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Books > Professional & Technical > Industrial chemistry & manufacturing technologies > Industrial chemistry > Pharmaceutical technology

Physicochemical Principles of Pharmacy - In Manufacture, Formulation and Clinical Use (Paperback, 6th Revised edition):... Physicochemical Principles of Pharmacy - In Manufacture, Formulation and Clinical Use (Paperback, 6th Revised edition)
Alexander T. Florence, David Attwood
R1,133 R1,027 Discovery Miles 10 270 Save R106 (9%) Shipped within 7 - 11 working days

An established textbook that provides you with full coverage of the physicochemical principles essential to the modern pharmacist and pharmaceutical scientist. This sixth edition has a broad chemical and physicochemical base and covers every aspect of drug properties from the design of dosage forms to their delivery by all routes to sites of action in the body. Now with more clinical examples, new questions and extra case studies.

Sample Preparation of Pharmaceutical Dosage Forms - Challenges and Strategies for Sample Preparation and Extraction (Hardcover,... Sample Preparation of Pharmaceutical Dosage Forms - Challenges and Strategies for Sample Preparation and Extraction (Hardcover, Edition.)
Beverly Nickerson
R4,416 R3,605 Discovery Miles 36 050 Save R811 (18%) Shipped within 7 - 12 working days

This book is intended to serve as a resource for analysts in developing and troubleshooting sample preparation methods. These are critical activities in providing accurate and reliable data throughout the lifecycle of a drug product. This book is divided into four parts: * Part One covers dosage form and diluent properties that impact sample preparation of pharmaceutical dosage forms and the importance of sampling considerations in generating data representative of the drug product batch. * Part Two reviews specific sample preparation techniques typically used with pharmaceutical dosage forms. * Part Three discusses sample preparation method development for different types of dosage forms including addressing drug excipient interactions and post extraction considerations, as well as method validation and applying Quality by Design (QbD) principles to sample preparation methods. * Part Four examines additional topics in sample preparation including automation, investigating aberrant potency results, green chemistry considerations for sample preparation and the ideal case where no sample preparation is required for sample analysis.

Pharmaceutical Biotechnology - Concepts and Applications (Paperback): Gary Walsh Pharmaceutical Biotechnology - Concepts and Applications (Paperback)
Gary Walsh
R1,383 R1,070 Discovery Miles 10 700 Save R313 (23%) Shipped within 7 - 13 working days

Pharmaceutical Biotechnology offers students taking Pharmacy and related Medical and Pharmaceutical courses a comprehensive introduction to the fast-moving area of biopharmaceuticals. With a particular focus on the subject taken from a pharmaceutical perspective, initial chapters offer a broad introduction to protein science and recombinant DNA technology- key areas that underpin the whole subject. Subsequent chapters focus upon the development, production and analysis of these substances. Finally the book moves on to explore the science, biotechnology and medical applications of specific biotech products categories. These include not only protein-based substances but also nucleic acid and cell-based products. * introduces essential principles underlining modern biotechnology- recombinant DNA technology and protein science* an invaluable introduction to this fast-moving subject aimed specifically at pharmacy and medical students* includes specific 'product category chapters' focusing on the pharmaceutical, medical and therapeutic properties of numerous biopharmaceutical products.* entire chapter devoted to the principles of genetic engineering and how these drugs are developed.* includes numerous relevant case studies to enhance student understanding* no prior knowledge of protein structure is assumed

Handbook of Polymers for Pharmaceutical Technologies - Biodegradable Polymers (Hardcover, Volume 3): Vijay Thakur, Manju Kumari... Handbook of Polymers for Pharmaceutical Technologies - Biodegradable Polymers (Hardcover, Volume 3)
Vijay Thakur, Manju Kumari Thakur
R4,137 R2,897 Discovery Miles 28 970 Save R1,240 (30%) Shipped within 7 - 13 working days

Polymers are one of the most fascinating materials of the present era finding their applications in almost every aspects of life. Polymers are either directly available in nature or are chemically synthesized and used depending upon the targeted applications.Advances in polymer science and the introduction of new polymers have resulted in the significant development of polymers with unique properties. Different kinds of polymers have been and will be one of the key in several applications in many of the advanced pharmaceutical research being carried out over the globe. This 4-partset of books contains precisely referenced chapters, emphasizing different kinds of polymers with basic fundamentals and practicality for application in diverse pharmaceutical technologies. The volumes aim at explaining basics of polymers based materials from different resources and their chemistry along with practical applications which present a future direction in the pharmaceutical industry. Each volume offer deep insight into the subject being treated. Volume 1: Structure and Chemistry Volume 2: Processing and Applications Volume 3: Biodegradable Polymers Volume 4: Bioactive and Compatible Synthetic/Hybrid Polymers

Proteinases as Drug Targets (Hardcover): Ben Dunn Proteinases as Drug Targets (Hardcover)
Ben Dunn
R3,210 Discovery Miles 32 100 Shipped within 7 - 12 working days

This unique book describes newly discovered proteolytic enzymes and their biological function. In many cases, these enzymes are targets for new drug discovery in order to provide new therapeutic approaches to control human diseases and/or metabolic conditions. The chapters in this book will help other investigators to pursue drug discovery by detailing methods of production and assay of the enzymes. In addition, the latest structural studies that are described in the book will permit rapid advances in drug design. The most important elements of this book are the state-of-the-art, detailed descriptions of the properties of the proteolytic enzymes. The chapters in the book, written by leading experts in the field, collect the best work on the topics with complete bibliographies for each target enzyme. The illustrations are highly informative to aid and facilitate a new design of inhibitors that can be developed as drug candidates. Key chapters include those by Mark Gorrell and Catherine Abbott, both describing dipeptidyl peptidases, which have been implicated in a number of metabolic conditions including diabetes. The chapters are written from two very different perspectives, thus enriching the literature in this area. In addition, the chapter by Sheena McGowan focuses on aminopeptidases from the malaria parasite, Plasmodium falciparum, and the chapter by Ben Dunn deals with the aspartic peptidases from the same organism.

New Synthetic Technologies in Medicinal Chemistry (Hardcover): Elizabeth Farrant New Synthetic Technologies in Medicinal Chemistry (Hardcover)
Elizabeth Farrant
R2,419 Discovery Miles 24 190 Shipped within 7 - 12 working days

The modern synthetic chemist applies all the tools available to identify the drug-like molecules with the best chances of becoming novel drugs. This book will act as a primer for graduates and postgraduates interested in a career in drug discovery. It covers both synthetic technologies currently impacting medicinal chemistry and emerging areas. The chapters focus on topics including: parallel medicinal chemistry; solid supported reagents; microwave assisted chemistry; flow synthesis, and high throughput reaction screening.

Genotoxicity and Carcinogenicity Testing of Pharmaceuticals (Paperback, 1st ed. 2015): Michael J Graziano, David Jacobson-Kram Genotoxicity and Carcinogenicity Testing of Pharmaceuticals (Paperback, 1st ed. 2015)
Michael J Graziano, David Jacobson-Kram
R2,875 R2,363 Discovery Miles 23 630 Save R512 (18%) Shipped within 7 - 12 working days

This book provides an overview of the nonclinical testing strategies that are used to asses and de-risk the genotoxicity and carcinogenicity properties of human pharmaceuticals. It includes a review of relevant ICH guidelines, numerous case studies where follow-up studies were conducted to further investigate positive findings, and practical considerations for the use of alternative and emerging tests. With contributions from recognized experts in the pharmaceutical industry and health authorities, this volume presents a balanced view on the interpretation and application of genotoxicity and carcinogenicity regulatory guidances. Genotoxicity and Carcinogenicity Testing of Pharmaceuticals is a valuable resource for scientists, regulators, and consultants that are engaged in the conduct, reporting, and review of nonclinical studies. This book will also help academicians better understand and appreciate the complexity of the regulations and breadth of toxicology research that are necessary to support the development and marketing of new drugs.

High-Throughput Formulation Development of Biopharmaceuticals - Practical Guide to Methods and Applications (Hardcover):... High-Throughput Formulation Development of Biopharmaceuticals - Practical Guide to Methods and Applications (Hardcover)
Vladimir I. Razinkov, Gerd Kleemann
R3,184 R2,615 Discovery Miles 26 150 Save R569 (18%) Shipped within 7 - 11 working days

High Throughput Formulation Development of Biopharmaceuticals: Practical Guide to Methods and Applications provides the latest developments and information on the science of stable and safe drug product formulations, presenting a comprehensive review and detailed description of modern methodologies in the field of formulation development, a process starting with candidate and pre-formulation screening in its early development phase and then progressing to the refinement of robust formulations during commercialization in the later phases of development. The title covers topics such as experiment design, automation of sample preparation and measurements, high-throughput analytics, stress-inducing methods, statistical analysis of large amounts of formulation study data, emerging technologies, and the presentation of several case studies, along with a concluding summary.

Sedimentation Velocity Analytical Ultracentrifugation - Discrete Species and Size-Distributions of Macromolecules and Particles... Sedimentation Velocity Analytical Ultracentrifugation - Discrete Species and Size-Distributions of Macromolecules and Particles (Hardcover)
Peter Schuck
R1,954 Discovery Miles 19 540 Shipped within 7 - 12 working days

A follow-up to the experimental and instrumental aspects described in Basic Principles of Analytical Ultracentrifugation, the volume Sedimentation Velocity Analytical Ultracentrifugation: Discrete Species and Size-Distributions of Macromolecules and Particles describes the theory and practice of data analysis. Mathematical models for the sedimentation process and the evolution of detected signals are developed in a comprehensive framework, jointly with the description of current and historical strategies for how to extract from noisy experimental data the physical parameters of interest, such as size, mass, and shape, composition, and polydispersity of sedimenting particles. The methods are extensively illustrated, and supported with practical applications, as well as cross-references where to find the methods in the public domain software SEDFIT and SEDPHAT. The systems covered are discrete or polydisperse mixtures of sedimenting molecules or particles in dilute solution, such as proteins and other biomolecules and their stable complexes, man-made polymers, and nanoparticles, observed in different optical systems. A useful reference for researchers and graduate students of macromolecular disciplines, these methods form the essential foundation for the analysis of dynamic interacting systems, which are covered in the volume Sedimentation Velocity Analytical Ultracentrifugation: Interacting Systems. Software referenced in the book is available for download at: https://sedfitsedphat.nibib.nih.gov/default.aspx

Drug Discovery for Nervous System Diseases (Paperback, New): Franz F. Hefti Drug Discovery for Nervous System Diseases (Paperback, New)
Franz F. Hefti
R2,994 R2,100 Discovery Miles 21 000 Save R894 (30%) Shipped within 7 - 13 working days

The neurosciences have been an especially difficult field for drug discovery. Because of the huge complexity of the nervous system and poor understanding of most psychiatric and neurological diseases, most drugs currently available are the result of chance observations rather than a truly comprehensive approach. However, this situation has begun to change. Enormous progress in molecular biology has yielded breakthrough discoveries of the causes of nervous system diseases, opening the door for better-targeted and entirely novel therapies.
Reflecting these recent advances, Drug Discovery for Nervous System Diseases presents the latest techniques and approaches for drug discovery, organizing them according to diseases rather than classes of drugs or drug targets, as past books have done. Written with optimistic anticipation of great progress still to come, this text provides both a guide to present realities and a look to future possibilities in this burgeoning field.
Coverage in Drug Discovery for Nervous System Diseases includes:
* Fundamentals of drug discovery-receptors, target selection, and drug development
* Schizophrenia
* Depression
* Anxiety disorders
* Alzheimer's disease
* Parkinson's disease
* Ischemic stroke, brain, and spinal cord injury
* Other neurodegenerative diseases
* Sleep disorders
* Epilepsy
* Pain
This practical handbook features a uniform presentation for each chapter, with a brief description of existing drugs leading to recent molecular biological and genetic findings, translational research and the interface to clinical trials, and finally an outlook on future drug targets. Rich illustrations-schematic diagrams and tables-provide a dynamic visual experience throughout the text.
A unique and up-to-date guide to a field currently undergoing a major growth spurt, Drug Discovery for Nervous System Diseases offers both practitioners and advanced students an unparalleled resource.

Biological and Pharmaceutical Nanomaterials (Hardcover): Challa S. S. R. Kumar Biological and Pharmaceutical Nanomaterials (Hardcover)
Challa S. S. R. Kumar
R4,528 R3,996 Discovery Miles 39 960 Save R532 (12%) Shipped within 7 - 12 working days

This first comprehensive yet concise overview of all important classes of biological and pharmaceutical nanomaterials presents in one volume the different kinds of natural biological compounds that form nanomaterials or that may be used to purposefully create them. This unique single source of information brings together the many articles published in specialized journals, which often remain unseen by members of other, related disciplines. Covering pharmaceutical, nucleic acid, peptide and DNA-Chitosan nanoparticles, the book focuses on those innovative materials and technologies needed for the continued growth of medicine, healthcare, pharmaceuticals and human wellness.
For chemists, biochemists, cell biologists, materials scientists, biologists, and those working in the pharmaceutical and chemical industries.

Seafood and Freshwater Toxins - Pharmacology, Physiology, and Detection, Third Edition (Hardcover, 3rd New edition): Luis M.... Seafood and Freshwater Toxins - Pharmacology, Physiology, and Detection, Third Edition (Hardcover, 3rd New edition)
Luis M. Botana
R5,342 Discovery Miles 53 420 Shipped within 7 - 12 working days

The last few years have brought about many changes in the field of marine and freshwater toxins, with advances in analytical technology and the realization that these toxins are a global issue. Offering a complete reference guide, Seafood and Freshwater Toxins: Pharmacology, Physiology, and Detection, Third Edition addresses all aspects of the social and scientific influence of phytotoxins, from legislation and monitoring to new drug development. Covering many new topics, the book examines three main aspects: monitoring of toxins; chemical, mechanistic, and toxicological diversity; and detection technologies. New to this edition: 35 new chapters and 5 updated chapters A focus on state-of-the-art methodology Coverage of new technologies to cultivate algae and to identify, isolate, and quantify toxins Regulatory changes Climate change evidence Expanded information on toxicology Part I of the book includes an overview and reviews general issues related to toxin detection, ecology, and diversity, and effects of climate change. Part II covers impacts of toxins regarding epidemiology, toxicology, economics, and surveillance. Part III explores available detection technologies, such as functional assays, biosensors, mass spectrometry, nanotechnology, and more. In addition, standard reference materials for toxins are discussed. Parts IV to VI provide detailed descriptions of toxin chemical diversity, biological sources, and modes of action. Part VII addresses the use of toxins as starting points for therapeutic drugs for cancer, neurological disorders, and for novel antibiotics.

Iminosugars - From Synthesis to Therapeutic Applications (Hardcover): Philippe Compain, Oliver R. Martin Iminosugars - From Synthesis to Therapeutic Applications (Hardcover)
Philippe Compain, Oliver R. Martin
R3,256 R2,287 Discovery Miles 22 870 Save R969 (30%) Shipped within 7 - 13 working days

Iminosugars form undoubtedly the most attractive class of carbohydrate mimics reported so far. In these structures, the substitution of the endocyclic oxygen of sugars by a basic nitrogen atom leads to remarkable biological properties and raises many challenges in organic synthesis. Since the discovery of their biological activity as glycosidase inhibitors in the 1970's, these polyvalent molecules have progressively made their way from the laboratory to the clinic.

The impressive series of discoveries in the field over the past ten years indicates clearly that it is "a boom time" for iminosugar chemistry and biology. The scope of their profile as inhibitors has been extended to a number of enzymes such as phosphorylases, glycosyltransferases or metalloproteinases, and iminosugars now constitute lead compounds for the development of new therapeutic agents for a wide range of diseases including diabetes, viral infections, lysosomal storage disorders and tumor metastasis.

Latest developments, from iminosugar synthesis to their use in clinical studies, are presented in this book, which contains contributions from over fifteen of the major chemists, biochemists and drug developers in this rapidly expanding field. An extensive table correlating the structures of more than 600 iminosugars of therapeutic interest with their biological activities is also included in the book and should prove particularly useful to aid with the design and the discovery of novel bioactive substances.

"Iminosugars: From Synthesis to Therapeutic Application" provides a unique resource for academic and industrial researchers working in the field of iminosugars and glycomimetics of biological and/ortherapeutic interest: organic chemists, medicinal chemists, carbohydrate chemists and medical scientists.

Computational Chemogenomics (Hardcover): Edgar Jacoby Computational Chemogenomics (Hardcover)
Edgar Jacoby
R2,443 Discovery Miles 24 430 Shipped within 7 - 12 working days

This book focuses on applications of compound library design and virtual screening to expand the bioactive chemical space, to target hopping of chemotypes to identify synergies within related drug discovery projects or to repurpose known drugs, to propose mechanism of action of compounds, or to identify off-target effects by cross-reactivity analysis. Both ligand-based and structure-based in silico approaches, as reviewed in this book, play important roles for all these applications. Computational chemogenomics is expected to increase the quality and productivity of drug discovery and lead to the discovery of new medicines.

Biodiversity, Natural Products And Cancer Treatment (Hardcover): Victor Kuete, Efferth Thomas Biodiversity, Natural Products And Cancer Treatment (Hardcover)
Victor Kuete, Efferth Thomas
R2,121 R1,969 Discovery Miles 19 690 Save R152 (7%) Shipped within 7 - 12 working days

This book is the first of its kind in bringing together biodiversity, chemical ecology, phytochemistry and cancer therapy. The highlight of the book is an exhaustive compilation of scientific data on biodiversity of medicinal plants, biodiversity and metagenomics, chemical ecology of medicinal plants, chemical ecology of marine organisms, natural products from terrestrial microbial organisms with activity towards cancer cells, marine organisms, ethnopharmacology and phytotherapy, contribution of African flora in world fight against cancer, natural products derived from terrestrial plants with activity towards cancer cells and established anticancer drugs from natural origin.The book discusses the state-of-the-art of each topic to serve as reference resource tools for graduate students as well as scientists and scholars in pharmaceutical sciences, pharmacology, organic chemistry and biochemistry, pharmacognosy, phytochemistry, ethnomedicine and ethnopharmacology, complementary and alternative medicine, medical and public health sciences and others. It includes cutting-edge developments in anticancer discovery from both medicinal plants and organisms.

Polymer Gels - Synthesis and Characterization (Hardcover, 1st ed. 2018): Vijay Kumar Thakur, Manju Kumari Thakur Polymer Gels - Synthesis and Characterization (Hardcover, 1st ed. 2018)
Vijay Kumar Thakur, Manju Kumari Thakur
R2,450 R2,189 Discovery Miles 21 890 Save R261 (11%) Shipped within 7 - 12 working days

This book addresses a range of synthesis and characterization techniques that are critical for tailoring and broadening the various aspects of polymer gels, as well as the numerous advantages that polymer gel-based materials offer. It presents a comprehensive collection of chapters on the recent advances and developments in the science and fundamentals of both synthetic and natural polymer-based gels. Topics covered include: synthesis and structure of physically/chemically cross-linked polymer-gels/polymeric nanogels; gel formation through non-covalent cross-linking; molecular design and characterization; polysaccharide-based polymer gels: synthesis, characterization, and properties; modified polysaccharide gels: silica-based polymeric gels as platforms for the delivery of pharmaceuticals; gel-based approaches in genomic and proteomic sciences; emulgels in drug delivery; and organogels. The book provides a cutting-edge resource for researchers and scientists working in various fields involving polymers, biomaterials, bio-nanotechnology and functional materials.

Lipase - An Industrial Enzyme Through Metagenomics (Hardcover): B.K. Konwar, Kalpana Sagar Lipase - An Industrial Enzyme Through Metagenomics (Hardcover)
B.K. Konwar, Kalpana Sagar
R2,566 R2,432 Discovery Miles 24 320 Save R134 (5%) Shipped within 7 - 11 working days

Microbial lipases are industrially important and have gained attention due to their stability, selectivity, and broad substrate specificity. Lipases are used as medicine, and they also aid in indigestion, heartburn, allergy to gluten in wheat products (celiac disease), Crohn's disease, and cystic fibrosis. This volume considers the industrial demand for new sources of lipases with different catalytic characteristics that stimulate the isolation, growth, and development of new microbial strains. The volume narrates the challenging metagenomic approach with the isolation of the lipase gene, its cloning into Escherichia coli, culture of the recombinant bacteria, and extraction and assessment of the lipase enzyme. Lipase-producing bacteria are available in different habitats, such as industrial wastes, vegetable oil processing factories, dairy plants, and soils contaminated with oil and oil seeds, among others. This volume is the effort of the authors to document the scientific findings carried out over the last eight years in the area of un-culturable soil microorganisms. The book presents the physic-chemical features of lipases and their specific applications in different commercial industries. The in-depth study looks at metagenomics for lipases from all angles and provides a truly informative resource. It describes the biochemical characterization of lipase enzymes with the high activity in the presence of 1% tributyrin. A wide review has been presented in the book on lipase enzymes purified from a large collection of microbes present in soil, seawater, waste-dumping sites, animal systems (including human beings), and the atmosphere. Stability of enzymes over changing environments of the industry is indeed a big issue, and the book deals at length with the changing temperatures and pH and metal ion concentrations.

Essentials of Pharmaceutical Chemistry (Paperback, 4th Revised edition): Donald Cairns Essentials of Pharmaceutical Chemistry (Paperback, 4th Revised edition)
Donald Cairns
R969 R877 Discovery Miles 8 770 Save R92 (9%) Shipped within 7 - 11 working days

An introduction to pharmaceutical chemistry for undergraduate pharmacy, chemistry and medicinal chemistry students. Essentials of Pharmaceutical Chemistry is a chemistry introduction that covers all of the core material necessary to provide an understanding of the basic chemistry of drug molecules. Now a core text on many university courses, it contains numerous worked examples and problems. The 4th edition includes new chapters on Chromatographic Methods of Analysis, and Medicinal Chemistry - The Science of Drug Design.

Pharmacokinetics and Pharmacodynamics of Biotech Drugs - Principles and Case Studies in Drug Development (Hardcover): Bernd... Pharmacokinetics and Pharmacodynamics of Biotech Drugs - Principles and Case Studies in Drug Development (Hardcover)
Bernd Meibohm
R3,333 R2,967 Discovery Miles 29 670 Save R366 (11%) Shipped within 7 - 12 working days

This first ever coverage of the pharmacokinetic and pharmacodynamic characteristics of biopharmaceuticals meets the need for a comprehensive book in this field. It spans all topics from lead identification right up to final-stage clinical trials.

Following an introduction to the role of PK and PD in the development of biotech drugs, the book goes on to cover the basics, including the pharmacokinetics of peptides, monoclonal antibodies, antisense oligonucleotides, as well as viral and non-viral gene delivery vectors. The second section discusses such challenges and opportunities as pulmonary delivery of proteins and peptides, and the delivery of oligonucleotides. The final section considers the integration of PK and PD concepts into the biotech drug development plan, taking as case studies the preclinical and clinical drug development of tasidotin, as well as the examples of cetuximab and pegfilgrastim.

The result is vital reading for all pharmaceutical researchers.

The Organic Chemistry of Drug Design and Drug Action (Hardcover, 3rd edition): Richard B. Silverman, Mark W Holladay The Organic Chemistry of Drug Design and Drug Action (Hardcover, 3rd edition)
Richard B. Silverman, Mark W Holladay 1
R1,920 R1,642 Discovery Miles 16 420 Save R278 (14%) Shipped within 7 - 12 working days

"The Organic Chemistry of Drug Design and Drug Action, Third Edition," represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows the reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition reflects significant changes in the process of drug design over the last decade. It preserves the successful approach of the previous editions while including significant changes in format and coverage.

New to this edition: Updates to all chapters, including new examples and referencesChapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the bookChapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistryChapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexantChapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesisChapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinibfor transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazidfor slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptinChapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examplesChapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolitesChapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody-drug conjugates

Metal-based Anticancer Agents (Hardcover): Angela Casini, Anne Vessieres, Samuel M Meier-Menches Metal-based Anticancer Agents (Hardcover)
Angela Casini, Anne Vessieres, Samuel M Meier-Menches
R3,911 Discovery Miles 39 110 Shipped within 7 - 12 working days

Metal-based anticancer drugs are among the most successful therapeutic agents, as evidenced by the frequent prescription of selected platinum and arsenic compounds to patients. Metal-based Anticancer Agents covers the interdisciplinary world of inorganic drug discovery and development by introducing the most prominent compound classes based on different transition metals, discussing emerging concepts and enabling methods, as well as presenting key pre-clinical and clinical aspects. Recent progress on the unique features of next-generation targeted metal-based anticancer agents, including supramolecular coordination complexes used for both therapy and drug delivery, promise a bright future beyond the benefits of pure cytotoxic activity. With contributions from global leaders in the field, this book will serve as a useful reference to established researchers as well as a practical guide to those new to metallodrugs, and postgraduate students of medicinal chemistry and metallobiology.

Computational and Structural Approaches to Drug Discovery - Ligand-Protein Interactions (Hardcover): Robert Stroud, Janet... Computational and Structural Approaches to Drug Discovery - Ligand-Protein Interactions (Hardcover)
Robert Stroud, Janet Finer-Moore
R3,506 Discovery Miles 35 060 Shipped within 7 - 12 working days

Computational methods impact all aspects of modern drug discovery and most notably these methods move rapidly from academic exercises to becoming drugs in clinical trials.

This insightful book represents the experience and understanding of the global experts in the field and spotlights both the structural and medicinal chemistry aspects of drug design. The need to 'encode' the factors that determine adsorption, distribution, metabolism, excretion and toxicology are explored, as they remain the critical issues in this area of research. This indispensable resource provides the reader with:
A rich understanding of modern approaches to docking;
A comparison and critical evaluation of state-of-the-art methods;
Details on harnessing computational methods for both analysis and prediction;
An insight into prediction potencies and protocols for unbiased evaluations of docking and scoring algorithms;
Critical reviews of current fragment based methods with perceptive applications to kinases.

Addressing a wide range of uses of protein structures for drug discovery the Editors have created an essential reference for professionals in the pharmaceutical industry and moreover an indispensable core text for all graduate level courses covering molecular interactions and drug discovery.

Nanoparticulate Drug Delivery Systems - Strategies, Technologies, and Applications (Hardcover): Yoon Yeo Nanoparticulate Drug Delivery Systems - Strategies, Technologies, and Applications (Hardcover)
Yoon Yeo
R2,997 R2,101 Discovery Miles 21 010 Save R896 (30%) Shipped within 7 - 13 working days

"Frank discussions of opportunities and challenges point the way to new, more effective drug delivery systems"

Interest in nanomedicine has grown tremendously, fueled by the expectation that continued research will lead to the safe, efficient, and cost-effective delivery of drugs or imaging agents to human tissues and organs. The field, however, has faced several challenges attempting to translate novel ideas into clinical benefits. With contributions from an international team of leading nanomedicine researchers, this book provides a practical assessment of the possibilities and the challenges of modern nanomedicine that will enable the development of clinically effective nanoparticulate drug delivery products and systems.

"Nanoparticulate Drug Delivery Systems" focuses on the rationales and preclinical evaluation of new nanoparticulate drug carriers that have yet to be thoroughly reviewed in the literature. The first chapter sets the stage with a general overview of targeted nanomedicine. The book then explores new and promising nanoparticulate drug delivery systems, including: Lipid nanoparticles for the delivery of nucleic acidsMultifunctional dendritic nanocarriersPolymer drug nanoconjugates

Next, the book presents new opportunities and challenges for nanoparticulate drug delivery systems, including: Clearance of nanoparticles during circulationDrug delivery strategies for combatting multiple drug resistanceToxicological assessment of nanomedicine

Chapters offer state-of-the-technology reviews with extensive references to facilitate further investigation. Moreover, each chapter concludes with an expert assessment of remaining challenges, pointing the way to solutions and new avenues of research.

With its frank discussions of opportunities and challenges, "Nanoparticulate Drug Delivery Systems" sets a solid foundation for new research leading to the discovery and development of better nanomedicines.

How Medicines Are Born: The Imperfect Science Of Drugs (Hardcover): Lisa Vozza, Maurizio D'Incalci How Medicines Are Born: The Imperfect Science Of Drugs (Hardcover)
Lisa Vozza, Maurizio D'Incalci; Translated by Andreas Gescher
R1,330 R1,243 Discovery Miles 12 430 Save R87 (7%) Shipped within 7 - 12 working days

This book is an excursion into the drug development process, from the initial conception in a chemical or molecular biology lab, via tests in isolated cells and animals, to the stage of clinical trials. The human body is a complex ecosystem where little is conclusively known in terms of its response to medication, for both sick and healthy individuals. The considerable degree of uncertainty inherent in health-related research can lead to approval of controversial medicines, particularly in high-stakes scenarios and medical crises. Real-life examples are drawn on here to explain the decision making processes behind the acceptance of new drugs, disproving misconceptions around medicines by delving into the history and current practice of the drug development process.Originally written in Italian, How Medicines are Born helps patients, students, public health officials physicians, healthcare practitioners and biomedical scientists make informed decisions on the benefits and disadvantages of select medicine based on an understanding of the history of drug development.Published in Italian (2014), M D'Incalci & L Vozza, Come Nascono le Medicine; La scienza imperfetta dei farmaci. Bologna: Zanichelli

Immunopharmacology and Inflammation (Hardcover, 1st ed. 2018): Carlo Riccardi, Francesca Levi-Schaffer, Ekaterini Tiligada Immunopharmacology and Inflammation (Hardcover, 1st ed. 2018)
Carlo Riccardi, Francesca Levi-Schaffer, Ekaterini Tiligada
R3,547 R2,771 Discovery Miles 27 710 Save R776 (22%) Shipped within 7 - 12 working days

A comprehensive overview of the current research on inflammation and immunopharmacology, with particular attention to the use of anti-inflammatory drugs, this book discusses future trends in this area of pharmacological research. It addresses an audience with basic knowledge in the inflammatory process, immune system and pharmacology. The book meets the needs of graduate students, junior and senior researchers and is useful as a source of the most current information for those already working in these fields.

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