Your cart is empty
Create delicious dishes that friends and family will enjoy and let everyone in on the secret - Surprise! It's Gluten-free! No matter whether you have a gluten sensitivity, perhaps live with someone who is coeliac, or just want to give cutting out gluten a go, you'll love these recipes -there are more than 100 for you to try, covering breakfast, lunch, dinner, and dessert. Enjoy tasty homemade dishes, such as a classic lasagne or fish and chip supper, and treat yourself and your family and friends to donuts, tarts, cupcakes, and more. So, if you're fed up with turning down your favourite foods, give Surprise! It's Gluten-free! a go - you really can bake your cake and eat it, too.
Cancer Immunology is intended as an up-to-date, clinically relevant review of cancer immunology and immunotherapy. This volume focuses on the immunopathology and immunotherapy of organ cancers in detail. It clearly explains their immunology and describes novel immunotherapy for specific cancers, including pediatric solid tumors, hematologic malignancies, gastrointestinal tumors, skin cancers, bone and connective tissue tumors, central nervous system tumors, lung cancers, genitourinary tract tumors and breast cancers. In so doing, it builds on the previous two volumes in Cancer Immunology, placing basic knowledge on tumor immunology and immunotherapy into a clinical perspective with the aim of educating clinicians on advances in cancer immunology and the most recent approaches in the immunotherapy of various tumors. This translational, clinically oriented book will be of special value to clinical immunologists, hematologists and oncologists.
Primary immunodeficiency diseases (PIDs) are a heterogeneous group of inherited disorders characterized by different defects in the development and function of the immune system. These defects render patients susceptible to a variety of infectious diseases. Knowledge of normal immunity and specific warning signs and symptoms can help physicians to identify those children with underlying PIDs. This book aims to increase the clinical awareness and knowledge of practicing clinicians regarding the diagnosis and management of PIDs. In order to achieve this goal, about 90 cases drawn from real life are presented, along with approximately 300 related questions. The selected case reports are the result of the invaluable cooperation of more than 40 scientists in the field of immunodeficiency. They focus both on the presenting features of patients with PIDs and on the required further investigation and management. Although the case scenarios relate to real histories, some modifications have been made for educational purposes. Each of the numbered cases is followed by the questions, their answers, and additional discussion. Each question focuses on a particular aspect of the PID under consideration, and the topics covered include clinical diagnosis, laboratory findings, molecular mechanisms, and therapy. This practical, case-oriented book will be an invaluable source of guidance on the diagnosis and treatment of patients with PIDs and will be relevant for those working in a variety of specialties and subspecialties.
Vast numbers of different prokaryotic microorganisms shape the biosphere, with diverse metabolic capabilities. Determination of genome sequences for a wide range of bacteria and archaea now requires an in-depth knowledge of prokaryotic metabolic function to give biochemical, physiological and ecological meaning to the genomic information. This new edition describes up-to-date knowledge of the key metabolic processes that occur under different conditions, and the cellular processes that determine prokaryotic roles in the environment, biotechnology and human health. Essential for students of microbiology, applied microbiology, biotechnology, genomics and systems biology, this advanced textbook covers prokaryotic structure, composition, nutrient transport, biosynthesis and growth. Newly characterised metabolic pathways are included, as well as the latest understanding of metabolic regulation and stress responses. Additionally, the link between energetics, growth and survival is discussed as well as the maintenance of genetic integrity by the bacterial immune system.
As the COVID-19 pandemic has affected every corner of the world, changing our relationship to our communities, to our jobs, and to each other, the most pressing question has been--when will it end? Researchers around the globe are urgently trying to answer this question by racing to test and distribute a vaccine that could end the greatest public health threat of our time. In How to Make a Vaccine, an expert who has firsthand experience developing vaccines tells an optimistic story of how three hundred years of vaccine discovery and a century and a half of immunology research have come together at this powerful moment--and will lead to multiple COVID-19 vaccines. Dr. John Rhodes draws on his experience as an immunologist, including working alongside a young Anthony Fauci, to unravel the mystery of how vaccines are designed, tested, and produced at scale for global deployment. Concise and accessible, this book describes in everyday language how the immune system evolved to combat infection, how viruses responded by evolving ways to evade our defenses, and how vaccines do their work. That history, and the pace of current research developments, make Rhodes hopeful that multiple vaccines will protect us. Today the complex workings of the immune system are well understood. The tools needed by biomedical scientists stand ready to be used, and more than 160 vaccine candidates have already been produced. But defeating COVID-19 won't be the end of the story: Rhodes describes how discoveries today are also empowering scientists to combat future threats to global health, including a recent breakthrough in the development of genetic vaccines, which have never before been used in humans. As the world prepares for a vaccine, Rhodes offers a current and informative look at the science and strategies that deliver solutions to the crisis.
This book is a comprehensive compendium on the medical and surgical treatment of chronic rhinosinusitis (CRS), with or without polyposis. Detailed coverage is provided of a wide range of topics, including medical and surgical management of CRS and its subsets, medical therapy in the pre- and postoperative period and specific medical therapeutic classes currently employed in CRS patients. Each chapter highlights key aspects of specific therapies, including mechanism of action, indications, dosages, side-effects and available clinical efficacy data and emphasizes practical management pearls and pitfalls. Operative techniques for endoscopic sinonasal procedures for CRS are also outlined. The book will be a valuable resource for practicing general otolaryngologists, rhinologists and allergists as well as residents and fellows in training. It will also serve as a reference guide for physician assistants, nurse practitioners and nurses involved in the care of CRS patients.
This book comprehensively and thoroughly reviews the current literature regarding the impact of health disparities and socioeconomic factors on allergic diseases outcomes: such as food allergies and anaphylaxis. The morbidity associated with these conditions is significantly higher in under-privileged populations around the world, including groups who have experienced greater social or economic obstacles to health based on racial, socioeconomic, gender, geographic location. Health Disparities in Allergic Diseases presents evidence and reviews studies from both developed and developing countries that witness health disparities in allergic disease. Concise in format, Health Disparities in Allergic Diseases: An Evidence-Based Look at Causes, Conditions, and Outcomes is made up of 11 expertly written chapters and divided into two parts. It begins with an introductory on global health through an analysis of the theoretical framework of epidemiologic transition. Subsequent chapters then review the socioeconomic and racial variables in treating allergic diseases using a multifactorial approach. Part II discusses disparities in allergic conditions, including asthma health, rhinitis and rhinosinusitis, food allergy, and atopic dermatitis. The book concludes with an exploration of potential strategies to providing solutions for asthmatic impoverished populations. Health Disparities in Allergic Diseases is a practical resource that can be used by researchers and clinicians in the field of allergy who are interested in learning about health related disparities in the context of allergic conditions or who seek solutions for this important issue.
This book provides fundamental information on various techniques for the detection of SARS-CoV-2 including reverse transcriptase (RT) PCR, loop-mediated isothermal amplification, immunodiagnostic tests, and CRISPR-Cas. It reviews various testing kits and detection methodologies that are currently being used for the detection of SARS-CoV-2 and examines strategies for the post-treatment detection and monitoring of SARS-CoV-2. Further, it assesses the diagnostic potential of several SARS-CoV-2 proteins; and analyzes their structural determinants and immunogenicity. In turn, the book evaluates the potential of CRISPR-Cas 12-based assays for the detection of SARS-CoV-2 using RNA extracted from patients. Lastly, it discusses the use of miniaturized biosensors for the detection of other types of coronavirus.
This book covers the broad area related to Notch-mediated regulation of the immune system and tumorigenesis. Notch signaling was originally identified as a crucial pathway to regulate cell fate choice. Subsequent studies, however, have revealed that Notch regulates many steps of immune cell differentiation or development as well as tumorigenesis of cells. Although there are still many controversial issues regarding the functions or regulatory mechanism of Notch, it is important to summarize all data together in one volume to help facilitate this research area. Also, the studies regarding the functions of Notch in immune cells and tumor cells have motivated researchers and pharmaceutical companies to develop drugs for treating immune-mediated diseases and tumors. Therefore, this book covering the broad area of Notch in immunology and tumorigenesis will be attractive to many researchers including faculty members and postdoctoral fellows in academia and researchers in the pharmaceutical industry.
The Sunday Times bestseller that explains the new science behind weight loss and how we can get in shape without counting calories. 'A compelling look at the science of appetite and metabolism' Vogue 'This book tells us the truth about weight loss' Dr Rangan Chatterjee _______________ We've all heard the golden rule: eat less, exercise more and you'll lose weight. But what if it isn't that simple? For over two decades, weight loss surgeon Dr Andrew Jenkinson has treated thousands of people who have become trapped in the endless cycle of dieting. Why We Eat (Too Much), combines case studies from his practice and the new science of metabolism to illuminate how our appetite really works. Debunking myths of about body and systematically explaining why dieting is counter-productive, this unflinching book investigates every aspect of nutrition: from the 'set weight point' that is unique to all of us, to good and bad fats, and from how genes impact our weight to how our hormones are affected after a diet ends. With a new chapter about the link between obesity and COVID-19, this incredible book will help you understand your body better than ever before. _______________ 'Articulate, clear, a joy to read, this is a book that really needed written' Joanna Blythman, author of Swallow This 'Highly persuasive . . . a radical approach to weight loss' Sunday Times 'Debunks the myths around dieting and weight-loss' Telegraph
Learn the basics and more of gastrointestinal diseases. Gastrointestinal diseases have become a major medical, social and economic burden worldwide. The larger the number of patients suffering from gastric ulcer and colorectal cancer, the greater the need to properly diagnose and cure. This book is a comprehensive guide through GI diseases, which can be used by practitioners and patients. It will allow: - to explore the mechanisms underlying GI diseases - to accurately diagnose and find the best treatment - to learn how to alleviate GI disease symptoms by changing diet and lifestyle This guide has been written by experts in the field who understand the needs of doctors and their patients. With this book, you will make sure that the GI disease can be properly managed.
When Corin and Brian Mullins started their company, HapiFoods, in 2009 with just $129, they had no idea that in less than a decade they would be shipping millions of bags of cereals around the world. They just wanted to make a nourishing product that would both taste good and be compatible with Brian's food allergiesand perhaps sell it locally for a bit of extra retirement income. After much experimentation, Corin came across the tiny black chia seeda complete protein, rich in omega 3 fatty acids as well as minerals, antioxidants and fibre. Corin blended chia with nutrient-rich buckwheat and hulled hemp seeds and, inspired by an enthusiastic comment from one of their first customers, she and Brian decided to label their first creation "Holy Crap, the World's Most Amazing Cereal." Thanks in part to an appearance on the hit CBC show Dragons' Den, their products gained the attention of Canadian consumers, many of whom became loyal customers. Starting with HapiFoods' cereals and adding other healthy ingredients, this inspirational cookbook emphasizes a plant-based, gluten-free diet and includes over 60 simple-to-prepare but simply awesome recipes that harness the power of superfoods. From protein-packed breakfast fare like refreshing smoothies and perfect pancakes, to satisfying savory dishes and decadent desserts that don't sacrifice nutrition for flavour, all the recipes in The Holy Crap Cookbook are in keeping with the Holy Crap philosophy: what you eat should be good for you and taste great."
This book provides essential information on the epidemiology, molecular and genetic features, anti-CCR4 antibody therapy and a nationwide study of transplantation on human T-leukemia virus type-I (HTLV-1) and adult T-cell leukemia/lymphoma (ATL). This rare but important disease has restricted endemic areas and distinct clinical features such as a high frequency of hypercalcemia, strong predisposition to infection and poor response to chemotherapy, aspects which set ATL apart from other types of non-Hodgkin lymphoma. Given the small number of patients, enrollment in clinical trials has not been feasible, and establishing treatment standard has been difficult but new evidence, such as results of nationwide studies on transplantation, have shown new insights and potential treatments. Based on recent evidence, the book presents new treatment methods for ATL and infection prevention of HTLV-1, enabling clinicians, researchers and post-docs specializing in hematology and virology to gain a valuable overview of the disease.
This book provides up-to-date information on immunogenetics of fungal diseases in the context of primary and acquired immunodeficiencies. Different aspects of this emerging field are covered, including epidemiology of fungal diseases, innate and adaptive antifungal immunity, and the role of immunogenetics in defining susceptibility to fungal diseases in primary (CMC, CGD, etc.) immunodeficiencies and hematologic patients. The available information will also be discussed in the scope of new biomarker discovery and development of immunotherapeutic approaches for personalized diagnostics and therapy. The book addresses Professors, researchers and advanced students of Medicine, Immunology, Microbiology and Genetics.
A simple, clear, scientifically proven plan to boost metabolic health and help our immunity to the virus Covid-19 by one of the world's most influential cardiologists.
Dr Aseem Malhotra, a leading NHS cardiologist, has led the way in citing obesity, Type 2 diabetes and heart disease as frequent factors in those hospitalised with coronavirus. He shows how they result from poor metabolic health, including an over-dependence on ultra-processed foods, which seriously affects our immune response.
In this life-changing 21 Day Plan he brings us the good news that we can reverse our health and rapidly improve our resilience to infection and disease through just a few simple lifestyle changes - to our diet, how we exercise and sleep, and reduce stress.
The third edition of this acclaimed work provides clinicians and investigators with a wealth of state-of-the-art information that will lead to fresh approaches in thinking about liver physiology and liver diseases. Developed by a panel of renowned international authors, this edition outlines a range of important advances in our understanding of the liver's role as an immune organ and the functions of innate and adaptive immunity in the pathogenesis of all liver diseases. Indeed, the liver is a vitally important immune organ producing liver-derived products that can trigger the innate and adaptive immune system to initiate, mediate, regulate, and resolve systemic inflammation. The book begins with an analysis of the core concepts of immunology, including the definition of autoimmunity and its unique application to the liver, a tolerogenic organ. Subsequent chapters then explore the biological elements of liver diseases caused by epigenetics, genetics, and innate and adaptive immunity. Specific clinical presentations and aspects of liver diseases are also examined, such as Hepatitis C, non-alcoholic fatty liver disease and parasitic infections. Closing chapters then discuss liver diseases among specific populations, including pediatrics, those with comorbidities and preexisting conditions, pregnant women, and finally patients with transplanted organs. A timely and invaluable update to the clinical literature, Liver Immunology: Principles and Practice, Third Edition, is once again a comprehensive work that will not only enhance the understanding of liver diseases but also provide the kind of novel insights that greatly accelerates the evidence-based care of children and adults afflicted with these diseases. This volume is again a must-read for clinicians at all levels, for investigators and for students.
Embrace veganism and keep the whole household happy and well-fed -
without making a different meal for everyone.
Fungal infections have taken a new spectrum due to the increased incidence of multi-drug resistant fungal pathogens. Freedom of choice for drugs to treat fungal infections is also narrow because of lesser probability of discovering drugs that would bypass affecting human cells and target fungal cells producing fewer side effects in patients. An approach has gained prominence in research is to look for bioactive antifungal compounds from natural to synthetic sources. It is necessary to discover new classes of antifungals to control the recent emergence of multi-drug resistant fungal infections. This book proposed a details top to bottom outline of antifungal compounds derived naturally or synthetically. The details of their modifications or synthetic analogues have been described, helpful to understand the structure-activity relationship which leads to new compound development in antifungal chemotherapy. Each chapter begins with a comprehensive, top-bottom in-depth discussion of antifungal agents with updated bibliographic references. This compendium will serve as a companion not only for Scientists, Researchers, and Professors, Medical Practitioners but also a valuable reference text for the university students.
This fully updated and extended second edition provides a comprehensive overview on the basic concepts of the rapidly developing field of osteoimmunology and also offers in-depth insights into the molecular mechanisms of bone diseases. Clinical data is presented and put into context with the latest research findings. This second edition in addition discusses the latest topics in transplantation immunology. The book addresses scientists and physicians working in immunology, pathophysiology and osteology.
This unifying theme of this book-with sections on mechanisms of defense and neuropathogenesis, neurological diseases, infections of the nervous system, neuropharmacology, and novel therapies-is interactions of the immune and nervous systems. It also discusses the role of inflammation as a key mediator of different brain disorders. There have been significant scientific advances in the multidisciplinary field of neuroimmunology / neuroinflammation in the past decade, and this book, edited under the guidance of Professor P. N. Tandon, fosters communication between those who share an interest in this exciting area, including neuroscientists, immunologists, cell biologists, clinicians and neuropharmacologists.
This book addresses important issues regarding the interaction between the nervous system, the immune system, and the digestive system. Gut flora has a profound influence on the shaping of the immune response, not only in the gastrointestinal system but also in the nervous system. Fascinatingly, manipulation of intestinal immune responses can be used to modulate neurological disease. Conversely, the nervous system and the psyche have significant effects on the functioning of the gut and liver. After introductory chapters on the neurology, the immunology and microbiology of the gut, the effects of the gut immune system and gut flora and its manipulation on neurological disease are discussed, followed by molecular mimicry and immune tolerance in neuroimmune diseases. Additionally, several chapters deal with gastrointestinal manifestations of neurological diseases. Neuro-Immuno-Gastroenterology is aimed at neurologists, gastroenterologists, and immunologists.
The book presents the latest findings on C-type lectin receptors, focusing on individual receptors and their signaling. In recent years there have been great advances in the understanding of the function of these receptors as a newly emerging family of pattern-recognition receptors (PRRs) for pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Comprising four parts: ITAM-coupled Activating Receptors; HemITAM-bearing Receptors; ITIM-bearing Receptors; and Other Receptors and Related Topics, this comprehensive review covers a broad range of C-type lectin receptors. The updated information on C-type lectin receptors and their ligands provided will appeal to a wide readership, from basic immunologists to physicians and surgeons. In addition, sections on novel drug development make this a valuable resource for pharmaceutical scientists.
This book examines how the growing knowledge of the huge range of animal-bacterial interactions, whether in shared ecosystems or intimate symbioses, is fundamentally altering our understanding of animal biology. Individuals from simple invertebrates to human are not solitary, homogenous entities but consist of complex communities of many species that likely evolved during a billion years of coexistence. Defining the individual microbe-host conversations in these consortia, is a challenging but necessary step on the path to understanding the function of the associations as a whole. The hologenome theory of evolution considers the holobiont with its hologenome as a unit of selection in evolution. This new view may have profound impact on understanding a strictly microbe/symbiont-dependent life style and its evolutionary consequences. It may also affect the way how we approach complex environmental diseases from corals (coral bleaching) to human (inflammatory bowel disease etc). The book is written for scientists as well as medically interested persons in the field of immunobiology, microbiology, evolutionary biology, evolutionary medicine and corals.
This book provides obligatory study material on courses on autoimmune bullous diseases. Residents and researchers in dermatology and adjacent disciplines can use the book as a quick reference guide when dealing with these patients. The book contains protocols and follows international guidelines. Currently there is no quick primer on Autoimmune Bullous Diseases for dermatologists who wish to learn the subtleties of diagnosis and management of this group of mucocutaneous diseases. Since mucous membranes are also included the following medical disciplines might be interested too: oral medicine and stomatology, ENT, ophthalmology, gynaecology, gastro-enterology. The Center for Blistering Diseases in Groningen has organized since the year 2000 an annual course on Bullous Diseases for dermatologists and pathologists. The staff is selected from the faculty. The course is interactive and problem-oriented. The proposed book would represent the documented practical knowledge of the staff on these diseases. The information should be clear and practical with examples and questions for self-assessment.
You may like...
What Mummy Makes - Cook just once for…
Rebecca Wilson Hardcover (1)
How the Immune System Works
Lauren M. Sompayrac Paperback R775 Discovery Miles 7 750
The 28-Day Immunity Plan - A vital food…
Rosemary Conley Paperback
Immunology Made Ridiculously Simple
Massoud Mahmoudi Paperback R604 Discovery Miles 6 040
New Insights on Antiviral Probiotics…
Imad Al Kassaa Hardcover R3,776 Discovery Miles 37 760
Sinus Headache, Migraine, and the…
Mark E. Mehle Hardcover R3,940 Discovery Miles 39 400
The Autoimmune Solution - Prevent and…
Amy Myers Paperback
Evolution of Atopic Dermatitis in the…
Ichiro Katayama, Hiroyuki Murota, … Paperback R2,994 Discovery Miles 29 940
Dr Sarah Karabus, Kath Megaw, … Paperback (1)
Protein-Protein and Domain-Domain…
Pandjassarame Kangueane, Christina Nilofer Paperback R2,942 Discovery Miles 29 420