0
Your cart

Your cart is empty

Browse All departments
Price
  • R100 - R250 (24)
  • R250 - R500 (68)
  • R500+ (1,067)
  • -
Status
Format
Author / Contributor
Publisher

Books > Medicine > Other branches of medicine > Pharmacology > Medical toxicology

Validation of Alternative Methods for Toxicity Testing (Hardcover, 1st ed. 2016): Chantra Eskes, Maurice Whelan Validation of Alternative Methods for Toxicity Testing (Hardcover, 1st ed. 2016)
Chantra Eskes, Maurice Whelan
R4,384 R3,532 Discovery Miles 35 320 Save R852 (19%) Shipped within 20 - 25 working days

This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem cells and transcriptomics, and for methods derived from pathway-based concepts in toxicology. Validation of Alternative Methods for Toxicity Testing is divided into two sections, in the first, practical insights are given on the state-of-the-art and on approaches that have resulted in successfully validated and accepted alternative methods. The second section focuses on the evolution of validation principles and practice that are necessary to ensure fit-for-purpose validation that has the greatest impact on international regulatory acceptance of alternative methods. In this context validation needs to keep pace with the considerable scientific advancements being made in toxicology, the availability of sophisticated tools and techniques that can be applied in a variety of ways, and the increasing societal and regulatory demands for better safety assessment. This book will be a useful resource for scientists in the field of toxicology, both from industry and academia, developing new test methods, strategies or techniques, as well as Governmental and regulatory authorities interested in understanding the principles and practicalities of validation of alternative methods for toxicity testing.

Histological Techniques - An Introduction for Beginners in Toxicology (Hardcover): Robert Maynard, Noel Downes, Brenda Finney Histological Techniques - An Introduction for Beginners in Toxicology (Hardcover)
Robert Maynard, Noel Downes, Brenda Finney
R2,380 R1,850 Discovery Miles 18 500 Save R530 (22%) Shipped within 15 - 19 working days

Histological techniques form the basis of many areas of research, yet they can often be poorly understood. Aimed at postgraduate students and those at an early stage of their career, this title provides a detailed and comprehensive introduction to histological techniques. With detailed images and slides, this book provides a unique overview of the area while providing the reader with a guide to how to use and incorporate histological techniques within their own research. Written by experts working within the field, this book is an essential handbook for anyone wanting to learn more about histological methods and how to apply them successfully.

Chemical Warfare Toxicology - Volume 2: Management of Poisoning (Hardcover): Franz Worek, John Jenner, Horst Thiermann Chemical Warfare Toxicology - Volume 2: Management of Poisoning (Hardcover)
Franz Worek, John Jenner, Horst Thiermann
R4,530 Discovery Miles 45 300 Shipped within 20 - 25 working days

Describes the toxicology of chemical warfare agents Recent worldwide events make this an important topic MedChemComm, Toxicology Research, Drug Discovery Series Toxicologists, biochemists and weapons specialists working in industry and academia. Covers current known and potential chemical warfare agents.

Chemical Warfare Toxicology - Volume 1: Fundamental Aspects (Hardcover): Franz Worek, John Jenner, Horst Thiermann Chemical Warfare Toxicology - Volume 1: Fundamental Aspects (Hardcover)
Franz Worek, John Jenner, Horst Thiermann
R4,528 Discovery Miles 45 280 Shipped within 20 - 25 working days

Describes the toxicology of chemical warfare agents Recent worldwide events make this an important topic MedChemComm, Toxicology Research, Drug Discovery Series Toxicologists, biochemists and weapons specialists working in industry and academia. Covers current known and potential chemical warfare agents.

Toxicology, Survival and Health Hazards of Combustion Products (Hardcover): David A. Purser, Robert L. Maynard, James C.... Toxicology, Survival and Health Hazards of Combustion Products (Hardcover)
David A. Purser, Robert L. Maynard, James C. Wakefield
R4,560 Discovery Miles 45 600 Shipped within 20 - 25 working days

1. Highlights the effects on human health from products of combustion 2. Fires are a common source of exposure to smoke and a range of toxicologically active chemicals. 3. Toxicologists, health and safety officers, environmental scientists 4. Drug Discovery Series, Toxicology Research 5. This book provides comprehensive and detailed information on combustion processes, dispersion of combustion products, estimation of rate of production of products of combustion, dispersion of these products and their effects on health.

Deceit and Denial - The Deadly Politics of Industrial Pollution (Paperback, First Edition, with a New Epil ed.): Gerald... Deceit and Denial - The Deadly Politics of Industrial Pollution (Paperback, First Edition, with a New Epil ed.)
Gerald Markowitz, David Rosner
R704 R548 Discovery Miles 5 480 Save R156 (22%) Shipped within 20 - 25 working days

"Deceit and Denial" details the attempts by the chemical and lead industries to deceive Americans about the dangers that their deadly products present to workers, the public, and consumers. Gerald Markowitz and David Rosner pursued evidence steadily and relentlessly, interviewed the important players, investigated untapped sources, and uncovered a bruising story of cynical and cruel disregard for health and human rights. This resulting expose is full of startling revelations, provocative arguments, and disturbing conclusions - all based on remarkable research and information gleaned from secret industry documents. This book reveals for the first time the public relations campaign that the lead industry undertook to convince Americans to use its deadly product to paint walls, toys, furniture, and other objects in America's homes, despite a wealth of information that children were at risk for serious brain damage and death from ingesting this poison. This book highlights the immediate dangers ordinary citizens face because of the relentless failure of industrial polluters to warn, inform, and protect their workers and neighbors. It offers a historical analysis of how corporate control over scientific research has undermined the process of proving the links between toxic chemicals and disease. The authors also describe the wisdom, courage, and determination of workers and community members who continue to voice their concerns in spite of vicious opposition. Readable, ground-breaking, and revelatory, "Deceit and Denial" provides crucial answers to questions of dangerous environmental degradation, escalating corporate greed, and governmental disregard for its citizens' safety and health. After eleven years, Markowitz and Rosner update their work with a new epilogue that outlines the attempts these industries have made to undermine and create doubt about the accuracy of the information in this book.

Principles and Practice of Skin Toxicology (Hardcover): Robert Chilcott, Shirley Price Principles and Practice of Skin Toxicology (Hardcover)
Robert Chilcott, Shirley Price
R2,852 R2,545 Discovery Miles 25 450 Save R307 (11%) Shipped within 20 - 25 working days

Written by experts in the field, "Principles and Practice of Skin" "Toxicology" provides a "bottom up" approach to studying skin toxicology. It provides a clear outline of basic concepts, citing both historical and modern references, and contains a glossary of key terms for quick and easy reference.

Arranged in a user friendly and logical sequence, the book covers the five main areas of dermatotoxicology:

Principles of skin absorption. Explains the factors influencing dermal absorption and associated methods of measurement. Methods for assessing skin toxicity. An overview of both "in vivo" and "in vitro" approaches to testing, with particular emphasis on the validation and use of alternative test strategies. Clinical and occupational skin toxicity. A basic introduction to dermatology and related applications central to understanding dermal exposure to chemicals. Regulatory aspects. An overview of national and international legislation governing the safe marketing of pharmaceuticals, cosmetics and industrial chemicals.

This book will be especially useful to scientists who are new to the area of dermal toxicology, as well as practitioners of toxicology, clinical researchers, and researchers in industry and academia.

Neurobehavioral Toxicology: Neurological and Neuropsychological Perspectives, Volume II - Peripheral Nervous System... Neurobehavioral Toxicology: Neurological and Neuropsychological Perspectives, Volume II - Peripheral Nervous System (Paperback)
James W. Albers, Stanley Berent
R746 Discovery Miles 7 460 Shipped within 20 - 25 working days

This book, the second of three volumes, concentrates on peripheral nervous system disorders. Examining the effects of neurotoxicants on nerve, muscle and the neuromuscular junction, it builds on the scientific principles outlined in volume 1 by looking at the application of the methods discussed, particularly in terms of the evaluation and diagnosis of individual patients and the related process of establishing causation. Neurobehavorial Toxicology, Volume 2 will be of interest to practicing neurologists and neuropsychologists, as well as to occupational medicine physicians and medical toxicologists.

Biomolecular Free Radical Toxicity - Causes and Prevention (Hardcover): Helen Wiseman, Peter Goldfarb, Tim Ridgway, Alan Wiseman Biomolecular Free Radical Toxicity - Causes and Prevention (Hardcover)
Helen Wiseman, Peter Goldfarb, Tim Ridgway, Alan Wiseman
R5,436 R4,813 Discovery Miles 48 130 Save R623 (11%) Shipped within 20 - 25 working days

Biomolecular Free Radical Toxicity: Causes and Prevention provides a comprehensive overview of biomolecular injury. By discussing recent research and providing interpretations of the available data, this unique and timely book explores the causes of biomolecular injury and the possible routes to its prevention. Split into three sections, the book covers:
* macromolecular mechanisms of injury and the role of antioxidants;
* gene expression and cell mediated mechanisms of toxicity expression; and,
* human and environmental health effects.
Written by experts in the field, Biomolecular Free Radical Toxicity: Causes and Prevention will be invaluable to researchers specialising in food and nutrition-based toxicology, biomolecular sciences, biochemistry, genetics, environmental biomonitoring, drug metabolism and carcinogenesis.

The Carcinogenicity of Metals - Human Risk Through Occupational and Environmental Exposure (Hardcover): Alan B.G. Lansdown The Carcinogenicity of Metals - Human Risk Through Occupational and Environmental Exposure (Hardcover)
Alan B.G. Lansdown
R4,065 Discovery Miles 40 650 Shipped within 20 - 25 working days

This book re-evaluates epidemiological and occupational health studies, experimental studies in animals and in vitro experiments relating to the toxicity of 27 metal and metalloid elements for which evidence of carcinogenicity has been presented. Human carcinogenic risk is substantiated in relation to arsenic, beryllium, thorium, chromium, radioactive elements, probably lead, and some nickel and cobalt compounds, and respirable silica particles, but the carcinogenicity of iron, aluminium, titanium, tungsten, antimony, bismuth, mercury, precious metals, and certain related compounds in humans is unresolved. The toxicity and carcinogenicity of each element is specific but correlates poorly with its position in the Periodic Table. Carcinogenicity differs according to the valency of the ion and its ability to interact with and penetrate membranes in target cells and to bind, denature or induce mutations by genotoxic or epigenetic mechanisms. This important text comprehensively examines each of the elements providing detailed information on the carcinogenicity and toxicity and detailing the most up-to-date research in this area. The book will be an essential tool for toxicologists, medicinal and biochemists, and environmental scientists working in both industry and academia.

Toxicology of Herbal Products (Hardcover, 1st ed. 2017): Olavi Pelkonen Toxicology of Herbal Products (Hardcover, 1st ed. 2017)
Olavi Pelkonen
R4,675 R4,116 Discovery Miles 41 160 Save R559 (12%) Shipped within 20 - 25 working days

This volume provides a comprehensive overview of the hazards inherent in herbal medicinal products, with systematic coverage of major toxicities. Topics include composition and quality control, toxicokinetics, interactions, safety pharmacology, approaches to studying complex mixtures including metabolomics and systems network pharmacology, and long-term toxicity. The volume also discusses various organ toxicities with a special emphasis on basic mechanisms of actions and the multicomponent and multi-target nature of herbal products. It concludes with a look to future challenges and opportunities. With contributions from noted experts, Toxicology of Herbal Products is a necessary resource for physicians, pharmacists, and toxicologists interested in complex plant-derived products.

Clinical Toxicological Analysis - Methods, Procedures, Interpretation, 2 Volume Set (Hardcover): Wolf-Rudiger Kulpmann Clinical Toxicological Analysis - Methods, Procedures, Interpretation, 2 Volume Set (Hardcover)
Wolf-Rudiger Kulpmann
R6,456 R5,923 Discovery Miles 59 230 Save R533 (8%) Shipped within 20 - 25 working days

This first, complete reference on standardized methods for laboratory analysis is tailor-made for clinical toxicologists, containing all relevant data and protocols for routine and specialized laboratory analysis. All the procedures described conform to standards stipulated by the International Standards Organisation (ISO) and academic societies, such as the IUPAC and ICC.

Neatly divided into two volumes, the first chapters deal with requirements for toxicological analyses, quality assessment, the evaluation of analytical results, forensic aspects, clinical chemistry and therapeutic drug monitoring, while the majority of chapters contain detailed protocols for the analysis of all classes of toxicants.

A handy desktop reference for the practitioner.

Forensic Toxicology - Drug Use and Misuse (Hardcover): Susannah Davies, Atholl Johnston, David Holt Forensic Toxicology - Drug Use and Misuse (Hardcover)
Susannah Davies, Atholl Johnston, David Holt; Contributions by Atholl Johnston, Nigel Langford, …
R2,119 Discovery Miles 21 190 Shipped within 18 - 22 working days

New designer drugs, access to databases, and changing availability of samples for analysis have changed the face of modern forensic toxicology in recent years. Forensic Toxicology: Drug Use and Misuse brings together the latest information direct from experts in each sub-field of the discipline providing a broad overview of current thinking and the most innovative approaches to case studies. The text begins with an in-depth discussion of pharmaco-epidemiology, including information on the value of nationwide databases in forensic toxicology. The use and abuse of drugs in driving, sport and the workplace are then discussed by industry experts who are conducting case work in their field. Not only are new drug groups discussed (NPS), but also their constantly changing impact on drug legislation. Synthetic cannabinoids, khat and mephodrone are discussed in detail. Following a section devoted to legislation and defence, readers will find comprehensive chapters covering sample choice reflecting the increasing use of hair and oral fluid, and also the less commonly used sweat and nail analysis. New and old case examples are compared and contrasted in the final part of the book, which will enable readers to understand how drugs impact on each other and how the interpretative outcome of a case are dependent on many aspects. From use of pharmaceutical drugs in a clinical setting, through smart drugs to new psychoactive drugs, this book documents the wide range in which drugs today are abused. This book will be an essential resource for postgraduate students in forensic toxicology, and for researchers in forensic toxicology laboratories who need the latest data and knowledge.

Lead Exposure & Poisoning - Clinical Symptoms, Medical Management & Preventive Strategies (Hardcover): Leonard Horton Lead Exposure & Poisoning - Clinical Symptoms, Medical Management & Preventive Strategies (Hardcover)
Leonard Horton
R2,438 R1,646 Discovery Miles 16 460 Save R792 (32%) Shipped within 20 - 25 working days

Lead is a heavy metal used since ancient times and is still employed for several industrial purposes due to its suitable physical and chemical properties. It is non-biodegradable and is very persistent in the environment. Human exposure can lead, however, to a wide range of biological effects. Lead (Pb) exposure is known to induce a wide range of physiological and biochemical dysfunctions in humans and animals. This books reviews works collected in international literature dealing with the effects of lead; the environmental contamination of lead and its associated public health risks; the influence of lead at different doses on the structure of intestinal microbial community in vivo and its relationships to intestinal epithelium in vitro; and finally, the effects of fractions of the edible halophyte, Sarcocornia perennis on human kidney cells after Pb intoxication.

Nanotoxicity - From In Vivo and In Vitro Models to Health Risks (Hardcover): Saura C. Sahu, Daniel A. Casciano Nanotoxicity - From In Vivo and In Vitro Models to Health Risks (Hardcover)
Saura C. Sahu, Daniel A. Casciano
R3,565 R3,174 Discovery Miles 31 740 Save R391 (11%) Shipped within 20 - 25 working days

Nanomaterials - substances smaller than 100 nanometers in size - have been added in recent years to an increasing numbers of consumer products used in day-to-day life; in food packaging, medical devices, pharmaceuticals, cosmetics, odor-resistant textiles and household appliances. The extensive application of nanomaterials in a wide range of products for human use poses a potential for toxicity risk to human health and the environment. Such adverse effects of nanomaterials on human health have triggered the development of a new scientific discipline known as "nanotoxicity" - the study of the toxicity of nanomaterials.

"Nanotoxicity: From" in vivo "and" in vitro "Models to Health Risks" provides up-to-date state-of-the-art information presented by recognized experts in this emerging new field in toxicology. It discusses the safety evaluation of nanomaterials in foods, drugs, medical devices, cosmetics and other regulated products and its use in risk analysis for potential regulatory use. Topics covered include: biomarkers for nanotoxicity assessmentnanotoxicity assessment by gene expression analysis"in vivo" and "in vitro" models for nanotoxicity testingmechanisms of nanotoxicitypharmakokinetics of nanomaterialsnanotoxicity of foods including food processing, food packaging and food safetynanotoxicity of drugs including drug development and drug deliverynanotoxicity of cosmetics and consumer productshealth and environmental impact of nanotoxicitysafety evaluation of nanomaterialsregulatory impact of nanomaterials

"Nanotoxicity: From" in vivo "and" in vitro "Models to Health Risks" is a valuable authoritative source of information for readers from a wide range of disciplines such as toxicology, pharmacology, drug toxicity and food and environmental sciences. The book will be useful to the research community in academia, industry, hospitals and government, as well as to government regulators and risk assessors of foods, drugs and environmental and agricultural products.

Ibuprofen - A Critical Bibliographic Review (Hardcover): Kim D Rainsford Ibuprofen - A Critical Bibliographic Review (Hardcover)
Kim D Rainsford
R5,446 Discovery Miles 54 460 Shipped within 20 - 25 working days

Ibuprofen is widely used throughout the world for a variety of conditions. This reference work provides a comprehensive and critical review of the basic science and clinical aspects of the drug. The book begins with the history and development of the drug and its current patterns of use world- wide before moving on to examine its basic pharmaceutical attributes and medicinal chemistry. The properties of various formulations are described (oral prescription and OTC, topical and others) are described. The pharmacokinetics of ibuprofen in animals and humans is discussed - highlighting the factors affecting absorption, distribution, metabolism and elimination. The clinical pharmacology and toxicology and the drug's mechanisms of action in different disease states and conditions are covered. The therapeutic uses in various acute and inflammatory conditions is detailed. Also considered are the safety versus efficacy issues and the pharmacoepidemiological data.

Is It Safe? - BPA and the Struggle to Define the Safety of Chemicals (Hardcover): Sarah A. Vogel Is It Safe? - BPA and the Struggle to Define the Safety of Chemicals (Hardcover)
Sarah A. Vogel
R1,371 R1,025 Discovery Miles 10 250 Save R346 (25%) Shipped within 20 - 25 working days

We are all just a little bit plastic. Traces of bisphenol A or BPA, a chemical used in plastics production, are widely detected in our bodies and environment. Is this chemical, and its presence in the human body, safe? What is meant by safety? Who defines it, and according to what information? "Is It Safe?" narrates how the meaning of the safety of industrial chemicals has been historically produced by breakthroughs in environmental health research, which in turn trigger contests among trade associations, lawyers, politicians, and citizen activists to set new regulatory standards. Drawing on archival research and extensive interviews, author Sarah Vogel explores the roots of the contemporary debate over the safety of BPA, and the concerns presented by its estrogen-like effects even at low doses. Ultimately, she contends that science alone cannot resolve the political and economic conflicts at play in the definition of safety. To strike a sustainable balance between the interests of commerce and public health requires recognition that powerful interests will always try to shape the criteria for defining safety, and that the agenda for environmental health research should be protected from capture by any single interest group.

Pathology for Toxicologists - Principles and Practices of Laboratory Animal Pathology for Study Personnel (Hardcover):... Pathology for Toxicologists - Principles and Practices of Laboratory Animal Pathology for Study Personnel (Hardcover)
Elizabeth McInnes
R2,906 R2,591 Discovery Miles 25 910 Save R315 (11%) Shipped within 20 - 25 working days

Non-pathologists, such as toxicologists and study personnel, can find it difficult to understand the data they receive from pathologists. Toxicological pathologists write long, detailed and highly technical reports. Study personnel are under daily pressure to decide whether lesions described in pathology reports are treatment-related and thus important to the pharmaceutical company or whether the lesions are background changes and thus of little significance. Written by experienced toxicological pathologists, Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel serves to bridge the gap in the understanding of pathology data, enabling non-pathologists to more easily comprehend pathology reports, better integrate pathology data into final study reports and ask pathologists relevant questions about the test compound. This succinct, fully referenced, full colour book is suitable for toxicologists at all stages of their training or career who want to know more about the pathology encountered in laboratory animals used in safety studies. Key features include important chapters on spontaneous and target organ lesions in rats, mice, non-human primates, mini pigs, rabbits and beagle dogs as well as information on general pathology, macroscopic target organ lesions, ancillary pathology techniques, haematology, biochemistry and adversity. Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel includes: * Colour diagrams explaining how lesions are caused by either external compounds or spontaneously * The anatomic variations and background lesions of laboratory animals * Advice on sampling tissues, necropsy, ancillary pathology techniques and recording data * A chapter on the haematology and biochemistry of laboratory animals * Full colour photographs of common macroscopic lesions encountered in laboratory animals * A comprehensive glossary

Standards for Ocular Toxicology and Inflammation (Hardcover, 1st ed. 2018): Brian C Gilger, Cynthia S. Cook, Michael H. Brown Standards for Ocular Toxicology and Inflammation (Hardcover, 1st ed. 2018)
Brian C Gilger, Cynthia S. Cook, Michael H. Brown
R3,252 R2,489 Discovery Miles 24 890 Save R763 (23%) Shipped within 20 - 25 working days

This book is an international effort to standardize the language, terms, and methods used in ocular toxicology.With over 300 color illustrations this consensus volume provides standards and harmonization for procedures, terminology, and scoring schemes for ocular toxicology. it is essential for industry, pharmaceutical companies, and governmental agencies to help improve the drug development process and to reduce and refine the use of animals in research. Standards for Ocular Toxicology and Inflammation is endorsed by the American College of Veterinary Ophthalmologists.

16 Weeks and Everything After... - A Thalidomide Survivor's Journey to Self Discovery (Paperback): Paul Whymark 16 Weeks and Everything After... - A Thalidomide Survivor's Journey to Self Discovery (Paperback)
Paul Whymark
R498 R384 Discovery Miles 3 840 Save R114 (23%) Shipped within 20 - 25 working days

At the 16 week foetal stage, Paul Whymark's brain development was frozen as a consequence of the drug, Thalidomide. His journey is one of considerable self discovery, but also reveals greater societal insights. "16 Weeks and Everything After..." uncovers the remarkable fact that over the last 50-60 years the establishment has failed to genuinely independently review Thalidomide, and as a consequence, harms on developing life continue to have the potential to occur into the future. Worse is that the insidious nature of many of the unacknowledged harms of Thalidomide are still not related to the drug. Hence such consequences are unrecognised and are at odds with official and textbook accounts even over 50 years on. Therefore, as well as appealing to general readers and other professionals, this book urgently needs to be on every medical personnel's (or trainee personnel's) required reading list. "16 Weeks and Everything After..." manages to communicate the minutia of subtle but all-important detail to uncover a quite different picture to that has been reported thus far. It has been written in an uplifting and heart-warming way, with the attitude of turning negatives into positives, but without losing sight of the underlying issues. The author has sought to stand up for his late mother, who like all mothers of children harmed by drugs consumed during pregnancy, carry the resulting additional challenges. This has sustained Paul's drive through the years of both official impasse and life's ups and downs. The book comprises a set of micro-narratives, but join together to reveal a significant personal journey in addition to a much larger and wider untold picture.

Handbook of Systems Toxicology - 2 Volume Set (Hardcover, New): Daniel A. Casciano, Saura C. Sahu Handbook of Systems Toxicology - 2 Volume Set (Hardcover, New)
Daniel A. Casciano, Saura C. Sahu
R7,046 R6,248 Discovery Miles 62 480 Save R798 (11%) Shipped within 20 - 25 working days

In the first handbook to comprehensively cover the emerging area of systems toxicology, the "Handbook of Systems Toxicology" provides an authoritative compilation of up-to-date developments presented by internationally recognised investigators. Focusing on two rapidly developing cutting edge technologies - "omics" technology and nanotechnology with special emphasis on their applications - the scope and structure reflects the multidimensional character of these areas of toxicological research. Cutting edge molecular technologies such as microarray, proteomics, metabolomics, informatics, biomarkers, in vivo and in vitro models as well as the use of these new technologies in regulatory environments are addressed. An insight into the current trends and future directions of research in this rapidly developing field is also provided, offering an excellent source of authoritative and up-to-date information for investigators, toxicologists, risk assessors and regulators in academia, industry and government.

New online resource available now

In 2011, the content from the "Handbook of Systems Toxicology" merged with the third edition of the six-volume "General and Applied Toxicology." The result? "General, Applied and Systems Toxicology" - a new online resource combining traditional toxicology with the latest developments to present the ultimate reference in toxicology For full details visit wileyonlinelibrary.com/ref/gast

Spider Venoms (Hardcover, 1st ed. 2016): P. Gopalakrishnakone, Gerardo A. Corzo, Elia Diego-Garcia, Maria Elena De Lima Spider Venoms (Hardcover, 1st ed. 2016)
P. Gopalakrishnakone, Gerardo A. Corzo, Elia Diego-Garcia, Maria Elena De Lima
R6,272 R5,606 Discovery Miles 56 060 Save R666 (11%) Shipped within 20 - 25 working days

This volume provides an overview of the biochemical characterization, structure-function studies, proteomics, bioinformatics, molecular biology, transcriptomics and genomics of various spider species. The book also covers our current knowledge of venom components, toxins and their modes of action. The first section of Spider Venom includes contributions regarding the wide diversity of spider venom components and depicts some of their biological effects (antimicrobial, ion channel modulators, insecticides, this includes peptide and non-peptide toxins), and emphasizes spiders of public health importance. The second section covers transcriptomes, proteomes (and peptidomics), bioinformatics and molecular dynamics. The last section describes antimicrobial, insecticidal toxins, envenomation and the medical potential of spider venoms. Spider venoms are a great and extensive source of bioactive compounds, and as such form a boundless and bountiful area awaiting discovery. It is by virtue of dedicated scientists that new toxins are discovered and that new insights arise, leading the way towards the investigation of their pharmacological effects, and hopefully, as a consequence, arriving at the discovery of venom components as new drug candidates.

The AH Receptor in Biology and Toxicology (Hardcover, New): Raimo Pohjanvirta The AH Receptor in Biology and Toxicology (Hardcover, New)
Raimo Pohjanvirta
R3,196 R2,852 Discovery Miles 28 520 Save R344 (11%) Shipped within 20 - 25 working days

This book provides a thorough and up-to-date overview of the aryl hydrocarbon receptor (AHR) and its unique dual role in toxicology and biology. The coverage includes epigenetic mechanisms, gene expression, reproductive and developmental toxicity, signal transduction, and transgenic animal models. Featuring an internationally recognized team of authors at the forefront of AHR research, this resource provides a comprehensive reference for readers interested in understanding the full spectrum of AHR, from basic concepts, toxicology analysis, and models to polymorphism and related diseases.

Ecotoxicology of Nanoparticles in Aquatic Systems (Hardcover): Julian Blasco, Ilaria Corsi Ecotoxicology of Nanoparticles in Aquatic Systems (Hardcover)
Julian Blasco, Ilaria Corsi
R3,237 Discovery Miles 32 370 Shipped within 20 - 25 working days

The use of nanoparticles in medicine, industrial, and other applications has triggered an interest in their potential. This book explores the use of nanoparticles related to their occurrence in the environment, their impact on biota in aquatic systems, application of new methodologies, and changes associated with new global scenarios. The book also covers the bioaccumulation and internalization of nanoparticles as key aspects to assess their uptake and discusses the methodologies for testing ENPs ecotoxicity at different trophic levels.

Perspectives in Molecular Toxinology (Hardcover): A. Menez Perspectives in Molecular Toxinology (Hardcover)
A. Menez
R10,850 Discovery Miles 108 500 Shipped within 20 - 25 working days

In this volume the editors have reviewed the most recent major advances in our understanding of toxins from venomous animals and microbes and their targets in mammals, insects and other animals. To approach these challenging aspects, the authors have posed crystal-clear questions based on the most precise acquired knowledge.

  • What can be learnt from genomics and proteomics?

  • What are the intimate modes of action of toxins on ion channels, receptors, enzymes, cell membranes?

  • What is the molecular basis of specificity and more generally of pleiotropism of toxins?

  • What else can be learnt about toxin tertiary structures and dynamics?

  • How can we enhance our understanding of target architecture and complex toxin-target structures?

  • Are toxins subject to accelerated evolution?

  • Can they be exploited as models for the design of new drugs?

  • What does the future hold for the treatment of snake bites?
These are just some of the many questions that have been addressed in this book. Complete answers may not always be readily apparent, but the attendant reasoning shows how toxinology has become an important area of biochemistry, directly associated with advances in cellular microbiology, molecular pharmacology, molecular physiology, cell biology, protein engineering, and other disciplines.
Free Delivery
Pinterest Twitter Facebook Google+
You may like...
The Inheritor's Powder - A Cautionary…
Sandra Hempel Paperback  (1)
R245 R213 Discovery Miles 2 130
Expert Report Writing in Toxicology…
Michael D. Coleman Paperback R787 R727 Discovery Miles 7 270
Metabolism of Drugs and Other…
Pavel Anzenbacher, Ulrich M. Zanger Hardcover R4,609 R3,866 Discovery Miles 38 660
What the Eyes Don't See - A Story of…
Mona Hanna-Attisha Paperback R343 R278 Discovery Miles 2 780
Handbook of Forensic Toxicology for…
D. K. Molina, M.D., Veronica Hargrove Paperback R1,670 Discovery Miles 16 700
Pathology for Toxicologists - Principles…
Elizabeth McInnes Paperback R1,103 R1,005 Discovery Miles 10 050
Free Radicals in Biology and Medicine
Barry Halliwell, John M.C. Gutteridge Paperback R2,007 Discovery Miles 20 070
Predictive Toxicology - From Vision to…
Friedlieb Pfannkuch, Laura Suter-Dick Hardcover R2,826 R2,625 Discovery Miles 26 250
Hayes' Handbook of Pesticide Toxicology
Robert Krieger Hardcover R11,011 R9,187 Discovery Miles 91 870
Cigarette Smoke Toxicity - Linking…
David Bernhard Hardcover R2,243 R2,111 Discovery Miles 21 110

 

Partners