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Books > Professional & Technical > Industrial chemistry & manufacturing technologies > Industrial chemistry > Pharmaceutical technology

Microbial Infections and Cancer Therapy (Hardcover): Ananda M. Chakrabarty, Arsenio M. Fialho Microbial Infections and Cancer Therapy (Hardcover)
Ananda M. Chakrabarty, Arsenio M. Fialho
R3,122 Discovery Miles 31 220 Shipped within 7 - 11 working days

This book deals with the emerging concept that certain pathogenic bacteria and viruses, when infecting people with cancer, actively fight tumors, allowing their regression. Although such observations go back more than 100 years, use of specific bacterial strains, or viruses, usually genetically modified with known anticancer drugs, and their protein/peptide products, has gained ground in recent years, allowing significant cancer regression in clinical trials with stage III/IV cancer patients or even in pediatric brain tumor patients, often without any demonstration of toxicity. It is composed of 12 chapters written by pioneers in microbial, biotech, and cancer research and covers the emerging roles of various microorganisms and their products in cancer therapy. The book highlights the benefits of using conventional cancer treatments (such as chemo- and radiotherapies) with microbial-based therapies. Such combinatorial therapies have gained particular attention as a strategy to overcome drug resistance, and the readers of the book will discover their impact on fundamental research and promising results from clinical trials.

Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms (Hardcover, 4th New edition): Linda A. Felton Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms (Hardcover, 4th New edition)
Linda A. Felton
R2,568 Discovery Miles 25 680 Shipped within 7 - 12 working days

Aqueous-based film coating has become routine in the pharmaceutical industry. This process eliminates the use of organic solvents and thus avoids economic, environmental, and toxicological issues related to residual solvents and solvent recovery. Aqueous-based coating, however, is complex and many variables may impact the final product and its performance. This fourth edition of Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms aims to provide insight into the factors and parameters that should be considered and controlled for the successful development and commercialization of a coated product. The fourth edition has been revised and expanded to reflect the most recent scientific advancements from the literature. The contributing authors explain in detail, using illustrated examples, appropriate steps to solve and ideally avoid formulation, processing, and stability problems and to achieve an optimized dosage form. Trade names and chemical names of commercially marketed coatings are used throughout the text to help familiarize the reader with the various materials available for pharmaceutical applications. This book will be a valuable resource for anyone in the pharmaceutical industry working in the area of aqueous-based film coating.

The Analysis of Controlled Substances (Paperback): Michael D Cole The Analysis of Controlled Substances (Paperback)
Michael D Cole
R1,442 R1,107 Discovery Miles 11 070 Save R335 (23%) Shipped within 7 - 13 working days

It is now recognized that to ensure the validity of a forensic science analysis, a number of criteria need to be met, including ensuring that the:

  • sample is suitable for the analysis
  • analysis to be undertaken will answer the question being asked
  • analysis has been correctly carried out
  • data has been correctly recorded
  • data has been correctly interpreted
  • findings are correctly reported
The aim of this text is to provide an understanding into the analysis of drugs of abuse within the context of their control, an appreciation of the different methods that can be used for drug analysis and the reasons for their use.

The major classes of drugs of abuse are addressed, the analysis of which follows a systematic framework, including description, presumptive testing, thin layer chromatography, instrumental methods and data analysis. Throughout the text, regular questions and answers are used to further develop an understanding of the processes being used.

This book will appeal to undergraduate and postgraduate students of forensic science, and to forensic science practitioners who are new in post or receiving additional or refresher training. It will also appeal to those who are studying controlled substances as broadening courses in other scientific disciplines

Drug Transporters - Volume 1: Role and Importance in ADME and Drug Development (Hardcover): Glynis Nicholls, Kuresh Youdim Drug Transporters - Volume 1: Role and Importance in ADME and Drug Development (Hardcover)
Glynis Nicholls, Kuresh Youdim
R4,320 Discovery Miles 43 200 Shipped within 7 - 12 working days

This book provides a comprehensive guide to state-of-the-art knowledge, techniques and tools in the transporter sciences relating to drug metabolism and pharmacokinetics. There are currently no books that can be referred to by students and industrial scientists alike for clear, detailed information on relevant drug transporter science. Regulatory authorities and pharmaceutical companies have recognized the need to understand and quantify the effects of drug transporters within the human body. Case studies and information on emerging areas will be included throughout the book. The book will be relevant to those working in drug discovery and development and can be cross promoted with other titles in the RSC Drug Discovery Series. It could also be cross-promoted with the Biomolecular Series Books and the jounal MedChemComm.

Drug Transporters - Volume 2: Recent Advances and Emerging Technologies (Hardcover): Glynis Nicholls, Kuresh Youdim Drug Transporters - Volume 2: Recent Advances and Emerging Technologies (Hardcover)
Glynis Nicholls, Kuresh Youdim
R3,826 Discovery Miles 38 260 Shipped within 7 - 12 working days

This book provides a comprehensive guide to state-of-the-art knowledge, techniques and tools in the transporter sciences relating to drug metabolism and pharmacokinetics. There are currently no books that can be referred to by students and industrial scientists alike for clear, detailed information on relevant drug transporter science. Regulatory authorities and pharmaceutical companies have recognized the need to understand and quantify the effects of drug transporters within the human body. Case studies and information on emerging areas will be included throughout the book. The book will be relevant to those working in drug discovery and development and can be cross promoted with other titles in the RSC Drug Discovery Series. It could also be cross-promoted with the Biomolecular Series Books and the jounal MedChemComm.

Nanoparticulate Drug Delivery Systems (Hardcover): Raj K. Keservani, Anil K. Sharma Nanoparticulate Drug Delivery Systems (Hardcover)
Raj K. Keservani, Anil K. Sharma
R2,739 Discovery Miles 27 390 Shipped within 7 - 12 working days

Focusing on nanoparticulate nanocarriers and recent advances in the field of drug delivery, the volume begins with chapters that provide an informative introduction to polymeric nanoparticles-their general physicochemical features and characteristics, their applications in drug delivery systems, and the challenges involved. Specific applications are discussed, with attention paid to treatment of particular diseases and disorders and the targeting of specific organs. Part 2 looks at more specific applications and techniques of nanoparticulate nanocarriers for drug delivery, such as the use of magnetic nanoparticles, gold nanoparticles in therapeutics, and superparamagnetic iron oxide nanoparticles (SPIONs) for the treatment of cancer. Part 3 discusses lipid-based nanoparticulates for various applications, including skin care. The last section of the book explores some of the newer nanoarchitectures, including dendrimers in gene delivery and carbon nanotubes for drug delivery. Together, the insightful research presented here provides valuable information for those involved in this area, including scientists and researchers and faculty and upper-level students, as well as for industry professionals.

Oral Formulation Roadmap from Early Drug Discovery to Development (Hardcover): Elizabeth Kwong Oral Formulation Roadmap from Early Drug Discovery to Development (Hardcover)
Elizabeth Kwong
R2,807 R1,970 Discovery Miles 19 700 Save R837 (30%) Shipped within 7 - 13 working days

Detailing formulation approaches by stage of discovery to early development, this book gives a playbook of practical and efficient strategies to formulate drug candidates with the least chance of failing in clinical development. Comes from contributing authors with experience developing formulations on the frontlines of the pharmaceutical industry Focuses on pre (or non-) clinical and early stage development, the phases where most compounds are used in drug research Features case studies to illustrate practical challenges and solutions in formulation selection Covers regulatory filing, drug metabolism and physical and chemical properties, toxicology formulation, biopharmaceutics classification system (BCS), screening approaches, early stage clinical formulation development, and outsourcing

Protein Analysis using Mass Spectrometry - Accelerating Protein Biotherapeutics from Lab to Patient (Hardcover): Mike S. Lee,... Protein Analysis using Mass Spectrometry - Accelerating Protein Biotherapeutics from Lab to Patient (Hardcover)
Mike S. Lee, Qin C Ji
R3,306 R2,325 Discovery Miles 23 250 Save R981 (30%) Shipped within 7 - 13 working days

Presents Practical Applications of Mass Spectrometry for Protein Analysis and Covers Their Impact on Accelerating Drug Discovery and Development * Covers both qualitative and quantitative aspects of Mass Spectrometry protein analysis in drug discovery * Principles, Instrumentation, Technologies topics include MS of peptides, proteins, and ADCs , instrumentation in protein analysis, nanospray technology in MS protein analysis, and automation in MS protein analysis * Details emerging areas from drug monitoring to patient care such as Identification and validation of biomarkers for cancer, targeted MS approaches for biomarker validation, biomarker discovery, and regulatory perspectives * Brings together the most current advances in the mass spectrometry technology and related method in protein analysis

How Medicines Are Born: The Imperfect Science Of Drugs (Paperback): Lisa Vozza, Maurizio D'Incalci How Medicines Are Born: The Imperfect Science Of Drugs (Paperback)
Lisa Vozza, Maurizio D'Incalci; Translated by Andreas Gescher
R509 Discovery Miles 5 090 Shipped within 7 - 12 working days

This book is an excursion into the drug development process, from the initial conception in a chemical or molecular biology lab, via tests in isolated cells and animals, to the stage of clinical trials. The human body is a complex ecosystem where little is conclusively known in terms of its response to medication, for both sick and healthy individuals. The considerable degree of uncertainty inherent in health-related research can lead to approval of controversial medicines, particularly in high-stakes scenarios and medical crises. Real-life examples are drawn on here to explain the decision making processes behind the acceptance of new drugs, disproving misconceptions around medicines by delving into the history and current practice of the drug development process.Originally written in Italian, How Medicines are Born helps patients, students, public health officials physicians, healthcare practitioners and biomedical scientists make informed decisions on the benefits and disadvantages of select medicine based on an understanding of the history of drug development.Published in Italian (2014), M D'Incalci & L Vozza, Come Nascono le Medicine; La scienza imperfetta dei farmaci. Bologna: Zanichelli

Drug Delivery Across Physiological Barriers (Hardcover): Silvia Muro Drug Delivery Across Physiological Barriers (Hardcover)
Silvia Muro
R2,349 Discovery Miles 23 490 Shipped within 7 - 12 working days

Transport of pharmaceutical agents in the body is paramount to therapeutic efficacy. Advances in the past decades have rendered a remarkable improvement of drug delivery strategies, which has helped to increase the bioavailability of therapeutic agents by protecting them from degradation, targeting them to diseased sites, and controlling their circulation time and release rate. Additionally, for most therapeutics, reaching the targets of action require penetration across tissues and/or entry within cells. The design of strategies to control the transport of therapeutic compounds through these physiological barriers has become an imperative and a challenging need in the quest for better therapeutics. This book provides an overview of the current advances in this field, including considerations on the biological regulation and natural mechanisms overcoming these barriers, as well as drug delivery strategies facilitating the transport of drugs and their carriers at the tissue, cell, and subcellular levels.

Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals (Hardcover): Feroz Jameel, Susan Hershenson Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals (Hardcover)
Feroz Jameel, Susan Hershenson
R4,229 R2,966 Discovery Miles 29 660 Save R1,263 (30%) Shipped within 7 - 13 working days

A real-world guide to the production and manufacturing of biopharmaceuticals

While much has been written about the science of biopharmaceuticals, there is a need for practical, up-to-date information on key issues at all stages of developing and manufacturing commercially viable biopharmaceutical drug products. This book helps fill the gap in the field, examining all areas of biopharmaceuticals manufacturing, from development and formulation to production and packaging.

Written by a group of experts from industry and academia, the book focuses on real-world methods for maintaining product integrity throughout the commercialization process, clearly explaining the fundamentals and essential pathways for all development stages. Coverage includes:

Research and early development phase-appropriate approaches for ensuring product stability

Development of commercially viable formulations for liquid and lyophilized dosage forms

Optimal storage, packaging, and shipping methods

Case studies relating to therapeutic monoclonal antibodies, recombinant proteins, and plasma fractions

Useful analysis of successful and failed products

Formulation and Process Development Strategies for Manufacturing Biopharma-ceuticals is an essential resource for scientists and engineers in the pharmaceutical and biotech industries, for government and regulatory agencies, and for anyone with an interest in the latest developments in the field.

Aquaporins in Health and Disease - New Molecular Targets for Drug Discovery (Hardcover): Graca Soveral, Soren Nielsen, Angela... Aquaporins in Health and Disease - New Molecular Targets for Drug Discovery (Hardcover)
Graca Soveral, Soren Nielsen, Angela Casini
R4,427 Discovery Miles 44 270 Shipped within 7 - 12 working days

Since the discovery of Aquaporin-1 (AQP1) as a water channel, many studies have revealed the importance of aquaporins in mammalian physiology and pathophysiology as well as plant and microbial biology. The studies have also shown aquaporins as potential drug targets and targets for improving crop properties. Written by an international group of contributors at the forefront of the field, Aquaporins in Health and Disease: New Molecular Targets for Drug Discovery presents the latest research advances in aquaporins and other major intrinsic protein (MIP) channels. The first section of the book describes the general concepts of aquaporin channel function, genomic research, structure-function analysis of aquaporins and glycerol facilitators, and regulation by gating and trafficking, including yeast aquaporin regulation and function. The second section discusses the physiological and pathophysiological roles of aquaporins in humans and microbes. The final section covers the development of inhibitors of aquaporin function. The book's epilogue offers future perspectives and directions, mainly in the area of aquaporin-based diagnostics and therapeutics. Stimulating future research on this important protein family, this book facilitates a paradigm shift in the understanding and roles of aquaporin membrane proteins in all biological settings. It encourages scientists to develop novel approaches for the treatment of human diseases based on aquaporin function or dysfunction.

Polysaccharide Hydrogels - Characterization and Biomedical Applications (Hardcover): Pietro Matricardi, Franco Alhaique,... Polysaccharide Hydrogels - Characterization and Biomedical Applications (Hardcover)
Pietro Matricardi, Franco Alhaique, Tommasina Coviello
R2,978 Discovery Miles 29 780 Shipped within 7 - 12 working days

Hydrogels are an emerging area of interest in medicine as well as pharmaceutics, and their physico-chemical characterization is fundamental to their practical applications. Compared with synthetic polymers, polysaccharides that are widely present in living organisms and come from renewable sources are extremely advantageous for hydrogel formation. Furthermore, polysaccharides are usually non-toxic and biocompatible and show a number of peculiar physico-chemical properties that make them suitable for a wide variety of biomedical applications. This book bridges the gap between the preparation of hydrogels and their characterization techniques. It aims to offer a valid support that can help the readers find appropriate keys to open the doors to the complex world of polysaccharide hydrogels.

Analysis of Drug Impurities (Hardcover): Richard J Smith, Michael L. Webb Analysis of Drug Impurities (Hardcover)
Richard J Smith, Michael L. Webb
R3,606 R3,207 Discovery Miles 32 070 Save R399 (11%) Shipped within 7 - 12 working days

A key component of the overall quality of a pharmaceutical is control of impurities, as their presence, even in small amounts, may affect drug safety and efficacy. The identification and quantification of impurities to acceptable standards presents a significant challenge to the analytical chemist. Analytical science is developing rapidly and provides increasing opportunity to identify the structure, and therefore the origin and safety implications of these impurities, and the challenges of their measurement drives the development of modern quantitative methods.
Written for both practicing and student analytical chemists, Analysis of Drug Impurities provides a detailed overview of the challenges and the techniques available to permit accurate identification and quantification of drug impurities.

Statistical Methods for Drug Safety (Hardcover): Robert D. Gibbons, Anup Amatya Statistical Methods for Drug Safety (Hardcover)
Robert D. Gibbons, Anup Amatya
R1,696 Discovery Miles 16 960 Shipped within 7 - 12 working days

Explore Important Tools for High-Quality Work in Pharmaceutical Safety Statistical Methods for Drug Safety presents a wide variety of statistical approaches for analyzing pharmacoepidemiologic data. It covers both commonly used techniques, such as proportional reporting ratios for the analysis of spontaneous adverse event reports, and newer approaches, such as the use of marginal structural models for controlling dynamic selection bias in the analysis of large-scale longitudinal observational data. Choose the Right Statistical Approach for Analyzing Your Drug Safety Data The book describes linear and non-linear mixed-effects models, discrete-time survival models, and new approaches to the meta-analysis of rare binary adverse events. It explores research involving the re-analysis of complete longitudinal patient records from randomized clinical trials. The book discusses causal inference models, including propensity score matching, marginal structural models, and differential effects, as well as mixed-effects Poisson regression models for analyzing ecological data, such as county-level adverse event rates. The authors also cover numerous other methods useful for the analysis of within-subject and between-subject variation in adverse events abstracted from large-scale medical claims databases, electronic health records, and additional observational data streams. Advance Statistical Practice in Pharmacoepidemiology Authored by two professors at the forefront of developing new statistical methodologies to address pharmacoepidemiologic problems, this book provides a cohesive compendium of statistical methods that pharmacoepidemiologists can readily use in their work. It also encourages statistical scientists to develop new methods that go beyond the foundation covered in the text.

Particles and Nanoparticles in Pharmaceutical Products - Design, Manufacturing, Behavior and Performance (Hardcover, 1st ed.... Particles and Nanoparticles in Pharmaceutical Products - Design, Manufacturing, Behavior and Performance (Hardcover, 1st ed. 2018)
Henk G. Merkus, Gabriel M. H. Meesters, Wim Oostra
R3,328 R2,640 Discovery Miles 26 400 Save R688 (21%) Shipped within 7 - 12 working days

This edited volume brings together the expertise of numerous specialists on the topic of particles - their physical, chemical, pharmacological and toxicological characteristics - when they are a component of pharmaceutical products and formulations. The book discusses in detail properties such as the composition, size, shape, surface properties and porosity of particles with respect to how they impact the formulations and products in which they are used and the effective delivery of pharmaceutical active ingredients. It considers all dosage forms of pharmaceuticals involving particles, from powders to tablets, creams to ointments, and solutions to dry-powder inhalers, also including the latest nanomedicine products. Further, it discusses examples of particle toxicity, as well as the important subject of pharmaceutical industry regulations, guidelines and legislation. The book is of interest to researchers and practitioners who work on testing and developing pharmaceutical dosage and delivery systems.

Tapping Molecular Wilderness - Drugs from Chemistry-Biology--Biodiversity Interface (Hardcover): Yongyuth Yuthavong Tapping Molecular Wilderness - Drugs from Chemistry-Biology--Biodiversity Interface (Hardcover)
Yongyuth Yuthavong
R834 Discovery Miles 8 340 Shipped within 7 - 12 working days

This book is for readers with some background in science, concerning the search for drugs, starting from molecular diversity in nature or molecular wilderness. Drug molecules may be used as such, or as starting points for improved drugs obtained from the interface of chemistry and biology. In some cases, the essential molecular features for drug properties from natural molecules may be identified and modified to more effective ones. In other cases, nature provides the targets, such as essential enzymes from infectious microorganisms, from which synthetic drugs can be designed. The mechanisms of action of drugs can be discerned by studying target-drug interactions. Nature may fight back, as in cases when microorganisms become resistant to drugs, but we can again use the chemistry-biology interface to obtain drugs which overcome the resistance. The battle goes on, hopefully with victory for both humans and balance of nature. This book differs from those available on the subject of natural products and drugs derived therefrom in that it looks at the broad picture on how materials and organisms from nature affect our health and how we have combined our knowledge in chemistry, biology, and biodiversity to promote our wellness from resources in the "molecular wilderness," with caveats on sustainable utilization of these resources. It is therefore suitable, not only for readers interested in science and medicine, but also for those with interest in policy issues concerning sustainable development, environment, and issues concerning interaction of science and society in general.

Antineoplastic Drugs - Organic Syntheses (Hardcover): Daniel Lednicer Antineoplastic Drugs - Organic Syntheses (Hardcover)
Daniel Lednicer
R1,897 R1,341 Discovery Miles 13 410 Save R556 (29%) Shipped within 7 - 13 working days

The past decade has seen a significant increase of research aimed at discovering new drugs for treating cancer, and the increasing number of new antineoplastic drugs approved by regulatory agencies reflects this. Until now, details on the synthesis of these newer agents have been scattered in various journals and in US and European patents. This timely volume deals with the organic chemistry involved in the synthesis of the agents found within antineoplastic drugs, including descriptions of the synthetic schemes for the preparation of over 200 compounds that have been granted non-proprietary names. Compounds are collected in chapters based on the mechanism of action rather than on their chemical structures. Each individual chapter is preceded by a brief description of that mechanism and includes detailed flow charts of the preparation of those compounds accompanied by discussions of the organic chemistry involved in each step. The first half of this volume is dedicated to the syntheses of established chemotherapy drugs. Kinase inhibitors occupy the following chapters with the largest single chapter dealing with the fifty compounds that inhibit tyrosine kinase. This class stands out since over twenty compounds in this group have been approved for treating patients; a rare track record compared to any other class of therapeutic agents. Antineoplastic Drugs: Organic Syntheses is written to appeal to organic and medicinal chemists in industry and academia. It is beneficial to those composing grant proposals for NCI and related organizations. The book is accessible to advanced undergraduates as well as graduates and researchers as well as those with a thorough grasp of organic chemistry.

Biological and Pharmaceutical Applications of Nanomaterials (Hardcover): Polina Prokopovich Biological and Pharmaceutical Applications of Nanomaterials (Hardcover)
Polina Prokopovich
R2,561 Discovery Miles 25 610 Shipped within 7 - 12 working days

Biological and Pharmaceutical Applications of Nanomaterials presents the findings of cutting-edge research activities in the field of nanomaterials, with a particular emphasis on biological and pharmaceutical applications. Divided into four sections-nanomaterials for drug delivery, antimicrobial nanomaterials, nanomaterials in biosensors, and safety of nanomaterials-this book: Covers topics such as stimuli-responsive nanostructured silica matrixes, gold nanoparticles, and liposomes for targeting drug delivery and dental applications Describes the use of nanocarriers and nanoparticles as cancer and peptide therapeutics, the influence of surface characteristics on microbial adhesion, and the latest developments in antimicrobial nanostructured polymers for medical applications Discusses recent advances in nanodiagnostic techniques for infectious agents, chromogenic biosensors for pathogen detection, electrochemical biosensors for detecting DNA damage and genotoxicity, and molecular imaging with quantum dots including surface modifications by polymers for biosensing applications Featuring contributions from field experts and researchers in industry and academia, Biological and Pharmaceutical Applications of Nanomaterials provides state-of-the-art information on nanomaterials and their use in drug delivery, infection control, and biomedicine.

Biophysical Techniques in Drug Discovery (Hardcover): Angeles Canales Biophysical Techniques in Drug Discovery (Hardcover)
Angeles Canales
R3,478 Discovery Miles 34 780 Shipped within 7 - 12 working days

Biophysical techniques are used in many key stages of the drug discovery process including in screening for new receptor ligands, in characterising drug mechanisms, and in validating data from biochemical and cellular assays. This book provides an overview of the biophysical methods applied in drug discovery today, including traditional techniques and newer developments. Perspectives from academia and industry across a spectrum of techniques are brought together in a single volume. Small and biotherapeutic approaches are covered and strengths and limitations of each technique are presented. Case studies illustrate the application of each technique in real applied examples. Finally, the book covers recent developments in areas such as electron microscopy with discussions of their possible impact on future drug discovery. This is a go-to volume for biophysicists, analytical chemists and medicinal chemists providing a broad overview of techniques of contemporary interest in drug discovery.

The Greening of Pharmaceutical Engineering - Theories and Solutions (Hardcover, Volume 2): M. r. Islam, Jaan S Islam, Gary M.... The Greening of Pharmaceutical Engineering - Theories and Solutions (Hardcover, Volume 2)
M. r. Islam, Jaan S Islam, Gary M. Zatzman, M. Safiur Rahman, M. A. H. Mughal
R3,650 R2,554 Discovery Miles 25 540 Save R1,096 (30%) Shipped within 7 - 13 working days

This is the second volume in a four-volume series aimed at guiding the pharmaceutical industry toward sustainability. After analyzing and exposing some of the backward and ill-conceived notions that guide the present state of the industry, this volume presents key theories and new, groundbreaking solutions for re-thinking the processes involved in the engineering of pharmaceuticals and offers a fundamental paradigm shift. The 4 volumes in this ambitious project are: - Volume 1: Practice, Analysis, and Methodology - Volume 2: Theories and Solutions - Volume 3: Applications for Mental Disorder Treatments - Volume 4: Applications for Physical Disorder Treatments This ground-breaking set of books is a unique and state-of-the-art study that only appears here, within these pages. A fascinating study for the engineer, scientist, and pharmacist working in the pharmaceutical industry and interested in sustainability, it is also a valuable textbook for students and faculty studying these subjects.

Biocatalysis - An Industrial Perspective (Hardcover): Pablo Dominguez de Maria Biocatalysis - An Industrial Perspective (Hardcover)
Pablo Dominguez de Maria; Contributions by Roger Sheldon, Rebecca Buller, Tom Moody, Aline Machado de Castro, …
R3,925 Discovery Miles 39 250 Shipped within 7 - 12 working days

Implementing biocatalytic strategies in an industrial setting at a commercial scale is a challenging task, necessitating a balance between industrial need against economic viability. With invited contributions from small and large-scale chemical and pharmaceutical companies, this book bridges the gap between academia and industry. Contributors discuss current processes, types of biocatalysts and improvements, industrial motivation and key aspects to economically succeed. With its focus on industry related issues, this book will be a useful tool for future research by both practitioners and academics.

Food and Nutritional Supplements - Their Role in Health and Disease (Hardcover, 2001 ed.): J. K. Ransley, Judith K. Donnelly,... Food and Nutritional Supplements - Their Role in Health and Disease (Hardcover, 2001 ed.)
J. K. Ransley, Judith K. Donnelly, N.W. Read
R2,467 R2,044 Discovery Miles 20 440 Save R423 (17%) Shipped within 7 - 12 working days

Consumer interest in diet and nutritional supplements is increasing dramatically. Patients and members of the public are seeking advice from health professionals, nutritionists and food scientists. This book is designed to meet the needs of those professionals who are called upon to advise patients and the general public. It provides also a valuable text for those who are researchers or decision makers in the food and pharmaceutical industries. The text presents a thorough account of this topical subject and enables the reader to appreciate the functions of nutrients in health and common disease states, to understand the current debates over the roles of nutrients and supplements in the diet, and to answer those questions frequently asked by patients and consumers.

New Horizons in Predictive Toxicology - Current Status and Application (Hardcover): Alan G. E. Wilson New Horizons in Predictive Toxicology - Current Status and Application (Hardcover)
Alan G. E. Wilson; Series edited by David E Thurston, David P. Rotella; Contributions by Ann Richard, Chihae Yang, …
R4,336 Discovery Miles 43 360 Shipped within 7 - 12 working days

Modelling and simulation technologies have improved dramatically over the past decade and their applications in toxicity prediction and risk assessment are of great importance. Such approaches will become increasingly necessary as industrial chemicals advance and as new pharmaceuticals enter the market. In this comprehensive discussion of predictive toxicology and its applications, leading experts express their views on the technologies currently available and the potential for future developments. The book covers a wide range of topics including the in silico, in vitro and in vivo approaches being used in the safety assessment of chemical substances. It reflects the growing and urgent need to strengthen our ability to predict the risks posed by industrial and pharmaceutical chemicals in humans. Extensive information on the use of current animal models used for various toxicities and target-mediated toxicities is included. Also discussed are the recently introduced regulatory initiatives.

3D Printing of Pharmaceuticals (Hardcover, 1st ed. 2018): Abdul W. Basit, Simon Gaisford 3D Printing of Pharmaceuticals (Hardcover, 1st ed. 2018)
Abdul W. Basit, Simon Gaisford
R3,091 R2,532 Discovery Miles 25 320 Save R559 (18%) Shipped within 7 - 12 working days

3D printing is forecast to revolutionise the pharmaceutical sector, changing the face of medicine development, manufacture and use. Potential applications range from pre-clinical drug development and dosage form design through to the fabrication of functionalised implants and regenerative medicine. Within clinical pharmacy practice, printing technologies may finally lead to the concept of personalised medicines becoming a reality. This volume aims to be the definitive resource for anyone thinking of developing or using 3D printing technologies in the pharmaceutical sector, with a strong focus on the translation of printing technologies to a clinical setting. This text brings together leading experts to provide extensive information on an array of 3D printing techniques, reviewing the current printing technologies in the pharmaceutical manufacturing supply chain, in particular, highlighting the state-of-the-art applications in medicine and discussing modern drug product manufacture from a regulatory perspective. This book is a highly valuable resource for a range of demographics, including academic researchers and the pharmaceutical industry, providing a comprehensive inventory detailing the current and future applications of 3D printing in pharmaceuticals. Abdul W. Basit is Professor of Pharmaceutics at the UCL School of Pharmacy, University College London. Abdul's research sits at the interface between pharmaceutical science and gastroenterology, forging links between basic science and clinical outcomes. He leads a large and multidisciplinary research group, and the goal of his work is to further the understanding of gastrointestinal physiology by fundamental research. So far, this knowledge has been translated into the design of new technologies and improved disease treatments, many of which are currently in late-stage clinical trials. He has published over 350 papers, book chapters and abstracts and delivered more than 250 invited research presentations. Abdul is also a serial entrepreneur and has filed 25 patents and founded 3 pharmaceutical companies (Kuecept, Intract Pharma, FabRx). Abdul is a frequent speaker at international conferences, serves as a consultant to many pharmaceutical companies and is on the advisory boards of scientific journals, healthcare organisations and charitable bodies. He is the European Editor of the International Journal of Pharmaceutics. Abdul was the recipient of the Young Investigator Award in Pharmaceutics and Pharmaceutical Technology from the American Association of Pharmaceutical Scientists (AAPS) and is the only non-North American scientist to receive this award. He was also the recipient of the Academy of Pharmaceutical Sciences (APS) award. Simon Gaisford holds a Chair in Pharmaceutics and is Head of the Department of Pharmaceutics at the UCL School of Pharmacy, University College London. He has published 110 papers, 8 book chapters and 4 authored books. His research is focused on novel technologies for manufacturing medicines, particularly using ink-jet printing and 3D printing, and he is an expert in the physico-chemical characterisation of compounds and formulations with thermal methods and calorimetry.

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