Your cart is empty
The first book on clinical guide to transplantation in lymphoma to present cutting edge knowledge on how to integrate, transplantation and novel therapies in patients with lymphoid malignancies * Provides practical management guidance on how to integrate, transplantation and novel therapies in patients with lymphoid malignancies * Covers an overview of transplantation in lymphoma, and management of the lymphoid malignancies * Discusses organizational aspects of transplant patients and managing a transplant program * Appendices provide practical quick-reference information on follow-up after autologous and allogenic stem cell transplantation in lymphoma
This volume provides a comprehensive and world-class review of the field of histiocytic neoplasms and hemophagocytic lymphohistiocytosis (HLH). It reviews all the advances in the field of histiocytoses during the last ten years, particularly with regards to the genomic findings in LCH and other histiocytic neoplasms and the new suggested classification of the histiocytic disorders. Additionally, it features a state-of-the art update on the most recent treatment strategies for LCH, including the results of the last LCH-III international trial, salvage therapies such as reduced-intensity conditioning (RIC) stem cell transplant (SCT), and targeted therapies with BRAF and MEK inhibitors, as well as the challenging cases of CNS-neurodegenerative LCH and its therapeutic perspectives. For primary and secondary HLH the book updates the most recent genetic and pathophysiological findings, including macrophage-activation syndrome (MAS), and includes a special chapter on HLH in adults. Treatment chapters encompass therapy for newly diagnosed HLH and refractory disease as well as stem-cell transplantation and novel therapies. The text also highlights the most recent advances in the treatment of the uncommon histiocytic disorders, such as Erdheim-Chester disease (ECD), Juvenile xanthogranuloma (JXG) and JXG-like conditions, Rosai-Dorfman disease (RDD), and the very rare malignant histiocytoses. Written by international experts in the field, Histiocytic Disorders is a valuable resource for clinicians, researchers, fellows and residents who are interested in or manage histiocytic disorders in children and adults.
For those preparing for certification or recertification in hematology or oncology, Hoffman and Abeloff's Hematology-Oncology Review is a single-volume source of authoritative, up-to-date exam preparation. This unique question and answer review helps you succeed on today's board exams with more than 1,000 board-style questions, answers, and rationales; comprehensive coverage of essential exam topics, and online practice tests. Includes 1,000+ board-style questions with answers and rationales explaining both correct and incorrect answers. Features three online practice tests per specialty that follow the ABIM exams blueprint, ensuring that complex content is delivered in easily digestible segments for more efficient review. Covers a broad range of topics compiled by experts in hematology and oncology, including cancer biology and genomics, immunotherapy, hematologic malignancies, solid tumor malignancies, non-malignant hematology, and supportive care. Uniquely designed as both a standalone review and a study companion to Abeloff's Clinical Oncology and Hematology: Basic Principles and Practice. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
This concise and practical resource brings together recent advances in identifying and managing anemia of chronic disease (inflammation), genetically related anemia and anemia related to chronic end organ damage. Chapters provide a detailed analysis of the current science of anemia, approaches to different patient populations, comorbid conditions and nutritional aspects of anemia. Novel therapies focused on physiological pathways are introduced and discussed. Controversies from the perspective of subspecialists focused in treating major causes of anemia within their specific disciplines are also presented. Easy-to-reference and authored by experts in each clinical scenario, Management of Anemia is the launching point for learning more about this challenging and common condition.
This book is a comprehensive guide to the diagnosis and treatment of blood and immunological disorders and cancer in foetuses and newborns. Divided into eight sections, the text begins with detailed discussion on foetal haematology, antenatal diagnosis of disorders, red blood cell disorders and anaemia in the newborn, and coagulation and platelet conditions. The following chapters cover foetal and neonatal malignancies and blood transfusion, followed by a final section on immunological disorders. Each topic explains new advances, all current treatment protocols, new drugs, and management approaches. Chapters are further enhanced by clinical images and tables. Key points Comprehensive guide to diagnosis and treatment of blood and immunological disorders and cancer in foetuses and newborns Presented in an easy to follow format, explaining new advances, treatment protocols, new drugs, and management approaches Includes discussion on neonatal malignancies and blood transfusion Highly illustrated with clinical images and tables
This volume describes up-to-date techniques used in understanding the molecular biology of acute myeloid leukemia (AML) and addressing advances in diagnosis, classification, prognostication, and therapeutic strategies to potentially impact overall patient survival. The chapters in this book cover topics such as: cytochemical staining, single-cell mass cytometry of AML and Leukemia stem/progenitor cells, microsphere-based assessment of DNA methylation for AML prognosis, a zebrafish model for evaluating the function of human leukemic gene IDH1 and its mutation, and the isolation of biologically active exosomes from plasma of patients with cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Acute Myeloid Leukemia: Methods and Protocols is a valuable resource for scientists and researchers to further their studies and advancements in the field of AML.
Accurate analysis of blood gases is vital to give information on a patient's respiratory and circulation state as well as the adequacy of resuscitation. This book guides the reader, with the help of clarifying cartoons, through the basic principles and a new and easy to grasp system of interpretation.
This book will provide an overview of how to manage patients with lymphoma in the format of a series of engaging case studies. Lymphomas are cancers that originate in the lymphatic system. There are two main types of lymphoma: Hodgkin lymphoma and non-Hodgkin lymphoma. These lymphomas comprise various subtypes with prognosis and treatment depending on the stage and type of the cancer. Lymphoma is a major global health problem; non-Hodgkin lymphoma in particular is the tenth most common type of cancer worldwide. In response to this there have been a number of significant advances in the available treatment options for lymphoma with new breakthrough drugs being approved or registered for approval. In light of this, this case study book will be an extremely timely guide for all hematologists, oncologists, and healthcare professionals wishing to keep up-to-date with these recent developments. The format of this book is also particularly appealing as it offer readers a practical approach to the clinical management of patients with these conditions as suggested by leading physicians from the City of Hope National Medical Center in California, USA in an era of vast therapeutic development.
Designed to help students develop the professional entry-level competencies they need for certification and career success, this 6th edition of Clinical Hematology strengthens the pedagogy that set the quality benchmark for hematology and includes the current, competency-based content needed by MLT and MLS students. In addition to state-of-the-art content, many, fully developed case studies with critical thinking discussion questions, and a strong emphasis on emerging molecular diagnostics and genomic medicine, the 6th edition encompasses the professional knowledge guidelines recommended by ASCLS Entry Level and Professional Body of Knowledge competencies in hematology, hemostasis and coagulation, and molecular applications. Throughout the text, a logical eight-part organization, clear explanations, and multiple learning tools help students master the theory underlying clinical hematology and the procedures used to diagnose and treat disorders of the blood and bone marrow. Expanded coverage of Next Generation Sequencing (NGS) in the Molecular Techniques chapter reflects the importance of molecular diagnostics and genomic medicine in today's medical laboratories. Numerous Clinical Case Studies with critical thinking group discussion questions link concepts and procedures to laboratory practice. Two dedicated chapters provide step-by-step procedure instructions, enabling students to confidently perform important clinical procedures. Learning Outcomes and Review questions - now identified as core and advanced content-clarify what MLT and MLS students should know upon successful completion of each chapter. More algorithms and other student desired visual learning formats (figures, tables and boxes) clarify key points. In-text learning aids (Learning Outcomes, Chapter Highlights and Review Questions) organized by major topic to facilitate concept mastery. A streamlined Phlebotomy chapter focuses on the newest content with additional information moved online for easy access. Bulleted Chapter Highlights facilitate quick review of each chapter's material. Key Terms italicized in the text and defined in the glossary help students master the vocabulary of hematology. Certification-style Review Questions help students assess their knowledge as they advance through each chapter. Updated full-color images offer a visual guide to the concepts and procedures presented in the text. Updated references reflect the latest research in the field.
This text is the only book of its kind to provide specific guidance applicable to limited resource settings and builds up from the foundation of general practitioner or general pediatrician competence. Written and edited by leaders in the field, this manual educates physicians on the essential components of the discipline, filtered through the experience of specialists from developing countries, with immediate applicability in the specific healthcare environment in these countries. Typically, manuals of pediatric hematology-oncology are written by specialists from high-income countries, and usually target an audience with a sub-specialist level of training, often assisted by cutting-edge diagnostic and treatment facilities. However, approximately 80% of new cases of cancer in children appear in mid- and low-income countries. Almost invariably, general practitioners or general pediatricians without special training in oncology will look after children with malignancies who enter the health care system in these countries. The diagnostic facilities are usually limited, as are the treatment options. The survival figures in these conditions are somewhere below 20%, while in high-income countries they are in the range of 80% for many childhood cancers. This book includes simplified therapy protocols, pain therapy and palliation, as well as ward procedures such as bone marrow aspiration/biopsies, intravenous therapy and chemotherapy drugs mixing. It provides an overview of pediatric cancer epidemiology, cancer registration and organizing support networks and features the management of cancers with associated pathology like AIDS, malnutrition, malaria and tuberculosis.
The HDL Handbook: Biological Functions and Clinical Implications, Third Edition, brings laboratory research in HDL from bench to bedside in a reference format for both researchers and clinicians studying cholesterol, lipids, epidemiology, biochemistry, molecular medicine, and pathophysiology of cardiovascular diseases. Information presented is valuable for the development of clinical trials with the aim of improvement of HDL-C levels and the prevention of cardiovascular events. Highlights of this new edition include the science underpinning HDL metabolism including information on HDL-C metabolism, gene expression, gene-bioactive compounds interaction, and post-translational modifications of gene expression of apo-lipoproteins.
This issue of Clinics in Laboratory Medicine entitled "Risk, Error and Uncertainty: Laboratory Quality Management in the Age of Metrology" will be guest edited by Sten Westgard, James Westgard, and David Armbruster. The issue will cover a broad range of topics related to management in the laboratory including but not limited to: Metrology Perspectives; Biologic Variation Approach to Daily Laboratory; Clinical Outcome Approach to Goal Setting; Six Sigma Quality Management System; Traceability and Comparability; MU, Risk, and Sigma-metrics at Sunway; and Quality Indicators for the Total Testing Process, among others.
This volume provides state-of-the-art techniques for studying various aspects of cholesterol homeostasis, including its uptake, synthesis and efflux from the cell, as well as its trafficking within the cell. Chapters also cover techniques for studying the regulation of cholesterol homeostasis at both the transcriptional and post-translational levels, as well as studying the membrane topology and structure of cholesterol-related proteins. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cholesterol Homeostasis: Methods and Protocols aims to provide key techniques in tackling the investigation of cholesterol homeostasis.
This issue of Primary Care: Clinics in Office Practice, guest edited by Drs. Maureen M. Okam and Aric Parnes, is devoted to Hematologic Diseases. Articles in this issue include: Anemia; Thrombocytopenia; Leukopenia and Pancytopenia; Leukocytosis and Leukemia; Polycythemia and Thrombocytosis; Eosinophilia; Thrombosis, Hypercoagulable States and Anticoagulants; Bleeding; Lymphoma; Plasma Cell Diseases; Transfusion Medicine; and Stem Cell Transplant.
Cyclic AMP was a major molecule of interest, which played an important role as second messenger, contributing to signal transduction in the regulation of cellular function by peptide hormones. Afterwards, calmodulin and protein kinase C were discovered as modulator proteins of intracellular calcium signaling in hormonal action. After that, manifold proteins and their related molecules were demonstrated to participate in novel signaling pathways related to various cytokines in different types of cells. The author of this book discovered a novel protein known as regucalcin, which suppresses manifold signaling pathways related to transcription activity. After subsequent studies, regucalcin has been established to play a pivotal role in maintaining cell homeostasis and protecting it from disorders in various types of cells and tissues. This book will provide information regarding regucalcin that plays a pivotal role in cell homeostasis and disorder. This book is composed of eighteen chapters. These chapters include the following content: the discovery of regucalcin (Chapter One); chemical property and structure of regucalcin (Chapter Two); the regucalcin gene and its translational regulation (Chapter Three); the role of regucalcin in intracellular calcium homeostasis (Chapter Four); the role of regucalcin in cell nuclear function (Chapter Five); the role of regucalcin in protein synthesis and proteolysis (Chapter Six); the suppressive role of regucalcin in cell proliferation (Chapter Seven); how regucalcin protects apoptotic cell death (Chapter Eight); the protective role of regucalcin in oxidative stress (Chapter Nine); the involvement of regucalcin in liver metabolic disorder (Chapter Ten); the role of regucalcin in kidney cell homeostasis: involvement in renal failure (Chapter Eleven); the role of regucalcin in heart calcium signaling: insight into cardiac disorder (Chapter Twelve); the role of regucalcin in brain calcium homeostasis: disorder with aging (Chapter Thirteen); the role of regucalcin in bone homeostasis and osteoporosis (Chapter Fourteen); the role of regucalcin in lipid metabolism and diabetes (Chapter Fifteen); the role of regucalcin as a suppressor protein in carcinogenesis (Chapter Sixteen); the clinical aspects of regucalcin as a biomarker for disease (Chapter Seventeen); and conclusive remarks (Chapter Eighteen). This book will provide information regarding regucalcin and its pivotal role in cell homeostasis and disorder.
Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. A full-color clinical reference covering both common and uncommon blood disorders - referenced to the world's leading hematology text Williams Manual of Hematology, Ninth Edition provides a quick-access summary of the epidemiology, etiology, pathogenesis, diagnostic criteria, differential diagnosis, and therapy of blood cell and coagulation protein disorders. The 93 chapters of the Manual are a distillation of the disease- and therapy-focused chapters from the Ninth Edition of Williams Hematology. The book has been carefully edited to deliver only the most clinical point-of-care facts, making differential diagnosis faster, easier, and more efficient. Concise but comprehensive, this complete guide includes sections on: * Initial Clinical Evaluation * Disorders of Red Cells * Disorders of Granulocytes * Disorders of Monocytes and Macrophages * Principles of Therapy for Neoplastic Hematological Disorders * The Clonal Myeloid Disorders * The Polyclonal Lymphoid Diseases * The Clonal Lymphoid and Plasma Cell Diseases * Disorders of Platelet and Hemostasis * Disorders of Coagulation Proteins * Thrombosis and Antithrombotic Therapy * Transfusion and Hemapheresis
Hematology is the study of blood, its chemistry, and components. The most common blood test is a complete blood count (CBC). This test determines the number and type of white and red blood cells circulating in the bloodstream. It is most often used to check for signs of inflammation or infection (revealed by changes in the number and appearance of different kinds of white blood cells). Determining the number, size, and hemoglobin content of red blood cells helps identify disorders such as anemia. Platelets are also examined during a CBC; changes in platelets can help identify blood clotting disorders. If a pet has a specific problem at the time of the examination, the veterinarian may perform additional tests that are not generally part of a routine physical examination. For example, examination of a dog with suspected vision problems might include tests that assess overall vision, examination with an ophthalmoscope and various stains, and determination of the pressure within the eye (intraocular pressure). Similarly, examination of a lame horse might include a hands-on examination of the affected leg, blood and biochemical tests, muscle biopsy, and various types of imaging techniques. Hematology techniques are important for the general and emergency care of animals and should be a commonly utilized tool for veterinary technicians. The field of hematology involves the study of normal and diseased conditions related to the blood. One of the primary techniques used to study the blood is histology, which involves studying the microscopic anatomy of the cells in the blood to determine their relative abundance, phenotype and function. Histology is a major focus of this book, although other techniques are discussed. Along with general overviews of histology and histopathology, numerous examples are provided regarding specific diseases and their diagnosis using hematology. Some of the diseases, conditions and treatments discussed in this book include Monensin Toxicosis infection, Kidney ischaemia reperfusion injury, hormone replacement therapies, endosulfan, tadalafil and ochratoxin-A therapies, hepatitis, burns and cancer which is discussed in detail. Along with veterinary technicians, animal owners and other veterinary professionals may gain insights into hematology through reviewing this material.
Lanzkowsky's Manual of Pediatric Hematology and Oncology, Sixth Edition, is a comprehensive book on patient management, replete with algorithms and flow diagrams on diagnosis and management. Reflecting the considerable advances in the treatment and management of hematologic and oncologic diseases in children, the sixth edition of this successful clinical manual has been entirely updated to incorporate all current treatment protocols, new drugs, and management approaches. Its concise and easy-to-read format will enable readers to make accurate diagnoses and permit them to treat patients without having to reference larger medical textbooks. Based on the new standards of genetic classification and prognostic information that have arisen in the past five years, the sixth edition includes two new chapters (Diagnostic, Molecular, and Genomic Methodologies for the Hematologist, Transfusion Medicine) and several new expanded chapters that were previously sections in consolidated chapters (Myelodysplasia, Myeloid Leukemias, Lymphoid Leukemias, Hemolytic Anemia, and Disorders of Coagulation).
The subject matter of volume 1 of the 2-volumes-handbook focusses on leiomyosarcoma, low-grade and high-grade endometrial sarcoma and undifferentiated uterine sarcoma of the whole female genitalia. A separate extensive chapter is devoted to the variants of leiomyoma (angio-, lipo-, cotyledonoid, cellular, mitotically active, epithelioid and myxoid leiomyoma, leiomyoma with bizarre nuclei), atypical smooth muscle tumors (smooth muscle tumors with uncertain malignant potential), and disseminated peritoneal leiomyomatosis, benign metastasizing leiomyoma, and intravenous leiomyomatosis. Furthermore, endometrial stromal tumors - endometrial stromal nodules, endometrial stromal tumor with sex cord-like elements (ESTSCLE), uterine tumor resembling ovarian sex-cord tumor (UTROSCT) - and similar tumors are described in detail. The book provides a description at length of the epidemiology, etiology, pathological anatomy, prognosis, diagnosis, differential diagnosis, imaging and comprehensive therapy of each primary, relapsed, and metastasized tumor including surgery, chemo-, hormone- and radio- and targeted therapy. Another chapter is devoted to the prevention of subjecting sarcomas to inadequate surgical therapeutic measures under the assumed diagnosis of leiomyoma, and includes a diagnostic-therapeutic flowchart with a diagnostic score. The book aims to identify and provide diagnostic and therapeutic guidance. The listed tumor entities also constitute a particular diagnostic challenge for pathologists that contains numerous pitfalls and difficulties. This book, therefore, addresses gynecologists and pathologists in both clinical and private practice, but also surgeons and hemato-oncologists.
This volume is a collection of immunohematology and transfusion medicine cases, comprised of clinical vignettes and antibody panels with questions based on each case, arranged in a workbook format. The cases are based on real patient problems which are typically encountered and covers a number of common issues and challenging problems in blood banking and transfusion practice. Discussion and resolution of each case is provided in a separate answer section, including up-to-date information on pertinent advances in the field. Written by experts in the field, Immunohematology and Transfusion Medicine: A Case Study Approach provides an interactive tool to help make blood banking and transfusion medicine memorable, practical, and relevant to residents and fellows.
You may like...
Marcus Hentrich, Stefan K. Barta Hardcover R4,496 Discovery Miles 44 960
Immunophenotyping for Haematologists…
Barbara J. Bain, Mike Leach Hardcover R2,271 Discovery Miles 22 710
Medical and Surgical Complications of…
Ahmed Al-Salem Hardcover R3,890 Discovery Miles 38 900
Multiple Myeloma and Other Plasma Cell…
Meletios A. Dimopoulos, Thierry Facon, … Hardcover R3,758 Discovery Miles 37 580
Yoji Ishida, Yoshiaki Tomiyama Hardcover R4,791 Discovery Miles 47 910
Hematopathology - Advances in…
Renu Saxena, Hara Prasad Pati Paperback R2,603 Discovery Miles 26 030
Light Chain Amyloidosis - Special Topic…
Morie Gertz, Iuliana Vaxman Paperback R751 Discovery Miles 7 510
Blood - An Epic History of Medicine and…
Douglas Starr Paperback R419 Discovery Miles 4 190
Hoffbrand's Essential Haematology
A. Victor Hoffbrand, David P. Steensma Paperback R1,310 Discovery Miles 13 100
Gastrointestinal Bleeding - A Practical…
Aurora D. Pryor, Theodore N. Pappas, … Hardcover R3,857 Discovery Miles 38 570