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First published in 1991. Routledge is an imprint of Taylor & Francis, an informa company.
There is no clearer testament to the importance and efficacy of in vitro fertilization in the treatmentof the infertilepatient than the fact that over one million babies have been born since its clinical introduction in 1978. The successof this worldwideendeavorhas evolvedto treat some of the formerly most intractable forms of infertility and requires individuals with different skills and insights whose activities are often compartmentalized into clinical, laboratory and research functions. The intent of Essential lVF is to present current issues in clinical IVF that encompass the varied activities of those engaged in this enterprise. By integrating clinical, basic research and laboratory-related aspects of human reproduction, readers with diverse interests should obtain a more complete understanding of the impact, importance and inter-relatedness of each in the progress of infertility treatment, and an appreciation of whether emerging technologies will or should contribute to this progress in the near future. The topics selected for this volume include research that has begun to explain the origins of differential follicular, gamete, embryo and uterine competence, and specific laboratory procedures and protocols that may have important clinical implications forthe generation ofdevelopmentally viable embryos. Human embryoresearchoverthe past 25 years has notonly confirmed that the developmental potential of each embryo is unique, but more importantly, demonstrated how genetic and nongenetic factors for sperm and oocyte determineembryo competencewell before fertilization. Several chapters deal with the origins of normal and compromised gametes and how those with high competence can be identified and isolated for fertilization.
For anyone struggling to conceive or have a child naturally, this straightforward self-help book could be the answer. Written in an easy-to-read style by consultant gynaecologist and obstetrician, Dr. Sean Watermeyer, the aim of the book is to enrich the knowledge of both individuals and couples so that the dream of having a child becomes a reality. Dr. Watermeyer has been helping couples to conceive, carry and deliver babies for over a decade, and now wants to share his expertise with as many people as possible. This comprehensive book explores the causes of infertility and miscarriage, available investigations and options and potential benefits, risks, and outcomes. It also provides a step-by-step guide to IVF. Filled with insightful detail, clinical case studies and clear diagrams, this book will also be a valuable tool for health professionals supporting couples experiencing fertility problems.
The second edition of this comprehensive reference provides practitioners with the latest advances in the use of ultrasound for diagnosis and management of subfertility. Divided into thirteen chapters, the book begins with an introduction to the principles and applications of ultrasound, and examination techniques and in pelvic assessment. The next sections cover the use of ultrasound for the diagnosis of different gynaecological conditions that may affect fertility, followed by ultrasound-guided procedures in assisted reproduction and potential complications. The text concludes with chapters on ultrasound in male infertility, and three-dimensional ultrasound in subfertility. Edited by recognised experts in the field, the text is further enhanced by more than 400 ultrasound images and is accompanied by an interactive DVD ROM providing video clips for each clinical scenario described in the book. Key points Second edition presenting latest advances in use of ultrasound in subfertility Includes DVD ROM of video clips demonstrating clinical scenarios Internationally recognised editor team Previous edition (9789351520108) published in 2014
Due to the paucity of reviews on this subject, this volume aims to be timely and promote additional basic and translational research on these proteins in reproductive system development and function within the fields of Anatomy, Embryology and Cell Biology. The breadth of the work being conducted within Reproduction is exemplified by the contributors to this series who will provide reviews on: Grp78 roles in female reproduction, small heat shock proteins/co-chaperones as players in uterine smooth muscle function, the role of heat shock proteins in sperm function and maternal contribution to oogenesis and early embryogenesis, heat shock factors and testes development, HSP90 in ovarian biology and pathology, and the role of HSP70 in regulation of autophagy in pregnancy and parturition.
"Evaluation and Management of Cleft Lip and Palate: A Developmental Perspective" provides fundamental knowledge of cleft palate anomalies and the current state of evidence-based practice relative to evaluation and management. This text contains information on the standard of care for children born with craniofacial anomalies from a developmental perspective along with clinical case studies to help facilitate understanding of the material.This book features:*A developmental focus that provides a better understanding of the nature of craniofacial problems and the timetable for management and treatment.*A focus on information needed by the school-based SLP.*An emphasis on oral conditions (dental and occlusal) that impact speech in the school-aged child.*A blend of scholarly and clinical information.This is a graduate level text that targets speech-language pathology students, as well as audiology students, medical students, and graduate students studying communication disorders.
This manual is a comprehensive guide to Assisted Reproductive Technologies (ART) and Clinical Embryology. Beginning with an introduction to ART, the book discusses embryology and provides a step by step description of different types of ART. With contributions from international experts, this book includes a DVD illustrating different laboratory and cryobiology protocols. A section on the challenges of ART and possible problems that may be encountered is also included.
The new edition of this infertility manual has been fully revised to provide clinicians with the latest advances in the diagnosis and management of infertility. Divided into seven sections, the book provides step by step guidance on each stage of the process, from initial examination and identifying the causes of infertility in both females and males, to ovarian stimulation and assisted reproduction techniques. The final section is dedicated to laboratory management covering topics such as follicular fluid screening and oocyte assessment, culture systems, and cryopreservation. The fourth edition includes new chapters on molecular mechanisms such as endometrial receptivity, and implantation; and current trends such as the embryoscope and assisted hatching. The comprehensive text is further enhanced by case studies, clinical photographs, diagrams, flowcharts and tables. Key points Fully revised, new edition providing latest advances in diagnosis and management of infertility Fourth edition features new chapters on molecular mechanisms and current trends Highly illustrated with clinical images, flowcharts and tables Previous edition (9788184486179) published in 2009
This is the 1st edition of the book Handbook on Managing Infertility (Meeting the Challenges in Low-Resource Settings). The text is comprehensive, updated as per the present day requirements in the subject of infertility. In this edition of the book an effort is made to highlight the special problems and hurdles to provide infertility treatment in low resource setups. The book has 26 chapters. The first chapter deals with history of human assisted reproductive technology. Chapter two provides a comprehensive description of infertility in developing world. Next four chapters are dedicated to ART unit in low resource setting. Chapters from 9 to 12 deal with different conditions associated with infertility. Subsequent chapters describe setting up of ART unit, assisted reproductive technology and law and ethics related to ART. A comprehensive index is given at last.
Already established as a classic comprehensive reference for the whole team at the IVF clinic, this new edition has been extensively revised, with the addition of several important new contributions on laboratory ( including advanced sperm selection techniques for ICSI, human embryo biopsy procedures, oocyte activation, managing an oocyte bank, artificial gametes, and epigenetics) as well as on clinical topics (including GnRH agonist triggering, segmentation of IVF treatment, uterus transplantation, and risk and safety management). As previously, methods, protocols, and techniques of choice are presented by eminent contributors internationally.
This volume provides key molecular biological protocols and experimental strategies currently employed to study the various stages of mammary gland development. Chapters are divided into four parts covering genetically modified mouse models that exhibit prenatal and pubertal mammary gland phenotypes, 2D and 3D-model culture systems, methodologies for mammary stem cell isolation, and translational applications that provide a bridge between experimental studies of mammary gland development and the study of human breast cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mammary Gland Development: Methods and Protocols will be useful for researchers whose primary interest is in mammary gland development; developmental biologists, epithelial cell biologists, and those with an interest in molecular mechanisms underlying breast cancer.
Long regarded as biological waste, the placenta is gaining momentum as a viable product for clinical use. Due to their unique properties, placental cells and derivatives show great promise in curing various diseases. Utilizing contributions from world-renowned experts, Placenta: The Tree of Life considers the therapeutic potential of these cells. It examines new stem cell-based strategies and highlights recent studies that advance the range of treatment for a number of illnesses. Emphasizing the potential research and therapeutic use of stem cells, the book discusses the development, structure, and functions of the human placenta. It introduces overall aspects of the immune system, explains some of the immune mechanisms during pregnancy, and shows the role of the placenta in these mechanisms. Current scientific research is presented that focuses on the mechanisms of action underlying the therapeutic benefit of cells isolated from different placental regions. An exhaustive examination, this pivotal work: Considers how perinatal cells may represent an important source for cell therapy approaches in the near future, in both human and veterinary medicine Describes the clinical potential of placenta-derived cells in regenerative medicine-specifically in neurological disorders, metabolic liver diseases, inflammatory diseases, and autoimmune diseases Explains how cells isolated from different placental tissues share basic properties Placenta: The Tree of Life summarizes the advantages of perinatal tissue as a source of cells with therapeutic potential and is designed for use in the study of genetics, stem cell science, placental function, reproductive biology, regenerative medicine, and related fields.
The new edition of this well-known text brings undergraduates fully up to date with the latest information on human embryology. Beginning with an overview of genetics, the female reproductive system, fertilisation, and early development of the embryo, the following sections each examine the development of a different embryonic system. The genetic and molecular aspects of each system are presented in tabular format and clinical correlations are highlighted in separate boxes to enhance learning. The eleventh edition features new chapters on genetics and molecular biology, the skeletal and muscular system, clinical applications, and embryology ready reckoner. The text is highly illustrated with clinical photographs and tables and each chapter includes case scenarios and review questions for self-assessment. Key points Fully revised, new edition presenting undergraduates with the latest information on human embryology Eleventh edition includes several new chapters Features case scenarios and review questions for self-assessment Previous edition (9789351521181) published in 2014
This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology. Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.
This is an up-to-date evidence-based textbook for junior
obstetricians and gynaecologists. It contains all the material
relevant to everyday practice and the new RCOG curriculum. It has
been written and edited by inspiring teams that combine juniors,
new and established consultants working in a range of settings and
many of the UK's top experts in obstetrics and gynaecology.
Making a Good Life takes a timely look at the ideas and values that inform how people think about reproduction and assisted reproductive technologies. In an era of heightened scrutiny about parenting and reproduction, fears about environmental degradation, and the rise of the biotechnology industry, Katharine Dow delves into the reproductive ethics of those who do not have a personal stake in assisted reproductive technologies, but who are building lives inspired and influenced by environmentalism and concerns about the natural world's future. Moving away from experiences of infertility treatments tied to the clinic and laboratory, Dow instead explores reproduction and assisted reproductive technologies as topics of public concern and debate, and she examines how people living in a coastal village in rural Scotland make ethical decisions and judgments about these matters. In particular, Dow engages with people's ideas about nature and naturalness, and how these relate to views about parenting and building stable environments for future generations. Taking into account the ways daily responsibilities and commitments are balanced with moral values, Dow suggests there is still much to uncover about reproductive ethics. Analyzing how ideas about reproduction intersect with wider ethical struggles, Making a Good Life offers a new approach to researching, thinking, and writing about nature, ethics, and reproduction.
Compiled by two experts in Reproductive Medicine, with contributions from internationally respected specialists, this innovative text lets the whole team in Reproductive Medicine get literally on the same page. Taking a cook-book approach to the operational procedures in the laboratory and in the clinic, it details what needs to be prepared in advance, what needs to be prepared earlier the same day, and what steps to take before, during, and after the procedure itself. This is an essential tool for ensuring all staff - whether experienced or starters - can be confident in their tasks and are in touch with what is expected of them and their colleagues.
This book delineates how systems biology, pharmacogenomic, and behavioral approaches, as applied to neurodevelopmental toxicology, provide a structure to arrange information in a biological model. The text reviews and discusses approaches that can be used as effective tools to dissect mechanisms underlying pharmacological and toxicological phenomena associated with the exposure to drugs or environmental toxicants during development. The book intends to elaborate functional outcomes of component-to-component relationships using rodent and nonhuman primate in vitro and in vivo models that allow for the directional and quantitative description of the complete organism in response to environmental perturbations. In addition, attention has also been directed to some of the more recent methodologies, including genomics, proteomics and metabolomics, applied in the evolutionary neurobiological field.
This book focuses on four of the hallmarks of aging: aspartic acid racemization, advanced glycation end products, telomere shortening and mitochondrial mutations; describing their role in aging and diseases; and their application to age-at-death estimation in forensic sciences in greater depth, displaying the interconnecting pathways among these processes. An additional chapter related to Epigenetics and its role in aging, diseases, and forensic age estimation is also included. This book is aimed at a broad audience: from students being introduced to aging, diseases, and forensic science research to scientists in biomedicine and forensics complementing their knowledge in their respective fields while also increasing their knowledge in other disciplines.
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