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Books > Medicine > Other branches of medicine > Pharmacology > Medical toxicology

The Inheritor's Powder - A Cautionary Tale of Poison, Betrayal and Greed (Paperback): Sandra Hempel The Inheritor's Powder - A Cautionary Tale of Poison, Betrayal and Greed (Paperback)
Sandra Hempel 1
R245 R213 Discovery Miles 2 130 Save R32 (13%) Shipped within 20 - 25 working days

In the nineteenth century it was criminally easy to bump off unwanted relatives. A Household Thrown into Chaos Plumstead village, 2 November 1833. Wealthy landlord, George Bodle is taken violently ill. He dies within hours. When his wife, daughter and two maids are also taken ill, there is only one terrifying explanation . . . arsenic poisoning. A Murder Most Foul Yet, while arsenic was readily available over the counter in the 1800s, poisoning was almost impossible to prove. As the evidence mounted up, a picture emerged of bitter family rivalries, brewing resentment, greed and ill-will. A Sensational Tale In this account of one of history's most notorious poisonings, Sandra Hempel tells the story of the birth of toxicology - the science of poison - and of a mystery which gripped the nation.

Hayes' Handbook of Pesticide Toxicology (Hardcover, 3rd edition): Robert Krieger Hayes' Handbook of Pesticide Toxicology (Hardcover, 3rd edition)
Robert Krieger
R11,011 R9,187 Discovery Miles 91 870 Save R1,824 (17%) Shipped within 20 - 25 working days

The "Handbook of Pesticide Toxicology" is a comprehensive, two-volume reference guide to the properties, effects, and regulation of pesticides that provides the latest and most complete information to researchers investigating the environmental, agricultural, veterinary, and human-health impacts of pesticide use. Written by international experts from academia, government, and the private sector, the "Handbook of Pesticide Toxicology" is an in-depth examination of critical issues related to the need for, use of, and nature of chemicals used in modern pest management. This updated 3e carries on the book s tradition of serving as the definitive reference on pesticide toxicology and recognizes the seminal contribution of Wayland J. Hayes, Jr., co-Editor of the first edition.
Feature: Presents a comprehensive look at all aspects of pesticide toxicology in one reference work.
Benefit: Saves researchers time in quickly accessing the very latest definitive details on toxicity of specific pesticides as opposed to searching through thousands of journal articles.

Feature: Clear exposition of hazard identification and dose response relationships in each chapter featuring pesticide agents and actions
Benefit: Connects the experimental laboratory results to real-life applications in human health, animal health and the environment.

Feature: All major classes of pesticide considered.
Benefit: Provides relevance to a wider variety of researchers who are conducting comparative work in pesticides or their health impacts.

Feature: Different routes of exposure critically evaluated.
Benefit: Connects the loop between exposure and harmful affects to those who are researching the affects of pesticides on humans or wildlife.
"

Predictive Toxicology - From Vision to Reality (Hardcover): Friedlieb Pfannkuch, Laura Suter-Dick Predictive Toxicology - From Vision to Reality (Hardcover)
Friedlieb Pfannkuch, Laura Suter-Dick; Series edited by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
R2,826 R2,625 Discovery Miles 26 250 Save R201 (7%) Shipped within 20 - 25 working days

Tailored to the needs of scientists developing drugs, chemicals, cosmetics and other products this one-stop reference for medicinal chemists covers all the latest developments in the field of predictive toxicology and its applications in safety assessment. With a keen emphasis on novel approaches, the topics have been tackled by selected expert scientists, who are familiar with the theoretical scientific background as well as with the practical application of current methods. Emerging technologies in toxicity assessment are introduced and evaluated in terms of their predictive power, with separate sections on computer predictions and simulation methods, novel in vitro systems including those employing stem cells, toxicogenomics and novel biomarkers. In each case, the most promising methods are discussed and compared to classical in vitro and in vivo toxicology assays. Finally, an outlook section discusses such forward-looking topics as immunotoxicology assessment and novel regulatory requirements. With its wealth of methodological knowledge and its critical evaluation of modern approaches, this is a valuable guide for toxicologists working in pharmaceutical development, as well as in safety assessment and the regulation of drugs and chemicals.

Cigarette Smoke Toxicity - Linking Individual Chemicals to Human Diseases (Hardcover): David Bernhard Cigarette Smoke Toxicity - Linking Individual Chemicals to Human Diseases (Hardcover)
David Bernhard
R2,243 R2,111 Discovery Miles 21 110 Save R132 (6%) Shipped within 20 - 25 working days

Smoking causes and contributes to a large number of human diseases, yet due to the large number of potentially hazardous compounds in cigarette smoke -- almost 5,000 chemicals have been identified, establishing the link between smoking and disease has often proved difficult. This unbiased and scientifically accurate overview of current knowledge begins with an overview of the chemical constituents in cigarette smoke, their fate in the human body, and their documented toxic effects on various cells and tissues. Recent results detailing the many ways components of cigarette smoke adversely affect human health are also presented, highlighting the role of smoking in cardiovascular, respiratory, infectious and other diseases. A final chapter discusses current strategies for the treatment and prevention of smoking-induced illness. Despite the obvious importance of the topic, this is the first comprehensive reference on tobacco smoke toxicity, making for essential reading for all toxicologists and healthcare professionals dealing with smoking-related diseases.

Metabolism of Drugs and Other Xenobiotics (Hardcover): Pavel Anzenbacher, Ulrich M. Zanger Metabolism of Drugs and Other Xenobiotics (Hardcover)
Pavel Anzenbacher, Ulrich M. Zanger
R4,609 R3,866 Discovery Miles 38 660 Save R743 (16%) Shipped within 20 - 25 working days

A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides
systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews
the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three
main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from
five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse
including nicotine, alcohol and "designer" drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular
toxicology.
Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.

Staying Alive in Toxic Times - A Seasonal Guide to Lifelong Health (Hardcover): Jenny Goodman Staying Alive in Toxic Times - A Seasonal Guide to Lifelong Health (Hardcover)
Jenny Goodman 1
R470 R382 Discovery Miles 3 820 Save R88 (19%) In stock

The must-have health bible that explains exactly how to stay in radiant, optimal health all year round. Are you confused about what supplements you should be taking? Do you want to know how you can reverse the effects of pollution on your body? Would you like to eat seasonally? Drawing on Dr Jenny Goodman's 20+ years' experience as a medical doctor, lecturer and qualified nutritionist, Staying Alive in Toxic Times sets out exactly what to eat in order to live our healthiest lives, and how to adapt our lifestyle according to the season we are in. Dr Jenny Goodman lays out how to safely and effectively supplement your diet with vitamins and minerals, explains what really works in terms of detoxing your body, and sorts through the confusing myriad of diets and healthy eating fads, using her expertise to myth-bust. Staying Alive in Toxic Times also reveals how to avoid seasonal health hazards, such as indoor pollution, hay fever and SAD. With so many people feeling tired, ill and run-down, this timely guide is what everyone needs to read in order to live vibrant, happy and long lives.

Encyclopedia of Toxicology (Hardcover, 3rd edition): Encyclopedia of Toxicology (Hardcover, 3rd edition)
R24,775 Discovery Miles 247 750 Shipped within 20 - 25 working days

The third edition of the "Encyclopedia of Toxicology" presents entries devoted to key concepts and specific chemicals, and is updated to reflect current advances in the field. It contains new information on nanotoxicology, epigenetics, persistent organic pollutants, computational toxicology and bioinformatics, controversial chemicals, and much more. Along with the traditional scientific entries, new articles focus on worldwide initiatives, the potential health and environmental effects of new technologies, and the societal implications of global legal and regulatory issues.

With thoroughly updated articles, references, and resources for recommended reading, the third edition has been expanded in length, breadth, and depth, and continues to provide an extensive overview of the many facets of toxicology.
Provides easy access to content on chemicals and all core areas of toxicologyThoroughly updated with the latest advances in toxicology, including epigenetics, nanotoxicology, computational toxicology, and translational toxicology New topics include implications of global legal and regulatory issues, persistent organic pollutants, REACH, SAICM, e-waste, and many more

Handbook on the Toxicology of Metals (Hardcover, 4th edition): Gunnar F. Nordberg, Bruce A. Fowler, Monica Nordberg Handbook on the Toxicology of Metals (Hardcover, 4th edition)
Gunnar F. Nordberg, Bruce A. Fowler, Monica Nordberg
R6,641 R6,289 Discovery Miles 62 890 Save R352 (5%) Shipped within 20 - 25 working days

Handbook on the Toxicology of Metals, Fourth Edition bridges the gap between established knowledgebase and new advances in metal toxicology to provide one essential reference for all those involved in the field. This book provides comprehensive coverage of basic toxicological data, emphasizing toxic effects primarily in humans, but also those of animals and biological systems in vitro. The fourth edition also contains several new chapters on important topics such as nanotoxicology, metals in prosthetics and dental implants, gene-environment interaction, neurotoxicology, metals in food, renal, cardiovascular, and diabetes effects of metal exposures and more. Volume I covers "General Considerations" and Volume II is devoted to "Specific Metals." A multidisciplinary resource with contributions from internationally-recognized experts, the fourth edition of the Handbook on the Toxicology of Metals is a prominent and indispensable reference for toxicologists, physicians, pharmacologists, engineers, and all those involved in the toxicity of metals.

Principles and Practice of Mixtures Toxicology (Hardcover): Moiz Mumtaz Principles and Practice of Mixtures Toxicology (Hardcover)
Moiz Mumtaz
R3,536 R3,352 Discovery Miles 33 520 Save R184 (5%) Shipped within 20 - 25 working days

This first comprehensive treatment of the subject for more than a decade includes the latest research on nanoparticle toxicology. The practical handbook addresses all areas where toxic mixtures are encountered, from environmental via occupational to medical settings, giving special consideration to air and water, and to the specific requirements for study design in mixture toxicology. While no extensive prior knowledge or toxicological experience is required, the practice-oriented case studies and examples in the second part make this the ideal companion for the professional toxicologist in industry or healthcare institutions with little time for academic study.

Expert Report Writing in Toxicology - Forensic, Scientific and Legal Aspects (Hardcover): Michael D. Coleman Expert Report Writing in Toxicology - Forensic, Scientific and Legal Aspects (Hardcover)
Michael D. Coleman
R2,038 R1,827 Discovery Miles 18 270 Save R211 (10%) Shipped within 20 - 25 working days

Every year throughout the world, individuals health is damaged by their exposure to toxic chemicals at work. In most cases these problems will resolve, but many will sustain permanent damage. Whilst any justified claim for compensation requires medical and legal evidence a crucial and often controversial component of this process is the establishment of a causal link between the individual s condition and exposure to a specific chemical or substance. Causation, in terms of how a substance or substances led the claimant to his or her current plight, can be difficult to establish and the main purpose of this book, is to provide the aspiring expert report writer with a concise, practical guide that uses case histories to illuminate the process of establishing causation in occupational toxicity proceedings. In summary: * A practical, accessible guide to the preparation of balanced, scientifically sound expert reports in the context of occupational toxicology. * Focuses on the scientist s role in establishing a causal link between exposure to toxins and an individual s ill health. * Includes real-life case histories drawn from the Author s 15 years experience in this area to illustrate the principles involved. Expert Report Writing in Toxicology: Forensic, Scientific and Legal Aspects proves invaluable to scientists across a range of disciplines needing guidance as to what is expected of them in terms of the best use of their expertise and how to present their findings in a manner that is authoritative, balanced and informative.

Expert Report Writing in Toxicology - Forensic, Scientific and Legal Aspects (Paperback): Michael D. Coleman Expert Report Writing in Toxicology - Forensic, Scientific and Legal Aspects (Paperback)
Michael D. Coleman
R787 R727 Discovery Miles 7 270 Save R60 (8%) Shipped within 20 - 25 working days

Every year throughout the world, individuals health is damaged by their exposure to toxic chemicals at work. In most cases these problems will resolve, but many will sustain permanent damage. Whilst any justified claim for compensation requires medical and legal evidence a crucial and often controversial component of this process is the establishment of a causal link between the individual s condition and exposure to a specific chemical or substance. Causation, in terms of how a substance or substances led the claimant to his or her current plight, can be difficult to establish and the main purpose of this book, is to provide the aspiring expert report writer with a concise, practical guide that uses case histories to illuminate the process of establishing causation in occupational toxicity proceedings. In summary: * A practical, accessible guide to the preparation of balanced, scientifically sound expert reports in the context of occupational toxicology. * Focuses on the scientist s role in establishing a causal link between exposure to toxins and an individual s ill health. * Includes real-life case histories drawn from the Author s 15 years experience in this area to illustrate the principles involved. Expert Report Writing in Toxicology: Forensic, Scientific and Legal Aspects proves invaluable to scientists across a range of disciplines needing guidance as to what is expected of them in terms of the best use of their expertise and how to present their findings in a manner that is authoritative, balanced and informative.

Toluene - Chemical Properties, Applications & Toxicology (Hardcover): Marco C Palminteri Toluene - Chemical Properties, Applications & Toxicology (Hardcover)
Marco C Palminteri
R2,116 R1,424 Discovery Miles 14 240 Save R692 (33%) Shipped within 20 - 25 working days

Toluene, also known as methylbenzene, phenylmethane and tolulol, is a colourless and clear liquid with a distinct smell, characteristic of the aromatic hydrocarbon family of chemical compounds including benzene. In this book, the authors discuss the chemical properties, applications and toxicology characteristics of toluene. Topics include a toxicokinetic and toxicologic study of toluene and inhalation exposure levels; the immediate and persisting effect of toluene chronic exposure on hippocampal cell loss, learning and memory in adolescent and adult rats; the inhibitory, toxic and structure effects of toluene on microbial consortia involved in wastewater treatment; and the influence of toluene on postnatal neurogenesis of limbic and motor systems, metabolism and behaviour of animals and correction of disturbance by antioxidants.

Cadmium Toxicity - New Aspects in Human Disease, Rice Contamination, and Cytotoxicity (Hardcover, 1st ed. 2019): Seiichiro... Cadmium Toxicity - New Aspects in Human Disease, Rice Contamination, and Cytotoxicity (Hardcover, 1st ed. 2019)
Seiichiro Himeno, Keiko Aoshima
R3,254 R2,491 Discovery Miles 24 910 Save R763 (23%) Shipped within 20 - 25 working days

This volume focuses on cadmium (Cd) exposure, its effects on human health, the mechanism of Cd accumulation and the development of mitigation technologies. Further, it discusses clinical, epidemiological, agricultural, toxicological, and biochemical aspects of Cd pollution and presents recent biochemical studies on molecular mechanisms of Cd cytotoxicity and cellular transport as well as the mechanism of Cd-induced disturbances in phosphorus (P) metabolism. It also provides insights into the pathophysiology of itai-itai disease, a serious condition caused by Cd pollution. Cadmium -New Aspects in Human Disease, Rice Contamination, and Cytotoxicity- is a valuable resource for scientists involved in heavy metal toxicology, botanical sciences, and regulatory sciences. Addressing the features of Cd pollution in the past and in the present, as well as future perspectives, this is a must-have book for students, researchers and practitioners interested in global and local metal pollution.

Manure Pathogens: Manure Management, Regulations, and Water Quality Protection (Hardcover, Ed): Dwight D. Bowman Manure Pathogens: Manure Management, Regulations, and Water Quality Protection (Hardcover, Ed)
Dwight D. Bowman
R2,769 R2,626 Discovery Miles 26 260 Save R143 (5%) Shipped within 20 - 25 working days

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. A Complete Guide to Manure Pathogen Management This comprehensive volume provides in-depth information on the management of potentially harmful pathogens present in the manure of agricultural animals, including cattle, pigs, and chickens. Developed by the Water Environment Federation, this book brings together experts in the fields of pathogens, manure management, water purification, and regulations. Manure Pathogens offers strategies for ensuring the protection of the animals producing the manure, the public that may be exposed to these wastes, and the environment. Regulatory guidelines are included throughout the book. Manure Pathogens covers: Concentrated animal feeding operations Pathogen removal from drinking water Viral transmission through animal manure Bacterial pathogens, parasites, and antibiotics in manure The effects of manure pathogens on humans Persistence and transport of pathogens in soil and water Detecting parasites in environmental samples Pathogen destruction in solids and effluents Industrial composting On-farm manure processing Value-added products from manure and municipal biosolids

Goldfrank's Manual of Toxicologic Emergencies (Paperback, Ed): Robert S. Hoffman, Lewis S. Nelson, Mary Ann Howland, Neal... Goldfrank's Manual of Toxicologic Emergencies (Paperback, Ed)
Robert S. Hoffman, Lewis S. Nelson, Mary Ann Howland, Neal A. Lewin, Neal E. Flomenbaum, …
R1,601 Discovery Miles 16 010 Shipped within 20 - 25 working days

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. Concise, "at the bedside" guidelines for toxicologic emergencies--derived from the premier reference in the field A Doody's Core Title ESSENTIAL PURCHASE! 4 STAR DOODY'S REVIEW! "This manual is for ready use at a patient's bedside or for an overview of medical toxicology for housestaff, medical/pharmacy/nursing students, and other individuals who do not need the in-depth treatment or references/citations offered by the main text. This is more than a bedside aid -- it contains a wealth of information on the current practice of clinical toxicology. Wonderful!" -- Doody's Review Service This practical and portable bedside manual is condensed for instant application from the masterwork regarded for a quarter of a century as the "gold standard" reference in the field of emergency toxicology: Goldfrank's Toxicologic Emergencies. You will find trusted information on the scientific principles that explain how toxins affect vital signs, neurotransmitters, metabolic processes, and organs and systems throughout the body. Covers the full range of toxins Includes pharmaceuticals, recreational drugs, and substances of abuse; food and plant toxins; envenomations; household toxins; pesticides and herbicides; rodenticides; metals; poison gases; and environmental toxins Systematically reviews toxicokinetics, pathophysiology, clinical manifestations, diagnostic testing, and management for each toxin Provides "Antidotes in Brief"--at-a-glance guides to specific antidotes and their primary applicationsAuthoritative answers--at your fingertips How to manage the poisoned or overdosed patient What techniques effectively eliminate toxins Which imaging modalities yield the best results More

Computational Systems Pharmacology and Toxicology (Hardcover): Rudy J. Richardson Computational Systems Pharmacology and Toxicology (Hardcover)
Rudy J. Richardson; Edited by (editors-in-chief) Diana Anderson; Series edited by Tim Marrs; Translated by Michael D Waters; Contributions by Dale E Johnson, …
R3,724 Discovery Miles 37 240 Shipped within 20 - 25 working days

This book will be important for scientists involved in environmental research particularly in filling data gaps for risk assessment. It also will highlight key methods used in studying biological targets both from a toxicity standpoint and pharmacological activity. It provides a systems pharmacology/toxicology approach to computational toxicology, linking chemical exposures to genes, diseases, and complex biological/disease pathways. It also provides the discussion of new approaches to study chemical such as biological target elucidation and move this into computational models. Overall the book expands the computational focus of chemicals and biological interactions into the field of herbal and traditional medicines. It is noteworthy that the book reaches beyond pharmaceutical toxicology. The book will be a useful academic course book for both graduate and undergraduates studying pharmacology. It applies to areas such as Computational Toxicology; Systems biology; chemical-protein interactions; Interactions between Traditional Chinese Medicines/herbal medicines and Western therapeutics. Cross-promote this book with Big Data in Predictive Toxicology.

Toxicogenomics in Predictive Carcinogenicity (Hardcover): Michael D Waters, Russell S. Thomas Toxicogenomics in Predictive Carcinogenicity (Hardcover)
Michael D Waters, Russell S. Thomas; Edited by (editors-in-chief) Diana Anderson; Contributions by Michael D Waters, Luoping Zhang, …
R4,201 Discovery Miles 42 010 Shipped within 20 - 25 working days

Toxicogenomics in Predictive Carcinogenicity describes toxicogenomics methods in predictive carcinogenicity testing, mode of action and safety evaluation, and cancer risk assessment. It illustrates these methods using case studies that have yielded significant new information on compounds and classes of compounds that have proven difficult to evaluate using conventional methods alone. This book additionally covers current and potential toxicogenomic research using stem cells as well as new bioinformatics methods for drug discovery and environmental toxicology.The information is needed because it has not previously been available. With the increasing complexity of research in mode of action investigations it is important to gain a better understand of approaches to data integration and health risk assessment. Furthermore, it is essential to consider how novel test systems and newer methods and approaches may be used in future to gain a better understanding of mechanisms. The proposed publication will provide details of chemical case studies not available in previous volumes and will demonstrate how various data is assembled and integrated to arrive at an informed assessment of chemical safety and human health risk. It will be the most current volume which comprehensively covers the subject. This publication is an indispensable tool for postgraduates, academics and industrialists working in biochemistry, genomics, carcinogenesis, pathology, pharmaceuticals, food technology, bioinformatics, risk assessment and environmental toxicology. Societies: American Association for Cancer Research AACR (http://www.aacr.org/) Environmental Mutagenesis and Genomics Society (http://www.emgs/org) International Association of Environmental Mutagen Societies (http://www.iaems/org) International Union of Toxicology (http://www.iutox.org/) Society of Toxicology (http://www.toxicology.org/) Journals for reviews: Cancer Research Mutation Research Toxicology Research Toxicology and Applied Pharmacology Regulatory Toxicology and Pharmacology Toxicology Toxicology Letters Critical Reviews in Toxicology Archives of Toxicology Pharmacology & Toxicology Fundamental and Applied Toxicology Toxicologic Pathology Clinical Toxicology Human and Experimental Toxicology International Journal of Toxicology Toxicology and Industrial Health Drug and Chemical Toxicology Drug safety Journal of Toxicology Toxicological Sciences Websites: American Association for Cancer Research AACR (http://www.aacr.org/) Environmental Mutagenesis and Genomics Society (http://www.emgs/org) International Association of Environmental Mutagen Societies (http://www.iaems/org) International Union of Toxicology (http://www.iutox.org/) Society of Toxicology (http://www.toxicology.org/) Cross-promote with the textbook Fundamental Toxicology

Masked Mycotoxins in Food - Formation, Occurrence and Toxicological Relevance (Hardcover): Chiara Dall'Asta, Franz... Masked Mycotoxins in Food - Formation, Occurrence and Toxicological Relevance (Hardcover)
Chiara Dall'Asta, Franz Berthiller
R3,483 Discovery Miles 34 830 Shipped within 20 - 25 working days

1.Provides an overview of the topic of masked mycotoxins 2.Mycotoxins can cause severe health effects in humans 3.Toxicology research, Food and Function 4.Toxicologists, biochemists, food scientists and agricultural regulators working in industry and academia. 5.Masked mycotoxins cannot be detected using standard methods, therefore they provide a high health risk.

General and Applied Toxicology - 6 Volume Set (Hardcover, 3rd Edition): Bryan Ballantyne, Timothy C. Marrs, Tore Syversen General and Applied Toxicology - 6 Volume Set (Hardcover, 3rd Edition)
Bryan Ballantyne, Timothy C. Marrs, Tore Syversen
R27,006 Discovery Miles 270 060 Shipped within 20 - 25 working days

Encompassing 150 articles written by leading scientists in the field, the third edition of "General and Applied Toxicology" provides a comprehensive and in-depth review of the basic science of toxicology, its specializations, and the application of toxicological knowledge.

This new edition reflects developments within the field that have taken place since the second edition was published in 1999. These include: New information developed in the areas of both the fundamental and applied aspects of toxicology Considerable increase in the development of fundamental information and its applications, refinement of technical methods, advances in mechanistic toxicology, and greater interest in areas of toxicology previously regarded as of limited scope Changing approaches to methodological, interpretative, regulatory, and ethical aspects of basic and applied toxicology

"General and Applied Toxicology, 3rd Edition" is the first port of call for academic researchers, industrial researchers, regulatory professionals, and advanced students looking for timely and authoritative information in the field. Due to the increase in public and media interest in exposure to toxic substances, this provides an indispensable general reference source for general physicians, lawyers, law enforcement agencies, information resource facilities, and members of the general public.

New online resource available now

In 2011, the content from the third edition of "General and Applied Toxicology" merged with the two-volume "Handbook of Systems Toxicology." The result? "General, Applied and Systems Toxicology" - a new online resource combining traditional toxicology with the latest developments to present the ultimate reference in toxicology For full details visit wileyonlinelibrary.com/ref/gast

Developmental Toxicology - Methods and Protocols (Hardcover, 2nd ed. 2019): Jason M. Hansen, Louise M. Winn Developmental Toxicology - Methods and Protocols (Hardcover, 2nd ed. 2019)
Jason M. Hansen, Louise M. Winn
R3,976 R3,130 Discovery Miles 31 300 Save R846 (21%) Shipped within 20 - 25 working days

This thorough edition explores numerous methodological approaches that can be extremely informative for our understanding of the developmental toxicant mechanisms, characterization of developmental outcomes, and development of potential interventions that are clinically relevant. Presenting both staple and state-of-the-art approaches, the book focuses on numerous cellular models (induced pluripotent stem cells, neural crest culture, etc.), some less frequently used but important animal models (chick, zebrafish), in vitro approaches using whole embryos (rat, mouse and rabbit), and specific outcome methodologies to assess changes on the morphological to molecular level. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and expert implementation advice that allows for smooth processes in the lab. Authoritative and practical, Developmental Toxicology: Methods and Protocols, Second Edition serves as an ideal aid to support further investigation into the specific mechanisms and outcomes of developmental exposures.

Arsenic is Everywhere: Cause for Concern? (Hardcover): William R. Cullen, Kenneth J. Reimer Arsenic is Everywhere: Cause for Concern? (Hardcover)
William R. Cullen, Kenneth J. Reimer
R1,605 Discovery Miles 16 050 Shipped within 20 - 25 working days

Arsenic is a naturally occurring element and, as such, it is present in the environment and in our food and drink. It can even be involved in supporting life processes. However, due to its toxicity, there is concern about its presence in our diet. This book examines the real risks and impacts of arsenic in our lives. Looking at arsenic and its compounds, this book explores the presence of arsenic in food and water, the need to clarify its toxicity, and current scientific and public misconceptions about arsenic. It also looks at the use of arsenic in medicine, from cancer treatments to alternative therapies such as homeopathy. Following on from "Is Arsenic an Aphrodisiac?: The Sociochemistry of an Element", this book continues the authors work in addressing the issues surrounding arsenic. It is a fascinating read for general readers as it unveils the reality of our exposure to arsenic in our daily lives.

The Toxicology of Carbon Nanotubes (Hardcover, New): Ken Donaldson, Craig Poland, Rodger Duffin, James Bonner The Toxicology of Carbon Nanotubes (Hardcover, New)
Ken Donaldson, Craig Poland, Rodger Duffin, James Bonner
R2,180 R2,011 Discovery Miles 20 110 Save R169 (8%) Shipped within 20 - 25 working days

The widespread and increasing use of carbon nanotubes in scientific and engineering research and their incorporation into manufactured goods has urged an assessment of the risks and hazards associated with exposure to them. The field of nanotoxicology studies the toxicology of nanoparticles such as carbon nanotubes and has become a major growth area aimed towards risk assessment of nanoparticles. Compiled by a team of leading experts at the forefront of research, this is the first book dedicated to the toxicology of carbon nanotubes. It provides state-of-the-science information on how and why they are so potentially dangerous if breathed in, including their similarities to asbestos. The book examines various aspects of carbon nanotubes, from their manufacture and aerodynamic behaviour to their effects at molecular level in the lungs. It is invaluable to the many groups involved with research in this area, as well as to regulators and risk assessors.

The Comet Assay in Toxicology (Hardcover, 2nd New edition): Diana Anderson, Alok Dhawan The Comet Assay in Toxicology (Hardcover, 2nd New edition)
Diana Anderson, Alok Dhawan
R4,209 Discovery Miles 42 090 Shipped within 20 - 25 working days

Concerns about the adverse effects of chemicals present in the environment have created a need for better systems to assess their potential consequences on human health. One potential solution is the versatile and state-of-the-art Comet assay. Simple, sensitive, rapid and visual, this modern toxicological method allows quantitative and qualitative assessment of DNA damage in single cells. This assay is used in diverse fields ranging from clinical applications, human monitoring and environmental toxicology through to genetic toxicity testing. This updated and revised edition of The Comet Assay in Toxicology provides the latest information on this important tool. It addresses, in-depth, the different protocols, statistical analyses and applications used worldwide. It also includes the guidelines recommended by the Working Group on Comet Assay. The book begins with a review of the genesis of the assay for those new to the technique and goes on to explain procedures followed to assess different types of DNA damage, various applications of the assay, and guidelines for the conduct of the assay in in vitro and in vivo systems. New chapters written for this edition will provide information on the most contemporary approaches and applications, including in silico approaches, on meta-analysis of data and on the application of the Comet Assay in nanotoxicology. This book will serve as both a reference and a guide to students as well as investigators in the biomedical, biochemical and pharmaceutical sciences fields.

Human Stem Cell Toxicology (Hardcover): James L. Sherley Human Stem Cell Toxicology (Hardcover)
James L. Sherley; Edited by (editors-in-chief) Diana Anderson; Contributions by Dipak Datta, Wenbin Deng, William G. Thilly, …
R3,951 Discovery Miles 39 510 Shipped within 20 - 25 working days

This book addresses a long-standing problem in environmental toxicology and drug development, which new research advances are beginning to address. It will advance the scientific knowledge of toxicologists in a several different application areas, including environmental health sciences, pharmaceutical drug development, and medicine. It is relevant for Academics, Postgraduates, Undergraduates and Industrialists working in the areas of Toxicology, Pharmaceutical Sciences, Tissue Cell Biology and Stem Cell Biology. Competing books include the 2014 Handbook of Nanotoxicology, Nanomedicine, and Stem Cell Use in Toxicology. Cross-promote with Stem Cells: Regenerative Pharmacology, Drug Discovery & Development, edited by Timothy Allsopp and Chris Mason and planned for publication in the Drug Discovery Series in 2016.

Aerobiology - The Toxicology of Airborne Pathogens and Toxins (Hardcover): Harry Salem, Sidney A. Katz Aerobiology - The Toxicology of Airborne Pathogens and Toxins (Hardcover)
Harry Salem, Sidney A. Katz; Series edited by Tim Marrs; Edited by (editors-in-chief) Diana Anderson; Contributions by Terry J. Henderson, …
R4,200 Discovery Miles 42 000 Shipped within 20 - 25 working days

Aerobiology is the study of airborne organic particulates in the environment, such as bacteria or fungal spores. These can be either naturally occurring or artificially introduced into the air. Some of the toxicological, pharmacological, and physiological effects of bioaerosols include infections, allergies, and cancer. Research efforts in aerobiology range from remediating household mould to combating bioterrorism. This book focusses on the toxicological aspects of aerobiology, considering the adverse health effects associated with the inhalation of specific bioaerosols, such as anthrax and ricin. Additionally, chapters cover techniques for generating, sampling and characterizing airborne biological materials as well as methods for establishing standards of exposure. Moreover, mitigation of exposure and protection against exposure are described. Bringing together the contemporary status of information in the area, this book will be a valuable reference book for pulmonary specialists, general practitioners of medicine, public health and public safety officers, first responders, military personnel, and students studying toxicology and related disciplines.

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