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A fascinating and long overdue examination of viruses - from what they are and what they do, to the vital role they have played in human history. What are viruses? Do they rely on genes, like all other forms of life? Do they follow the same patterns of evolution as plants and animals? Frank Ryan answers these questions and many more in a sweeping tour of illnesses caused by viruses. For example, the common cold, measles, chicken pox, herpes and mumps, rubella, as well as less familiar examples, such as rabies, `breakbone' fever, haemorrhagic fevers like Ebola, and virus-induced cancers. Along the way, readers will learn about the behaviours and ultimate goals of viruses, gaining a deeper understanding of their importance in relation to the origins and the evolution of life, as well as they ways viruses have changed us at the most intimate level, to help make us quintessentially human.
Now in its eleventh edition, De Haan’s Health of Southern Africa has been updated so that it is aligned with new as well as legacy nursing qualifications, and remains a ‘must-have’ source of information.
Text on the Sustainable Development Goals, antimicrobial stewardship and infection control practices surrounding Ebola have been added. The three chapters on environmental health have been revised and strengthened. All content focuses on the situation in southern Africa and the local burden of disease.
The interpretation of melanocytic tumors represents probably the most difficult task in the field of dermatopathology. The second edition of this text and atlas depicts a broad range of the most important and most challenging melanocytic lesions. Each individual case is illustrated with at least three high-quality color photographs and is commented on at length, highlighting the diagnostic clues. The goal of the authors is to assist the ordinary pathologist in making a precise workable diagnosis in their daily practice. They achieve this by providing simple criteria that will serve as a sound basis for an unequivocal diagnosis of either a benign or a malignant melanocytic neoplasm. The reader will find Histological Diagnosis of Nevi and Melanoma to be an invaluable guide to correct diagnosis even in difficult or rare cases.
This book is divided into 3 main sections: cysts and odontogenic tumors (lesions related to the dentition); fibro-osseous lesions and giant cell lesions, which are unique to the maxillofacial skeleton; and bone lesions, which also occur in other parts of the body. Individual diseases are described with a special emphasis on histomorphological aspects. Some lesions may pose considerable diagnostic problems due to shared microscopical features and the authors' aim is to provide reliable diagnostic guidelines for the surgical pathologist who has to deal with specimens from this area. The majority of the currently available textbooks on head and neck pathology are mainly devoted to soft tissue lesions, paying less attention to the pathology of the diseases that involve the hard tissues. Texts on general skeletal pathology cannot address this gap, as the maxillofacial skeleton differs from the bones elsewhere in the body in several respects. Therefore, the book discusses both bone disorders that are restricted to the head and neck, and diseases that also occur in the extragnathic skeleton.
Kidney Cancer: Principles and Practice is a comprehensive and interdisciplinary textbook that encompasses all clinically relevant aspects of the disease. This new edition has been extensively updated and includes brand new material covering the most recent developments in kidney cancer diagnosis and therapy. The user-friendly and clinically oriented content of the book guarantees that it will be of great interest to a wide range of medical professionals, and every effort has been made to ensure that contributions are both easy to understand and directly related to patient care. Content presentation departs from the usual dense chapter format featuring a lengthy series of paragraphs. Instead, each chapter contains several boxed sections, including one that summarizes essential "take home points" for the busy clinician and another that presents a patient-oriented case highlighting the clinical application of elements discussed in that chapter. In addition, accessible original images, illustrations, and diagrams (some in full color) are used to simplify particularly complex material. This book will be of value for clinicians, researchers, residents, fellows, students, and knowledgeable lay people. The contributors comprise an international group of authors with expertise in kidney cancer epidemiology, molecular biology, pathology, diagnosis, clinical features, staging, prognostic and predictive factors, surgery, systemic therapy, and emerging investigational approaches, among others.
This cutting-edge monograph on advanced clinical anatomy and pathoanatomy of the shoulder, written by the world's leading authors, reflects recent significant advances in understanding of anatomy and pathology. It is beautifully illustrated with exquisite photographs of anatomical specimens, and images from arthroscopy, histology, and radiology complete the picture. The accompanying text brings out the clinical, biomechanical, and functional relevance and focuses on aspects important to the high-performance athlete. In addition, the book closely assesses how each component of the normal anatomy responds to trauma, disease, and degeneration. The finer points of the pathoanatomy are demonstrated with clinical cases, histology, radiology, arthroscopy, and open surgery. The text details how the pathoanatomy affects the patient presentation, clinical examination, and imaging. It is also explained how the pathology affects the natural history and the outcome of physical therapy and influences recommendations for surgical treatments. This book will be of immense value both to trainees and to specialists who manage disorders of the shoulder, including orthopedic surgeons, sports physicians, and physiotherapists. It will also be of great interest to anatomists and pathologists.
This book provides the reader with an up-to-date, practical and succinct overview of basic neuropathology. It does not replace large reference textbooks in neuropathology but emphasizes key concepts and basic principles including recent advances, genetics and classification, and discusses important aspects of specific neuropathological disorders. It also gives practical hints on aspects of neuropathology, including how to best use the neuropathology service and interpret the results of pathological tests. The reader will gain a sufficiently broad basic knowledge of neuropathology which will be of use in their future clinical careers. Neuropathology Simplified is aimed at trainees and residents in neurology, neurosurgery and psychiatry around the world. It may also be of use to basic scientists involved in neuroscience research and also to general histopathology trainees and residents.
This book is a comprehensive compendium of current knowledge on inherited and autoimmune blistering diseases that relates advances in our understanding of the pathogenetic mechanisms to management of the individual diseases. The aim is to provide a detailed reference for dermatologists who care for patients with these conditions and a useful "one-stop information shop" for specialists outside of dermatology. The book opens by describing the structure and biology of the epidermis and basement membrane zone and discussing the genes and proteins that are targets for mutations and autoantibodies. The role of the various diagnostic tests is explained, and clinical manifestations of the specific diseases are presented with the aid of many high-quality illustrations. The forms of treatment appropriate in specific conditions are then described in depth, with coverage of dressings, drugs, surgical procedures, gene therapy, and other novel approaches. Helpful algorithms are included both for testing and monitoring and for treatment.
This book is a comprehensive, in-depth, and up-to-date resource on eye pathology that will be of great practical value for ophthalmic and general pathologists and ophthalmologists. Congenital abnormalities, inflammatory conditions, infections, injuries, degenerative diseases, and tumors are all covered with the aid of more than 700 images. In the case of tumors, the wide variety of neoplasms that occur in the eyelid, conjunctiva, retina, uveal tract, lacrimal gland and sac, orbit, and optic nerve are comprehensively reviewed, and the most recent knowledge on the relation between genetics and prognosis is presented. Entries on specific diseases are organized in a standard way, with information on etiology, epidemiology, clinical presentation, pathological characteristics, differential diagnosis, therapy, and prognosis. The authors are all recognized experts and members of the European and American ophthalmic pathology societies. "
This volume fulfills the need for an easy-to-use and authoritative synopsis of intra-abdominal organ cytopathology. Part of the Essentials in Cytopathology book series, the book is heavily illustrated with a full color art program, while the text follows a user-friendly outline format. The book also fits into the lab coat pocket and is ideal for portability and quick reference. Written by authorities in the field, Cytopathology of the Liver, Biliary Tract, Kidney and Adrenal Glands is a concise and valuable resource to pathologists on the subject of intra-abdominal organ cytopathology.
This book contains a compilation of high-yield, at-a-glance summaries in quick reference format for various topics that are frequently encountered by pathologists in the daily practice or on the boards. The focus is not organ-based histologic criteria, but rather everything else that goes into pathologic diagnoses but is difficult to keep committed to memory. The emphasis is on immunohistochemistry, special stains, grading systems, molecular markers, tumor syndromes, and helpful clinical references. Also included are morphologic summaries that encompass high-yield material cutting across all organ systems, such as an illustrated guide for microorganisms, tumor differentials, and an illustrated glossary of pathologic descriptors. The book has a unique format in that the information is presented primarily in tables and diagrams accompanied by brief and to-the-point explanatory text. The guiding principle was to boil the information down to the essentials but with just enough commentary to be accessible to a newcomer to pathology and to serve as a quick reference to a practicing pathologist. In the 7 years since its initial publication, there have been considerable advances in surgical pathology, particularly immunohistochemical stains, molecular diagnostics, and histologic grading schemes. In the second edition, the content has been thoroughly updated to incorporate these developments, while retaining the overall scope and concise format of the first edition. In addition, the reader will find summaries for many new topics as well as multiple new cartoon illustrations and diagrams.
Reinforce your understanding of complex pathophysiology subjects! Developed and updated by learning experts, Pathophysiology Online for Understanding Pathophysiology, 8th Edition is a collection of 20 online modules that complement the McCance Pathophysiology: The Biologic Basis for Disease in Adults and Children textbook. This unique online course uses animations, interactive activities, case studies, online testing, open discussion boards, and various multimedia learning aids to make the process of mastering textbook material fun and engaging. Duration for access to this product is for the life of the edition. More than 80 specially created, narrated animations help you to visualize some of the most complex pathophysiologic processes. Module pre-tests help you test your knowledge of normal structure and function before alternations in function are introduced. Immediate feedback on activities and assignments throughout help to reinforce learning and encourage subject mastery. 20 complete modules supplement the textbook and provide experience with application of the material with online activities, animation, interactivity. Module Exams measure your progress as soon as you're completed. Case studies throughout encourage development of critical thinking skills and application of knowledge about pathophysiology to real-world situations. Rationales for all pre-tests and exams make it easy for you to understand the nature of both correct and incorrect answers. Over 600 images including figures, charts and diagrams keep you engaged and strengthen your understanding of the material. Narrated algorithms describe complex health and disease processes to help you visualize how reactions progress and interact. Guided Reading Assignments make learning and review more effective by allowing you to focus on the most vital content. Outlines for each module provide a complete overview of content to help you quickly and conveniently navigate through the course. Clear objectives highlight the most important material for each module. Further Exploration sections help you review and strengthen your understanding of the content before moving on. NEW! More than 20 new animations help to visually engage you throughout the course. NEW! Thoroughly updated to reflect content from the main text.
This comprehensive volume reviews current topics and controversies in diagnostic breast pathology, and addresses frequently encountered diagnostic problems using a question and answer format and case presentations. Emphasis is placed on the diagnostic approach as it relates to morphology, clinical and radiographic correlation, differential diagnosis, and ancillary testing including immunohistochemical and molecular analyses. Answers are provided and serve as a practical, evidence-based, and problem solving guide to diagnostic issues having significant impacts on clinical management. Common but diagnostically challenging entities such as papillary lesions and fibroepithelial lesions are discussed in detail, as well as special types of breast cancer including solid papillary carcinoma, lobular lesions and its variants. Uncommon breast lesions such as mesenchymal, lymphoid, and metastatic lesions are also covered. Chapters discuss genetic alterations and molecular abnormalities in breast cancer, and commonly encountered interpretation dilemmas on immunohistochemistry in breast cancer and metastatic cancer to the breast with a focus on prognostic and predictive tumor biomarkers.
The book compiles important clinical cases in Microbiology and Infectious Diseases for students and specialists concerning prevalent types of infections and their management. Contributors involved are well known locally, regionally and internationally. The book is designed to address undergraduate med students (Med I and Med II mainly). It serves as a reference for Med III and MED IV students, since it sheds light on a variety of infectious diseases tackling different types of microorganisms. All books currently available deal merely with medical microbiology in relation to Infectious diseases.
Thoughtful, revealing, chilling and always unputdownable, Unnatural Causes is the true crime book of the year. If you liked This is Going to Hurt, War Doctor and All That Remains you'll love this. 'One of the most fascinating books I have read in a long time. Engrossing, a haunting page-turner. A book I could not put down' The Times __________ Meet the forensic pathologist, Dr Richard Shepherd. A detective in his own right, he must solve the mystery of sudden and unexplained deaths. He has performed over 23,000 autopsies, including some of the most high-profile cases of recent times; the Hungerford Massacre, the Princess Diana inquiry, and 9/11. He has faced serial killers, natural disaster, 'perfect murders' and freak accidents. His evidence has put killers behind bars, freed the innocent, and turned open-and-shut cases on their heads. Yet all this has come at a huge personal cost. Unnatural Causes tells the story of not only the cases and bodies that have haunted him the most, but also how to live a life steeped in death. __________ Included in The Times Books of the Year 2018 'Puts the reader at his elbow as he wields the scalpel' Guardian 'Fascinating, gruesome yet engrossing' Richard and Judy, Daily Express 'Heart-wrenchingly honest' Professor Sue Black, author of All That Remains 'Fascinating, insightful, candid, compassionate' Observer
Atlas of Esophagus and Stomach Pathology provides an image-based resource for those studying normal histology of the upper gastrointestinal tract, as well as the microscopic manifestations of developmental abnormalities, toxic insults, infectious diseases, inflammatory and autoimmune conditions, and neoplasia in the esophagus and stomach. Because modern gastrointestinal pathology practice centers on specimens obtained during endoscopic examination, the atlas focuses on biopsy pathology, providing "real-world" microscopic images and ancillary diagnostic studies for most commonly-encountered abnormalities and diseases affecting these two organs. The book is supplemented with endoscopic and special study images. Authored by nationally and internationally recognized pathologists, Atlas of Esophagus and Stomach Pathology is a valuable tool for both pathologists-in-training seeking to make "new acquaintances", and practicing surgical pathologists in need of a quick visual reference in recalling "old friends" in the world of diagnostic gastrointestinal pathology.
"The Atlas of Forensic Pathology, For Police, Forensic Scientists, Attorneys and Death Investigators" is a Major Reference Work that is specifically is designed for non-pathologists who normally interact with forensic pathologists. Chapters 1 through 6 will provide background information regarding medicine, pathology, forensic pathology, death investigation, cause, manner and mechanism of death, death certification, and anatomy and physiology. The next 3 chapters will deal with general topics within forensic pathology, including the forensic autopsy, postmortem changes and time of death, and body identification. Chapters 10 through 20 will detail the major types of deaths encountered by forensic pathologists, including natural deaths, drug/toxin deaths, blunt force injuries, gunshot wounds, sharp force injuries, asphyxia, drowning, electrocution, temperature-related injuries, burns and fires, and infant/childhood deaths. The final chapter includes brief descriptions dealing with various miscellaneous topics, such as in-custody deaths, homicidal deaths related to underlying natural disease, and artifacts in forensic pathology. This atlas differs from competition in that no atlas currently exists that address material for non-pathologists (detectives, forensic entomologists and pathologists), who normally interact with forensic pathologists. The book will present such images that are or interest to not only forensic pathologists but also of interest to odontology, anthropology, crime scene investigators, fingerprints specialists, DNA specialists and entomologists, etc. The competing atlases present images of interest mostly to medical examiners, forensic pathologists and pathologists and consist mostly of wounds, and trauma with some coverage of diseases. The color photographs will come from the collection of over 50,000 slides in the Adelaide Australia collection and some 100,000 slides from the collection compiled by Dr. Prahlow that includes slides from Cook County, Indianapolis, and North Carolina.
Surgical pathologists play a central role in patient surveillance and treatment by surgeons, radiation oncologists, and medical oncologists. Although salivary gland tumors are uncommon overall, their histopathologic diversity and challenge command the attention of practicing surgical pathologists. Atlas of Salivary Gland Pathology focuses on the diagnostic approach to salivary gland neoplasia-one of the more challenging fields within surgical pathology-emphasizing the need to understand downstream implications with respect to patient surveillance and treatment. The presence of formidable histologic mimicry in salivary gland neoplasia is well-documented in the pathology literature and has also been observed in the consultation practice of the volume editor. This textbook is designed with the needs of practicing surgical pathologists and pathologists-in-training in mind, providing a comprehensive overview of both common and rare salivary gland neoplasms. The primary educational objectives for readers include the following: 1) distinguish benign from low-grade malignant salivary gland neoplasms, 2) effectively use histochemical, immunohistochemical, and cytogenetic studies in challenging cases, 3) understand which diagnoses merit additional surgery and/or adjuvant therapy (radiation, chemotherapy), and 4) enhance pathologist-to-clinician communication in the setting of salivary gland disease.
This book provides practitioners with a single volume that reviews the clinical and pathologic features of rarely encountered cutaneous neoplasms. The text includes an in-depth discussion of the clinical findings, as well as the histologic and immunologic features of these diseases that are rarely encountered, reported, or recognized. Additional laboratory data used to make and support the diagnoses with some therapeutic and prognostic hints are discussed for each entity. The volume is organized into general categories correlating with the cell(s) of origin. An atlas of clinical manifestations is presented for each entity that will serve as a bedside clinical reference, followed by a series of photomicrographs depicting the histologic changes. In all cases, recent updates on molecular tools helpful in attaining the diagnosis are added to the sections on histology and immunohistochemistry. Rare Malignant Skin Tumors is a valuable bedside reference for the practicing dermatopathologist, general pathologist reviewing skin biopsies, general dermatologists, cutaneous oncologists and Mohs' surgeons.
Atlas of Endocrine Pathology provides a comprehensive compendium of photomicrographs of common and uncommon entities in endocrine pathology. The volume includes histologic features of normal features, reactive conditions, hyperplasia, and tumors. The most helpful diagnostic features are illustrated to provide direction and clues to the diagnosis of endocrine tumors. Furthermore, photomicrographs highlight the most pertinent diagnostic features in problematic diagnoses in endocrine pathology. Authored by a nationally and internationally recognized pathologist, Atlas of Endocrine Pathology is an important learning tool for those becoming familiar with the diverse entities encountered in endocrine pathology and a valuable reference for practicing pathologists faced with challenging diagnoses in endocrine pathology.
Molecular diagnostics are increasingly used to help guide targeted therapy in solid organ tumors and hematologic malignancies. A large proportion of molecular testing is performed on limited-volume samples obtained via minimally invasive techniques, such as fine needle aspiration. Increasingly, cytopathologists play an essential role in this process, both in the triage of specimens during rapid on-site evaluation and in the evaluation of archival samples to determine suitability for ancillary testing. Therefore, it is imperative that practicing cytopathologists stay abreast of up-to-date diagnostic, prognostic, and predictive ancillary tests that can be used on limited cytologic material. This is a challenge since the landscape of known genomic alterations is constantly evolving and the subsequent set of testing options is ever expanding. The proposed text will provide a user-friendly quick-reference handbook to serve as a useful resource for practicing pathologists and laboratory personnel dealing with, and interested in, this evolving field of molecular cytopathology. Essential components to be presented include: 1) pre-analytic factors that affect sample selection and evaluation; 2) specimen preparation to maximize confidence in results; 3) interpretation of results; 4) potential limitations; and 5) workflow algorithms. In addition, specific disease specific molecular testing details will be outlined to provide the reader with resources for quick reference. All chapters will be written by experts in their fields and will include the most up-to-date scientific and clinical information. Molecular Diagnostics in Cytopathology will be of value to Cytopathologists, Cytotechnologists, Cytotechnology students, Cytopathology fellows, Surgical pathologists, Pathology residents and fellows, Molecular Pathologists, Molecular pathology fellows, Molecular technologists, as well as Translational researchers with an interest in molecular cytopathology.
The second edition of this book has been extensively revised and updated. There have been numerous scientific advances in the radiology, pathology and risk assessment of benign breast lesions since the publication of the first edition. The first edition concentrated on screen-detected lesions, which has since been rectified; new symptomatic and screen-detected lesions are discussed in the second edition and include: mastitis and breast abscesses, idiopathic granulomatous mastitis, diabetic mastopathy, phyllodes tumours, gynaecomastia and pseudoangiomatous stromal hyperplasia. The chapters on columnar cell lesions and mucocele- like lesions have been extensively updated. Where applicable, genetic analysis of the benign lesions, which is becoming part of personalised medicine in the field of breast cancer, has been included. The book also presents detailed analyses of the main models, such as the Gail Model, used to assess the subsequent risk of breast cancer in individuals. The current trend in the management of all cancers is preventative. Screening mammography detects early curable cancers as well as indeterminate lesions, the latter of which are invariably pathologically benign. The author has collated important benign lesions and, based on peer-reviewed publications, has documented the relative risk of subsequent cancer to allow the patient and the clinician to implement preventative measures where possible. This book will therefore serve as an essential component of multidisciplinary management of patients with symptomatic and screen-detected benign breast lesions.
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