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Books > Professional & Technical > Industrial chemistry & manufacturing technologies > Industrial chemistry > Pharmaceutical technology

Prodrugs and Targeted Delivery - Towards Better ADME Properties (Hardcover): Jarkko Rautio Prodrugs and Targeted Delivery - Towards Better ADME Properties (Hardcover)
Jarkko Rautio; Series edited by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
R3,553 R2,899 Discovery Miles 28 990 Save R654 (18%) Shipped within 7 - 12 working days

This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs.
Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.

Flow Cytometry in Drug Discovery and Development (Hardcover): Virginia Litwin, Philip Marder Flow Cytometry in Drug Discovery and Development (Hardcover)
Virginia Litwin, Philip Marder
R2,609 R1,836 Discovery Miles 18 360 Save R773 (30%) Shipped within 7 - 13 working days

"This book covers the unique application of flow cytometry in drug discovery and development. The first section includes two introductory chapters, one on flow cytometry and one on biomarkers, as well as a chapter on recent advances in flow cytometry. The second section focuses on the unique challenges and added benefits associated with the use of flow cytometry in the drug development process. The third section contains a single chapter presenting an in depth discussion of validation considerations and regulatory compliance issues associated with drug development"--Provided by publisher.

Biofilm Eradication and Prevention - A Pharmaceutical Approach to Medical Device Infections (Hardcover): Tamilvanan... Biofilm Eradication and Prevention - A Pharmaceutical Approach to Medical Device Infections (Hardcover)
Tamilvanan Shunmugaperumal
R3,412 R2,392 Discovery Miles 23 920 Save R1,020 (30%) Shipped within 7 - 13 working days

"Biofilm Eradication and Prevention"s presents the basics of biofilm formation on medical devices, diseases related to this formation, and approaches pharmaceutical researchers need to take to limit this problem. Split into three parts, the first deals with the development and characterization of biofilm on the surfaces of implanted or inserted medical devices. Questions as to why biofilms form over medical device surfaces and what triggers biofilm formation are addressed. In the second section, the author discusses biofilm-mediated chronic infections occurred in various organs (eyes, mouth, wounds) and pharmaceutical and drug delivery knowledge gained from research in these area. The third part explores pharmaceutical approaches like lipid-and polymer-based drug delivery carriers for eradicating biofilm on device-related infections. In addition, this section also explores the topic of novel small molecule (like iron and its complexes/metal chelators) and a quorum-sensing inhibitors to control medical biofilm formation.

Assay Development - Fundamentals and Practices (Hardcover): Ge Wu Assay Development - Fundamentals and Practices (Hardcover)
Ge Wu
R3,162 R2,221 Discovery Miles 22 210 Save R941 (30%) Shipped within 7 - 13 working days

Essential principles and practice of assay development

The first comprehensive, integrated treatment of the subject, Assay Development: Fundamentals and Practices covers the essentials and techniques involved in carrying out an assay project in either a biotechnology/drug discovery setting or a platform setting.

Rather than attempting comprehensive coverage of all assay development technologies, the book introduces the most widely used assay development technologies and illustrates the art of assay development through a few commonly encountered biological targets in assay development (e.g., proteases, kinases, ion channels, and G protein-coupled receptors). Just enough biological background for these biological targets is provided so that the reader can follow the logics of assay development. Chapters discuss:

The basics of assay development, including foundational concepts and applications

Commonly used instrumental methods for both biochemical assays and cell-based assays

Assay strategies for protein binding and enzymatic activity

Cell-based assays

High-throughput screening

An in-depth study of the now popular Caliper's off-chip kinase assay provides an instructive, real-world example of the assay development process.

Biomarkers in Drug Development - A Handbook of Practice, Application, and Strategy (Hardcover): Michael R. Bleavins, Claudio... Biomarkers in Drug Development - A Handbook of Practice, Application, and Strategy (Hardcover)
Michael R. Bleavins, Claudio Carini, Malle Jurima-Romet, Ramin Rahbari
R3,697 R2,594 Discovery Miles 25 940 Save R1,103 (30%) Shipped within 7 - 13 working days

Discover how biomarkers can boost the success rate of drug development efforts

As pharmaceutical companies struggle to improve the success rate and cost-effectiveness of the drug development process, biomarkers have emerged as a valuable tool. This book synthesizes and reviews the latest efforts to identify, develop, and integrate biomarkers as a key strategy in translational medicine and the drug development process. Filled with case studies, the book demonstrates how biomarkers can improve drug development timelines, lower costs, facilitate better compound selection, reduce late-stage attrition, and open the door to personalized medicine.

"Biomarkers in Drug Development" is divided into eight parts:

Part One offers an overview of biomarkers and their role in drug development.

Part Two highlights important technologies to help researchers identify new biomarkers.

Part Three examines the characterization and validation process for both drugs and diagnostics, and provides practical advice on appropriate statistical methods to ensure that biomarkers fulfill their intended purpose.

Parts Four through Six examine the application of biomarkers in discovery, preclinical safety assessment, clinical trials, and translational medicine.

Part Seven focuses on lessons learned and the practical aspects of implementing biomarkers in drug development programs.

Part Eight explores future trends and issues, including data integration, personalized medicine, and ethical concerns.

Each of the thirty-eight chapters was contributed by one or more leading experts, including scientists from biotechnology and pharmaceutical firms, academia, and the U.S. Food and Drug Administration. Their contributions offer pharmaceutical and clinical researchers the most up-to-date understanding of the strategies used for and applications of biomarkers in drug development.

Autophagy in Health and Disease - Potential Therapeutic Approaches (Paperback, Softcover Reprint Of The Original 1st Ed. 2018):... Autophagy in Health and Disease - Potential Therapeutic Approaches (Paperback, Softcover Reprint Of The Original 1st Ed. 2018)
Kursad Turksen
R3,319 Discovery Miles 33 190 Shipped within 7 - 11 working days
Drug Delivery for the Retina and Posterior Segment Disease (Paperback, Softcover Reprint Of The Original 1st Ed. 2018):... Drug Delivery for the Retina and Posterior Segment Disease (Paperback, Softcover Reprint Of The Original 1st Ed. 2018)
Jayvadan K. Patel, Vijaykumar Sutariya, Jagat Rakesh Kanwar
R4,892 Discovery Miles 48 920 Shipped within 7 - 11 working days
Pharmaceutical Data Mining - Approaches and Applications for Drug Discovery (Hardcover): Konstantin V. Balakin Pharmaceutical Data Mining - Approaches and Applications for Drug Discovery (Hardcover)
Konstantin V. Balakin; Series edited by Sean Ekins
R3,013 R2,118 Discovery Miles 21 180 Save R895 (30%) Shipped within 7 - 13 working days

Leading experts illustrate how sophisticated computational data mining techniques can impact contemporary drug discovery and development

In the era of post-genomic drug development, extracting and applying knowledge from chemical, biological, and clinical data is one of the greatest challenges facing the pharmaceutical industry. Pharmaceutical Data Mining brings together contributions from leading academic and industrial scientists, who address both the implementation of new data mining technologies and application issues in the industry. This accessible, comprehensive collection discusses important theoretical and practical aspects of pharmaceutical data mining, focusing on diverse approaches for drug discovery--including chemogenomics, toxicogenomics, and individual drug response prediction. The five main sections of this volume cover: A general overview of the discipline, from its foundations to contemporary industrial applicationsChemoinformatics-based applicationsBioinformatics-based applicationsData mining methods in clinical developmentData mining algorithms, technologies, and software tools, with emphasis on advanced algorithms and software that are currently used in the industry or represent promising approaches

In one concentrated reference, Pharmaceutical Data Mining reveals the role and possibilities of these sophisticated techniques in contemporary drug discovery and development. It is ideal for graduate-level courses covering pharmaceutical science, computational chemistry, and bioinformatics. In addition, it provides insight to pharmaceutical scientists, principal investigators, principal scientists, research directors, and all scientists working in the field of drug discovery and development and associated industries.

The Biochemistry of Drug Metabolism - Principles, Redox Reactions, Hydrolyses, Two Volume Set (Paperback): Bernard Testa,... The Biochemistry of Drug Metabolism - Principles, Redox Reactions, Hydrolyses, Two Volume Set (Paperback)
Bernard Testa, Stefanie D. Kramer
R2,707 R1,928 Discovery Miles 19 280 Save R779 (29%) Shipped within 7 - 13 working days

Offering a conceptual and factual presentation of the metabolism of drugs and other xenobiotics, these two volumes distinctly focus on the biochemistry, with an emphasis on xenobiotic-metabolizing enzymes, their reactions and regulations.
The first volume is divided into three parts. Part One begins by introducing xenobiotics in the broad context of physiological metabolism, and continues with an overview of the processes of drug disposition and metabolism. It then goes on to summarize the macroscopic and microscopic locations of drug metabolism in animals and humans. This is followed by an introduction to the all-important issue of the consequences of drug and xenobiotic metabolism, providing an initial overview of pharmacokinetic, pharmacological and toxicological consequences. The last chapter examines drug metabolism in the context of drug research, with a focus on medicinal chemistry.
The second part is a major component of the book, corresponding to the role of oxidoreductases as major agents of metabolism. Cytochromes P450 receive particular attention, namely their multiplicity, structure, catalytic mechanisms, and the various reactions they catalyze, while other oxidoreductases are also presented, such as flavin monooxygenases, monoamine oxidases and other amine oxidases, aldehyde oxidase and xanthine dehydrogenase, peroxidases, and dehydrogenases-reductases. Each drug-metabolizing enzyme or enzyme family begins with an Enzyme Identity Card summarizing its nomenclature and biochemical essentials.
Part Three begins with a survey of the classification, properties and catalytic mechanism of the innumerable hydrolases known or suspected to play a role in xenobiotic metabolism. The focus then shifts to a systematic presentation of the various substrates classes, namely carboxylic esters, amides and peptides, lactams and lactones, esters of inorganic acids, alkene and arene epoxides, and some miscellaneous hydrolyzable moieties.
Volume Two contains the last four parts of this work. Part 4 is devoted to the huge field of conjugation reactions, with much information being given on transferases. As in the two preceding parts, each drug-metabolizing enzyme or enzyme family begins with an Enzyme Identity Card summarizing its nomenclature and biochemical essentials. The reactions examined here include methylation, sulfation, glucuronidation, acetylation, conjugation with glutathione, while there is also a rigorous presentation of the pivotal role of xenobiotic-coenzyme A conjugates as a crossroads to various metabolic reactions.
The next part examines the consequences of drug and xenobiotic metabolism in a pharmacological and toxicological perspective, with due attention paid to full activation, as is found with prodrugs, and to the worrying case of xenobiotic toxification.
Parts 6 and 7 cover the inter-individual and intra-individual factors that influence drug metabolism, starting with an introduction to evolutionary events leading to species differences in the metabolism of xenobiotics and to polymorphisms within a particular species. Focusing on humans, the most relevant polymorphic drug-metabolizing enzymes are discussed, concentrating on ethnic differences and on the consequences for the pharmacokinetic behavior of affected drugs, while also introducing sex-dependent metabolic reactions.
The final part introduces the mechanisms leading to increases or decreases in enzyme activities as the concept of enzyme induction via nuclear receptors and the different mechanisms of enzyme inhibition are explained. With these basics in mind, various influencing factors are discussed, including physiological and pathological conditions, as well as drugs, nutrients and environmental agents with a special focus on drug-drug interactions.
With a foreword by Prof Leslie Z. Benet, the renowned biopharmaceutical scientist.

Pharmaceutical Extrusion Technology (Hardcover, 2nd New edition): Isaac Ghebre-Sellassie, Charles E. Martin, Feng Zhang, James... Pharmaceutical Extrusion Technology (Hardcover, 2nd New edition)
Isaac Ghebre-Sellassie, Charles E. Martin, Feng Zhang, James DiNunzio
R2,993 R2,767 Discovery Miles 27 670 Save R226 (8%) Shipped within 7 - 12 working days

The first edition of Pharmaceutical Extrusion Technology, published in 2003, was deemed the seminal book on pharmaceutical extrusion. Now it is expanded and improved, just like the usage of extrusion has expanded, improved and evolved into an accepted manufacturing technology to continuously mix active pharmaceutical ingredients with excipients for a myriad of traditional and novel dosage forms. Pharmaceutical Extrusion Technology, Second Edition reflects how this has spawned numerous research activities, in addition to hardware and process advancements. It offers new authors, expanded chapters and contains all the extrusion related technical information necessary for the development, manufacturing, and marketing of pharmaceutical dosage forms.

Nuclear Receptors in Drug Metabolism (Hardcover): Wen Xie Nuclear Receptors in Drug Metabolism (Hardcover)
Wen Xie
R2,513 R1,769 Discovery Miles 17 690 Save R744 (30%) Shipped within 7 - 13 working days

This book gives you an updated and expert overview of nuclear hormone receptors in drug metabolism and drug development and equips you with the interdisciplinary understanding of these receptors and how they can be regulated. Pharmaceutical researchers will find this extremely useful in developing drugs for cancer, heart disease, and diabetes treatment. This comprehensive resource collects scattered materials into one handy, informative volume.

Preclinical Safety Evaluation of Biopharmaceuticals - A Science-Based Approach to Facilitating Clinical Trials (Hardcover): Joy... Preclinical Safety Evaluation of Biopharmaceuticals - A Science-Based Approach to Facilitating Clinical Trials (Hardcover)
Joy A. Cavagnaro
R3,846 R2,698 Discovery Miles 26 980 Save R1,148 (30%) Shipped within 7 - 13 working days

"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies."
--From the Afterword by Anthony D. Dayan
Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, "Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials"

  • Includes an overview of biopharmaceuticals with information on regulation and methods of production
  • Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan
  • Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals
  • Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals
  • Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.
Sweeteners - Pharmacology, Biotechnology, and Applications (Hardcover, 1st ed. 2018): Jean-Michel Merillon, Kishan Gopal Ramawat Sweeteners - Pharmacology, Biotechnology, and Applications (Hardcover, 1st ed. 2018)
Jean-Michel Merillon, Kishan Gopal Ramawat
R5,747 R4,710 Discovery Miles 47 100 Save R1,037 (18%) Shipped within 7 - 12 working days

This handbook compiles comprehensive reference information on sweeteners for academic researchers and professionals. It discusses both natural as well as synthetic products, considering health-related and economical aspects. Renowned authors mostly from academia, but also from the industry, summarize information about the chemistry, biological and pharmacological aspects, as well as bioavailability and applications of sweeteners. The book introduces various substance classes of sweeteners, which are mainly plant-derived, including glycosidic and terpenoid sweeteners, peptidic sweeteners, sweet-tasting proteins and protein-derived sweeteners (e.g. stevioside, sucralose, aspartame, thaumatin, brazzein and many more). Chapters address topics such as the isolation and purification of the compounds, their physical, chemical and biological properties, pharmacological activities, and also critically discuss their applications in view of health and ecotoxicological aspects. A special emphasis is on low or no-calorie sweeteners, for which there is an increasing demand and intensified research activities currently. This reference work hence provides the readers with key information and will serve the needs of graduate students and scholars, researchers and professionals working in the fields of chemistry, botany, biotechnology, or pharmacological or agricultural research, as well as in the food industry or the marketing of sweeteners.

Drug Design Research Perspectives (Hardcover, Illustrated Ed): Stanley P Kaplan Drug Design Research Perspectives (Hardcover, Illustrated Ed)
Stanley P Kaplan
R3,922 R2,963 Discovery Miles 29 630 Save R959 (24%) Shipped within 7 - 12 working days

Drug design is the approach of finding drugs by design, based on their biological targets. Typically a drug target is a key molecule involved in a particular metabolic or signalling pathway that is specific to a disease condition or pathology, or to the infectivity or survival of a microbial pathogen. Some approaches attempt to stop the functioning of the pathway in the diseased state by causing a key molecule to stop functioning. Drugs may be designed that bind to the active region and inhibit this key molecule. However these drugs would also have to be designed in such a way as not to affect any other important molecules that may be similar in appearance to the key molecules. Sequence homologies are often used to identify such risks. Other approaches may be to enhance the normal pathway by promoting specific molecules in the normal pathways that may have been affected in the diseased state. The structure of the drug molecule that can specifically interact with the biomolecules can be modelled using computational tools. These tools can allow a drug molecule to be constructed within the biomolecule using knowledge of its structure and the nature of its active site. Construction of the drug molecule can be made inside out or outside in depending on whether the core or the R-groups are chosen first. However many of these approaches are plagued by the practical problems of chemical synthesis. Newer approaches have also suggested the use of drug molecules that are large and proteinaceous in nature rather than as small molecules. There have also been suggestions to make these using mRNA. Gene silencing may also have therapeutical applications. This book presents leading-edge research from around the world.

Peptidomics - Methods and Applications (Hardcover, New): Mikhail Soloviev, Per Andren, Chris Shaw Peptidomics - Methods and Applications (Hardcover, New)
Mikhail Soloviev, Per Andren, Chris Shaw
R2,799 R1,967 Discovery Miles 19 670 Save R832 (30%) Shipped within 7 - 13 working days

The definitive guide to peptidomics- a hands-on lab reference
The first truly comprehensive book about peptidomics for protein and peptide analysis, this reference provides a detailed description of the hows and whys of peptidomics and how the techniques have evolved. With chapters contributed by leading experts, it covers naturally occurring peptides, peptidomics methods and new developments, and the peptidomics approach to biomarker discovery. Explaining both the principles and the applications, Peptidomics: Methods and Applications:
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Features examples of applications in diverse fields, including pharmaceutical science, toxicity biomarkers, and neuroscience
*
Details the successful peptidomic analyses of biological material ranging from plants to mammals
*
Describes a cross section of analytical techniques, including traditional methodologies, emerging trends, and new techniques for high throughput approaches
An enlightening reference for experienced professionals, this book is sufficiently detailed to serve as a step-by-step guide for beginning researchers and an excellent resource for students taking biotechnology and proteomics courses. It is an invaluable reference for protein chemists and biochemists, professionals and researchers in drug and biopharmaceutical development, analytical and bioanalytical chemists, toxicologists, and others.

Introduction to Biologic and Biosimilar Product Development and Analysis (Paperback, Softcover Reprint Of The Original 1st Ed.... Introduction to Biologic and Biosimilar Product Development and Analysis (Paperback, Softcover Reprint Of The Original 1st Ed. 2018)
Karen M. Nagel
R2,157 Discovery Miles 21 570 Shipped within 7 - 11 working days
Combating the Threat of Pandemic Influenza - Drug Discovery Approaches (Hardcover): Paul F. Torrence Combating the Threat of Pandemic Influenza - Drug Discovery Approaches (Hardcover)
Paul F. Torrence
R3,289 R2,303 Discovery Miles 23 030 Save R986 (30%) Shipped within 7 - 13 working days

Drug discovery for influenza antivirals
Priorities for combating pandemic influenza include rapid detection and identification, the quick administration of available drugs to treat the infection, the development of new antivirals, and the development of vaccines. Since lead-time may be required to produce an effective vaccine, antivirals would serve as a key first line of defense in containing an outbreak. Diverse antivirals, acting through different mechanisms, would help stay the development of resistant viruses. Thus, drug discovery for influenza antivirals is an important public health-related endeavor.
With chapters contributed by leading international specialists, this guide gets readers up to speed on the latest advances and technologies in diverse approaches to drug discovery, covering:
*
Existing antivirals, including broadly effective anti-respiratory virus agents
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The development of high-throughput screening assays
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IFN resistance
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The development of nucleic acid-based antiviral drugs
*
Antiviral RNAi strategies targeting influenza virus
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Other promising antiviral drug discovery strategies
Combating the Threat of Pandemic Influenza: Drug Discovery Approaches consolidates the latest information on diverse approaches into one comprehensive resource. It is an invaluable, hands-on reference for researchers in medicinal chemistry, pharmaceutical chemistry, drug discovery, biochemistry, virology, microbiology, and public health.

Drug Discovery Research - New Frontiers in the Post-Genomic Era (Hardcover): Ziwei Huang Drug Discovery Research - New Frontiers in the Post-Genomic Era (Hardcover)
Ziwei Huang
R3,592 R2,518 Discovery Miles 25 180 Save R1,074 (30%) Shipped within 7 - 13 working days

Post Genomics Drug Discovery and Research explores and discusses some of the most important topics in post-genomics life and biopharmaceutical sciences. It provides an introduction to the field, outlining examples of many techniques currently used, as well as those still under development, which are important for the research of biopharmaceutical discovery in the post-genomics era.* Integrates several developing and cutting-edge technologies and methods like bioinformatics, experimental therapeutics, and molecular recognition* Includes discussion on topics such as: computer-aided ligand design; peptide and protein chemistry and synthesis; synthesis of active natural products; and the use of emerging technologies like proteomics, nanotechnology, or bioengineering.

Tuning Innovation with Biotechnology (Hardcover): Dong Hwa Kim Tuning Innovation with Biotechnology (Hardcover)
Dong Hwa Kim
R2,099 R1,947 Discovery Miles 19 470 Save R152 (7%) Shipped within 7 - 12 working days

This book deals with evolving intelligence systems and their use in immune algorithm (IM), particle swarm optimization (PSO), bacterial foraging (BF), and hybrid intelligent system to improve plants, robots, etc. It discusses the motivation behind research on and background of evolving intelligence systems and illustrates IM-based approach for parameter estimation required for designing an intelligent system. It approaches optimal intelligent tuning using a hybrid genetic algorithm-particle swarm optimization (GA-PSO) and illustrates hybrid GA-PSO for intelligent tuning of vector system.

3D Cell-Based Biosensors in Drug Discovery Programs - Microtissue Engineering for High Throughput Screening (Hardcover):... 3D Cell-Based Biosensors in Drug Discovery Programs - Microtissue Engineering for High Throughput Screening (Hardcover)
William S. Kisaalita
R3,488 Discovery Miles 34 880 Shipped within 7 - 12 working days

Advances in genomics and combinatorial chemistry during the past two decades inspired innovative technologies and changes in the discovery and pre-clinical development paradigm with the goal of accelerating the process of bringing therapeutic drugs to market. Written by William Kisaalita, one of the foremost experts in this field, 3D Cell-Based Biosensors in Drug Discovery Programs: Microtissue Engineering for High Throughput Screening provides the latest information - from theory to practice - on challenges and opportunities for incorporating 3D cell-based biosensors or assays in drug discovery programs. The book supplies a historical perspective and defines the problem 3D cultures can solve. It also discusses how genomics and combinatorial chemistry have changed the way drug are discovered and presents data from the literature to underscore the less-than-desirable pharmaceutical industry performance under the new paradigm. The author uses results from his lab and those of other investigators to show how 3D micro environments create cell culture models that more closely reflect normal in vivo-like cell morphology and function. He makes a case for validated biomarkers for three-dimensionality in vitro and discusses the advantages and disadvantages of promising tools in the search of these biomarkers. The book concludes with case studies of drugs that were abandoned late in the discovery process, which would have been discarded early if tested with 3D cultures. Dr. Kisaalita presents evidence in support of embracing 3D cell-based systems for widespread use in drug discovery programs. He goes to the root of the issue, establishing the 3D cell-based biosensor physiological relevance by comparing 2D and 3D culture from genomic to functional levels. He then assembles the bioengineering principles behind successful 3D cell-based biosensor systems. Kisaalita also addresses the challenges and opportunities for incorporating 3D cell-based biosensors or cultures in current discovery and pre-clinical development programs. This book makes the case for widespread adoption of 3D cell-based systems, rendering their 2D counterparts, in the words of Dr. Kisaalita "quaint, if not archaic" in the near future.

Heterocyclic Chemistry in Drug Discovery (Hardcover): Jie Jack Li Heterocyclic Chemistry in Drug Discovery (Hardcover)
Jie Jack Li
R3,044 R2,149 Discovery Miles 21 490 Save R895 (29%) Shipped within 7 - 13 working days

Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds

Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls.

"Heterocyclic Chemistry in Drug Discovery" is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discoveryStep-by-step descriptions of synthetic methods and practical techniquesExamination of the physical properties for each heterocycle, including NMR data and quantum calculationsDetailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles

"Heterocyclic Chemistry in Drug Discovery" is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.

New Drug Discovery and Development (Hardcover): Daniel Lednicer New Drug Discovery and Development (Hardcover)
Daniel Lednicer
R2,748 R1,927 Discovery Miles 19 270 Save R821 (30%) Shipped within 7 - 13 working days

A case history approach to drug synthesis and discovery

Discover the origins of some of today's most popular drug therapies. Explore case histories and gain insight into major classes of antibiotics, antiviral drugs, analgesics, steroids, compounds designed to lower cholesterol, and more. Review the steps required for FDA approval. This is a great reference for students in medicinal chemistry, researchers in pharmaceuticals, and medical practitioners.

Fusion Protein Technologies for Biopharmaceuticals - Applications and Challenges (Hardcover, New): Stefan R. Schmidt Fusion Protein Technologies for Biopharmaceuticals - Applications and Challenges (Hardcover, New)
Stefan R. Schmidt
R3,934 R2,769 Discovery Miles 27 690 Save R1,165 (30%) Shipped within 7 - 13 working days

The state of the art in biopharmaceutical FUSION PROTEIN DESIGN

Fusion proteins belong to the most lucrative biotech drugs--with Enbrel(R) being one of the best-selling biologics worldwide. Enbrel(R) represents a milestone of modern therapies just as Humulin(R), the first therapeutic recombinant protein for human use, approved by the FDA in 1982 and Orthoclone(R) the first monoclonal antibody reaching the market in 1986. These first generation molecules were soon followed by a plethora of recombinant copies of natural human proteins, and in 1998, the first de novo designed fusion protein was launched.

"Fusion Protein Technologies for Biopharmaceuticals" examines the state of the art in developing fusion proteins for biopharmaceuticals, shedding light on the immense potential inherent in fusion protein design and functionality. A wide pantheon of international scientists and researchers deliver a comprehensive and complete overview of therapeutic fusion proteins, combining the success stories of marketed drugs with the dynamic preclinical and clinical research into novel drugs designed for as yet unmet medical needs.

The book covers the major types of fusion proteins--receptor-traps, immunotoxins, Fc-fusions and peptibodies--while also detailing the approaches for developing, delivering, and improving the stability of fusion proteins. The main body of the book contains three large sections that address issues key to this specialty: strategies for extending the plasma half life, the design of toxic proteins, and utilizing fusion proteins for ultra specific targeting. The book concludes with novel concepts in this field, including examples of highly relevant multifunctional antibodies.

Detailing the innovative science, commercial realities, and brilliant potential of fusion protein therapeutics, "Fusion Protein Technologies for Biopharmaceuticals" is a must for pharmaceutical scientists, biochemists, medicinal chemists, molecular biologists, pharmacologists, and genetic engineers interested in determining the shape of innovation in the world of biopharmaceuticals.

The Life-Cycle of Pharmaceuticals in the Environment (Hardcover): Rhiannon Braund, B.M. Peake, Alfred Tong, Louis Tremblay The Life-Cycle of Pharmaceuticals in the Environment (Hardcover)
Rhiannon Braund, B.M. Peake, Alfred Tong, Louis Tremblay
R2,994 Discovery Miles 29 940 Shipped within 7 - 11 working days

The Life-Cycle of Pharmaceuticals in the Environment identifies pathways of entry of pharmaceuticals into the environment, beginning with the role of global prescribing and disposal practices. The book then discusses typical levels of common pharmaceuticals and how they can be determined in natural waters such as raw and treated sewage, and in potable water. In addition, sections examine methods currently available to degrade pharmaceuticals in natural waters and some of their ecotoxicological impacts, along with future considerations and the growing concept of product stewardship.

Mass Spectrometry for Drug Discovery and Drug Development (Hardcover, New): Walter A. Korfmacher Mass Spectrometry for Drug Discovery and Drug Development (Hardcover, New)
Walter A. Korfmacher
R2,501 R1,767 Discovery Miles 17 670 Save R734 (29%) Shipped within 7 - 13 working days

Facilitates the discovery and development of new, effective therapeutics

With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading pharmaceutical and analytical scientists. Their contributions are based on a thorough review of the current literature as well as their own experience developing new mass spectrometry techniques to improve the ability to discover and develop new and effective therapeutics.

"Mass Spectrometry for Drug Discovery and Drug Development" begins with an overview of the types of mass spectrometers that facilitate drug discovery and development. Next it covers: HPLC-high-resolution mass spectrometry for quantitative assaysMass spectrometry for siRNAQuantitative analysis of peptidesMass spectrometry analysis of biological drugsApplications that support medicinal chemistry investigationsMass spectrometry imaging and profiling

Throughout the book, detailed examples underscore the growing role of mass spectrometry throughout the drug discovery and development process. In addition, images of mass spectra are provided to explain how results are interpreted. Extensive references at the end of each chapter guide readers to the primary literature in the field.

"Mass Spectrometry for Drug Discovery and Drug Development" is recommended for readers in pharmaceutics, including medicinal chemists, analytical chemists, and drug metabolism scientists. All readers will discover how mass spectrometry can streamline and advance new drug discovery and development efforts.

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