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Books > Professional & Technical > Industrial chemistry & manufacturing technologies > Industrial chemistry > Pharmaceutical technology

Inhaled Sedation in the Intensive Care Unit - A New Option and Its Technical Prerequisites (Paperback, 1st Ed. 2019): Andreas... Inhaled Sedation in the Intensive Care Unit - A New Option and Its Technical Prerequisites (Paperback, 1st Ed. 2019)
Andreas Meiser
R1,317 R1,186 Discovery Miles 11 860 Save R131 (10%) Shipped within 7 - 12 working days
Label-Free Technologies For Drug Discovery (Hardcover, New): Matthew A Cooper, Lorenz M. Mayr Label-Free Technologies For Drug Discovery (Hardcover, New)
Matthew A Cooper, Lorenz M. Mayr
R2,705 R1,901 Discovery Miles 19 010 Save R804 (30%) Shipped within 7 - 13 working days

Over the past two decades the benefits of label-free biosensor analysis have begun to make an impact in the market, and systems are beginning to be used as mainstream research tools in many drug discovery laboratories.

"Label-Free Technologies For Drug Discovery" summarises the latest and emerging developments in label-free detection systems, their underlying technology principles and end-user case studies that reveal the power and limitations of label-free in all areas of drug discovery.

Label-free technologies discussed include SPR, NMR, high-throughput mass spectrometry, resonant waveguide plate-based screening, transmitted-light imaging, isothermal titration calorimetry, optical and impedance cell-based assays and other biophysical methods. The technologies are discussed in relation to their use as screening technologies, high-content technologies, hit finding and hit validation strategies, mode of action and ADME/T, access to difficult target classes, cell-based receptor/ligand interactions particularly orphan receptors, and antibody and small molecule affinity and kinetic analysis.

"Label-Free Technologies For Drug Discovery" is an essential guide to this emerging class of tools for researchers in drug discovery and development, particularly high-throughput screening and compound profiling teams, medicinal chemists, structural biologists, assay developers, ADME/T specialists, and others interested in biomolecular interaction analysis.

Process Architecture in Biomanufacturing Facility Design (Hardcover): Jeffery Odum, Michael C Flickinger Process Architecture in Biomanufacturing Facility Design (Hardcover)
Jeffery Odum, Michael C Flickinger
R3,286 R2,306 Discovery Miles 23 060 Save R980 (30%) Shipped within 7 - 13 working days

Essential information for architects, designers, engineers, equipment suppliers, and other professionals who are working in or entering the biopharmaceutical manufacturing field Biomanufacturing facilities that are designed and built today are radically different than in the past. The vital information and knowledge needed to design and construct these increasingly sophisticated biopharmaceutical manufacturing facilities is difficult to find in published literature--and it's rarely taught in architecture or design schools. This is the first book for architects and designers that fills this void. Process Architecture in Biomanufacturing Facility Design provides information on design principles of biopharmaceutical manufacturing facilities that support emerging innovative processes and technologies, use state-of-the-art equipment, are energy efficient and sustainable, and meet regulatory requirements. Relying on their many years of hands-on design and operations experience, the authors emphasize concepts and practical approaches toward design, construction, and operation of biomanufacturing facilities, including product-process-facility relationships, closed systems and single use equipment, aseptic manufacturing considerations, design of biocontainment facility and process based laboratory, and sustainability considerations, as well as an outlook on the facility of the future. Provides guidelines for meeting licensing and regulatory requirements for biomanufacturing facilities in the U.S.A and WHO--especially in emerging global markets in India, China, Latin America, and the Asia/Pacific regions Focuses on innovative design and equipment, to speed construction and time to market, increase energy efficiency, and reduce footprint, construction and operational costs, as well as the financial risks associated with construction of a new facility prior to the approval of the manufactured products by regulatory agencies Includes many diagrams that clarify the design approach Process Architecture in Biomanufacturing Facility Design is an ideal text for professionals involved in the design of facilities for manufacturing of biopharmaceuticals and vaccines, biotechnology, and life-science industry, including architects and designers of industrial facilities, construction, equipment vendors, and mechanical engineers. It is also recommended for university instructors, advanced undergraduates, and graduate students in architecture, industrial engineering, mechanical engineering, industrial design, and industrial interior design.

Bioinformatics and Drug Discovery (Hardcover, 3rd ed. 2019): Richard S. Larson, Tudor I. Oprea Bioinformatics and Drug Discovery (Hardcover, 3rd ed. 2019)
Richard S. Larson, Tudor I. Oprea
R3,765 R2,979 Discovery Miles 29 790 Save R786 (21%) Shipped within 7 - 12 working days

This third edition volume expands on the previous editions with new topics that cover drug discovery through translational bioinformatics, informatics, clinical research informatics, as well as clinical informatics. The chapters discuss new methods to study target identification, genome analysis, cheminformatics, protein analysis, and text mining. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials, software workflows, reagents and on-line resources, together with step-by-step, readily reproducible laboratory and computational protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Bioinformatics and Drug Discovery, Third Edition is a valuable resource for anyone interested in drug design, including academicians (biologists, informaticists and data scientists, chemists, and biochemists), clinicians, and pharmaceutical scientists.

Adaptive Designs for Sequential Treatment Allocation (Hardcover): Alessandra Giovagnoli, Alessandro Baldi Antognini Adaptive Designs for Sequential Treatment Allocation (Hardcover)
Alessandra Giovagnoli, Alessandro Baldi Antognini
R1,337 Discovery Miles 13 370 Shipped within 7 - 12 working days

Adaptive Designs for Sequential Treatment Allocation presents a rigorous theoretical treatment of the results and mathematical foundation of adaptive design theory. The book focuses on designing sequential randomized experiments to compare two or more treatments incorporating information accrued along the way. The authors first introduce the terminology and statistical models most commonly used in comparative experiments. They then illustrate biased coin and urn designs that only take into account past treatment allocations as well as designs that use past data, such as sequential maximum likelihood and various types of doubly adaptive designs. The book also covers multipurpose adaptive experiments involving utilitarian choices and ethical issues. It ends with adaptive methods that include covariates in the design. The appendices present basic tools of optimal design theory and address Bayesian adaptive designs. This book helps readers fully understand the theoretical properties behind various adaptive designs. Readers are then equipped to choose the best design for their experiment.

Pharmacology - From Drug Development to Gene Therapy (Hardcover): Robert A. Meyers Pharmacology - From Drug Development to Gene Therapy (Hardcover)
Robert A. Meyers
R7,030 R6,236 Discovery Miles 62 360 Save R794 (11%) Shipped within 7 - 12 working days

This 2 volume set is a carefully chosen collection of articles on pharmacology from the successful R.A. Meyer's "Encyclopedia of Molecular Cell Biology and Molecular Medicine," The book is divided into four sections covering general aspects of drug development as well as more focused sections on cancer and gene therapy.

This collection of high-quality articles on pharmacology includes essential reading on the hottest topics of the field and is an invaluable resource for all pharmacologists, medicinal chemists and cell biologists. No science or medical library should be without this book. It is also essential reading for everybody working in the pharmaceutical industry.

Hallmark features: Uniform structure of the articles makes them very easy to use Designed for readers at any level of expertise Every chapter usefully includes: a keyword glossary a concise summary of the article comprehensive references to guide the reader deeper into the literature Derived from the "Encyclopedia of Molecular Cell Biology and Molecular Medicine," the most comprehensive and most detailed treatment of molecular biology, cell biology and molecular medicine available - designed in collaboration with a founding board of 12 Nobel laureates, including the 2007 Nobel Prize winner in medicine, Sir Martin Evans

Praise for the "Encyclopedia of Molecular Cell Biology and Molecular Medicine: "

"This series can be recommended without hesitation to a broad readership including students and qualified researchers... articles... set-up facilitates easy reading and rapid understanding... overwhelming amount of valuable data."
--"Molecular Biology Reports"

.,." It goes without saying that no librarycan afford to be without this [Encyclopedia]. Everyone working in the areas of molecular biology, genome research, medical science, or clinical research needs to have access to these volumes..."
--"Angewandte Chemie"

Predictive ADMET - Integrated Approaches in Drug Discovery and Development (Hardcover): Jianling Wang, Laszlo Urban Predictive ADMET - Integrated Approaches in Drug Discovery and Development (Hardcover)
Jianling Wang, Laszlo Urban
R2,923 R2,057 Discovery Miles 20 570 Save R866 (30%) Shipped within 7 - 13 working days

By guiding in the application of techniques and tools for predicting ADMET outcomes in drug candidates, Predictive ADMET offers a road map for drug discovery scientists to generate effective and safe drugs for unmet medical needs. Featuring case studies and lessons learned from real drug discovery and development, the text: helps users diagnose ADMET problems; presents appropriate recommendations; introduces the current clinical practice for drug discovery and development; and consolidates the tools and models to intelligently integrate existing in silico, in vitro and in vivo ADMET data.

Determination of Droplet Surface Temperature and Drying Kinetics of Protein Solutions Using an Ultrasonic Levitator... Determination of Droplet Surface Temperature and Drying Kinetics of Protein Solutions Using an Ultrasonic Levitator (Paperback)
Eva Cornelia Wulsten
R832 R619 Discovery Miles 6 190 Save R213 (26%) Shipped within 7 - 12 working days
Stereoselective Synthesis of Drugs and Natural Products - 2 Volume Set (Hardcover): Vasyl Andrushko, Natalia Andrushko Stereoselective Synthesis of Drugs and Natural Products - 2 Volume Set (Hardcover)
Vasyl Andrushko, Natalia Andrushko
R9,965 R6,973 Discovery Miles 69 730 Save R2,992 (30%) Shipped within 7 - 13 working days

Emphasizing synthetic strategy and practice, "Stereoselective Synthesis of Drugs and Natural Products" features experimental procedures for stereoselective synthetic reactions applicable to drug targets and natural products. Compiling material from leading contributors into one cohesive resource, this practical resource on synthetic methodology, reaction mechanisms, and applications for medicinal chemistry and drug discovery explores strategy and interdisciplinary work, laboratory synthesis for natural products, the preparative aspects of stereoselective synthesis for drugs, natural products, and potential biologically active compounds. The text also features experimental procedures for the different reaction methods covered.

Pharmaceutical Chemistry (Paperback): Jill Barber Pharmaceutical Chemistry (Paperback)
Jill Barber
R806 Discovery Miles 8 060 Shipped within 7 - 12 working days

Taking medication is a common occurrence for many people, whether it is to soothe an aching head, regulate blood sugars, or treat life-threatening conditions such as HIV or cancer. Examining how drugs are manufactured, formulated, and the way that they work in our bodies, PharmaceuticalChemistry provides a wide-ranging overview of organic chemistry as it is applied to the study and practice of pharmacy.
FEATURES
* Supports an integrated pharmacy education
* Focuses on the fundamental ideas that first-year students need to fully grasp before progressing in their studies
* Demonstrates the connections between scientific concepts and principles and how they are applied to pharmacy
* Written and edited by experts who have a wealth of teaching experience
COMPANION WEBSITE
For registered adopters of the book:
- Figures from the book, available to download
For students:
- Self-assessment questions for each chapter
- Related additional resources
ABOUT THE SERIES
The Integrated Foundations of Pharmacy series supports those who are at the beginning of their journey to become a pharmacist. Students will begin to understand how a drug molecule is made; the process that turns it into a medicine; the role the pharmacist has when dispensing that medicine; and what happens in the body when it is taken. Most importantly, the series shows how each of these aspects are integrated, reflecting the most up-to-date teaching practices.

A Biopharmaceutics Classification Scheme for the Development of New Drugs (Paperback): Marc Lindenberg A Biopharmaceutics Classification Scheme for the Development of New Drugs (Paperback)
Marc Lindenberg
R1,017 R743 Discovery Miles 7 430 Save R274 (27%) Shipped within 7 - 12 working days
Plant Biotechnology and Medicinal Plants - Periwinkle, Milk Thistle and Foxglove (Hardcover, 1st Ed. 2019): Mohamed Ramadan Rady Plant Biotechnology and Medicinal Plants - Periwinkle, Milk Thistle and Foxglove (Hardcover, 1st Ed. 2019)
Mohamed Ramadan Rady
R2,652 R2,365 Discovery Miles 23 650 Save R287 (11%) Shipped within 7 - 12 working days
Spider Venoms (Hardcover, 1st ed. 2016): P. Gopalakrishnakone, Gerardo A. Corzo, Elia Diego-Garcia, Maria Elena De Lima Spider Venoms (Hardcover, 1st ed. 2016)
P. Gopalakrishnakone, Gerardo A. Corzo, Elia Diego-Garcia, Maria Elena De Lima
R5,958 R5,333 Discovery Miles 53 330 Save R625 (10%) Shipped within 7 - 12 working days

This volume provides an overview of the biochemical characterization, structure-function studies, proteomics, bioinformatics, molecular biology, transcriptomics and genomics of various spider species. The book also covers our current knowledge of venom components, toxins and their modes of action. The first section of Spider Venom includes contributions regarding the wide diversity of spider venom components and depicts some of their biological effects (antimicrobial, ion channel modulators, insecticides, this includes peptide and non-peptide toxins), and emphasizes spiders of public health importance. The second section covers transcriptomes, proteomes (and peptidomics), bioinformatics and molecular dynamics. The last section describes antimicrobial, insecticidal toxins, envenomation and the medical potential of spider venoms. Spider venoms are a great and extensive source of bioactive compounds, and as such form a boundless and bountiful area awaiting discovery. It is by virtue of dedicated scientists that new toxins are discovered and that new insights arise, leading the way towards the investigation of their pharmacological effects, and hopefully, as a consequence, arriving at the discovery of venom components as new drug candidates.

Controlled Drug Delivery Systems - Towards New Frontiers in Patient Care (Paperback, 1st ed. 2016): Filippo Rossi, Giuseppe... Controlled Drug Delivery Systems - Towards New Frontiers in Patient Care (Paperback, 1st ed. 2016)
Filippo Rossi, Giuseppe Perale, Maurizio Masi
R1,200 R1,095 Discovery Miles 10 950 Save R105 (9%) Shipped within 7 - 12 working days

This book offers a state-of-the-art overview of controlled drug delivery systems, covering the most important innovative applications. The principles of controlled drug release and the mechanisms involved in controlled release are clearly explained. The various existing polymeric drug delivery systems are reviewed, and new frontiers in material design are examined in detail, covering a wide range of polymer modification techniques. The concluding chapter is a case study focusing on use of a drug-eluting stent. The book is designed to provide the reader with a complete understanding of the mechanisms and design of controlled drug delivery systems, and to this end includes numerous step-by-step tutorials. It illustrates how chemical engineers can advance medical care by designing polymeric delivery systems that achieve either temporal or spatial control of drug delivery and thus ensure more effective therapy that eliminates the potential for both under- and overdosing.

Immunopathology in Toxicology and Drug Development - Volume 1, Immunobiology, Investigative Techniques, and Special Studies... Immunopathology in Toxicology and Drug Development - Volume 1, Immunobiology, Investigative Techniques, and Special Studies (Hardcover, 1st ed. 2017)
George A Parker
R4,884 R4,120 Discovery Miles 41 200 Save R764 (16%) Shipped within 7 - 12 working days

This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 2, Organ Systems, offers summaries of organ-specific immunobiology and immunopathology as well as common responses to xenobiotics. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system.

Modern Biopharmaceuticals - Design, Development and Optimization 4 Volume Set (Hardcover, 3): Jorg Knablein Modern Biopharmaceuticals - Design, Development and Optimization 4 Volume Set (Hardcover, 3)
Jorg Knablein
R15,120 R13,377 Discovery Miles 133 770 Save R1,743 (12%) Shipped within 7 - 12 working days

Due to the impressive accumulation of out-standing results, presented by brilliant, privileged and creative thinkers, this unique book reads like the 'Who is Who' of biotechnology. Never before has such an impressive group of individuals contributed to one biotechnology book, including Nobel Prize laureates Robert Huber, Thomas R. Cech, and Manfred Eigen as well as authors from the world's most famous academic institutes and biotech companies, such as ETH Zurich, MIT, Stanford, Yale, Princeton, Harvard Medical School, Max-Planck-Institute, Fraunhofer-Institute, Moscow Academy of Sciences, London Imperial College and Baxter, Invitrogen, MorphoSys, Roche, and Schering AG. Published as a comprehensive four volume set, this title also includes a CD-ROM containing additional information and videos. "Modern Biopharmaceuticals" describes: the first cloned human embryo; the first myocardial regeneration with embryonic stem cells; the first artificial kidney; the first biopharmaceutical from a transgenic animal; the first individualized medicine; the first plasma-free Factor VIII; the first approved human cell line; and, the first oral insulin, etc. '...an outstanding collection of articles from groundbreaking scientists, comprehensively describing the many novel ways cells are being deployed toward human good . ..' - James D. Watson, 'DNA Codebreaker' and Nobel Prize Laureate (Physiology or Medicine, 1962). "Modern Biopharmaceuticals" is an essential reference work for biotechnologists, clinicians, medical doctors, pharmacists, pharmaceutical chemists, bio-chemists, molecular biologists, medicinal chemists, as well as all those working in the biotechnological and pharmaceutical industries, or medicinal institutes.

Principles of Safety Pharmacology (Hardcover, 2015 ed.): Michael K Pugsley, Michael John Curtis Principles of Safety Pharmacology (Hardcover, 2015 ed.)
Michael K Pugsley, Michael John Curtis
R6,677 R5,396 Discovery Miles 53 960 Save R1,281 (19%) Shipped within 7 - 12 working days

This book illustrates, in a comprehensive manner, the most current areas of importance to Safety Pharmacology, a burgeoning unique pharmacological discipline with important ties to academia, industry and regulatory authorities. It provides readers with a definitive collection of topics containing essential information on the latest industry guidelines and overviews current and breakthrough topics in both functional and molecular pharmacology. An additional novelty of the book is that it constitutes academic, pharmaceutical and biotechnology perspectives for Safety Pharmacology issues. Each chapter is written by an expert in the area and includes not only a fundamental background regarding the topic but also detailed descriptions of currently accepted, validated models and methods as well as innovative methodologies used in drug discovery.

ICH Quality Guidelines - An Implementation Guide (Hardcover): Andrew Teasdale, David Elder, Raymond W. Nims ICH Quality Guidelines - An Implementation Guide (Hardcover)
Andrew Teasdale, David Elder, Raymond W. Nims
R6,542 R4,555 Discovery Miles 45 550 Save R1,987 (30%) Shipped within 7 - 13 working days

Examining the implications and practical implementation of multi-disciplinary International Conference on Harmonization (ICH) topics, this book gives an integrated view of how the guidelines inform drug development strategic planning and decision-making. Addresses a consistent need for interpretation, training, and implementation examples of ICH guidelines via case studies Offers a primary reference point for practitioners addressing the dual challenge of interpretation and practical implementation of ICH guidelines Uses case studies to help readers understand and apply ICH guidelines Provides valuable insights into guidelines development, with chapters by authors involved in generating or with experience implementing the guidelines Includes coverage of stability testing, analytical method validation, impurities, biotechnology drugs and products, and good manufacturing practice (GMP)

Chromatographic Fingerprint Analysis of Herbal Medicines - Thin-layer and High Performance Liquid Chromatography of Chinese... Chromatographic Fingerprint Analysis of Herbal Medicines - Thin-layer and High Performance Liquid Chromatography of Chinese Drugs (Hardcover, 2nd ed. 2011)
Hildebert Wagner, Rudolf Bauer, Dieter Melchart, Pei-Gen Xiao, Anton Staudinger
R7,385 R6,049 Discovery Miles 60 490 Save R1,336 (18%) Shipped within 7 - 12 working days

This manual, to be published in two volumes, provides a condensed overview of the analytical investigation of 80 Chinese Herbal Drugs which are most frequently in use. Thin layer chromatographic-, high pressure liquid chromatographic- and gas chromatographic-fingerprint analytical techniques allow the detection of all main low-molecular constituents of a plant drug and even single constituents can be visualized. Analytical results thereof are shown in numerous color figures. The quality proof of the investigation meets the standard of the European Drug Regulatory Authority.

Furthermore, this volume gives a detailed description of the analytical methods used for several drugs. Bioactive constituents, pharmacological and biological activities of several single herbal drugs as well as their therapeutic applications are discussed.

Evolution of Venomous Animals and Their Toxins (Hardcover, 1st ed. 2017): P. Gopalakrishnakone Evolution of Venomous Animals and Their Toxins (Hardcover, 1st ed. 2017)
P. Gopalakrishnakone; Edited by Anita Malhotra
R5,946 R5,064 Discovery Miles 50 640 Save R882 (15%) Shipped within 7 - 12 working days

This volume contains a section on the wider evolutionary context of venom in animals, the molecular evolutionary processes involved in generating diversity, and the concept of venom evolution as being driven by an arms race that also involves evolution of resistance to toxins by prey. It also studies the relationship between the evolution of toxins and the evolution of the animals that they evolved within. The last section discusses the evolution of venom delivery systems. The definition of a venomous animal, as opposed to a poisonous one, encompasses the evolution not just of toxins but also a specialized mechanism for administering them by injection.

Propelling Innovation in New Drugs - Recommendations & Considerations (Hardcover): Marrok Remillard Propelling Innovation in New Drugs - Recommendations & Considerations (Hardcover)
Marrok Remillard
R2,848 R2,156 Discovery Miles 21 560 Save R692 (24%) Shipped within 7 - 12 working days

The past quarter-century has seen tremendous progress in biomedical research, leading to increasing understanding of cancer, heart disease, diabetes, and other devastating diseases. The Nation has led the world in such progress, due in significant part to wise investments by the Federal Government in basic biomedical research. These breakthroughs are beginning to pay off in terms of new therapies for American patients. Still, the pace of new therapeutic development has not kept up with the explosion in scientific knowledge. The number of novel drugs has remained constant for several decades, even though R&D budgets have substantially increased. This situation poses an increasing challenge for ensuring the creation of innovative therapies for patients and throughout the biomedical ecosystem. This book examines the efforts being made to double over the next decade, the rate of invention of innovative new medicines for patients, while increasing drug safety, in the hopes that these actions will advance the health of Americans, as well as provide economic growth for the Nation.

Natural Products - Structure, Bioactivity & Applications (Hardcover): Ramiro E. Goncalves, Marcos Cunha Pinto Natural Products - Structure, Bioactivity & Applications (Hardcover)
Ramiro E. Goncalves, Marcos Cunha Pinto
R3,161 R2,390 Discovery Miles 23 900 Save R771 (24%) Shipped within 7 - 12 working days

A natural product is a chemical compound or substance produced by a living organism - found in nature that usually has a pharmacological or biological activity for use in pharmaceutical drug discovery and drug design. A natural product can be considered as such even if it can be prepared by total synthesis. In this book, the authors present current research in the study of the structure, bioactivity and applications of natural products. Topics discussed include the in-vitro assessment of chromones and alkaloids from Caribbean plants as potential anti-tuberculars and chemopreventors; natural products as inhibitors of ubiquitin and ubiquitin-like protein-proteasome pathways; the biological activities of red propolis; nanoencapsulation of natural products; and natural products as a source of potential drugs for the treatment of fungal infections.

Hydrophilic Matrix Tablets for Oral Controlled Release (Hardcover, 2014 ed.): Peter Timmins, Samuel R. Pygall, Colin D. Melia Hydrophilic Matrix Tablets for Oral Controlled Release (Hardcover, 2014 ed.)
Peter Timmins, Samuel R. Pygall, Colin D. Melia
R4,121 R3,318 Discovery Miles 33 180 Save R803 (19%) Shipped within 7 - 12 working days

This detailed volume addresses key issues and subtle nuances involved in developing hydrophilic matrix tablets as an approach to oral controlled release. It brings together information from more than five decades of research and development on hydrophilic matrix tablets and provides perspective on contemporary issues. Twelve comprehensive chapters explore a variety of topics including polymers (hypromellose, natural polysaccharides and polyethylene oxide) and their utilization in hydrophilic matrices, critical interactions impacting tablet performance, in vitro physical and imaging techniques, and microenvironmental pH control and mixed polymer approaches, among others. In one collective volume, Hydrophilic Matrix Tablets for Oral Controlled Release provides a single source of current knowledge, including sections of previously unpublished data. It is an important resource for industrial and academic scientists investigating and developing these oral controlled release formulations.

Leading Pharmaceutical Innovation - How to Win the Life Science Race (Hardcover, 3rd ed. 2018): Oliver Gassmann, Alexander... Leading Pharmaceutical Innovation - How to Win the Life Science Race (Hardcover, 3rd ed. 2018)
Oliver Gassmann, Alexander Schuhmacher, Max Von Zedtwitz, Gerrit Reepmeyer
R1,778 R1,512 Discovery Miles 15 120 Save R266 (15%) Shipped within 7 - 12 working days

Pharmaceutical giants have been doubling their investments in drug development, only to see new drug approvals to remain constant for the past decade. This book investigates and highlights a set of proactive strategies, aimed at generating sustainable competitive advantage for its protagonists based on value-generating business practices. We focus on three sources of pharmaceutical innovation: new management methods in the drug development pipeline, new technologies as enablers for cutting-edge R&D, and new forms of internationalisation, such as outside-in innovation in the early phases of R&D.

Hot Deformation and Processing of Aluminum Alloys (Hardcover): Hugh J. McQueen, Stefano Spigarelli, Michael E. Kassner, Enrico... Hot Deformation and Processing of Aluminum Alloys (Hardcover)
Hugh J. McQueen, Stefano Spigarelli, Michael E. Kassner, Enrico Evangelista
R4,435 Discovery Miles 44 350 Shipped within 7 - 12 working days

A comprehensive treatise on the hot working of aluminum and its alloys, Hot Deformation and Processing of Aluminum Alloys details the possible microstructural developments that can occur with hot deformation of various alloys, as well as the kind of mechanical properties that can be anticipated. The authors take great care to explain and differentiate hot working in the context of other elevated temperature phenomena, such as creep, superplasticity, cold working, and annealing. They also pay particular attention to the fundamental mechanisms of aluminum plasticity at hot working temperatures. Using extensive analysis derived from polarized light optical microscopy (POM), transmission electron microscopy (TEM), x-ray diffraction (XRD) scanning electron-microscopy with electron backscatter imaging (SEM-EBSD), and orientation imaging microscopy (OIM), the authors examine those microstructures that evolve in torsion, compression, extrusion, and rolling. Further microstructural analysis leads to detailed explanations of dynamic recovery (DRV), static recovery (SRV), discontinuous dynamic recrystallization (dDRX), discontinuous static recrystallization (dSRX), grain defining dynamic recovery (gDRV) (formerly geometric dynamic recrystallization, or gDRX), and continuous dynamic recrystallization involving both a single phase (cDRX/1-phase) and multiple phases (cDRX/2-phase). A companion to other works that focus on modeling, manufacturing involving plastic and superplastic deformation, and control of texture and phase transformations, this book provides thorough explanations of microstructural development to lay the foundation for further study of the mechanisms of thermomechanical processes and their application.

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