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Over the past two decades the benefits of label-free biosensor analysis have begun to make an impact in the market, and systems are beginning to be used as mainstream research tools in many drug discovery laboratories.
"Label-Free Technologies For Drug Discovery" summarises the latest and emerging developments in label-free detection systems, their underlying technology principles and end-user case studies that reveal the power and limitations of label-free in all areas of drug discovery.
Label-free technologies discussed include SPR, NMR, high-throughput mass spectrometry, resonant waveguide plate-based screening, transmitted-light imaging, isothermal titration calorimetry, optical and impedance cell-based assays and other biophysical methods. The technologies are discussed in relation to their use as screening technologies, high-content technologies, hit finding and hit validation strategies, mode of action and ADME/T, access to difficult target classes, cell-based receptor/ligand interactions particularly orphan receptors, and antibody and small molecule affinity and kinetic analysis.
"Label-Free Technologies For Drug Discovery" is an essential guide to this emerging class of tools for researchers in drug discovery and development, particularly high-throughput screening and compound profiling teams, medicinal chemists, structural biologists, assay developers, ADME/T specialists, and others interested in biomolecular interaction analysis.
Essential information for architects, designers, engineers, equipment suppliers, and other professionals who are working in or entering the biopharmaceutical manufacturing field Biomanufacturing facilities that are designed and built today are radically different than in the past. The vital information and knowledge needed to design and construct these increasingly sophisticated biopharmaceutical manufacturing facilities is difficult to find in published literature--and it's rarely taught in architecture or design schools. This is the first book for architects and designers that fills this void. Process Architecture in Biomanufacturing Facility Design provides information on design principles of biopharmaceutical manufacturing facilities that support emerging innovative processes and technologies, use state-of-the-art equipment, are energy efficient and sustainable, and meet regulatory requirements. Relying on their many years of hands-on design and operations experience, the authors emphasize concepts and practical approaches toward design, construction, and operation of biomanufacturing facilities, including product-process-facility relationships, closed systems and single use equipment, aseptic manufacturing considerations, design of biocontainment facility and process based laboratory, and sustainability considerations, as well as an outlook on the facility of the future. Provides guidelines for meeting licensing and regulatory requirements for biomanufacturing facilities in the U.S.A and WHO--especially in emerging global markets in India, China, Latin America, and the Asia/Pacific regions Focuses on innovative design and equipment, to speed construction and time to market, increase energy efficiency, and reduce footprint, construction and operational costs, as well as the financial risks associated with construction of a new facility prior to the approval of the manufactured products by regulatory agencies Includes many diagrams that clarify the design approach Process Architecture in Biomanufacturing Facility Design is an ideal text for professionals involved in the design of facilities for manufacturing of biopharmaceuticals and vaccines, biotechnology, and life-science industry, including architects and designers of industrial facilities, construction, equipment vendors, and mechanical engineers. It is also recommended for university instructors, advanced undergraduates, and graduate students in architecture, industrial engineering, mechanical engineering, industrial design, and industrial interior design.
This third edition volume expands on the previous editions with new topics that cover drug discovery through translational bioinformatics, informatics, clinical research informatics, as well as clinical informatics. The chapters discuss new methods to study target identification, genome analysis, cheminformatics, protein analysis, and text mining. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials, software workflows, reagents and on-line resources, together with step-by-step, readily reproducible laboratory and computational protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Bioinformatics and Drug Discovery, Third Edition is a valuable resource for anyone interested in drug design, including academicians (biologists, informaticists and data scientists, chemists, and biochemists), clinicians, and pharmaceutical scientists.
Adaptive Designs for Sequential Treatment Allocation presents a rigorous theoretical treatment of the results and mathematical foundation of adaptive design theory. The book focuses on designing sequential randomized experiments to compare two or more treatments incorporating information accrued along the way. The authors first introduce the terminology and statistical models most commonly used in comparative experiments. They then illustrate biased coin and urn designs that only take into account past treatment allocations as well as designs that use past data, such as sequential maximum likelihood and various types of doubly adaptive designs. The book also covers multipurpose adaptive experiments involving utilitarian choices and ethical issues. It ends with adaptive methods that include covariates in the design. The appendices present basic tools of optimal design theory and address Bayesian adaptive designs. This book helps readers fully understand the theoretical properties behind various adaptive designs. Readers are then equipped to choose the best design for their experiment.
This 2 volume set is a carefully chosen collection of articles on pharmacology from the successful R.A. Meyer's "Encyclopedia of Molecular Cell Biology and Molecular Medicine," The book is divided into four sections covering general aspects of drug development as well as more focused sections on cancer and gene therapy.
This collection of high-quality articles on pharmacology includes essential reading on the hottest topics of the field and is an invaluable resource for all pharmacologists, medicinal chemists and cell biologists. No science or medical library should be without this book. It is also essential reading for everybody working in the pharmaceutical industry.
Hallmark features: Uniform structure of the articles makes them very easy to use Designed for readers at any level of expertise Every chapter usefully includes: a keyword glossary a concise summary of the article comprehensive references to guide the reader deeper into the literature Derived from the "Encyclopedia of Molecular Cell Biology and Molecular Medicine," the most comprehensive and most detailed treatment of molecular biology, cell biology and molecular medicine available - designed in collaboration with a founding board of 12 Nobel laureates, including the 2007 Nobel Prize winner in medicine, Sir Martin Evans
Praise for the "Encyclopedia of Molecular Cell Biology and Molecular Medicine: "
"This series can be recommended without hesitation to a broad
readership including students and qualified researchers...
articles... set-up facilitates easy reading and rapid
understanding... overwhelming amount of valuable data."
.,." It goes without saying that no librarycan afford to be
without this [Encyclopedia]. Everyone working in the areas of
molecular biology, genome research, medical science, or clinical
research needs to have access to these volumes..."
By guiding in the application of techniques and tools for predicting ADMET outcomes in drug candidates, Predictive ADMET offers a road map for drug discovery scientists to generate effective and safe drugs for unmet medical needs. Featuring case studies and lessons learned from real drug discovery and development, the text: helps users diagnose ADMET problems; presents appropriate recommendations; introduces the current clinical practice for drug discovery and development; and consolidates the tools and models to intelligently integrate existing in silico, in vitro and in vivo ADMET data.
Emphasizing synthetic strategy and practice, "Stereoselective Synthesis of Drugs and Natural Products" features experimental procedures for stereoselective synthetic reactions applicable to drug targets and natural products. Compiling material from leading contributors into one cohesive resource, this practical resource on synthetic methodology, reaction mechanisms, and applications for medicinal chemistry and drug discovery explores strategy and interdisciplinary work, laboratory synthesis for natural products, the preparative aspects of stereoselective synthesis for drugs, natural products, and potential biologically active compounds. The text also features experimental procedures for the different reaction methods covered.
Taking medication is a common occurrence for many people, whether
it is to soothe an aching head, regulate blood sugars, or treat
life-threatening conditions such as HIV or cancer. Examining how
drugs are manufactured, formulated, and the way that they work in
our bodies, PharmaceuticalChemistry provides a wide-ranging
overview of organic chemistry as it is applied to the study and
practice of pharmacy.
This volume provides an overview of the biochemical characterization, structure-function studies, proteomics, bioinformatics, molecular biology, transcriptomics and genomics of various spider species. The book also covers our current knowledge of venom components, toxins and their modes of action. The first section of Spider Venom includes contributions regarding the wide diversity of spider venom components and depicts some of their biological effects (antimicrobial, ion channel modulators, insecticides, this includes peptide and non-peptide toxins), and emphasizes spiders of public health importance. The second section covers transcriptomes, proteomes (and peptidomics), bioinformatics and molecular dynamics. The last section describes antimicrobial, insecticidal toxins, envenomation and the medical potential of spider venoms. Spider venoms are a great and extensive source of bioactive compounds, and as such form a boundless and bountiful area awaiting discovery. It is by virtue of dedicated scientists that new toxins are discovered and that new insights arise, leading the way towards the investigation of their pharmacological effects, and hopefully, as a consequence, arriving at the discovery of venom components as new drug candidates.
This book offers a state-of-the-art overview of controlled drug delivery systems, covering the most important innovative applications. The principles of controlled drug release and the mechanisms involved in controlled release are clearly explained. The various existing polymeric drug delivery systems are reviewed, and new frontiers in material design are examined in detail, covering a wide range of polymer modification techniques. The concluding chapter is a case study focusing on use of a drug-eluting stent. The book is designed to provide the reader with a complete understanding of the mechanisms and design of controlled drug delivery systems, and to this end includes numerous step-by-step tutorials. It illustrates how chemical engineers can advance medical care by designing polymeric delivery systems that achieve either temporal or spatial control of drug delivery and thus ensure more effective therapy that eliminates the potential for both under- and overdosing.
This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 2, Organ Systems, offers summaries of organ-specific immunobiology and immunopathology as well as common responses to xenobiotics. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system.
Due to the impressive accumulation of out-standing results, presented by brilliant, privileged and creative thinkers, this unique book reads like the 'Who is Who' of biotechnology. Never before has such an impressive group of individuals contributed to one biotechnology book, including Nobel Prize laureates Robert Huber, Thomas R. Cech, and Manfred Eigen as well as authors from the world's most famous academic institutes and biotech companies, such as ETH Zurich, MIT, Stanford, Yale, Princeton, Harvard Medical School, Max-Planck-Institute, Fraunhofer-Institute, Moscow Academy of Sciences, London Imperial College and Baxter, Invitrogen, MorphoSys, Roche, and Schering AG. Published as a comprehensive four volume set, this title also includes a CD-ROM containing additional information and videos. "Modern Biopharmaceuticals" describes: the first cloned human embryo; the first myocardial regeneration with embryonic stem cells; the first artificial kidney; the first biopharmaceutical from a transgenic animal; the first individualized medicine; the first plasma-free Factor VIII; the first approved human cell line; and, the first oral insulin, etc. '...an outstanding collection of articles from groundbreaking scientists, comprehensively describing the many novel ways cells are being deployed toward human good . ..' - James D. Watson, 'DNA Codebreaker' and Nobel Prize Laureate (Physiology or Medicine, 1962). "Modern Biopharmaceuticals" is an essential reference work for biotechnologists, clinicians, medical doctors, pharmacists, pharmaceutical chemists, bio-chemists, molecular biologists, medicinal chemists, as well as all those working in the biotechnological and pharmaceutical industries, or medicinal institutes.
This book illustrates, in a comprehensive manner, the most current areas of importance to Safety Pharmacology, a burgeoning unique pharmacological discipline with important ties to academia, industry and regulatory authorities. It provides readers with a definitive collection of topics containing essential information on the latest industry guidelines and overviews current and breakthrough topics in both functional and molecular pharmacology. An additional novelty of the book is that it constitutes academic, pharmaceutical and biotechnology perspectives for Safety Pharmacology issues. Each chapter is written by an expert in the area and includes not only a fundamental background regarding the topic but also detailed descriptions of currently accepted, validated models and methods as well as innovative methodologies used in drug discovery.
Examining the implications and practical implementation of multi-disciplinary International Conference on Harmonization (ICH) topics, this book gives an integrated view of how the guidelines inform drug development strategic planning and decision-making. Addresses a consistent need for interpretation, training, and implementation examples of ICH guidelines via case studies Offers a primary reference point for practitioners addressing the dual challenge of interpretation and practical implementation of ICH guidelines Uses case studies to help readers understand and apply ICH guidelines Provides valuable insights into guidelines development, with chapters by authors involved in generating or with experience implementing the guidelines Includes coverage of stability testing, analytical method validation, impurities, biotechnology drugs and products, and good manufacturing practice (GMP)
This manual, to be published in two volumes, provides a condensed overview of the analytical investigation of 80 Chinese Herbal Drugs which are most frequently in use. Thin layer chromatographic-, high pressure liquid chromatographic- and gas chromatographic-fingerprint analytical techniques allow the detection of all main low-molecular constituents of a plant drug and even single constituents can be visualized. Analytical results thereof are shown in numerous color figures. The quality proof of the investigation meets the standard of the European Drug Regulatory Authority.
Furthermore, this volume gives a detailed description of the analytical methods used for several drugs. Bioactive constituents, pharmacological and biological activities of several single herbal drugs as well as their therapeutic applications are discussed.
This volume contains a section on the wider evolutionary context of venom in animals, the molecular evolutionary processes involved in generating diversity, and the concept of venom evolution as being driven by an arms race that also involves evolution of resistance to toxins by prey. It also studies the relationship between the evolution of toxins and the evolution of the animals that they evolved within. The last section discusses the evolution of venom delivery systems. The definition of a venomous animal, as opposed to a poisonous one, encompasses the evolution not just of toxins but also a specialized mechanism for administering them by injection.
The past quarter-century has seen tremendous progress in biomedical research, leading to increasing understanding of cancer, heart disease, diabetes, and other devastating diseases. The Nation has led the world in such progress, due in significant part to wise investments by the Federal Government in basic biomedical research. These breakthroughs are beginning to pay off in terms of new therapies for American patients. Still, the pace of new therapeutic development has not kept up with the explosion in scientific knowledge. The number of novel drugs has remained constant for several decades, even though R&D budgets have substantially increased. This situation poses an increasing challenge for ensuring the creation of innovative therapies for patients and throughout the biomedical ecosystem. This book examines the efforts being made to double over the next decade, the rate of invention of innovative new medicines for patients, while increasing drug safety, in the hopes that these actions will advance the health of Americans, as well as provide economic growth for the Nation.
A natural product is a chemical compound or substance produced by a living organism - found in nature that usually has a pharmacological or biological activity for use in pharmaceutical drug discovery and drug design. A natural product can be considered as such even if it can be prepared by total synthesis. In this book, the authors present current research in the study of the structure, bioactivity and applications of natural products. Topics discussed include the in-vitro assessment of chromones and alkaloids from Caribbean plants as potential anti-tuberculars and chemopreventors; natural products as inhibitors of ubiquitin and ubiquitin-like protein-proteasome pathways; the biological activities of red propolis; nanoencapsulation of natural products; and natural products as a source of potential drugs for the treatment of fungal infections.
This detailed volume addresses key issues and subtle nuances involved in developing hydrophilic matrix tablets as an approach to oral controlled release. It brings together information from more than five decades of research and development on hydrophilic matrix tablets and provides perspective on contemporary issues. Twelve comprehensive chapters explore a variety of topics including polymers (hypromellose, natural polysaccharides and polyethylene oxide) and their utilization in hydrophilic matrices, critical interactions impacting tablet performance, in vitro physical and imaging techniques, and microenvironmental pH control and mixed polymer approaches, among others. In one collective volume, Hydrophilic Matrix Tablets for Oral Controlled Release provides a single source of current knowledge, including sections of previously unpublished data. It is an important resource for industrial and academic scientists investigating and developing these oral controlled release formulations.
Pharmaceutical giants have been doubling their investments in drug development, only to see new drug approvals to remain constant for the past decade. This book investigates and highlights a set of proactive strategies, aimed at generating sustainable competitive advantage for its protagonists based on value-generating business practices. We focus on three sources of pharmaceutical innovation: new management methods in the drug development pipeline, new technologies as enablers for cutting-edge R&D, and new forms of internationalisation, such as outside-in innovation in the early phases of R&D.
A comprehensive treatise on the hot working of aluminum and its alloys, Hot Deformation and Processing of Aluminum Alloys details the possible microstructural developments that can occur with hot deformation of various alloys, as well as the kind of mechanical properties that can be anticipated. The authors take great care to explain and differentiate hot working in the context of other elevated temperature phenomena, such as creep, superplasticity, cold working, and annealing. They also pay particular attention to the fundamental mechanisms of aluminum plasticity at hot working temperatures. Using extensive analysis derived from polarized light optical microscopy (POM), transmission electron microscopy (TEM), x-ray diffraction (XRD) scanning electron-microscopy with electron backscatter imaging (SEM-EBSD), and orientation imaging microscopy (OIM), the authors examine those microstructures that evolve in torsion, compression, extrusion, and rolling. Further microstructural analysis leads to detailed explanations of dynamic recovery (DRV), static recovery (SRV), discontinuous dynamic recrystallization (dDRX), discontinuous static recrystallization (dSRX), grain defining dynamic recovery (gDRV) (formerly geometric dynamic recrystallization, or gDRX), and continuous dynamic recrystallization involving both a single phase (cDRX/1-phase) and multiple phases (cDRX/2-phase). A companion to other works that focus on modeling, manufacturing involving plastic and superplastic deformation, and control of texture and phase transformations, this book provides thorough explanations of microstructural development to lay the foundation for further study of the mechanisms of thermomechanical processes and their application.
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