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In this accessible and informative guide, Sally Lewis explains how age, sexual infections, diet, excess weight, stress and anxiety affect fertility and offers practical advice and a holistic approach to help you conceive, including simple dietary and lifestyle changes and DIY complementary therapies. Discover the best time for conception. Understand the link between body, mind and fertility. Manage stress and relax to prevent anxiety.
This comprehensive review of the factors that affect the harvesting and preparation of oocytes and the management of embryos will allow practitioners to make evidence-based decisions for successful IVF. The book reviews and re-considers the value of strategies and outcomes in the management of fertility and conception rates, centred on the production of oocytes, and successful development of the embryo. Authored by leading experts in the field, chapters engage with treatments and strategies that affect the production of oocytes and embryos, optimizing outcomes in the management of female fertility, conception rates, and live births. This vital guide covers controlled ovarian hyperstimulation, the role of AMH in determining ovarian reserve, and primary stimulation agents and the use of adjuncts. Integral for all clinicians and embryologists working in reproductive medicine units, readers are provided with evidence-based, comprehensive advice and review of all factors affecting the management of oocytes and the embryo that are vital for successful IVF cycles.
In order to maximize the chance of IVF success, couples need to ensure that their preconceptual health is optimal to increase the quality of gametes and reproductive fitness. This text reviews the medical and lifestyle factors that can affect the body at preconception stage, such as micronutrients, stress, hormonal and gynecologic assessment, as well as environmental factors such as optimal weight and age for childbirth. This book will enable all medical practitioners and healthcare professionals to give evidence-based advice to influence the success rate of subsequent IVF cycles, and ensure that every child is born in the best possible condition. Part of a four-book series on optimizing different aspects of the IVF cycle, this book focusses on preparing the body for assisted conception. Other books in the series focus on the egg and embryo, the endometrium, and the sperm.
This clear, perceptive and incredibly helpful book enables women to empower themselves to deal with the difficult and emotionally fraught issues surrounding infertility. Written by experienced counsellor Claire Hall and fertility expert Dr Devora Lieberman, Empowered Fertility is a practical guide for women to help them through the experience of infertility and emerge with their mental wellbeing, friendships, relationships and finances intact. It contains clear, well-structured information and offers practical guidance. Each section of the book gives the reader information and support to address physical, psychological, emotional and social challenges that can arise when dealing with infertility, and also with IVF treatment. Subjects include managing expectations, dealing with fear, releasing control and handling changes in relationships. The reader can make use of the coaching tools and exercises to help with each step. For those who are starting or are in the midst of IVF treatment, the last section of the book forms an IVF Cycle Handbook, to guide women through their experience.
The last step in the IVF treatment cycle, embryo transfer, is also the process with the highest failure rate. No matter how good the laboratory technique is, a successful pregnancy will not be achieved without meticulous preparation of the uterus to accept the embryo. This book reviews the scientific evidence on endometrial receptivity, including histological, hormonal, biochemical, and immunological factors. Practical and concise, it supports gynecologists and embryologists to make evidence-based decisions that can influence the success rates of implantation and live births. Part of a series of books offering treatments and strategies for fertility and conception to optimize IVF outcomes, this volume is for all clinicians and embryologists working in reproductive medicine.
Why are boxers actually better than briefs? How can hamsters help determine what's wrong with my sperm? My wife's already moody enough - why am I injecting her with even more hormones? Do I have to fill the whole cup at the fertility clinic? If you're a man going through fertility treatments with your significant other, these might be just a few of the questions you've faced. And, much to your dismay, you've realised the answers are a lot harder to find than you'd like. Until now. "How to Make Love to a Plastic Cup" is the man's guide to anything and everything related to infertility. But it's not just the same old boring nuts and bolts (no pun intended). Author Greg Wolfe, who went through four cycles of IVF on his journey to fatherhood, lays it all out with side-splitting humor. From understanding a woman's cycle, to 'porn etiquette' at the clinic, to detailed instructions on administering hormone shots, this book has everything a man needs to know to get the job done. For those men tired of searching the bookshelves for a volume that speaks to their experiences in the wild world of infertility (and for those women whose men don't quite get it), there's no need to look further. "How to Make Love to a Plastic Cup" covers the whole gamut of information for couples dealing with infertility in a fresh, engaging way any man can appreciate.
This innovative book is one of the first resources to describe in detail the technique of digital time-lapse microscopy, a state-of-the-art analytical tool which is revolutionizing the field of assisted reproduction. Over 180 high-quality video sequences, accessible online via the password included in the book, provide a practical and highly visual guide to this new technology and the wealth of detail it can reveal about human embryo development. Written by a team of experts from across numerous clinical and scientific subspecialties, this book is a comprehensive guide to all aspects of the technique. It covers both the general principles of time-lapse microscopy and the specifics of working with various devices, with chapters on EmbryoScopeTM, Primo VisionTM and EevaTM as well as set-up and troubleshooting. Full electronic access to all text, images and supplementary videos makes this the ideal everyday reference for embryologists, clinicians and others working in IVF laboratories.
There is an increasing demand for gestational surrogacy in current reproductive medicine practice. Infertile couples often engage overseas surrogates, which increases the risk for legal and ethical complications. This book provides clinical guidance on the provision of gestational surrogacy on a worldwide basis, with brief summaries of the legal position within countries where it is offered. This volume provides a comprehensive overview of surrogacy for clinicians, counsellors, attorneys, legislators and anyone interested in reproductive health policy by filling an immediate niche as a resource for those interested in third-party reproductive treatments.
This book is a practical guide to the cryopreservation and transplantation of oocytes, embryos, and ovarian and testicular tissue for fertility preservation. Illustrated with a wealth of figures and photos, it provides updated techniques for clinicians, technicians, and researchers. This book also gives insights into in vitro activation (IVA), in vitro growing (IVG), and in vitro maturation (IVM), with both basic research and future directions. These techniques combined with cryopreservation will improve the chances of reproduction. Cryopreservation is essential to protect fertility in cancer patients who undergo treatment with radioiodine or chemotherapy, which may cause damage to their reproductive organs, and also for primary ovarian insufficiency patients. The book also includes a chapter on the risk of the presence of malignant cells in ovarian tissue. Both editors are pioneering researchers in this field.
An account from the frontline of fertility treatment, giving a unique insight into not only the medical and scientific advances involved but the human cost and rewards behind this life-changing technology. Simon Fishel worked with Robert Edwards during his pioneering early IVF research and was part of the team in the world's first IVF clinic, with all the trials and tribulations that involved at the time, including a writ for murder! As the science developed over the decades so did his career, as he sought to do more for patients and taught the new technologies to doctors all over the world. He came up against regulatory and establishment barriers, including fighting a 3-year legal case in the High Court of Justice and a death threat from a doctor if he refused to work with him. The clinic he founded has grown into the largest IVF group in the UK, developing exciting new procedures, and he has helped establish clinics throughout the world, even being invited to introduce IVF to China.
The Fallopian tube has until recently been a neglected structure, bypassed by IVF and seen only as a tube that transports the egg to the uterus. More recently, its central role as the site of fertilization and early embryogenesis has been recognized, along with the major effects of tubal disease, such as chlamydia trachomatis, on fertility. Tubal surgery is an option for those women who avoid IVF because of anxiety about medication side-effects or for religious reasons. The tube is also the site for female sterilization and its reversal. This definitive guide to the Fallopian tube and its disorders collates all these topics, with authoritative text covering the spectrum of clinically relevant topics in a digestible fashion. It will be of interest to gynecologists, specialists in reproductive medicine and infertility and family planning, and others with interest in this fascinating and underestimated organ of reproduction.
Since the first successful human in-vitro fertilization (IVF) treatment in 1978, IVF has transformed from an experimental procedure to an established standard of care that is practised throughout the world. As the proven methodologies become more established, patients and practitioners expect higher live birth rates and excellent quality controls. This practical book covers every stage in the life of an IVF laboratory, from designing and planning the laboratory to training the embryologists and ongoing management and troubleshooting, providing step-by-step protocols for today's best practice. Complex and specialized procedures are described by experts in the respective fields using a common structure, which allows the reader to translate into standard operating procedures. The editors bring together a portfolio of techniques that will work in almost every laboratory, providing a foundation of good working practice for both new and experienced embryologists.
Reproductive medicine and surgery is a major subspecialty in the practice of obstetrics and gynaecology. This textbook provides an introduction to the field of subfertility and reproductive endocrinology, with contributions written by leading experts in the field. This book is based on and compliments a training programme run jointly by the British Fertility Society and the Royal College of Obstetricians and Gynaecologists, making it an indispensable handbook for medical trainees. It will also appeal to clinicians embarking on a career in obstetrics and gynaecology who want an excellent grounding in this area. Specialist nurses will also find the book a valuable resource, and scientists specialising in reproductive medicine and embryology will gain insight into the related clinical areas.
Approximately five million children have been born worldwide as a result of assisted reproductive technology (ART). These techniques are now practised independently in most of the world's nations. Although the vast majority of ART parents and children are healthy following the procedures involved, there is an imperative to maintain a high standard of practice and monitor outcomes carefully. Interpretation of outcome data is difficult for a variety of reasons. As ART technologies evolve and new variants are established, the need for robust assessment of outcomes increases. This book gives a thorough review of potential complications of ART, with detailed analysis of outcome data for the various conditions described. A worldwide perspective is given throughout, with an international team of chapter authors.
A multidisciplinary group of prominent scholars investigates the historical relationship between sexually transmitted infections and infertility. Untreated gonorrhea and chlamydia cause infertility in a proportion of women and men. Unlike the much-feared venereal disease of syphilis--"the pox"--gonorrhea and chlamydia are often symptomless, leaving victims unaware of the threat to their fertility. Science did not unmask the causal microorganisms until the late nineteenth and twentieth centuries. Their effects on fertility in human history remain mysterious. This is the first volume to address the subject across more than two thousand years of human history. Following a synoptic editorial introduction, part 1 explores the enigmas of evidence from ancient and early modern medical sources. Part 2 addresses fundamental questions about when exactly these diseases first became human afflictions, with new contributions from bioarcheology, genomics, and the history of medicine, producing surprising new insights. Part 3 presents studies of infertility and its sociocultural consequences in nineteenth- and twentieth-century Africa, Oceania, and Australia. Part 4 examines the quite different ways the infertility threat from STIs was perceived--by scientists, the public, and government--in late nineteenth- and early twentieth-century Germany, France, and Britain, concluding with a pioneering empirical estimate of the infertility impact in Britain. Simon Szreter is Professor of History and Public Policy, University of Cambridge, and Fellow of St. John's College, Cambridge.
The fully revised and updated second edition of this practical handbook provides comprehensive coverage of all aspects of subfertility, including treatment and diagnosis. Each chapter is written by a recognized world expert in the field and, together, they aim to provide state of the art answers to all the problems of subfertility in a single volume. The introductory chapter provides a flow-chart approach to systematic diagnosis and treatment. Clearly written and easy to read, the subsequent chapters describe what questions to ask, how to investigate, and what each treatment requires. With an expanded international team of authors, this new edition also offers new chapters devoted to third party reproduction and in vitro maturation of oocytes. From medical students studying for examinations to consultant physicians, this volume is a 'must-have' reference for anyone dealing with couples who have fertility problems.
Compared to the famously fecund rabbit, for whom a single act of coitus has a 90% chance of creating a litter of up to 12 rabbits, humans are very infertile animals. Here in the UK, the average chance of conception is about 18% per month. And in 98% of cases, successful conception leads only to the birth of a single infant. It is unsurprising then that huge efforts have been made to increase our fertility. In vitro fertilisation, first attempted one hundred years ago, has now become big business. Market forces, combined with the desperation of many couples to fulfil their biological imperative, have pushed doctors and scientists closer to the boundaries of what is desirable or ethical. And as we are increasingly able to access and control the embryo, the opportunities of altering human genetics to eradicate disease, but also to change human characteristics, becomes a real, and to some, frightening possibility. A Child Against All Odds is a ground-breaking book for Robert Winston as it falls squarely in his area of expertise. It combines his work at Hammersmith Hospital as one of the country's leading fertility specialists, with a hard-hitting, sometimes humorous, often controversial look at the scientific, social and ethical background of man's struggle to discover and control the secrets of reproduction. Drawing on personal and professional experience, it is the definitive account of modern reproductive technology from a practitioner who has spent his professional life at the forefront of this most fascinating and emotive area of science.
The specialty of fertility preservation offers patients with cancer, who are rendered infertile by chemo- and radiotherapy, the opportunity to realize their reproductive potential. This gold-standard publication defines the specialty. The full range of techniques and scientific concepts is covered in detail, and the author team includes many of the world's leading experts in the field. The book opens with introductions to fertility preservation in both cancer and non-cancer patients, followed by cancer biology, epidemiology and treatment, and reproductive biology and cryobiology. Subsequent sections cover fertility preservation strategies in males and females, including medical/surgical procedures, ART, cryopreservation and transplantation of both ovarian tissue and the whole ovary, and in-vitro follicle growth and maturation. Concluding chapters address future technologies, as well as ethical, legal and religious issues. Richly illustrated throughout, this is a key resource for all clinicians specializing in reproductive medicine, gynecology, oncology, hematology, endocrinology and infertility.
This extensively updated new edition provides an indispensable account of modern in-vitro fertilization practice, building upon the popularity of previous editions. The authors initially give a comprehensive review of the biology of human gametes and embryos, before outlining basic to advanced IVF techniques. New developments in practical techniques and understanding are discussed, including in-vitro maturation, vitrification, preservation of fertility for cancer patients, stem cell technology, preimplantation genetic testing, and the role of epigenetics and imprinting. The revised introduction also incorporates a 'refresher' study review of fundamental principles of cell and molecular biology, now updated with current knowledge of meiosis in human oocytes, embryo metabolism and basic principles of genome editing. With high-quality illustrations and extensive, up-to-date reading lists, it is a must-have textbook for trainee and practising embryologists, as well as clinicians who are interested in the scientific principles that underpin successful IVF.
Written and edited by leading, internationally recognized clinicians and scientists in reproductive medicine and related fields, this unique text is a practical and comprehensive review of the clinical and scientific significance of unexplained male and female infertility and its management. The book is divided into thematic sections to ensure the most useful presentation of topics, opening with definitions and epidemiology of unexplained infertility, including discussion of the WHO's cutoff values for human semen characteristics and its ramifications. Sections covering male and female reproductive pathophysiology follow respectively, covering biological, genetic and environmental causative factors, with a subsequent section on evaluative techniques for male and female patients. Expectant, medical and surgical treatment strategies comprise the fifth section of the book, where active interventions and outcomes of each treatment modality are carefully considered. The final section discusses assisted reproductive techniques to manage unexplained infertility, such as intrauterine insemination and in vitro fertilization, as well as future perspectives. Thoughtful and enlightening, Unexplained Infertility: Pathophysiology, Evaluation and Treatment will be an invaluable resource for all clinicians and scientists working in the fields of reproductive medicine and infertility.
This book is a practical guide to the performance of ultrasonography in women of reproductive age for the diagnosis and treatment of infertility. The coverage includes the use of ultrasonography for evaluation of the various disorders associated with infertility, such as endometriosis, anovulatory disorders, tubal disease, and adenomyosis; its role in assisted reproductive techniques; and its application to assess the viability and early complications of pregnancy. The more recent advances in the field are all addressed, including assessment of ovarian reserve, new classifications of uterine malformations using three-dimensional ultrasonography, and novel ultrasonographic modalities for the evaluation of tubal patency. Within each chapter, the focus is especially on the performance of the ultrasound examination, with highlighting of useful technical tips. The contributors are acknowledged experts from across the world, and the book will be of value for physicians, ultrasonographers, and other medical staff involved in caring for patients with fertility issues.
For many years, the focus of fertility research and treatment has been the female. In reality, at least half of all infertility cases have a male factor as a major or contributing cause. Recent advances in the diagnosis and treatment of male infertility have enabled pregnancies in cases where the male partner was previously considered to be untreatable or even sterile. With contributions from world- renowned experts, this comprehensive overview of male infertility covers anatomy, evaluation, treatment and prevention. The elucidation of the molecular genetics underpinning spermatogenesis and the development of new sperm function tests have increased our understanding of male infertility and led to new treatments which are discussed and evaluated. This volume presents the latest scientific developments in a clinically useful and practical format. The book is packaged with a high-quality surgical atlas on CD- ROM. This text will be valuable for urologists and reproductive endocrinologists at all levels.
This comprehensive, up-to-date text, which brings together the key practical elements of the rapidly evolving field of sperm DNA and chromatin abnormalities, is divided thematically into five main sections. Part I discusses human sperm chromatin structure and nuclear architecture, while part II presents laboratory evaluation of sperm DNA damage, including SCSA, SCD, TUNEL and Comet assays, and cytochemical tests. Biological and clinical factors in the etiology of sperm DNA damage are discussed in part III, including oxidative stress, abortive apoptosis, cancer, and environmental and lifestyle factors. Part IV presents clinical studies on the utility of sperm DNA damage tests, both with natural and ART-assisted pregnancies, and debates the clinical utility of such tests. Finally, part V discusses current treatment options, such as antioxidant therapy, varicocelectomy, advanced sperm processing techniques and the use of testicular sperm. We are now beginning to better understand the unique organization of the sperm chromatin, as well as the nature and etiology of sperm DNA damage. Written and edited by worldwide experts in andrology, A Clinician's Guide to Sperm DNA and Chromatin Damage is an excellent resource for reproductive medicine and REI specialists, urologists, reproductive biologists and any professional working with the infertile male.
The second edition of this popular text systematically addresses all aspects of treatment of infertility using Chinese medicine. Clinically focused and with a new easy-to-navigate design, the book begins?by covering all the essential fundamentals you will need to understand and treat infertility, before going on to look at what Chinese medicine offers in the way of treatment for functional infertility in men and women, gynecological disorders which contribute to infertility and relevant lifestyle factors. Jane Lyttleton importantly devotes a large part of the book to discussing ways in which Chinese medicine and Western medicine might work together to overcome infertility, and details the increased experience over the past decade in working with IVF patients and their specialists. Leaps forward have also been made in the understanding of conditions such as Polycystic ovarian syndrome and immune infertility.
Greatly expanded section on the place of Chinese medicine and IVF in treatment of infertility
New information on Polycystic ovarian disease and immune infertility and how Chinese medicine approaches their treatment
Updated and balanced advice on pre-conception care
Clinically focused, with easy-to-navigate design
Infertility affects about 15% of couples in western societies. In addition to isolation, infertility challenges women's sense of identity, expectations of their life trajectory and their perceived value in society. This book presents current research on the genetic factors, treatment risk and benefits, and social and psychological consequences of infertility. Topics include the traditional Chinese medicine approach to fertility management; adverse outcomes of assisted reproduction techniques; the impact of follicular fluid components and embryo-endometrial cross-talk on the oocyte quality or embryo viability; iatrogenic damage incurred during fertility treatment upon gamete competence and embryonic viability; genetic factors of male infertility; animal models for studying female infertility; and treatment of endometriosis associated with infertility.
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