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Books > Professional & Technical > Industrial chemistry & manufacturing technologies > Industrial chemistry > Pharmaceutical technology

Hit and Lead Profiling - Identification and Optimization of Drug-like Molecules (Hardcover): Bernard Faller, Laszlo Urban Hit and Lead Profiling - Identification and Optimization of Drug-like Molecules (Hardcover)
Bernard Faller, Laszlo Urban; Series edited by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
R4,557 R3,653 Discovery Miles 36 530 Save R904 (20%) Shipped within 7 - 12 working days

The only reference on current methods to generate pharmacokinetic and safety profiles of drug candidates, as well as how they must be balanced against one other for the best selection of candidates for further development.
Following a brief introduction to the necessities of filtering and risk assessment of potential new drug molecules before actual drug development, the two equally important aspects of pharmacological (ADME) and safety (toxicity) profiling are covered in separate parts.
The ADME section covers the profiling of basic physicochemical parameters, such as solubility and permeability, as well as more complex traits, such as the likelihood of drug-drug interactions, metabolic clearance and protein binding properties.
The toxicology part addresses, among others, recent advances in early genetic toxicity testing, bioactivation screening, organ-specific toxicity assays for liver, heart, kidney and blood, as well as profiling for autoimmune reactions.
By addressing both drug efficiency and drug safety, this modern practical reference shows readers how each individual aspect figures in shaping the key decisions on which the entire drug development process hinges. In short, this is a complete toolbox for assessing the risk/benefit ratio for any novel compound during the early drug development stages, using both in vitro and in silico methods.
Both editors are based at one of the leading research-driven pharmaceutical companies, and the authors have been recruited from numerous other global players in the field.
Invaluable know-how for every medicinal chemist and drug developer.

Host - Pathogen Interaction - Microbial Metabolism, Pathogenicity and Antiinfectives (Hardcover): Gottfried Unden, Eckhard... Host - Pathogen Interaction - Microbial Metabolism, Pathogenicity and Antiinfectives (Hardcover)
Gottfried Unden, Eckhard Thines, Anja Schuffler; Series edited by Paul M. Selzer
R2,443 R2,182 Discovery Miles 21 820 Save R261 (11%) Shipped within 7 - 12 working days

In light of the rapidity increasing incidence rate of bacterial and fungal infections with multi-resistant pathogens, the metabolic changes associated with host-pathogen interactions offer one of the most promising starting points for developing novel antibiotics. . Part one of this comprehensive guide describes the metabolic adaptation of pathogenic microbes in humans, while part two points to routes for the development of novel antibiotics. This is volume six of the book series on drug discovery in infectious diseases by Paul Selzer.

Steroid Dimers - Chemistry and Applications in Drug Design and Delivery (Hardcover, New): Satyajit Sarker, Lutfun Nahar Steroid Dimers - Chemistry and Applications in Drug Design and Delivery (Hardcover, New)
Satyajit Sarker, Lutfun Nahar
R2,892 R2,033 Discovery Miles 20 330 Save R859 (30%) Shipped within 7 - 13 working days

Steroid dimers are an important group of compounds produced by various marine organisms, and also synthesized in the laboratories. This group of compounds possesses various pharmacological and biological properties, and can also be used to create "molecular umbrellas" for drug delivery.

"Steroid Dimers: Chemistry and Applications in Drug Design and Delivery" provides an up-to-date overview on the chemistry and applications of steroid dimers of natural and synthetic origins. The book includes easy-to-follow synthetic protocols for various classes of important dimeric steroids, source details, valuable spectroscopic data and depiction of unique structural features of natural steroidal dimers, and the Structure-Activity-Relationships (SARs) of some pharmacologically active dimeric steroids. Topics covered include: introduction to steroid dimers synthesis and chemistry of noncyclic and cyclic steroid dimersnaturally occurring steroid dimers - cephalostatins, ritterazines and crellastatinsbiological and pharmacological functions of steroid dimers and their application in drug design and discoverysteroid dimers as "molecular umbrellas" for drug delivery"Steroid Dimers: Chemistry and Applications in Drug Design and Delivery" is an essential guide to this important class of natural and synthetic compounds for researchers and students of natural products chemistry and biochemistry, synthetic organic and medicinal chemistry, and drug design, discovery and delivery.

Antitargets and Drug Safety (Hardcover): Laszlo Urban, Vinod Patel, Roy J. Vaz Antitargets and Drug Safety (Hardcover)
Laszlo Urban, Vinod Patel, Roy J. Vaz
R3,117 R2,505 Discovery Miles 25 050 Save R612 (20%) Shipped within 7 - 12 working days

With its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future. Divided into three major parts, the first section deals with novel technologies and includes the utility of adverse event reports to drug discovery, the translational aspects of preclinical safety findings, broader computational prediction of drug side-effects, and a description of the serotonergic system. The main part of the book looks at some of the most common antitarget-mediated side effects, focusing on hepatotoxicity in drug safety, cardiovascular toxicity and signaling effects via kinase and GPCR anti-targets. In the final section, several case studies of recently developed drugs illustrate how to prevent anti-target effects and how big pharma deals with them if they occur. The more recent field of systems pharmacology has gained prominence and this is reflected in chapters dedicated to the utility in deciphering and modeling anti-targets. The final chapter is concerned with those compounds that inadvertently elicit CNS mediated adverse events, including a pragmatic description of ways to mitigate these types of safety risks. Written as a companion to the successful book on antitargets by Vaz and Klabunde, this new volume focuses on recent progress and new classes, methods and case studies that were not previously covered.

Pharmacological Basis of Acute Care (Hardcover, 2015 ed.): Yoo Kuen Chan, Kwee Peng Ng, Debra Si Mui Sim Pharmacological Basis of Acute Care (Hardcover, 2015 ed.)
Yoo Kuen Chan, Kwee Peng Ng, Debra Si Mui Sim
R1,994 R1,631 Discovery Miles 16 310 Save R363 (18%) Shipped within 7 - 12 working days

This book is the 4th in a series of Acute Care books written with the aim to address the NEEDS of health care providers when handling the acutely ill patients. Globally it has become apparent that the study of pharmacology and subsequent clinical training has not always adequately equipped young doctors with the ability to administer drugs to their patients safely and confidently, particularly in the critically ill patient. Compounding this issue is the lack of resource material related to these pharmacological concepts contained in one book that can help health care providers to understand and manage drug therapy in the acute situation. In spite of progressively newer and more developed protocols, guidelines, algorithms and many other books addressing the technical aspects of what needs to be done, most health care providers still find it difficult to grasp the basic pharmacological knowledge and rationally deliver the CARE that is required in the acute phase of patient management. The editors/authors have therefore aimed for a book that highlights topics and pharmacological issues pertinent to management of patients in their hour of need. This is a multi-author book but the style has been guided by 3 editors. The editors have used a different perspective - that of normalizing abnormal physiological processes with pharmacological agents - to address the GAPS in a bedside to bench approach. The details are pared down but important principles/concepts are emphasized.

Modern Biopharmaceuticals - Recent Success Stories (Hardcover): Jorg Knablein Modern Biopharmaceuticals - Recent Success Stories (Hardcover)
Jorg Knablein
R5,181 R4,163 Discovery Miles 41 630 Save R1,018 (20%) Shipped within 7 - 12 working days

This collection of high-profile contributions provides a unique insight into the development of novel, successful biopharmaceuticals.

Outstanding authors, including Nobel laureate Robert Huber as well as prominent company researchers and CEOs, present valuable insider knowledge, limiting their scope to those procedures and developments with proven potential for the biotechnology industry. They cover all relevant aspects, from the establishment of biotechnology parks, the development of successful compounds and the implementation of efficient manufacturing processes, right up to the establishment of advanced delivery routes.

Mucoadhesive Materials and Drug Delivery Systems (Hardcover): Vitaliy V. Khutoryanskiy Mucoadhesive Materials and Drug Delivery Systems (Hardcover)
Vitaliy V. Khutoryanskiy
R2,797 R1,966 Discovery Miles 19 660 Save R831 (30%) Shipped within 7 - 13 working days

Mucoadhesion defined as attachment of synthetic or natural materials to mucosal tissues has been widely exploited in pharmaceutical forms. This multi-author book provides an up-to-date account of current research on mucoadhesive materials and drug delivery systems. The introductory section describes the structure and physiology of various mucosal surfaces (oral, nasal, ocular, gastrointestinal and vaginal mucosa). This is followed by chapters on the various methods used to study mucoadhesion and to characterise mucoadhesive properties of various dosage forms. The final section will summarise information on traditional and novel types of mucoadhesive materials, such as chitosan, thiomers, and liposome-based formulations. This book is unique as there is currently no modern book considering mucoadhesion - all other existing books on the topic are either narrowly focused or more than 10 years old. Furthermore, each contributor offers specialist perspectives from a variety of global locations in both industrial and academic research centres.

Drug Bioavailability - Estimation of Solubility, Permeability, Absorption and Bioavailability (Hardcover, 2nd Edition): Han Van... Drug Bioavailability - Estimation of Solubility, Permeability, Absorption and Bioavailability (Hardcover, 2nd Edition)
Han Van De Waterbeemd, Bernard Testa; Series edited by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
R4,451 R3,956 Discovery Miles 39 560 Save R495 (11%) Shipped within 7 - 12 working days

The gold standard for industrial research now completely revised in line with current trends in the field, with all contributions extensively updated or rewritten.
In 21 chapters readers can benefit from the key working knowledge of today's leading pharmaceutical companies, including Pfizer, AstraZeneca, and Roche. Drug developers from industry and academia present all the factors governing drug bioavailability, complete with practical examples and real-life data.
Part I focuses on in vitro and in vivo measurements of physicochemical properties, such as membrane permeability and ionization. Part II discusses solubility and gastrointestinal absorption, while the third part is devoted to metabolism and excretory mechanisms. The much revised and expanded part IV surveys current in silico approaches to predict drug properties needed to estimate the bioavailability of any new drug candidate. The final part shows how poor bioavailability may be improved by various approaches during the development process.
No other publication offers the same level of treatment on this crucial topic in modern drug development.

In vivo Models for Drug Discovery (Hardcover): Jose M. Vela, Rafael Maldonado, Michel Hamon In vivo Models for Drug Discovery (Hardcover)
Jose M. Vela, Rafael Maldonado, Michel Hamon; Series edited by Raimund Mannhold, Hugo Kubinyi, …
R3,247 R2,611 Discovery Miles 26 110 Save R636 (20%) Shipped within 7 - 12 working days

This one-stop reference is the first to present the complete picture -- covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases.
Addressing the needs of the pharmaceutical industry, this unique handbook adopts a broad perspective on the use of animals in the early part of the drug development process, including regulatory rules and limitations, as well as numerous examples from real-life drug development projects.
After a general introduction to the topic, the expert contributors from research-driven pharmaceutical companies discuss the basic considerations of using animal models, including ethical issues. The main part of the book systematically surveys the most important disease areas for current drug development, from cardiovascular to endocrine disorders, and from infectious to neurological diseases. For each area, the availability of animal models for target validation, hit finding and lead profiling is reviewed, backed by numerous examples of both successes and failures among the use of animal models. The whole is rounded off with a discussion of perspectives and challenges.
Key knowledge for drug researchers in industry as well as academia.

Peptides as Drugs - Discovery and Development (Hardcover): Bernd Groner Peptides as Drugs - Discovery and Development (Hardcover)
Bernd Groner
R3,533 R3,142 Discovery Miles 31 420 Save R391 (11%) Shipped within 7 - 12 working days

By covering the full spectrum of topics relevant to peptidic drugs, this timely handbook serves as an introductory reference for both drug developers and biomedical researchers interested in pharmaceutically active peptides, presenting both the advantages and challenges associated with this molecular class.
The first part discusses current approaches to developing pharmaceutically active peptides, including case studies of the use of peptidic drugs in cancer and AIDS therapy. The second part surveys strategies for the development and targeting of peptidic drugs.
With its integration of biochemical, pharmaceutical and clinical research, this work reveals the full picture of modern peptide drug research in a single volume, making it an invaluable reference for medicinal chemists, biochemists, biotechnologists, and those in the pharmaceutical and biotechnological industries.

Statistical Thinking for Non-Statisticians in Drug Regulation (Hardcover, 2nd Edition): Richard Kay Statistical Thinking for Non-Statisticians in Drug Regulation (Hardcover, 2nd Edition)
Richard Kay
R1,550 R1,193 Discovery Miles 11 930 Save R357 (23%) Shipped within 7 - 13 working days

Statistical Thinking for Non-Statisticians in Drug Regulation, Second Edition, is a need-to-know guide to understanding statistical methodology, statistical data and results within drug development and clinical trials. It provides non-statisticians working in the pharmaceutical and medical device industries with an accessible introduction to the knowledge they need when working with statistical information and communicating with statisticians. It covers the statistical aspects of design, conduct, analysis and presentation of data from clinical trials in drug regulation and improves the ability to read, understand and critically appraise statistical methodology in papers and reports. As such, it is directly concerned with the day-to-day practice and the regulatory requirements of drug development and clinical trials. Fully conversant with current regulatory requirements, this second edition includes five new chapters covering Bayesian statistics, adaptive designs, observational studies, methods for safety analysis and monitoring and statistics for diagnosis. Authored by a respected lecturer and consultant to the pharmaceutical industry, Statistical Thinking for Non-Statisticians in Drug Regulation is an ideal guide for physicians, clinical research scientists, managers and associates, data managers, medical writers, regulatory personnel and for all non-statisticians working and learning within the pharmaceutical industry.

Protein-Ligand Interactions (Hardcover): Holger Gohlke Protein-Ligand Interactions (Hardcover)
Holger Gohlke; Series edited by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
R2,999 R2,673 Discovery Miles 26 730 Save R326 (11%) Shipped within 7 - 12 working days

Innovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for development. The first part provides a basic understanding of the factors governing protein-ligand interactions, followed by a comparison of key experimental methods (calorimetry, surface plasmon resonance, NMR) used in generating interaction data. The second half of the book is devoted to insilico methods of modeling and predicting molecular recognition and binding, ranging from first principles-based to approximate ones. Here, as elsewhere in the book, emphasis is placed on novel approaches and recent improvements to established methods. The final part looks at unresolved challenges, and the strategies to address them. With the content relevant for all drug classes and therapeutic fields, this is an inspiring and often-consulted guide to the complexity of protein-ligand interaction modeling and analysis for both novices and experts.

Analogue-based Drug Discovery III (Hardcover): Janos Fischer, C. Robin Ganellin, David P. Rotella Analogue-based Drug Discovery III (Hardcover)
Janos Fischer, C. Robin Ganellin, David P. Rotella
R3,326 R2,684 Discovery Miles 26 840 Save R642 (19%) Shipped within 7 - 12 working days

Most drugs are analogue drugs. There are no general rules how a new drug can be discovered, nevertheless, there are some observations which help to find a new drug, and also an individual story of a drug discovery can initiate and help new discoveries. Volume III is a continuation of the successful book series with new examples of established and recently introduced drugs.
The major part of the book is written by key inventors either as a case study or a study of an analogue class. With its wide range across a variety of therapeutic fields and chemical classes, this is of interest to virtually every researcher in drug discovery and pharmaceutical chemistry, and -- together with the previous volumes -- constitutes the first systematic approach to drug analogue development.

Green Chemistry in the Pharmaceutical Industry (Hardcover): Peter J. Dunn, Andrew Wells, Michael T. Williams Green Chemistry in the Pharmaceutical Industry (Hardcover)
Peter J. Dunn, Andrew Wells, Michael T. Williams
R3,195 R2,578 Discovery Miles 25 780 Save R617 (19%) Shipped within 7 - 12 working days

Edited by three of the world's leading pharmaceutical scientists, this is the first book on this important and hot topic, containing much previously unpublished information. As such, it covers all aspects of green chemistry in the pharmaceutical industry, from simple molecules to complex proteins, and from drug discovery to the fate of pharmaceuticals in the environment. Furthermore, this ready reference contains several convincing case studies from industry, such as Taxol, Pregabalin and Crestor, illustrating how this multidisciplinary approach has yielded efficient and environmentally-friendly processes. Finally, a section on technology and tools highlights the advantages of green chemistry.

Applied Biophysics for Drug Discovery (Hardcover): Donald Huddler, Edward E Zartler Applied Biophysics for Drug Discovery (Hardcover)
Donald Huddler, Edward E Zartler
R2,889 R2,030 Discovery Miles 20 300 Save R859 (30%) Shipped within 7 - 13 working days

Applied Biophysics for Drug Discovery is a guide to new techniques and approaches to identifying and characterizing small molecules in early drug discovery. Biophysical methods are reasserting their utility in drug discovery and through a combination of the rise of fragment-based drug discovery and an increased focus on more nuanced characterisation of small molecule binding, these methods are playing an increasing role in discovery campaigns. This text emphasizes practical considerations for selecting and deploying core biophysical method, including but not limited to ITC, SPR, and both ligand-detected and protein-detected NMR. Topics covered include: Design considerations in biophysical-based lead screening Thermodynamic characterization of protein-compound interactions Characterizing targets and screening reagents with HDX-MS Microscale thermophoresis methods (MST) Screening with Weak Affinity Chromatography Methods to assess compound residence time 1D-NMR methods for hit identification Protein-based NMR methods for SAR development Industry case studies integrating multiple biophysical methods This text is ideal for academic investigators and industry scientists planning hit characterization campaigns or designing and optimizing screening strategies.

Pharmaceutical Emulsions - A Drug Developer's Toolbag (Hardcover): Dipak Kumar Sarker Pharmaceutical Emulsions - A Drug Developer's Toolbag (Hardcover)
Dipak Kumar Sarker
R1,271 R909 Discovery Miles 9 090 Save R362 (28%) Shipped within 7 - 13 working days

"Pharmaceutical Emulsions: A Drug Developer's Toolbag" covers all the key aspects of pharmaceutical emulsions, starting from the fundamental scientific basics, to the pharmaceutical forms and the chemical tests for its application. The author uses his extensive experience in both industry and academic experience to provide a concise, student friendly guide to the essential fundamentals of physical pharmacy.

Divided into three clear sections, the text begins with Section A - "Consideration for Product: Medicinal Formulation" which includes a historical perspective, explanation of what is an emulsion, stability and instability, and manufacture. Section B - "Forms, Use and Application" follows, with chapters on creams and ointments, pastes and bases, colloids, transdermal, gels and implants. The final Section, "Tests: Chemistry to control the quality," efficacy and fitness for purpose of the product includes chapters on physic-chemical properties, sizing and microscopy, rheology, QC and finally questions, calculations and dilemmas. Throughout the text there are numerous figures, diagrams and tables to engage the reader.

This is an invaluable reference for all students of pharmaceutical sciences, pharmacy industrial pharmaceutical sciences, physical pharmacy and pharmaceutical forms as well as industry professionals

Targeted Delivery of Small and Macromolecular Drugs (Hardcover): Ajit S. Narang, Ram I. Mahato Targeted Delivery of Small and Macromolecular Drugs (Hardcover)
Ajit S. Narang, Ram I. Mahato
R3,522 Discovery Miles 35 220 Shipped within 7 - 12 working days

Site-specific drug delivery and targeting is attracting much research interest from both academia and industry, but because of the many challenges faced in the development of these systems, only a handful of targeted therapies have successfully made it into clinical practice. Bringing together leading field experts, Targeted Delivery of Small and Macromolecular Drugs summarizes current progress with a focus on the novel ideas being explored to overcome these challenges.

Focuses on the Targeted Drug Delivery Technologies that Utilize
both Systemic and Local Routes of Administration
Leading experts discuss some of the most promising strategies for drug targeting. They also cover targeted drug delivery platforms and technologies at various stages of clinical and preclinical development, including:

? Active targeting
? Nucleic acid delivery and targeting
? Intracellular/Organelle-Specific Strategies
? Prodrug Strategies
? Organ or Tissue-Specific drug delivery
? Drug-Polymer Conjugates and Micelles
? Stimuli-Responsive systems

Targeted Delivery of Small and Macromolecular Drugs demonstrates why targeted delivery is one of the most exciting contributions pharmaceutical sciences can make to drug therapy.

Pharmaceutical Crystallography - A Guide to Structure and Analysis (Hardcover): Andrew Bond Pharmaceutical Crystallography - A Guide to Structure and Analysis (Hardcover)
Andrew Bond
R1,045 Discovery Miles 10 450 Shipped within 7 - 11 working days

The pharmaceutical industry has become acutely aware of the importance of the solid state, but pharmaceutical scientists often lack specific training in topics related to solid-state structure and crystallography. This book provides needed support in this topical area. Taking an intuitive and informal approach to solid-state structure and crystallographic concepts, this book is written for anyone who needs a clear understanding of modern crystallography, with specific reference to small-molecule pharmaceutical solids. The author describes molecular crystals and crystal structures, symmetry, space groups, single-crystal and powder X-ray diffraction techniques and the analysis and interpretation of crystallographic data. Useful technical details are presented where necessary and case studies from the pharmaceutical literature put theory into a practical context. Written by an internationally leading figure abd with its focus on molecular crystals, this book is equally applicable to anyone studying or working in solid-state chemistry and structure determination.

Handbook of Pharmaceutical Natural Products (Hardcover): Goutam Brahmachari Handbook of Pharmaceutical Natural Products (Hardcover)
Goutam Brahmachari
R8,276 R6,505 Discovery Miles 65 050 Save R1,771 (21%) Shipped within 7 - 12 working days

"...a useful addition to the bookshelf of every natural material specialist..." -Pharmazie in unserer Zeit, 2010 (review in German) Organized in a classical alphabetical format, this two-volume reference covers 1000 carefully screened natural product structures. For each compound or compund class, a basic chemical characterization is given, followed by a description of the biological source and a discussion of their pharmaceutical potential as lead molecules for new drugs. The letter takes into account the documented uses of many of these compounds in Asian traditional medicine. By way of its clearly structured articles, and with the aid of classification tables in the appendix, this dictionary is easy to use and provides quick and reliable information for researchers as well for scholars and student. Compounds have been selected from the following chemical classes: - Alkaloids - Phenolics - Antibiotics - Polyketides - Carbohydrates - Proteins - Chalcones - Steroids - Coumarins - Terpenoids - Flavonoids - Xanthonoids - Peptides

Cannabinoids (Hardcover): Vincenzo Di Marzo Cannabinoids (Hardcover)
Vincenzo Di Marzo
R2,349 R1,655 Discovery Miles 16 550 Save R694 (30%) Shipped within 7 - 13 working days

'Cannabinoids' is a broad term covering a group of natural products from Cannabis sativa, one of which locks on to specific receptors - protein molecules on the surface of cells - known as cannabinoid receptors. Over the past decades scientists have found that cannabinoid receptors and their endogenous ligands, the endocannabinoids, are involved in a vast array of physiological functions, including helping to control brain activity, energy metabolism, heart function, the immune system and even reproduction. In Cannabinoids, Vincenzo Di Marzo has assembled contributions from international experts to provide the definitive guide to what continues to be a rapidly developing research field. After an introductory historical chapter, the book continues by looking at the biochemical, genetic and molecular elements of cannabinoids, followed by chapters covering their role in health and disease. The final chapter outlines the need for a new nomenclature to reflect the complex and multi-disciplinary nature of this area.

Green and Sustainable Medicinal Chemistry - Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry... Green and Sustainable Medicinal Chemistry - Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry (Hardcover)
Louise Summerton, Helen F. Sneddon, Leonie C. Jones; Edited by (editors-in-chief) James H. Clark; Foreword by Murray Brown; Contributions by …
R3,588 Discovery Miles 35 880 Shipped within 7 - 12 working days

Pharmaceutical manufacturing was one of the first industries to recognize the importance of green chemistry, with pioneering work including green chemistry metrics and alternative solvents and reagents. Today, other topical factors also have to be taken into consideration, such as rapidly depleting resources, high energy costs and new legislation. This book addresses current challenges in modern green chemical technologies and sustainability thinking. It encompasses a broad range of topics covered by the CHEM21 project - Europe's largest public-private partnership project which aims to develop a toolbox of sustainable technologies for green chemical intermediate manufacture. Divided into two sections, the book first gives an overview of the key green chemistry tools, guidance and considerations aimed at developing greener processes, before moving on to look at cutting-edge synthetic methodologies. Featuring innovative research, this book is an invaluable reference for chemists across academia and industry wanting to further their knowledge and understanding of this important topic.

Pharmaceutical Process Chemistry (Hardcover): Takayuki Shioiri, Kunisuke Izawa, Toshiro Konoike Pharmaceutical Process Chemistry (Hardcover)
Takayuki Shioiri, Kunisuke Izawa, Toshiro Konoike
R3,243 R2,891 Discovery Miles 28 910 Save R352 (11%) Shipped within 7 - 12 working days

Covering the whole area of process chemistry in the pharmaceutical industry, this monograph provides the essential knowledge on the basic chemistry needed for future development and key industrial techniques, as well as morphology, engineering and regulatory compliances.
Application-oriented and well structured, the authors include recent examples of excellent industrial production of active pharmaceutical ingredients.

Antibacterial Agents - Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications (Paperback): Rosaleen J.... Antibacterial Agents - Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications (Paperback)
Rosaleen J. Anderson, Paul W. Groundwater, Adam Todd, Alan Worsley
R1,020 R741 Discovery Miles 7 410 Save R279 (27%) Shipped within 7 - 13 working days

Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function."Antibacterial Agents" is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated "lab-to-clinic" approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements.Agents covered include: agents targeting DNA - quinolone, rifamycin, and nitroimidazole antibacterial agentsagents targeting metabolic processes - sulfonamide antibacterial agents and trimethoprimagents targeting protein synthesis - aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinonesagents targeting cell wall synthesis - β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin

"Antibacterial Agents" will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.

Pharmaceuticals in the Environment (Hardcover): R.E. Hester, R.M. Harrison Pharmaceuticals in the Environment (Hardcover)
R.E. Hester, R.M. Harrison; Contributions by David Taylor, Benoit Roig, Sally Gaw, …
R1,662 Discovery Miles 16 620 Shipped within 7 - 12 working days

Medicines play an important role in the treatment and prevention of disease in humans and animals, but residues from these medicines can be released into the environment through a number of routes during their manufacture, use and disposal. It is only recently that the potential environmental impacts of this exposure to pharmaceuticals are being considered. The book explores where pharmaceutical residues can be found, e.g. in surface waters, drinking water, sediments and the marine environment; the sources of these residues, from manufacture through to disposal of unused medicines; how these residues break down; and how this all impacts on wildlife and human health. In reviewing the current position and examining further possible impacts, this book is an important reference for researchers working in the pharmaceutical industry, as well as for environmentalists, policy makers and students on pharmacy and environmental science courses wanting to better understand the impacts of pharmaceuticals on the environment.

Nonclinical Safety Assessment - A Guide to International Pharmaceutical Regulations (Hardcover): William J. Brock, Kenneth L... Nonclinical Safety Assessment - A Guide to International Pharmaceutical Regulations (Hardcover)
William J. Brock, Kenneth L Hastings, Kathy M. McGown
R2,895 R2,036 Discovery Miles 20 360 Save R859 (30%) Shipped within 7 - 13 working days

Bringing a new drug to market is a costly time-consuming process. Increased regional and international regulation over the last twenty years, while necessary, has only served to amplify these costs. In response to this escalation, developmental strategies have shifted towards a more global approach. In order to create the most cost-effective and safe processes, it is critical for those bringing drugs to market to understand both the globally accepted regulations and the local variations. "Nonclinical Safety Assessment: A Guide to International Pharmaceutical Regulations "provides a practical description of nonclinical drug development regulations and requirements in the major market regions.

It includes: ICH - the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human UseNational regulations, including US FDA, Canada, Mercosur and Brazil, South Africa, China, Japan, India and AustraliaRepeated dose toxicity studiesCarcinogenicity; Genotoxicity; Developmental and reproductive toxicology; ImmunotoxicologyBiotechnology-derived pharmaceuticalsVaccine developmentPhototoxicity and photocarcinogenicityDegradants, impurities, excipients and metabolites

Primarily intended for those professionals actively involved in the nonclinical and clinical development of a pharmaceutical product, including toxicologists, pharmacologists, clinicians and project managers, this book provides a roadmap for successful new drug approval and marketing.""

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