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Books > Professional & Technical > Industrial chemistry & manufacturing technologies > Industrial chemistry > Pharmaceutical technology

Drug Discovery and Evaluation: Pharmacological Assays (Hardcover, 4th ed. 2016): Franz J. Hock Drug Discovery and Evaluation: Pharmacological Assays (Hardcover, 4th ed. 2016)
Franz J. Hock
R32,093 R28,374 Discovery Miles 283 740 Save R3,719 (12%) Shipped within 7 - 12 working days

The 4th edition of this successful reference book contains an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Effects covered include cardiovascular, analgesic, endocrine, psychotropic, respiratory, renal and immunomodulatory activities. Each of the more than 1,000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. In addition, animal models of rare diseases are described. For this 4th edition, all existing chapters have been revised and completely updated. A large number of assays were added. Sections that have been specifically enlarged include - Pharmacological assays in thrombosis and haemostasis, - Antidiabetic activity (includes completely new chapters such as Biochemical Methods in Diabetology), - Anti-atherosclerotic activity. New chapters are added such as Auditory Pharmacology, Oncology Activity, Stem Cells, Omics, Personalized Medicine, etc.

Pharmaceutical Salts - Properties, Selection, and Use (Hardcover, 2nd Revised Edition): P.Heinrich Stahl, Camille Georges... Pharmaceutical Salts - Properties, Selection, and Use (Hardcover, 2nd Revised Edition)
P.Heinrich Stahl, Camille Georges Wermuth
R3,679 R3,275 Discovery Miles 32 750 Save R404 (11%) Shipped within 7 - 12 working days

The first edition of this handbook was a tremendous success, collating the scientific literature on this topic that had otherwise been rather limited and scattered throughout numerous journals and patents. The result was a comprehensive resource that addresses the preparation, selection, and use of pharmaceutically active salts, examining the opportunities for increased efficacy and improved drug delivery provided by the selection of an optimal salt. This second, revised edition is designed to meet the continued interest in both the topic and the book.
Altogether, the contributions to this book by international team of authors from academia and pharmaceutical industry reflect the multidisciplinary nature of the science involved in selection of suitable salt forms for new drug products. They present the necessary theoretical foundations as well as a wealth of detailed practical experience in the choice of pharmaceutically active salts, taking great care to address every conceivable aspect of the preparation of pharmaceutical salts.
An introductory chapter presents a concise review of the various objectives in the pursuit of pharmaceutically active salts, followed by the theoretical background of salt formation. There then follow chapters on the practice of salt formation in an industrial R&D environment, as well as regulatory and patent issues. Practical examples for the practitioners at the lab bench are provided, before the book concludes with a comprehensive annotated compilation of the individual salt-forming acids and bases with their relevant properties, followed by an appendix containing tables with the acids and bases sorted alphabetically and by pKa, supplemented with other useful facts and data.
An essential reference for students of medicinal and pharmaceutical chemistry, and an indispensable handbook for R&D chemists, analytical chemists, biologists, development pharmacists, regulatory and patent specialists, and medicinal scientists engaged in preclinical development of drugs. In addition, this comprehensive and up-to-date guide is an instructive companion for all scientists involved in the research and development of drugs and, in particular, of pharmaceutical dosage forms.

Parasitic Helminths - Targets, Screens, Drugs and Vaccines (Hardcover): Conor R. Caffrey Parasitic Helminths - Targets, Screens, Drugs and Vaccines (Hardcover)
Conor R. Caffrey; Series edited by Paul M. Selzer
R2,498 R2,018 Discovery Miles 20 180 Save R480 (19%) Shipped within 7 - 12 working days

This third volume in the successful 'Drug Discovery in Infectious Diseases' series is the first to deal with drug discovery in helminthic infections in human and animals. The result is a broad overview of different drug target evaluation methods, including specific examples of successful drug development against helminthes, and with a whole section devoted to vaccine development.
With its well-balanced mix of high-profile contributors from academia and industry, this handbook and reference will appeal to a wide audience, including parasitologists, pharmaceutical industry, epidemiologists, and veterinary scientists.

Medicinal Chemistry Approaches to Personalized Medicine (Hardcover): Karen Lackey, Bruce Roth Medicinal Chemistry Approaches to Personalized Medicine (Hardcover)
Karen Lackey, Bruce Roth; Series edited by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
R2,999 R2,395 Discovery Miles 23 950 Save R604 (20%) Shipped within 7 - 12 working days

Edited by two renowned medicinal chemists who have pioneered the development of personalized therapies in their respective fields, this authoritative analysis of what is already possible is the first of its kind, and the only one to focus on drug development issues. Numerous case studies from the first generation of "personalized drugs" are presented, highlighting the challenges and opportunities for pharmaceutical development. While the majority of these examples are taken from the field of cancer treatment, other key emerging areas, such as neurosciences and inflammation, are also covered. With its careful balance of current and future approaches, this handbook is a prime knowledge source for every drug developer, and one that will remain up to date for some time to come. From the content: * Discovery of Predictive Biomarkers for Anticancer Drugs * Discovery and Development of Vemurafenib * Targeting Basal-Cell Carcinoma * G-Quadruplexes as Therapeutic Targets in Cancer * From Human Genetics to Drug Candidates: An Industrial Perspective on LRRK2 Inhibition as a Treatment for Parkinson's Disease * Therapeutic Potential of Kinases in Asthma * DNA Damage Repair Pathways and Synthetic Lethality * Medicinal Chemistry in the Context of the Human Genome and many more

Phosphodiesterases and Their Inhibitors (Hardcover): Spiros Liras, Andrew S. Bell Phosphodiesterases and Their Inhibitors (Hardcover)
Spiros Liras, Andrew S. Bell; Series edited by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
R2,879 R2,279 Discovery Miles 22 790 Save R600 (21%) Shipped within 7 - 12 working days

Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug.
Beginning with a review of the first wave of phosphodiesterase (PDE) inhibitors, this book focuses on new and emerging PDE targets and their inhibitors. Drug development options for all major human PDE families are discussed and cover diverse therapeutic fields, such as neurological/psychiatric, cardiovascular/metabolic, pain, and allergy/respiratory diseases. Finally, emerging chemotherapeutic applications of PDE inhibitors against malaria and other tropical diseases are discussed.

Trypanosomatid Diseases - Molecular Routes to Drug Discovery (Hardcover): Timo Jager, Oliver Koch, Leopold Flohe Trypanosomatid Diseases - Molecular Routes to Drug Discovery (Hardcover)
Timo Jager, Oliver Koch, Leopold Flohe; Series edited by Paul M. Selzer
R3,113 R2,501 Discovery Miles 25 010 Save R612 (20%) Shipped within 7 - 12 working days

This is the first resource to provide researchers in academia and industry with an urgently needed update on drug intervention against trypanosomatides. As such, it
covers every aspect of the topic from basic research findings, via current treatments to translational approaches in drug development and includes both human and livestock diseases. The outstanding editor and contributor team reads like a Who's Who of the field, thus guaranteeing the outstanding quality of this ready reference.

Scaffold Hopping in Medicinal Chemistry (Hardcover): Nathan Brown Scaffold Hopping in Medicinal Chemistry (Hardcover)
Nathan Brown; Series edited by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
R2,989 R2,386 Discovery Miles 23 860 Save R603 (20%) Shipped within 7 - 12 working days

This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader's own projects. The first section serves as an introduction to the topic by describing the concept of scaffolds, their discovery, diversity and representation, and their importance for finding new chemical entities. The following part describes the most common tools and methods for scaffold hopping, whether topological, shape-based or structure-based. Methods such as CATS, Feature Trees, Feature Point Pharmacophores (FEPOPS), and SkelGen are discussed among many others. The final part contains three fully documented real-world examples of successful drug development projects by scaffold hopping that illustrate the benefits of the approach for medicinal chemistry. While most of the case studies are taken from medicinal chemistry, chemical and structural biologists will also benefit greatly from the insights presented here.

Drug Metabolism Prediction (Hardcover): Johannes Kirchmair Drug Metabolism Prediction (Hardcover)
Johannes Kirchmair; Series edited by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
R3,526 R2,795 Discovery Miles 27 950 Save R731 (21%) Shipped within 7 - 12 working days

The first professional reference on this highly relevant topic, for drug developers, pharmacologists and toxicologists. The authors provide more than a systematic overview of computational tools and knowledge bases for drug metabolism research and their underlying principles. They aim to convey their expert knowledge distilled from many years of experience in the field. In addition to the fundamentals, computational approaches and their applications, this volume provides expert accounts of the latest experimental methods for investigating drug metabolism in four dedicated chapters. The authors discuss the most important caveats and common errors to consider when working with experimental data. Collating the knowledge gained over the past decade, this practice-oriented guide presents methods not only used in drug development, but also in the development and toxicological assessment of cosmetics, functional foods, agrochemicals, and additives for consumer goods, making it an invaluable reference in a variety of disciplines.

Management of Chemical and Biological Samples for Screening Applications (Hardcover): Mark Wigglesworth, Terry Wood Management of Chemical and Biological Samples for Screening Applications (Hardcover)
Mark Wigglesworth, Terry Wood
R3,629 R2,872 Discovery Miles 28 720 Save R757 (21%) Shipped within 7 - 12 working days

Filling an obvious gap in the scientific literature, this practice-oriented reference is the first to tie together the working knowledge of large
screening centers in the pharmaceutical and biotechnological field. It spans the entire fi eld of this emerging discipline, from compound
acquisition to collection optimization for specific purposes, to technology and quality control. In so doing, it applies two decades of expertise gathered by several large pharmaceutical companies to current and future challenges in high-throughput screening. With its treatment of libraries of small molecules as well as biobanks containing biomolecules, microorganisms and tissue samples, this reference is universally applicable for any molecular scientist involved in a large screening program.

The The Biochemistry of Drug Metabolism, v. 1 - The Biochemistry of Drug Metabolism Principles, Redox Reactions, Hydrolyses... The The Biochemistry of Drug Metabolism, v. 1 - The Biochemistry of Drug Metabolism Principles, Redox Reactions, Hydrolyses (Paperback)
Bernard Testa, Stefanie D. Kramer
R1,825 R1,519 Discovery Miles 15 190 Save R306 (17%) Shipped within 7 - 12 working days

The first of the two volumes is divided into three parts. Part One begins by introducing xenobiotics in the broad context of physiological metabolism, and continues with an overview of the processes of drug disposition and metabolism. It then goes on to summarize the macroscopic and microscopic locations of drug metabolism in animals and humans. This is followed by an introduction to the all-important issue of the consequences of drug and xenobiotic metabolism, providing an initial overview of pharmacokinetic, pharmacological and toxicological consequences. The last chapter examines drug metabolism in the context of drug research, with a focus on medicinal chemistry.
The second part is a major component of the book, corresponding to the role of oxidoreductases as major agents of metabolism. Cytochromes P450 receive particular attention, namely their multiplicity, structure, catalytic mechanisms, and the various reactions they catalyze, while other oxidoreductases are also presented, such as flavin monooxygenases, monoamine oxidases and other amine oxidases, aldehyde oxidase and xanthine dehydrogenase, peroxidases, and dehydrogenases-reductases. Each drug-metabolizing enzyme or enzyme family begins with an Enzyme Identity Card summarizing its nomenclature and biochemical essentials.
Part Three begins with a survey of the classification, properties and catalytic mechanism of the innumerable hydrolases known or suspected to play a role in xenobiotic metabolism. The focus then shifts to a systematic presentation of the various substrate classes, namely carboxylic esters, amides and peptides, lactams and lactones, esters of inorganic acids, alkene and arene epoxides, and some miscellaneous hydrolyzable moieties.
With a foreword by Prof Leslie Z. Benet, the world's best and best-known biopharmaceutical scientist

NMR in Pharmaceutical Science (Hardcover): Jeremy R. Everett, John C. Lindon, Adrian Davis, Ian D. Wilson, Brian Marquez, Robin... NMR in Pharmaceutical Science (Hardcover)
Jeremy R. Everett, John C. Lindon, Adrian Davis, Ian D. Wilson, Brian Marquez, …
R2,378 R2,217 Discovery Miles 22 170 Save R161 (7%) Shipped within 7 - 13 working days

NMR in Pharmaceutical Sciences is intended to be a comprehensive source of information for the many individuals that utilize MR in studies of relevance to the pharmaceutical sector. The book is intended to educate and inform those who develop and apply MR approaches within the wider pharmaceutical environment, emphasizing the toolbox that is available to spectroscopists and radiologists. This book is structured on the key processes in drug discovery, development and manufacture, but underpinned by an understanding of fundamental NMR principles and the unique contribution that NMR (including MRI) can provide. After an introductory chapter, which constitutes an overview, the content is organised into five sections. The first section is on the basics of NMR theory and relevant experimental methods. The rest follow a sequence based on the chronology of drug discovery and development, firstly 'Idea to Lead' then 'Lead to Drug Candidate', followed by 'Clinical Development', and finally 'Drug Manufacture'. The thirty one chapters cover a vast range of topics from analytical chemistry, including aspects involved in regulatory matters and in the prevention of fraud, to clinical imaging studies. Whilst this comprehensive volume will be essential reading for many scientists based in pharmaceutical and related industries, it should also be of considerable value to a much wider range of academic scientists whose research is related to the various aspects of pharmaceutical R for them it will supply vital understanding of pharmaceutical industrial concerns and the basis of key decision making processes. About eMagRes Handbooks eMagRes (formerly the Encyclopedia of Magnetic Resonance) publishes a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of eMagRes Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of eMagRes articles. In consultation with the eMagRes Editorial Board, the eMagRes handbooks are coherently planned in advance by specially-selected Editors, and new articles are written to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry. Have the content of this handbook and the complete content of eMagRes at your fingertips! Visit: www.wileyonlinelibrary.com/ref/eMagRes

Metabolism of Drugs and Other Xenobiotics (Hardcover): Pavel Anzenbacher, Ulrich M. Zanger Metabolism of Drugs and Other Xenobiotics (Hardcover)
Pavel Anzenbacher, Ulrich M. Zanger
R4,378 R3,483 Discovery Miles 34 830 Save R895 (20%) Shipped within 7 - 12 working days

A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides
systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews
the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three
main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from
five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse
including nicotine, alcohol and "designer" drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular
Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.

Data Mining in Drug Discovery (Hardcover): Remy D. Hoffmann, Arnaud Gohier, Pavel Pospisil Data Mining in Drug Discovery (Hardcover)
Remy D. Hoffmann, Arnaud Gohier, Pavel Pospisil; Series edited by Raimund Mannhold, Hugo Kubinyi, …
R3,319 R2,678 Discovery Miles 26 780 Save R641 (19%) Shipped within 7 - 12 working days

Written for drug developers rather than computer scientists, this monograph adopts a systematic approach to mining scientifi c data sources, covering all key steps in rational drug discovery, from compound screening to lead compound selection and personalized medicine. Clearly divided into four sections, the first part discusses the different data sources available, both commercial and non-commercial, while the next section looks at the role and value of data mining in drug discovery. The third part compares the most common applications and strategies for polypharmacology, where data mining can substantially enhance the research effort. The final section of the book is devoted to systems biology approaches for compound testing. Throughout the book, industrial and academic drug discovery strategies are addressed, with contributors coming from both areas, enabling an informed decision on when and which data mining tools to use for one's own drug discovery project.

Antibiotics - Targets, Mechanisms and Resistance (Hardcover): Claudio O. Gualerzi, Letizia Brandi, Attilio Fabbretti, Cynthia... Antibiotics - Targets, Mechanisms and Resistance (Hardcover)
Claudio O. Gualerzi, Letizia Brandi, Attilio Fabbretti, Cynthia L. Pon
R3,348 R2,707 Discovery Miles 27 070 Save R641 (19%) Shipped within 7 - 12 working days

Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed.
Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their molecular mechanisms and the targets on which they act. Novel targets such as cell signaling networks, riboswitches and bacterial chaperones are covered here, alongside the latest information on the molecular mechanisms of current blockbuster antibiotics.
With its broad overview of current and future antibacterial drug development, this unique reference is essential reading for anyone involved in the development and therapeutic application of novel antibiotics.

Peptide Drug Discovery and Development - Translational Research in Academia and Industry (Hardcover): Miguel A. R. B. Castanho,... Peptide Drug Discovery and Development - Translational Research in Academia and Industry (Hardcover)
Miguel A. R. B. Castanho, Nuno Santos
R3,626 R2,869 Discovery Miles 28 690 Save R757 (21%) Shipped within 7 - 12 working days

Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the "bench to bedside" translational approach to drug development.
Clearly structured into three major parts, the book stakes out the boundaries of peptide drug development in the preclinical as well as clinical stages. The first part provides a general background and focuses on the characteristic strengths and weaknesses of peptide drugs. The second section contains five cases studies of peptides from diverse therapeutic fields, and the lessons to be learned from them, while the final part looks at new targets and opportunities, discussing several drug targets and diseases for which peptide drugs are currently being developed.

Lead Generation - Methods and Strategies (Hardcover): Jorg Holenz, Markus Haeberlein Lead Generation - Methods and Strategies (Hardcover)
Jorg Holenz, Markus Haeberlein; Series edited by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
R5,257 R4,670 Discovery Miles 46 700 Save R587 (11%) Shipped within 7 - 12 working days

In this comprehensive two-volume resource on the topic senior lead generation medicinal chemists present a coherent view of the current methods and strategies in industrial and academic lead generation. This is the first book to combine both standard and innovative approaches in comparable breadth and depth, including several recent successful lead generation case studies published here for the first time. Beginning with a general discussion of the underlying principles and strategies, individual lead generation approaches are described in detail, highlighting their strengths and weaknesses, along with all relevant bordering disciplines like e.g. target identification and validation, predictive methods, molecular recognition or lead quality matrices. Novel lead generation approaches for challenging targets like DNA-encoded library screening or chemical biology approaches are treated here side by side with established methods as high throughput and affinity screening, knowledge- or fragment-based lead generation, and collaborative approaches. Within the entire book, a very strong focus is given to highlight the application of the presented methods, so that the reader will be able to learn from real life examples. The final part of the book presents several lead generation case studies taken from different therapeutic fields, including diabetes, cardiovascular and respiratory diseases, neuroscience, infection and tropical diseases. The result is a prime knowledge resource for medicinal chemists and for every scientist involved in lead generation.

Transglutaminases - Multiple Functional Modifiers and Targets for New Drug Discovery (Hardcover, 1st ed. 2015): Kiyotaka... Transglutaminases - Multiple Functional Modifiers and Targets for New Drug Discovery (Hardcover, 1st ed. 2015)
Kiyotaka Hitomi, Soichi Kojima, Laszlo Fesus
R3,965 R3,189 Discovery Miles 31 890 Save R776 (20%) Shipped within 7 - 12 working days

This book presents basic and extensive information on the physiological and pathological significance of the protein-modifying enzymes, transglutaminases, which are involved in multiple biological events by catalyzing a unique and important posttranslational modification reaction, cross-linking of proteins, and interacting with a large number of proteins inside and outside of cells. Although several of their essential physiological roles have been revealed, many unknown and so far not fully understood functions have remained. In humans, there are eight active isozymes having distinct tissue and subcellular distribution patterns with different substrates and physiological roles. Accordingly, aberrant regulation of the enzyme reactions or expression may lead to or has been implicated in various pathologies including neurodegeneration, fibrosis, cancer, inflammation, celiac disease, and hemostasis disorders.To provide those who are new to the field with basic knowledge and recent information on transglutaminase structures and reactions, the mechanism by which transglutaminases modify substrate proteins and their contributions to multiple biological phenomena as well as disease phenotypes, the publication of the present transglutaminase book was planned, to consist of review articles by 17 expert investigators working in this exciting area of research. The book contains detailed information related to several transglutaminases from aspects in chemical and cellular biology, medical sciences, and biotechnology that will also supply starting points for drug discovery. Although many prominent findings have been published in recent years, this type of comprehensive review book has been missing in the scientific literature. This volume will be useful for investigators who either currently work on or will start addressing transglutaminase-related research, and beyond that, for a broad audience in the scientific community.

Biopharmaceutical Production Technology - 2 Volume Set (Hardcover): Ganapathy Subramanian Biopharmaceutical Production Technology - 2 Volume Set (Hardcover)
Ganapathy Subramanian
R8,534 R7,558 Discovery Miles 75 580 Save R976 (11%) Shipped within 7 - 12 working days

Cost-effective manufacturing of biopharmaceutical products is rapidly gaining in importance, while healthcare systems across the globe are looking to contain costs and improve efficiency. To adapt to these changes, industries need to review and streamline their manufacturing processes. This two volume handbook systematically addresses the key steps and challenges in the production process and provides valuable information for medium to large scale producers of biopharmaceuticals. It is divided into seven major parts: - Upstream Technologies - Protein Recovery - Advances in Process Development - Analytical Technologies - Quality Control - Process Design and Management - Changing Face of Processing With contributions by around 40 experts from academia as well as small and large biopharmaceutical companies, this unique handbook is full of first-hand knowledge on how to produce biopharmaceuticals in a cost-effective and quality-controlled manner.

Voigt's Pharmaceutical Technology (Hardcover): Alfred Fahr Voigt's Pharmaceutical Technology (Hardcover)
Alfred Fahr; Translated by Gerrit L. Scherphof
R2,166 R1,674 Discovery Miles 16 740 Save R492 (23%) Shipped within 7 - 13 working days

A textbook which is both comprehensive and comprehensible and that offers easy but scientifically sound reading to both students and professionals Now in its 12th edition in its native German, Voigt's Pharmaceutical Technology is an interdisciplinary textbook covering the fundamental principles of pharmaceutical technology. Available for the first time in English, this edition is produced in full colour throughout, with a concise, clear structure developed after consultation with students, instructors and researchers. This book: Features clear chapter layouts and easily digestible content Presents novel trends, devices and processes Discusses classical and modern manufacturing processes Covers all formulation principles including tablets, ointments, capsules, nanosystems and biopharmaceutics Takes account of legal requirements for both qualitative and quantitative composition Addresses quality assurance considerations Uniquely relates contrasting international pharmacopeia from EU, US and Japan to formulation principles Includes examples and text boxes for quicker data assimilation Written for both students studying pharmacy and industry professionals in the field as well as toxicologists, biochemists, medical lab technicians, Voigt's Pharmaceutical Technology is the essential resource for understanding the various aspects of pharmaceutical technology.

Analogue-based Drug Discovery II (Hardcover): Janos Fischer, C. Robin Ganellin Analogue-based Drug Discovery II (Hardcover)
Janos Fischer, C. Robin Ganellin
R4,152 R3,367 Discovery Miles 33 670 Save R785 (19%) Shipped within 7 - 12 working days

Born out of a project of the IUPAC's committee on Medicinal Chemistry and Drug Development, this reference addresses past and current strategies for successful drug analog development, extending the previously published volume by nine new analog classes and eight case studies. Like its precursor, this volume also contains a general section discussing universally applicable strategies for analog discovery and development. Spanning a wide range of therapeutic fields and chemical classes, the two volumes together constitute the first systematic approach to drug analog development.
Of interest to virtually every researcher working in drug discovery and pharmaceutical chemistry.

Natural Products Targeting Clinically Relevant Enzymes (Hardcover): Paula B. Andrade, Patricia Valentao, David M. Pereira Natural Products Targeting Clinically Relevant Enzymes (Hardcover)
Paula B. Andrade, Patricia Valentao, David M. Pereira
R3,431 R2,406 Discovery Miles 24 060 Save R1,025 (30%) Shipped within 7 - 13 working days

The past decade has seen the reappearance of natural products as a valuable source of potent therapeutics. Here, experts on bioactive natural products cover the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more. By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.

The Evolution of Drug Discovery - From Traditional Medicines to Modern Drugs (Hardcover): Enrique Ravina The Evolution of Drug Discovery - From Traditional Medicines to Modern Drugs (Hardcover)
Enrique Ravina; Foreword by Hugo Kubinyi
R1,838 R1,311 Discovery Miles 13 110 Save R527 (29%) Shipped within 7 - 13 working days

The discovery and use of medicines is just as fascinating a human scientific endeavor as space flight or the tracing of human evolution. It is also the everyday task of hundreds of thousands of pharmacists, pharmaceutical chemists and researchers worldwide. Based on his profound knowledge of past and present paradigms in the development of medicines, Enrique Ravina takes the reader from the very beginnings of pharmacology to the multibillion-dollar business it represents today. Recounting the often spectacular successes and failures of innovative drugs as well as the people who discovered them, he brings abstract science to life in anecdotal form. For anyone with a more than superficial interest in the science of drugs and all those interested in knowing how drugs have been developed, how they have reached us, and became part of our daily life. This book is beautifully illustrated, containing many rare and historical photographs of drugs and their discoverers, and abounds with references to the primary literature, listing seminal publications alongside more modern reviews for readers seeking further details. With a Foreword by Hugo Kubinyi

Bioinorganic Medicinal Chemistry (Hardcover): Enzo Alessio Bioinorganic Medicinal Chemistry (Hardcover)
Enzo Alessio
R3,117 R2,778 Discovery Miles 27 780 Save R339 (11%) Shipped within 7 - 12 working days

This book gives a comprehensive overview about medicinal inorganic chemistry. Topics like targeting strategies, mechanism of action, Pt-based antitumor drugs, radiopharmaceuticals are covered in detail and offer the reader an in-depth overview about this important topic.

Delivery Technologies for Biopharmaceuticals - Peptides, Proteins, Nucleic Acids and Vaccines (Hardcover): Lene Jorgenson,... Delivery Technologies for Biopharmaceuticals - Peptides, Proteins, Nucleic Acids and Vaccines (Hardcover)
Lene Jorgenson, Hanne Morck Nielson
R3,163 R2,220 Discovery Miles 22 200 Save R943 (30%) Shipped within 7 - 13 working days

Advances in biotechnology have provided scientists with an increasing number of biopharmaceuticals such as novel peptide and protein drugs as well as nucleic acid based drugs for gene therapy. However, successful delivery of these biopharmaceuticals is a major challenge because their molecular properties lead to poor physical and chemical stability in the body and limited membrane permeability. Therefore researchers are developing a range of new delivery technologies and materials to enable these new drugs to be delivered intact to their target sites.

"Delivery Technologies for Biopharmaceuticals" describes strategies to overcome the main barriers for successful delivery of therapeutic peptides, proteins, and nucleic acid-based drugs or vaccines related to the site of administration and the target site. Many of the approaches described are reported in formulations in current clinical trials as well as in marketed products. Contents include:

challenges in delivery of biopharmaceuticalsnovel formulation approaches for peptide and protein injectablesnon-viral chemical vectors and viral technology for delivery of nucleic acid based drugsimmune response, adjuvants and delivery systems for vaccinesseveral examples of delivery systems for different biopharmaceuticalsa critical assessment of delivery technologies for biopharmaceuticals

"Delivery Technologies for Biopharmaceuticals" is an essential single-volume introduction to the technologies used by researchers to ensure efficient delivery of this exciting new class of drugs. It will be of value to researchers and students working in drug delivery, formulation, biopharmaceuticals, medicinal chemistry, and new materials development.

Continuous Processing in Pharmaceutical Manufacturing (Hardcover): Ganapathy Subramanian Continuous Processing in Pharmaceutical Manufacturing (Hardcover)
Ganapathy Subramanian
R3,353 R2,988 Discovery Miles 29 880 Save R365 (11%) Shipped within 7 - 12 working days

With contributions from biotechnologists and bioengineers, this ready reference describes the state of the art in industrial biopharmaceutical production, with a strong focus on continuous processes. Recent advances in single-use technology as well as application guidelines for all types of biopharmaceutical products, from vaccines to antibodies, and from bacterial to insect to mammalian cells are covered. The efficiency, robustness, and quality control of continuous production processes for biopharmaceuticals are reviewed and compared to traditional batch processes for a range of different production systems.

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