations in Diagnostic Pathology series, is an essential text for residents and pathologists. Throughout this practical reference, traditional morphologic diagnostic pathology is supplemented with clinical, immunohistochemical, and molecular genetic information. Fully revised to include recent advances in the field, this affordable resource by Dr. Eric D. Hsi is ideal for study and review as well as everyday clinical practice. A highly templated format that includes clinical, imaging, and management/prognostic features; pathologic features; ancillary studies; differential diagnosis; and selected bibliography. A focus on the specific features of various entities, including differential diagnoses. Clinical features, pathologic features, and key facts summarized in quick-reference boxes for fast retrieval of information. Hundreds of full-color photomicrographs and gross photographs depict important pathologic features, enabling you to form a differential diagnosis and compare your findings with actual cases. Contributions from internationally recognized pathologists, keeping you up to date with the latest information in the field. New information on the pathology of hematological disease and the latest World Health Organization update on classification of hematologic malignancies. New chapter on the essentials of hemostasis. Completely revised chapter on platelets. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Thanks to scientific advances, individuals with thalassemia--a group of genetic blood disorders which includes Cooley's Anemia -- are now living into their 40's and 50's. Not only are individuals living longer, but their quality of life has increased. Scientific and clinical advancements have resulted in new iron-chelating drugs, early detection of organ failure, an understanding of adult complications associated with living with thalassemia (osteoporosis, heart failure, growth hormone deficiency, pulmonary hypertension, and infertility) and promising progress towards the ultimate magic bullet--a cure in the form of bone marrow and cord blood transplants, or gene therapy.
This volume integrates basic science and clinical research so that both scientists and clinicians can develop a mutual understanding of recent progress in thalassemia.
NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.
This title includes a Book & DVD. About The DVD: The best-selling book "Arterial Blood Gas Analysis Made Easy" discussion and excerpts are now also available in a DVD movie format. Watch this 55 minute presentation by Dr Anup, MD and learn complex topics like ABG Report, Sa02, Pulse Oximetry, Pa02, PACO2, PaCO2, Fi02, Sp02, A-a Gradient, Ca02, pH, BE and much more. Understand these parameters and common pitfalls while interpreting them. The presentation narrative uses very simple, easy-to-understand language. The viewer will find that the difficult to understand topic of ABGs becomes interesting and easy. This DVD is a must for any new resident in Internal Medicine, Casualty and intensive care units (ICU) and will further facilitate and expedite learning of the blood gas report analysis. Approximate running time: 55 minutes. About The Book: Learn basics about how to read a blood gas report. What are the principle components, how they are derived and what is their significance? This includes pH, PaCO2, PCO2, PaO2, PAO2, FiO2, CaO2, A-a gradient, SaO2, HCO3, Pulse oximetry, Carbon-monoxide poisoning, Hyperbaric Chamber. This is section I of the book. Section II of the book is a work book approach where the doctor learns to interpret blood gases from the given report (emphasis is not to use the graph) in a step by step manner. One learns to interpret simple and mixed disorders including Respiratory Acidosis, Metabolic Acidosis, Anion gap and Non Anion Gap Acidosis, Respiratory Alkalosis, Metabolic Alkalosis, Chloride Responsive and Non-Responsive Alkalosis, Mixed Disorders and common mistakes made while interpreting a blood gas report and how to avoid them. Each disorder is separately explained. Section III further challenges the resident with over 200 exercises on blood gases. Section IV is the summary of the book.
Clinical laboratory directors and staff working with blood samples will benefit from the essential information in this hematology focused publication in Clinics in Laboratory Medicine. Leading a field of expert authors are two renown physicians in the field - Dr Carlo Brugnara and Dr Alexander Kratz. They present topics such as White Blood Cell Counts: Reference Methodology; Integration of Automated Heme and Bone Marrow Analysis; Red Cell Dynamics; Red Cell Diagnosis other than Anemia; Laboratory and Genetic Assessment of Iron Deficiency in Blood Donors; Body Fluid Cell Counting; Platelets: The Few, the Young, and the Active; Reticulocytes; Quality Control of Automated Cell Counters; Digital Image Analysis of Blood Cells; Blood Cell Counters in Urgent Care Settings; Novel Parameters in Blood Cell Counters; and the Development and Future of Automated Blood Cell Counters.
This issue of Hematology/Oncology Clinics of North America, guest edited by Drs. Bipin Savani and Mohamad Mohty, is devoted to Bone Marrow Transplantation. Articles in this issue include: Acute Myeloid Leukemia (AML); Acute Lymphoid Leukemia (ALL); Myelodysplastic Syndrome (AML); Myeloproliferative disorders (MPD); Chronic Lymphoid Leukemia; Chronic Myeloid Leukemia (CML); Multiple Myeloma and Amyloidosis; Non-Hodgkin Lymphoma (NHL); Hodgkin Lymphoma (HL); Severe Aplastic Anemia (SAA) and Paroxysmal Nocturnal Hemoglobinuria (PNH); Sickle Cell Anemia; Thalassemia; Benign immunodeficiency diseases; and Referral to transplant centers.
This book covers recent advances in the understanding and management of essential hematological pathologies. In addition to updates on Hodgkin's lymphoma, acute myeloid leukemia and other disorders, it provides essential information on transplant pathology, and the molecular and genetic aspects of hematological disorders. Offering a practical approach to lymphoma diagnosis, the book will help hematologists and pathologists alike make accurate diagnoses in keeping with the latest classifications and methodologies. A wealth of photographs and algorithms help readers understand the laboratory approach to the diagnosis of hematological disorders, reflecting the latest advances in the field. The book offers a valuable resource for residents of MD pathology, DM hematopathology and clinical hematology, as well as practitioners of hematology.
The fifth edition of this practical textbook on transfusion medicine has been thoroughly revised with the latest in scientific and technological developments and edited by a leading team of international expert haematologists, including new co-editor Mark H. Yazer MD. * A succinct and user-friendly resource of transfusion medicine for clinicians, scientists and trainees with key points, charts and algorithms * Discusses practice in blood centres and hospitals including regulatory aspects, transfusion safety, production and storage, donor care, and blood transfusion in a global context * Coverage of cellular and tissue therapies and organ transplantation including stem cell collection and haematopoietic stem cell processing and storage * Review of the development of the evidence-base for transfusion medicine * Content on the clinical practice for transfusion and alternatives to transfusion
This book comprehensively describes the physiological changes and consequences that occur in humans during spaceflight. It specifically presents the adaptations of the cardiovascular and the respiratory system. Specific changes occurring after 10, 20 or more days in space are depicted. Furthermore, the book explains various effective countermeasures that are required upon return of the astronauts to Earth. The book is a must-have for all biomedical and clinical researchers in the field of cardiovascular biology and respiration, and a fascinating reading for all interested laymen, who wish to understand a bit more about spaceflight research and technology.
This issue of Hematology/Oncology Clinics, guest edited by Dr. Elliott Vichinsky, is devoted to Sickle Cell Disease, and focuses on pathophysiology of hemoglobinopathies, therapeutic targets, and new approaches to correcting ineffective erythropoiesis and iron dysregulation. Articles in this issue include Polymerization and red cell membrane changes; Overview on reperfusion injury in the pathophysiology of SCD; Regulation of ineffective erythropoiesis in iron metabolism; Altering oxygen affinity; Cellular adhesion and the endothelium; Arginine therapy; Role of the hemostatic system on SCD pathophysiology and potential therapeutics; Adenosine signaling and novel therapies; New approaches to correcting ineffective erythropoiesis and iron dysregulation; New approaches to correcting ineffective erythropoiesis and iron dysregulation; Fetal hemoglobin induction; Gene therapy for hemoglobinopathies; and Oxidative injury and the role of antioxidant therapy.
This issue of Hematology/Oncology Clinics is focused on Hodgkin's Lymphoma and covers such topics as First HRS-cell line L428 and the detection of the CD-30 Antigen , "Normal" CD30-B-lymphocytes, CD-30-Antigen, Combination-Chemo-Radiotherapy, Early intensification (escBEACOPP), Customized/Targeted Therapy, and more.
Molecular pathology has significantly matured over the past decade to establish itself as a discipline in its own right. Patient diagnosis, prognosis, management and care have been influenced by molecular pathology testing algorithms on a global scale. Whether it pertains to carrier status of deleterious genes, diagnosis by molecular techniques, assessment of appropriate remission post treatment, parentage or forensics testing - molecular pathology continues to increase its presence and influence in the diagnostic laboratory armamentarium. Furthermore, intellectualization and proprietization of molecular pathology with respect to the discovery of new genes and or new techniques continues to pose new challenges of test ownership, legalities, liabilities, widespread acceptance and utility. This issue of Laboratory Clinics seeks to provide selective state of the art understanding of molecular pathology with respect to its relationship to key pathology disciplines as well as the current challenges and promise for the future
This issue focuses on Sarcoma in areas such as: Gastrointestinal Stromal Tumors: Risk assessment and adjuvant therapy, Gastrointestinal Stromal Tumors: Management of metastatic disease and emerging therapies, Liposarcoma, Leiomyosarcoma, Update in treatment and targets in cartilage and bone tumors, Update in treatment and targets in Ewing sarcoma, Angiosarcoma and Epithelioid Hemangioendothelioma, Emerging therapies for sarcoma, and Treatment of localized sarcomas.
Make sure you are thoroughly prepared to work in a clinical lab. Rodak's Hematology: Clinical Principles and Applications, 6th Edition uses hundreds of full-color photomicrographs to help you understand the essentials of hematology. This new edition shows how to accurately identify cells, simplifies hemostasis and thrombosis concepts, and covers normal hematopoiesis through diseases of erythroid, myeloid, lymphoid, and megakaryocytic origins. Easy to follow and understand, this book also covers key topics including: working in a hematology lab; complementary testing areas such as flow cytometry, cytogenetics, and molecular diagnostics; the parts and functions of the cell; and laboratory testing of blood cells and body fluid cells. UPDATED nearly 700 full-color illustrations and photomicrographs make it easier for you to visualize hematology concepts and show what you'll encounter in the lab, with images appearing near their mentions in the text to minimize flipping pages back and forth. UPDATED content throughout text reflects latest information on hematology. Instructions for lab procedures include sources of possible errors along with comments. Hematology instruments are described, compared, and contrasted. Case studies in each chapter provide opportunities to apply hematology concepts to real-life scenarios. Hematology/hemostasis reference ranges are listed on the inside front and back covers for quick reference. A bulleted summary makes it easy for you to review the important points in every chapter. Learning objectives begin each chapter and indicate what you should achieve, with review questions appearing at the end. A glossary of key terms makes it easy to find and learn definitions. NEW! Additional content on cell structure and receptors helps you learn to identify these organisms. NEW! New chapter on Introduction to Hematology Malignancies provides and overview of diagnostic technology and techniques used in the lab.
This issue, focusing on Breast Cancer, includes topics such as: Radiation Therapy for DCIS, Axillary dissection, Pathology in the age of personalized breast cancer treatment:, Clinical implications for breast cancer subsets defined by molecular diagnostics, Management of CNS Metastases in Breast Cancer, Endocrine therapy for advanced breast cancer, Targeting the PI3K pathway in breast cancer, Treating the Older Breast Cancer Patient, Adjuvant chemotherapy in the age of targeted treatment, and Novel radiotherapy approaches for early breast cancer
This issue of Hematology/Oncology Clinics is guest edited by Dr. A. Koneti Rao and focuses on Disorder of the Platelets. Article titles include: Mechanisms of Platelet Activation and Inhibition, Testing Platelet Function, Clinical Implications of Platelet Genomics and Proteomics, Congenital Thrombocytopenias, Immune Thrombocytopenias, Heparin Induced Thrombocytopenia, and Functional defects: Chronic granulomatous disease (CGD) and beyond
2014 BMA Medical Book Awards Highly Commended in Internal Medicine category! This textbook on haematology in the Illustrated Colour Text series is suitable for medical students, junior doctors and others needing a concise and practical introduction to the subject. Concise and manageable coverage of the major blood diseases and their treatment. Does not overload the reader with science, unlike some competing books. Focus is on the haematology patient and on the practical aspects of the subject. Makes use of the attractive features of the ICT series - double page spreads, lots of colour illustrations, summary boxes. Updating to take account of recenty developments in stem cell biology. Increased emphasis on genomic and proteomic techniques in the diagnosis of haematological malignancy. Use of new imaging techniques including MRI and PET. Description of advances in treatment of leukaemia and lymphoma and in diagnosis and management of patients with thrombophilia and venous thrombosis. Development of new antimicrobial agents in management of immunosuppressed patients with infection. New double page spread on palliative care of patients with blood disorders. New illustrations.
This issue of Hematology/Oncology Clinics is guest edited by Dr. Christoph Klein and focuses on the topic of Neutropenia. Article titles include: Homeostasis and migration of neutrophil granulocytes, Granulocyte-colony Stimulating Factor (G-CSF) receptor signaling, New Granulocyte-colony Stimulating Factor (G-CSF) Receptor Signaling Pathways, Neutrophil elastase (ELANE) - Genetics and Pathophysiology, Autosomal recessive variants of Severe congenital neutropenia (SCN), Leukocyte Adhesion Deficiency (LAD), and Genotype-phenotype correlations in Severe congenital neutropenia (S
This issue of Hematology/Oncology Clinics is edited by Dr. Jennifer Brown and focuses on Chronic Lymphocytic Leukemia. Article topics include: What Have Recent Genomic Advances Taught us About CLL?, Biology of CLL in Different Microenvironments, What is the Significance of Stereotyped BCRs in CLL?, Understanding Immunodeficiency in CLL, MBL vs CLL: How Important is the Distinction?, Risk Stratification of CLL in 2012, Minimal Residual Disease Measurement in CLL, The BTK Inhibitor PCI-32765 in CLL, and Evolving Role of Stem Cell Transplantation in CLL
This book highlights the importance of the choroid plexus, which forms the blood-cerebrospinal fluid barrier and is the site of the major production of the cerebrospinal fluid (CSF). The authors show that this barrier is crucial for maintaining important compositional differences between the blood plasma and the CSF. The choroid plexus epithelial cells also prevent the spread of infectious agents and other blood-borne entities to the brain tissue. Chapter topics range from the production of CSF by electrolyte regulation in the choroid plexus, to details on the selectively transporting nature of this barrier. Further, the authors elaborate on the important roles of CSF in sustaining brain health by providing hydration, solutes, and nutrients to the brain tissue. Readers will also learn how CSF circulates signaling molecules within the compartments of the brain and removes waste products from the brain tissue. Elucidating the regulation of these processes in the choroid plexus is not only important for the readers' understanding of normal brain development and function, but is also crucial for resolving a variety of cerebral challenges that lead to brain edema, as well as developing treatments for diseases. The book discusses disease models like hydrocephalus, sleep disorders, and age-related dementia. Its comprehensive coverage makes this volume a valuable resource for researchers in cell and neurophysiology, as well as graduate students of the neurosciences.
Congenital and Acquired Bone Marrow Failure is a comprehensive guide to congenital and acquired bone marrow failure in adult and pediatric patients. Chapters are divided into two sections, acquired aplastic anemia and inherited bone marrow failure syndromes. Content ranges from the basic, to the translational, and from the epidemiology of acquired aplastic anemia and telomere biology, to the management, treatment, and supportive care of pediatric, adult, and geriatric patients. Contributors are world leading experts in the field of bone marrow failure. The book is required reading for residents, fellows, clinicians, and researchers across hematology, oncology, pathology, bone marrow transplantation, pediatrics, and internal medicine.
Blood services and Transfusion Medicine have become more clinical, scientific, well organised and consolidated over the last 20 years. More is known about the frequency and aetiology of the hazards of blood transfusions. The ABC of Transfusion is a well established introduction for all staff working in blood services, blood transfusion departments, surgical units and intensive care, and all prescribers and users of blood. It is a comprehensive, highly regarded guide to all the practical aspects of blood transfusion, including the various complications that can arise. This fourth edition of ABC of Transfusion includes five new chapters on all the latest issues including pre-transfusion testing, vCJD, stem cell transplantation, immunotherapy, and appropriate use of blood - reflecting the fact that transfusion medicine has been revolutionised. Useful as a practical guide, a refresher or for quick reference, it covers all essential transfusion matters and is an ideal source of information for all health professionals involved with safe and efficient use of blood.
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