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An ideal reference for infertility specialists and reproductive endocrinologists alike, this comprehensive text discusses current natural and mild approaches to in vitro fertilization (IVF) and the development of in vitro maturation (IVM) as a clinical treatment. It is divided thematically into four sections. Part I presents the basic science of ovarian endocrinology and the mechanism of oocyte maturation, including follicular development and the importance of mitochondrial changes. The differences between natural cycle IVF and stimulated IVF are presented in part II, including the standard ovarian stimulation protocols and their outcomes and the etiology, prevention and management of ovarian hyperstimulation syndrome (OHSS). Minimal and mild stimulation for IVF is discussed in part III, including mild stimulation protocols for oncofertility patients and the new minimally invasive INVO procedure. In vitro maturation as a clinical treatment is the subject of part IV, discussing the methodology of immature oocyte retrieval as well as other laboratory aspects and congenital and obstetrical outcomes of babies born from IVM. Combining expertise from thought leaders around the world, Development of In Vitro Maturation for Human Oocytes will be a go-to resource for infertility researchers and practitioners and reproductive endocrinologists working with infertile couples looking for safer and more cost-effective options for treatment.
The ready availability of donated sperm and eggs has made possible an entirely new form of family. Children of the same donor and their families, with the help of the internet, can now locate each other and make contact. Sometimes this network of families form meaningful connections that blossom into longstanding groups, and close friendships. This book is about unprecedented families that have grown up at the intersection of new reproductive technologies, social media and the human desire for belonging. Random Families asks: Do shared genes make you a family? What do couples do when they discover that their children shares half their DNA with a dozen or more other offspring from the same sperm donor? What do kids find in common with their donor siblings? What becomes of these chance networks once parents and donor siblings find one another? Based on over 350 interviews with children (ages 10-28) and their parents from all over the U.S., Random Families chronicles the chain of choices that couples and single mothers make from what donor to use to how to participate (or not) in donor sibling networks. Children reveal their understanding of a donor, the donor's spot on the family tree and the meaning of their donor siblings. Through rich first-person accounts of network membership, the book illustrates how these extraordinary relationships-woven from bits of online information and shared genetic ties- are transformed into new possibilities for kinship. Random Families offers down-to-earth stories from real families to highlight just how truly distinctive these contemporary new forms of family are.
Part of the Infertility Management Series, this book is a concise guide to the diagnosis and management of polycystic ovary syndrome (PCOS), caused by an imbalance of hormones in women, often leading to infertility if untreated. Beginning with an overview of prevalence, symptoms, genetics and physiology, the following sections examine different treatment options, from lifestyle management, to ovulation induction and surgical management. The final chapters discuss ART in women with PCOS, identification and treatment of ovarian hyper stimulation syndrome, and long term effects and metabolic syndrome. Edited by recognised experts in the field, the book is enhanced by clinical images and figures. Other titles in the Infertility Management Series include: Practical Management of Male Infertility, Intrauterine Insemination, and Investigating Infertility. Key Points Practical guide to diagnosis and management of PCOS Part of Infertility Management Series Covers all treatment methods, from lifestyle management, to surgical procedures Edited by recognised experts in the field
As a biological, cultural, and social entity, the human fetus is a multifaceted subject which calls for equally diverse perspectives to fully understand. The Anthropology of the Fetus seeks to achieve this by bringing together specialists in biological anthropology, archaeology, and cultural anthropology. Contributors draw on research in prehistoric, historic, and contemporary sites in Europe, Asia, North Africa, and North America to explore the biological and cultural phenomenon of the fetus, raising methodological and theoretical concerns with the ultimate goal of developing a holistic anthropology of the fetus.
The U.S. population is getting older, and Americans are living longer, on average, than they ever have before. As they age, people are healthier and more active than the generations before them and have fewer functional limitations such as difficulty walking or blindness. Studies show that people are happier on average as they advance into their later decades and enjoy high levels of accumulated knowledge and experience. Getting older is a time of social, emotional, mental, and physical change. Retirement might change how a person interacts socially every day, affecting a persons mood and well-being. Cognitive aging--the normal process of cognitive change as a person gets older--can begin, or a permanent change in physical function may arise. Technology offers a path for people who are navigating these changes potentially to prevent or minimise the risks associated with them and to enhance peoples ability to live their lives fully. The Presidents Council of Advisors on Science and Technology (PCAST), seeks to identify technologies and policies that will maximise the independence, productivity, and engagement of Americans in their later years. This book focuses on four key changes older Americans often experience: hearing loss; loss of social engagement and connectivity; cognitive change; and physical change.
One of the most challenging issues of the 21st century is the impending separation of sex (in bed) and reproduction (under the microscope) as a result of recent advances in contraception and assisted reproduction. Many of the ethical and societal issues associated with these new reproductive technologies, notably intracytoplasmic sperm injection (ICSI), are raised in an unusual format -- namely in dialogic form -- which is both entertaining and pedagogically informative.
Comprehension of the theories of aging requires rudimentary knowledge of oxidation and reduction reactions, protein function, cell organelles, mitosis, acquired immunity, and evolution, among other basic biological concepts. Without these fundamentals, students of biological aging struggle to learn the essentials of biological aging and how to appreciate the research advances in the field. Human Biological Aging: From Macromolecules To Organ-Systems is an introduction to human aging from the level of macromolecules to organ systems. Age changes in proteins, DNA, polysaccharides and lipids are discussed relative to known age-related alterations in structure and function produced by free radicals and oxidants. At the cellular level, age-dependent mechanisms that diminish organelle function are described. Cellular phenomena of replicative senescence apoptosis, autophagy and neuroplasticity are detailed as to their contribution to compromised cellular functions. Authored by a leader in the field, Human Biological Aging: From Macromolecules To Organ-Systems is an invaluable introduction for those studying human aging.
The Cassell Hospital Monograph Series, No. 1. The first in a series of monographs, intended to present accessible teaching material concerned with the practice of residential care.
Infertility is a widespread medical condition. As new technologies emerge, the rate at which our understanding of reproductive medicine grows can be overwhelming. The Biennial Review of Infertility provides the most up to date advances, ideas, and controversies together in one volume. Due to the distinctive nature of infertility, a panel of well-respected experts strives to present each chapter in a clear manner, specifically focused on evidence-based medicine. The Biennial Review of Infertility presents a balanced view of clinically relevant existing information for the evolving areas. Created to provide an ongoing appraisal of current knowledge, the Biennial Review of Infertility motivates communication amongst all those working to help couples resolve their infertility.
This book provides up-to-date research on the prevalence, risk factors and outcomes of recurrent pregnancy loss. Chapter One discusses immunopathogenetic aspects of recurrent miscarriages with infectious genesis. Chapter Two examines abnormal endometrial decidualisation in endocrine disorders associated with early recurrent pregnancy loss. Chapter Three focuses on the significance of the determination of antibodies to different phospholipids and some genetic factors for thrombophilia in patients with systemic lupus erythematosus. Chapter Four explains immunorehabilitation in miscarriages of pregnancies.
Bringing together the latest information on the organization, management and quality of in-vitro fertilization (IVF) units, this is the first true field guide for the clinician working in assisted reproductive technologies (ART). Divided thematically into four main sections, part one discussed the establishment and organization of the IVF unit, including location, design and construction, practical considerations for batching IVF cycles, and regulations and risk management. Part two, the largest section, covers the many aspects of overall quality management and its implementation - staff and patient management, cryobank and PGD/PGS management, and data management - as well as optimization of treatment outcomes and statistical process control analysis to assess quality variation. Part three addresses the relationship between IVF units and society at large, including the ethics of IVF treatment, as well as public/low-cost and private/corporate IVF units. Advertising and marketing for IVF units is discussed in part four, including the building and managing of websites and the use of traditional print and social media. With approximately five thousand IVF units worldwide and a growing number of training programs, Organization and Management of IVF Units is a key resource for clinic directors, unit managers, embryologists, quality experts, and students of reproductive medicine and clinical embryology.
The average physician and even cancer care-givers are not knowledgeable about the effects of cancer treatment on sex and reproductive life. They are even less aware of the options available for treatment of such patients. Cancer and Sexual Health fills a great need for a reference work devoted to the link between cancer and human sexuality. The volume is designed to give a comprehensive and state-of-the-art review of the sexual and reproductive consequences of cancer diagnosis and treatment. It will prove an invaluable resource for those clinicians caring for cancer patients as well as acting as a reference text for the sexual medicine clinician who may not see a large number of cancer patients.
This concise and practical book is the first of its kind to examine the use of assisted reproductive technologies (ART) in relation to blood-borne infectious diseases: human immunodeficiency virus (HIV), hepatitis B (HBV) and hepatitis C (HCV). The book opens with a discussion of the impact of these viruses on male and female fertility, followed by specific chapters of each of them, including ART with HIV and HCV serodiscordant couples (where either the male or female is positive) and the detection and impact of HBV and HCV in human gametes and embryos. An important character on laboratory safety when performing ART with blood-borne viruses follows, and the book concludes with a discussion of ART in austere and resource-poor settings, where these infections are often dominant due to lack of treatment and access to vaccines. Written and edited by an international array of experts in reproductive medicine, Assisted Reproductive Technologies and Infectious Diseases explores questions, techniques, and related issues with the aim of effectively helping clinicians working with serodiscordant couples wishing to have children.
Intimate and medicalized, natural and technological, reproduction poses some of the most challenging ethical dilemmas of our time. Reproduction presses the boundaries of humanity and ethical respect, the permissible limits of technology, conscientious objection by health care professionals, and social justice. This volume brings together scholars from multiple perspectives to address both traditional and novel questions about the rights and responsibilities of human reproducers, their caregivers, and the societies in which they live. Among issues treated in the volume are what it is to be a parent, the responsibilities of parents, and the role of society in facilitating or discouraging parenting. May gamete donors be anonymous? Is surrogacy in which a woman gestates a child for others ethically permissible when efforts are made to prevent coercion or exploitation? Should it be mandatory to screen newborns for potentially serious conditions, or permissible to sequence their genomes? Are both parties to a reproductive act equally responsible to support the child, even if one deceived the other? Are there ethical asymmetries between male and female parents, and is the lack of available contraceptives for men unjust? Should the costs of infertility treatment be socially shared, as they are for other forms of health care? Do parents have a duty to try to conceive children under the best circumstances they can - or to avoid conception if the child will suffer? What is the status of the fetus and what ethical limits constrain the use of fetal tissue? Reproduction is a rapidly changing medical field, with novel developments such as mitochondrial transfer or uterine transplantation occurring regularly. And there are emerging natural challenges, too, like the Zika virus. The volume gives readers tools not only to address the problems we now know, but ones that may emerge in the future as well.
Rationalization is concerned with making the most effective use of the resources available. In many places where this process is taking place it is plagued with public opposition and misunderstanding. Hitherto rationalization in the acute care sector has primarily been concerned with closing sites closing beds moving beds between services and moving beds from one site to another. This book discusses the need for rationalization in the context of health service reforms and future strategy. It considers recent changes in the health service the case for rationalization health care needs the role of public relations the future of the acute care hospital site and facilities appraisal and the costs of rationalization. The text is essential reading for managers and clinicians involved in acute care services non-executive members of boards and trusts and students of health services management.
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