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Books > Professional & Technical > Industrial chemistry & manufacturing technologies > Industrial chemistry > Pharmaceutical technology

Validation and Qualification in Analytical Laboratories (Hardcover, 2nd New edition): Ludwig Huber Validation and Qualification in Analytical Laboratories (Hardcover, 2nd New edition)
Ludwig Huber
R2,856 Discovery Miles 28 560 Shipped within 7 - 12 working days

This "Second Edition" discusses ways to improve pharmaceutical product quality while achieving compliance with global regulatory standards. With comprehensive step-by-step instructions, practical recommendations, standard operating procedures (SOPs), checklists, templates, and graphics for easy incorporation in a laboratory. This title serves as a complete source to the subject, and explains how to develop and implement a validation strategy for routine, non-routine, and standard analytical methods, covering the entire equipment, hardware, and software qualification process. It also provides guidance on qualification of certified standards, in-house reference materials, and people qualification, as well as internal and third party laboratory audits and inspections.

Accelerated Path to Cures (Hardcover, 1st ed. 2018): Josep Bassaganya-Riera Accelerated Path to Cures (Hardcover, 1st ed. 2018)
Josep Bassaganya-Riera
R1,469 R1,338 Discovery Miles 13 380 Save R131 (9%) Shipped within 7 - 12 working days

Accelerated Path to Cures provides a transformative perspective on the power of combining advanced computational technologies, modeling, bioinformatics and machine learning approaches with nonclinical and clinical experimentation to accelerate drug development. This book discusses the application of advanced modeling technologies, from target identification and validation to nonclinical studies in animals to Phase 1-3 human clinical trials and post-approval monitoring, as alternative models of drug development. As a case of successful integration of computational modeling and drug development, we discuss the development of oral small molecule therapeutics for inflammatory bowel disease, from the application of docking studies to screening new chemical entities to the development of next-generation in silico human clinical trials from large-scale clinical data. Additionally, this book illustrates how modeling techniques, machine learning, and informatics can be utilized effectively at each stage of drug development to advance the progress towards predictive, preventive, personalized, precision medicine, and thus provide a successful framework for Path to Cures.

The Analysis of Controlled Substances (Hardcover): Michael D Cole The Analysis of Controlled Substances (Hardcover)
Michael D Cole
R3,596 R2,515 Discovery Miles 25 150 Save R1,081 (30%) Shipped within 7 - 13 working days

This series of books provides coverage of all of the major analytical techniques and their application in the most important areas of physical, life and materials science. Each text is presented in an open learning/distance learning style, in which the learning objectives are clearly identified. The reader's understanding of the material is constantly evaluated by the use of self-assessment and discussion questions. Series Editor: David J. Ando

It is now recognized that, in order to ensure the validity of a forensic science analysis, a number of criteria need to be met. These include the following:

  • The sample under investigation is suitable for the analysis being carried out.

  • The analytical procedure adopted will answer the particular question(s) being asked, for example, with respect to identification, quantification and profiling (comparison of samples).

  • The data obtained are both correctly recorded and interpreted.

  • The findings are accurately reported.
The aim of this text is to provide an understanding into the analysis of drugs of abuse within the context of their control, an appreciation of the different techniques that can be employed for drug analysis and the reasons for their use.

In this book, the major classes of drugs of abuse are addressed, the analysis of which follows a systematic framework, including description, presumptive testing, thin layer chromatography, instrumental methods and data analysis. Throughout the text, regular questions and answers are used to further develop an understanding of the processes being employed.

This book will appeal to both undergraduate and postgraduate students of forensic science, as well as those practitioners who are new in post or receiving additional or refresher training. It should also be of benefit to those who are studying controlled substances as broadening courses in other scientific disciplines.

Biocatalysis in the Pharmaceutical and Biotechnology Industries (Hardcover): Ramesh N. Patel Biocatalysis in the Pharmaceutical and Biotechnology Industries (Hardcover)
Ramesh N. Patel
R3,858 Discovery Miles 38 580 Shipped within 7 - 12 working days

Because enzyme-catalyzed reactions exhibit higher enantioselectivity, regioselectivity, substrate specificity, and stability, they require mild conditions to react while prompting higher reaction efficiency and product yields. Biocatalysis in the Pharmaceutical and Biotechnology Industries examines the use of catalysts to produce fine chemicals and chiral intermediates in a variety of pharmaceutical, agrochemical, and other biotechnological applications.

Written by internationally recognized scientists in biocatalysis, the authors analyze the synthesis of chiral intermediates for over 60 brand-name pharmaceuticals for a wide range of drug therapies and treatments. From starting material to product, the chapters offer detailed mechanisms that show chiral intermediates and other by-products for each reaction-including hydrolytic, acylation, halogenation, esterification, dehalogenation, oxidation-reduction, oxygenation, hydroxylation, deamination, transamination, and C-C, C-N, C-O bonds formation. Cutting-edge topics include advanced methodologies for gene shuffling and directed evolution of biocatalysts; the custom engineering of enzymes; the use of microbial cells and isolated biocatalysts; the use of renewable starting materials; and generating novel molecules by combinatorial biocatalysis and high-throughput screening.

Focusing on industrial applications, the book also considers factors such as bulk processes, instrumentation, solvent selection, and techniques for catalyst immobilization, reusability, and yield optimization throughout. Biocatalysis in the Pharmaceutical and Biotechnology Industries showcases the practical advantages and methodologies for using biocatalysts todevelop and produce chiral pharmaceuticals and fine chemicals.

Liposome Technology (Hardcover, 3rd New edition): Gregory Gregoriadis Liposome Technology (Hardcover, 3rd New edition)
Gregory Gregoriadis
R8,900 Discovery Miles 89 000 Shipped within 7 - 12 working days

Offering step-by-step technical details, Liposome Technology, Third Edition, Three Volume Set provides comprehensive coverage of all aspects of liposome technology, including liposome preparation and analysis, entrapment of drugs and other materials into liposomes, and liposome interaction with the biological environment to be applied in the detection, therapy, or prevention of disease. The text offers critical discussions of the methodologies of each technology discussed so that readers can examine the benefits and limitations and compare it to other methods. This Third Edition features 55 chapters written by leading international experts. Because of the considerable progress in liposome related techniques and their application in therapy since the publication of the Second Edition in 1992, over half of the chapters are new to the edition, and the other chapters have been extensively updated. Liposome Technology, Third Edition, Three Volume Set is an ideal resource for pharmaceutical scientists, researchers, regulatory personnel, FDA personnel, and medicinal chemists working in this discipline.

Liposome Technology - Liposome Preparation and Related Techniques (Hardcover, 3rd New edition): Gregory Gregoriadis Liposome Technology - Liposome Preparation and Related Techniques (Hardcover, 3rd New edition)
Gregory Gregoriadis
R2,655 Discovery Miles 26 550 Shipped within 7 - 12 working days

Liposome Technology, Volume I: Liposome Preparation and Related Techniques, Third Edition, is a thoroughly updated and expanded new edition of a classic text in the field. Including step-by-step technical details, Volume I illustrates numerous methods for liposome preparation and auxiliary techniques necessary for the stabilization and characterization of liposomes. This source also offers critical discussions of the methodologies of each technology described so that readers can examine the benefits and limitations and compare it to other approaches.

Handbook of Polymers for Pharmaceutical Technologies - Bioactive and Compatible Synthetic / Hybrid Polymers (Hardcover, Volume... Handbook of Polymers for Pharmaceutical Technologies - Bioactive and Compatible Synthetic / Hybrid Polymers (Hardcover, Volume 4)
Vijay Thakur, Manju Kumari Thakur
R4,125 R2,886 Discovery Miles 28 860 Save R1,239 (30%) Shipped within 7 - 13 working days

Polymers are one of the most fascinating materials of the present era finding their applications in almost every aspects of life. Polymers are either directly available in nature or are chemically synthesized and used depending upon the targeted applications.Advances in polymer science and the introduction of new polymers have resulted in the significant development of polymers with unique properties. Different kinds of polymers have been and will be one of the key in several applications in many of the advanced pharmaceutical research being carried out over the globe. This 4-partset of books contains precisely referenced chapters, emphasizing different kinds of polymers with basic fundamentals and practicality for application in diverse pharmaceutical technologies. The volumes aim at explaining basics of polymers based materials from different resources and their chemistry along with practical applications which present a future direction in the pharmaceutical industry. Each volume offer deep insight into the subject being treated. Volume 1: Structure and Chemistry Volume 2: Processing and Applications Volume 3: Biodegradable Polymers Volume 4: Bioactive and Compatible Synthetic/Hybrid Polymers

Continuous Manufacturing of Pharmaceuticals (Hardcover): Peter Kleinebudde, Johannes Khinast, Jukka Rantanen Continuous Manufacturing of Pharmaceuticals (Hardcover)
Peter Kleinebudde, Johannes Khinast, Jukka Rantanen
R3,530 R2,477 Discovery Miles 24 770 Save R1,053 (30%) Shipped within 7 - 13 working days

A comprehensive look at existing technologies and processes for continuous manufacturing of pharmaceuticals As rising costs outpace new drug development, the pharmaceutical industry has come under intense pressure to improve the efficiency of its manufacturing processes. Continuous process manufacturing provides a proven solution. Among its many benefits are: minimized waste, energy consumption, and raw material use; the accelerated introduction of new drugs; the use of smaller production facilities with lower building and capital costs; the ability to monitor drug quality on a continuous basis; and enhanced process reliability and flexibility. Continuous Manufacturing of Pharmaceuticals prepares professionals to take advantage of that exciting new approach to improving drug manufacturing efficiency. This book covers key aspects of the continuous manufacturing of pharmaceuticals. The first part provides an overview of key chemical engineering principles and the current regulatory environment. The second covers existing technologies for manufacturing both small-molecule-based products and protein/peptide products. The following section is devoted to process analytical tools for continuously operating manufacturing environments. The final two sections treat the integration of several individual parts of processing into fully operating continuous process systems and summarize state-of-art approaches for innovative new manufacturing principles. * Brings together the essential know-how for anyone working in drug manufacturing, as well as chemical, food, and pharmaceutical scientists working on continuous processing * Covers chemical engineering principles, regulatory aspects, primary and secondary manufacturing, process analytical technology and quality-by-design * Contains contributions from researchers in leading pharmaceutical companies, the FDA, and academic institutions * Offers an extremely well-informed look at the most promising future approaches to continuous manufacturing of innovative pharmaceutical products Timely, comprehensive, and authoritative, Continuous Manufacturing of Pharmaceuticals is an important professional resource for researchers in industry and academe working in the fields of pharmaceuticals development and manufacturing.

Fluorine In Pharmaceutical And Medicinal Chemistry: From Biophysical Aspects To Clinical Applications (Hardcover): Veronique... Fluorine In Pharmaceutical And Medicinal Chemistry: From Biophysical Aspects To Clinical Applications (Hardcover)
Veronique Gouverneur, Klaus Muller
R2,922 R2,703 Discovery Miles 27 030 Save R219 (7%) Shipped within 7 - 12 working days

Fluorine chemistry is an expanding area of research that is attracting international interest, due to the impact of fluorine in drug discovery and in clinical and molecular imaging (e.g. PET, MRI). Many researchers and academics are entering this area of research, while scientists in industrial and clinical environments are also indirectly exposed to fluorine chemistry through the use of fluorinated compounds for imaging.This book provides an overview of the impact that fluorine has made in the life sciences. In the first section, the emphasis is on how fluorine substitution of amino acids, peptides, nucleobases and carbohydrates can provide invaluable information at a molecular level. The following chapters provide answers to the key questions posed on the importance of fluorine in drug discovery and clinical applications. For examples, the reader will discover how fluorine has found its place as a key element improving drug efficacy, with reference to some of the best-selling drugs on the market. Finally, a thorough review on the design, synthesis and use of 18F-radiotracers for positron emission tomography is provided, and this is complemented with a discussion on how 19F NMR has advanced molecular and clinical imaging.

Ultrasonic Production of Nano-emulsions for Bioactive Delivery in Drug and Food Applications (Paperback, 1st ed. 2018): Thomas... Ultrasonic Production of Nano-emulsions for Bioactive Delivery in Drug and Food Applications (Paperback, 1st ed. 2018)
Thomas Leong, Sivakumar Manickam, Gregory J. O. Martin, Wu Li, Muthupandian Ashokkumar
R880 R801 Discovery Miles 8 010 Save R79 (9%) Shipped within 7 - 12 working days

This SpringerBrief provides an overview of ultrasonic emulsification and an update on recent advances in developing stable emulsions for the creation of novel drugs and functional foods, with a focus on bioactive delivery in these products. Emulsification is the process of combining two or more immiscible liquids to form a semi-stable mixture. These two liquids generally consist of an organic (oil) phase and an aqueous (water) phase that is stabilized by the addition of an emulsifier. Most common emulsions are of the oil-in-water (O/W) type, but can also be of water-in-oil (W/O) or even multiple emulsion types (i.e. double emulsions) in the form of water-in-oil-in-water (W/O/W) or oil-in-water-in-oil (O/W/O) phases. The formation of an emulsion requires input of energy to distribute the disperse phase in the continuous phase in small-sized droplets that are able to resist instability. There is great interest in the use of ultrasound to produce emulsions, as it is able to do so relatively efficiently and effectively compared to existing techniques such as rotor stator, high-pressure homogenization and microfluidization. The interaction of ultrasound with the hydrocolloids and biopolymers that are often used to stabilize emulsions can offer advantages such as improved stability or greater control of formed droplet size distributions.

Decision Making in a World of Comparative Effectiveness Research - A Practical Guide (Hardcover, 1st ed. 2017): Howard G.... Decision Making in a World of Comparative Effectiveness Research - A Practical Guide (Hardcover, 1st ed. 2017)
Howard G. Birnbaum, Paul Greenberg
R2,967 R2,505 Discovery Miles 25 050 Save R462 (16%) Shipped within 7 - 12 working days

In the past decade there has been a worldwide evolution in evidence-based medicine that focuses on real-world Comparative Effectiveness Research (CER) to compare the effects of one medical treatment versus another in real world settings. While most of this burgeoning literature has focused on research findings, data and methods, Howard Birnbaum and Paul Greenberg (both of Analysis Group) have edited a book that provides a practical guide to decision making using the results of analysis and interpretation of CER. Decision Making in a World of Comparative Effectiveness contains chapters by senior industry executives, key opinion leaders, accomplished researchers, and leading attorneys involved in resolving disputes in the life sciences industry. The book is aimed at 'users' and 'decision makers' involved in the life sciences industry rather than those doing the actual research. This book appeals to those who commission CER within the life sciences industry (pharmaceutical, biologic, and device manufacturers), government (both public and private payers), as well as decision makers of all levels, both in the US and globally.

Nanostructures for Novel Therapy - Synthesis, Characterization and Applications (Hardcover): Denisa Ficai, Alexandru Mihai... Nanostructures for Novel Therapy - Synthesis, Characterization and Applications (Hardcover)
Denisa Ficai, Alexandru Mihai Grumezescu
R3,505 R2,943 Discovery Miles 29 430 Save R562 (16%) Shipped within 7 - 12 working days

Nanostructures for Novel Therapy: Synthesis, Characterization and Applications focuses on the fabrication and characterization of therapeutic nanostructures, in particular, synthesis, design, and in vitro and in vivo therapeutic evaluation. The chapters provide a cogent overview of recent therapeutic applications of nanostructured materials that includes applications of nanostructured materials for wound healing in plastic surgery and stem cell therapy. The book explores the promise for more effective therapy through the use of nanostructured materials, while also assessing the challenges their use might pose from both an economic and medicinal point of view. This innovative look at how nanostructured materials are used in therapeutics will be of great benefit to researchers, providing a greater understanding of the different ways nanomaterials could improve medical treatment, along with a discussion of the obstacles that need to be overcome in order to guarantee widespread availability.

Aspartic Acid Proteases as Therapeutic Targets (Hardcover): Arun K. Ghosh Aspartic Acid Proteases as Therapeutic Targets (Hardcover)
Arun K. Ghosh; Series edited by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
R4,788 R3,348 Discovery Miles 33 480 Save R1,440 (30%) Shipped within 7 - 13 working days

In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition. Parts two to five present various case studies of successful protease inhibitor drug design and development, as well as current and potential uses of such inhibitors in pharmaceutical medicine, covering the major therapeutic targets HIV-1 protease, renin, beta-secretase, gamma-secretase, plasmepsins and fungal proteases.
A ready reference aimed primarily at professionals in the pharmaceutical industry, as well as for anyone studying proteases and their function.

Ibuprofen - Discovery, Development and Therapeutics (Hardcover): Kim D Rainsford Ibuprofen - Discovery, Development and Therapeutics (Hardcover)
Kim D Rainsford
R2,904 R2,045 Discovery Miles 20 450 Save R859 (30%) Shipped within 7 - 13 working days

Ibuprofen has become one of the foremost pain-relieving medications world-wide with its proven safety and efficacy in a wide variety of painful and inflammatory conditions. It has also been widely investigated for application in a variety of painful and non-pain inflammatory states including cancer and neurodegenerative conditions, reflecting the unique and novel properties of the drug that would never have been foreseen from knowledge of the properties when it was initially discovered. * Edited by leading world expert with over 40 years record in research, teaching and as a scientific advisor in the field of anti-inflammatory/analgesic agents. Professor Kim Rainsford is also the founding Editor-in-Chief of the journal, Inflammopharmacology, as well as being an Associate Editor of The Journal of Pharmacy & Pharmacology. * Provides a thorough coverage of the medicinal chemistry and pharmaceutics of ibuprofen, and its pharmacokinetics in both humans and animals. * Includes molecular, pharmacological and toxicological studies, and discusses the safety and efficacy of non-prescription ibuprofen, including its side effects. Ibuprofen: Discovery, Development & Therapeutics provides a definitive reference on all the main aspects of the chemical and pharmaceutical properties, mechanisms of action and therapeutic uses of ibuprofen including its role in the prevention and treatment of rheumatic conditions, cancer and neurodegenerative conditions such as Alzheimer s and Parkinson s diseases. The book has its origins in a volume first published in 1999, since when there have been considerable advances in research and clinical studies on ibuprofen in the treatment of many inflammatory and even non-inflammatory states. This book will prove invaluable to scientists, clinicians, pharmacists and all those who need to know about the actions and uses of anti-inflammatory and analgesic drugs.

Natural Colorants for Food and Nutraceutical Uses (Hardcover): Francisco Delgado-Vargas, Octavio Paredes-Lopez Natural Colorants for Food and Nutraceutical Uses (Hardcover)
Francisco Delgado-Vargas, Octavio Paredes-Lopez
R4,312 Discovery Miles 43 120 Shipped within 7 - 12 working days

As our understanding of the science and functions of color in food has increased, the preferred colorants, forms of use, and legislation regulating their uses have also changed. Natural Colorants for Food and Nutraceutical Uses reflects the current tendency to use natural pigments. It details their science, technology, and applications as well as their nutraceutical properties.

Starting with the basics, the book creates an understanding of physical colors, discusses color measurement, and analyzes why natural pigments are preferred today. The authors present an overview of global colorants, including safety, toxicity and regulatory aspects. Information about inorganic and synthetic colorants is included. The book then focuses on applications of natural colorants, with special attention given to characteristics, extraction and processing stability, and the use of biotechnology and molecular biology to increase colorant production. Finally, the book examines the nutraceutical properties of natural colorants and compares them to other well-known nutraceutical components.

From the basics to highly specialized concepts and applications, Natural Colorants for Food and Nutraceutical Uses presents essential, practical information about pigments in the food industry. With its coverage of state-of-the-art technologies and future trends in the application of color to food, this book provides the most comprehensive, up-to-date survey of the field.

Pharmacokinetics in Drug Discovery and Development (Hardcover): Ronald D. Schoenwald Pharmacokinetics in Drug Discovery and Development (Hardcover)
Ronald D. Schoenwald
R2,019 Discovery Miles 20 190 Shipped within 7 - 12 working days

Pharmacokinetics has evolved from its origin into a complex discipline with numerous subspecialties and applications in patient management, drug development, and regulatory issues. This expansion has made it difficult for any one individual to become a full-fledged expert in all areas. Fulfilling the need for a wide-ranging guide to the many existing subspecialties in this field, Pharmacokinetics in Drug Discovery and Development details the different areas in the field providing the ideal comprehensive, quick access text and reference.

After an introduction of basic principles, the book is divided into sections that cover industrial and regulatory applications, clinical applications, and research applications. The following sections cover such topics as PK/PD approaches, clinical pharmacokinetic monitoring, population pharmacokinetics, linear systems approaches, and more. Fourteen authors, each an expert in his/her area of expertise, provide an extensive background into the subspeciality with emphasis on the section's theme. Covering the many sub-disciplines and providing pharmacokinetic concepts, terminology, and approaches, Pharmacokinetics in Drug Discovery and Development serves as a resource for professionals throughout this field.

Drug Targeting Technology - Physical Chemical Biological Methods (Hardcover): Hans Schreier Drug Targeting Technology - Physical Chemical Biological Methods (Hardcover)
Hans Schreier
R2,649 Discovery Miles 26 490 Shipped within 7 - 12 working days

Demonstrates how substitution of a variety of ligands can render albumin a versatile targeting tool for selective drug accumulation in various cell populations of the liver
This book discusses physical, chemical, and biological approaches to drug targeting technology, focusing on oral, dispersed system, topical, dermal, transdermal, and inhalation delivery, and the development of original formulations that are matched by innovative device design.
Considers the efforts in biotechnology and molecular biology to produce intelligent drug delivery devices by exploiting biological pathways
Containing over 1100 references to facilitate further study, Drug Targeting Technology
updates recent progress in oral and colonic targeting technology using pH- and enzyme-sensitive coating materials and novel polymer systems
shows how the systemic distribution of drugs can be modulated by lipid-based carriers taking alternative routes of transport, particularly lymph flow
details soft drugs that are rapidly metabolized to inactive and nontoxic metabolites and removed efficiently from the body
includes successful designs of virus-like liposomal delivery systems that offer the advantages of viral carriers
supplies examples of how viral delivery systems can be directed to cancer sites
and more
Suggesting harnessing biological processes as the ultimate approach to the delivery or expression of pharmacologically active agents, Drug Targeting Technology is a top-shelf reference for pharmacists, pharmacologists, and pharmaceutical scientists; analytical, surface, physical, and colloid chemists and biochemists; and upper-level undergraduate and graduate students in these disciplines.

Peptide and Protein Drug Analysis (Hardcover): Ronald E Reid Peptide and Protein Drug Analysis (Hardcover)
Ronald E Reid
R3,548 Discovery Miles 35 480 Shipped within 7 - 12 working days

Furthering efforts to simulate the potency and specificity exhibited by peptides and proteins in healthy cells, this remarkable reference supplies pharmaceutical scientists with a wealth of techniques for tapping the enormous therapeutic potential of these molecules-providing a solid basis of knowledge for new drug design.
Provides a broad, comprehensive overview of peptides and proteins as mediators of cell movement, proliferation, differentiation, and communication.
Written by more than 50 leading international authorities, Peptides and Protein Drug Analysis
discusses strategies for dealing with the complexity of peptides and proteins in conformational flexibility and amino acid sequence variability
analyzes drug formulations facilitated by solid-phase peptide synthesis and recombinant DNA technology
examines chemical purity analysis by high-pressure chromatographic, capillary electrophoretic, gel electrophoretic, and isoelectric focusing methods
highlights drug design elements derived from protein folding, bioinformatics, and computational chemistry
demonstrates uses of unnatural mutagenesis and combinatorial chemistry
explores mass spectrometry, protein sequence, and carbohydrate analysis
illustrates bioassays and other new functional analysis methods
surveys spectroscopic techniques such as ultraviolet, fluorescence, Fourier transform infrared, and nuclear magnetic resonance (NMR)
addresses ways of distinguishing between levels of therapeutic and endogenous agents in cells
reviews structural analysis tools such as ultracentrifugation and light, X-ray, and neutron scattering
and more
Featuring over 3400 bibliographic citations and more than 500 tables, equations, and illustrations, Peptide and Protein Drug Analysis is a must-read resource for pharmacists; pharmacologists; analytical, organic, and pharmaceutical chemists; cell and molecular biologists; biochemists; and upper-level undergraduate and graduate students in these disciplines.

Ibuprofen - A Critical Bibliographic Review (Hardcover): Kim D Rainsford Ibuprofen - A Critical Bibliographic Review (Hardcover)
Kim D Rainsford
R4,972 Discovery Miles 49 720 Shipped within 7 - 12 working days

Ibuprofen is widely used throughout the world for a variety of conditions. This reference work provides a comprehensive and critical review of the basic science and clinical aspects of the drug. The book begins with the history and development of the drug and its current patterns of use world- wide before moving on to examine its basic pharmaceutical attributes and medicinal chemistry. The properties of various formulations are described (oral prescription and OTC, topical and others) are described. The pharmacokinetics of ibuprofen in animals and humans is discussed - highlighting the factors affecting absorption, distribution, metabolism and elimination. The clinical pharmacology and toxicology and the drug's mechanisms of action in different disease states and conditions are covered. The therapeutic uses in various acute and inflammatory conditions is detailed. Also considered are the safety versus efficacy issues and the pharmacoepidemiological data.

Proteolysis in the Interstitial Space (Hardcover): Salvatore V. Pizzo, Roger L. Lundblad, Monte S. Willis Proteolysis in the Interstitial Space (Hardcover)
Salvatore V. Pizzo, Roger L. Lundblad, Monte S. Willis
R3,376 Discovery Miles 33 760 Shipped within 7 - 12 working days

Most clinical laboratory tests utilize interstitial and extravascular such as blood, urine, cerebral spinal fluid (CSF), and saliva. For example, CSF is monitored in the context of cancer for both diagnostic and therapeutic reasons. And yet, our understanding of the makeup of interstitial fluids, their relationships to disease, as well as their commercial importance in therapeutics and diagnostics remains rudimentary. Although sometimes perceived as static, interstitial and extravascular fluids are surprisingly dynamic. More than half of serum albumin is in the extravascular space. These fluids move rapidly between the intravascular and extravascular spaces - one entire plasma volume is exchanged very nine hours. In the first half of the book, the authors cover fundamental concepts of interstitial fluids, including their composition and function. They then further review the mechanisms by which interstitial fluids are regulated, characterizing the importance of hyaluronan - a major constituent of interstitial spaces and an a component of synovial fluid; and, outlining the regulation of proteolysis in the interstitial space. In the second half of the book, the authors focus on the coagulation system. This system has been studied extensively in the context of vascular spaces. But many of its components exist in the interstitial spaces. Chapters are devoted to the fibrinolytic system, kallikrein, matrix metalloproteinases, coagulation factors, and protease inhibitors - all are interstitial. By covering a unique array of topics with broad application to biomedical scientists, this book expands our understanding of the importance of interstitial spaces and the fluids that move through and reside in this extravascular environment.

Biological Approaches to Rational Drug Design (Hardcover): David B. Weiner, William V. Williams Biological Approaches to Rational Drug Design (Hardcover)
David B. Weiner, William V. Williams
R2,343 Discovery Miles 23 430 Shipped within 7 - 12 working days

Intended for medicinal chemists, pharmaceutical scientists, pharmacologists, immunologists, biochemists and microbiologists, this book provides both a broad overview of the current methodologies being applied to drug design and in-depth analyses of progress in specific fields. It offers state-of-the-art approaches to pharmaceutical development, including biological technologies currently used by some of the world's foremost laboratories. Features include: discussion of new techniques; previously unpublished data; and extensive reference lists.

Progress in the Chemistry of Organic Natural Products 106 (Hardcover, 1st ed. 2017): A. Douglas Kinghorn, Heinz Falk, Simon... Progress in the Chemistry of Organic Natural Products 106 (Hardcover, 1st ed. 2017)
A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Junichi Kobayashi
R5,164 R4,224 Discovery Miles 42 240 Save R940 (18%) Shipped within 7 - 12 working days

The first contribution presents coumarins, the largest group of 1-benzopyran derivatives found in plants. Coumarin chemistry remains one of the major interest areas of phytochemists, especially because of their structural diversity and medicinal properties, along with the wide-ranging bioactivities of these compounds, inclusive of analgesic, anticoagulant anti-HIV, anti-inflammatory, antimicrobial, antineoplastic, antioxidant, and immunomodulatory effects. The second contribution presents a comprehensive survey of the many aspects of PAD biochemistry and physiology. The third contribution gives a comprehensive overview of secondary metabolites from higher fungi, with more than 700 references highlighting the isolation, structure elucidation, biological activities, chemical synthesis, and biosynthesis of pigments, nitrogen-containing compounds, and terpenoids from mushrooms.

Inhaled Sedation in the Intensive Care Unit - A New Option and Its Technical Prerequisites (Paperback, 1st Ed. 2019): Andreas... Inhaled Sedation in the Intensive Care Unit - A New Option and Its Technical Prerequisites (Paperback, 1st Ed. 2019)
Andreas Meiser
R1,317 R1,186 Discovery Miles 11 860 Save R131 (10%) Shipped within 7 - 12 working days
Label-Free Technologies For Drug Discovery (Hardcover, New): Matthew A Cooper, Lorenz M. Mayr Label-Free Technologies For Drug Discovery (Hardcover, New)
Matthew A Cooper, Lorenz M. Mayr
R2,705 R1,901 Discovery Miles 19 010 Save R804 (30%) Shipped within 7 - 13 working days

Over the past two decades the benefits of label-free biosensor analysis have begun to make an impact in the market, and systems are beginning to be used as mainstream research tools in many drug discovery laboratories.

"Label-Free Technologies For Drug Discovery" summarises the latest and emerging developments in label-free detection systems, their underlying technology principles and end-user case studies that reveal the power and limitations of label-free in all areas of drug discovery.

Label-free technologies discussed include SPR, NMR, high-throughput mass spectrometry, resonant waveguide plate-based screening, transmitted-light imaging, isothermal titration calorimetry, optical and impedance cell-based assays and other biophysical methods. The technologies are discussed in relation to their use as screening technologies, high-content technologies, hit finding and hit validation strategies, mode of action and ADME/T, access to difficult target classes, cell-based receptor/ligand interactions particularly orphan receptors, and antibody and small molecule affinity and kinetic analysis.

"Label-Free Technologies For Drug Discovery" is an essential guide to this emerging class of tools for researchers in drug discovery and development, particularly high-throughput screening and compound profiling teams, medicinal chemists, structural biologists, assay developers, ADME/T specialists, and others interested in biomolecular interaction analysis.

Process Architecture in Biomanufacturing Facility Design (Hardcover): Jeffery Odum, Michael C Flickinger Process Architecture in Biomanufacturing Facility Design (Hardcover)
Jeffery Odum, Michael C Flickinger
R3,286 R2,306 Discovery Miles 23 060 Save R980 (30%) Shipped within 7 - 13 working days

Essential information for architects, designers, engineers, equipment suppliers, and other professionals who are working in or entering the biopharmaceutical manufacturing field Biomanufacturing facilities that are designed and built today are radically different than in the past. The vital information and knowledge needed to design and construct these increasingly sophisticated biopharmaceutical manufacturing facilities is difficult to find in published literature--and it's rarely taught in architecture or design schools. This is the first book for architects and designers that fills this void. Process Architecture in Biomanufacturing Facility Design provides information on design principles of biopharmaceutical manufacturing facilities that support emerging innovative processes and technologies, use state-of-the-art equipment, are energy efficient and sustainable, and meet regulatory requirements. Relying on their many years of hands-on design and operations experience, the authors emphasize concepts and practical approaches toward design, construction, and operation of biomanufacturing facilities, including product-process-facility relationships, closed systems and single use equipment, aseptic manufacturing considerations, design of biocontainment facility and process based laboratory, and sustainability considerations, as well as an outlook on the facility of the future. Provides guidelines for meeting licensing and regulatory requirements for biomanufacturing facilities in the U.S.A and WHO--especially in emerging global markets in India, China, Latin America, and the Asia/Pacific regions Focuses on innovative design and equipment, to speed construction and time to market, increase energy efficiency, and reduce footprint, construction and operational costs, as well as the financial risks associated with construction of a new facility prior to the approval of the manufactured products by regulatory agencies Includes many diagrams that clarify the design approach Process Architecture in Biomanufacturing Facility Design is an ideal text for professionals involved in the design of facilities for manufacturing of biopharmaceuticals and vaccines, biotechnology, and life-science industry, including architects and designers of industrial facilities, construction, equipment vendors, and mechanical engineers. It is also recommended for university instructors, advanced undergraduates, and graduate students in architecture, industrial engineering, mechanical engineering, industrial design, and industrial interior design.

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Trypanosomatid Diseases - Molecular…
Timo Jager, Oliver Koch, … Hardcover R3,113 R2,501 Discovery Miles 25 010
Biopharmaceutical Production Technology…
Ganapathy Subramanian Hardcover R8,534 R7,558 Discovery Miles 75 580
NMR in Pharmaceutical Science
Jeremy R. Everett, John C. Lindon, … Hardcover R2,378 R2,217 Discovery Miles 22 170
Medicinal Chemistry Approaches to…
Karen Lackey, Bruce Roth Hardcover R2,999 R2,395 Discovery Miles 23 950
Pharmaceutical Salts - Properties…
P.Heinrich Stahl, Camille Georges Wermuth Hardcover R4,138 R3,275 Discovery Miles 32 750
Management of Chemical and Biological…
Mark Wigglesworth, Terry Wood Hardcover R3,629 R2,872 Discovery Miles 28 720

 

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