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This timely new book, written by a transplant administrator with over sixteen years of experience, along with other expert contributors, covers the specifics of each aspect of transplant administration, providing information that will enable new administrators to quickly master essentials, help more seasoned administrators evaluate and improve their programs, and generally provide a knowledge base, focused on best-practices in light of regulatory requirements, for transplant surgeons, aspirant administrators and hospital administrators. * Comprehensively covers all aspects of transplant program administration, including management, finance, staffing, quality improvement, patient intake, communication and collaboration with clinical staff, and more. * Emphasizes practical application of best practices; uses bullet lists and other features to highlight essential information for each topic covered. * Accompanying "Toolkit", available via the book's companion website, provides forms, a procedural manual, program assessment materials and more which buyers can use "out of the box" or adapt for use in their own program. While the book and its supplemental materials have been created specifically with the US transplant community in mind, they still have considerable value for transplant administrators and related professionals outside the US, for instance, transplantation and health policy researchers, hospital management staff who are tasked with starting a transplant program from scratch and who need ready-made materials they can adapt to suit their own regulatory environment, and others.
By presenting the latest technological advances and growing national and international regulation, this new book explores state-of-the-art developments in the challenging field of tissue and cell processing. It provides a guide to easier and safer practice in operational principles of preservation, decontamination, and sterilization. Nearly half of the book is devoted completely to tissue- or cell-specific issues relating to processing. With lists of learning points and case studies which consist of sample processing protocols, descriptions of where processing went wrong, sample risk assessments, or validation studies, the authors help you find specific information fast.
This book builds on the success of previous editions, once again providing hepatologists the most current clinical guide on how to best treat the liver transplant recipient. With an international mix of experienced contributors, this new edition highlights initial indication and selection of the potential recipient, management of the donor organ, post-operative complications in the patient through to acute recovery, long-term follow-up, and continued health. This provides the user a complete guide to the correct clinical management of both the recipient and the donor organ through all stages of transplantation.
More than any other altruistic gesture, blood and organ donation
exemplifies the true spirit of self-sacrifice. Donors literally
give of themselves for no reward so that the life of an
individual--often anonymous--may be spared. But as the demand for
blood and organs has grown, the value of a system that depends
solely on gifts has been called into question, and the possibility
has surfaced that donors might be supplemented or replaced by paid
This new volume reviews current progress on different approaches of in vivo reprogramming technology. Leaders in the field discuss how in vivo cell lineage reprogramming can be used for tissue repair and regeneration in different organs, including brain, spinal cord, pancreas, liver and heart. Recent studies on in vivo cell reprogramming towards pluripotency are reviewed; examples are given to show its potential in regenerative medicine. In each chapter, the regenerative potential of different in vivo reprogramming approaches is discussed in detail. More specifically, how different tissue failures or damages can be treated with this technology is explained. Examples from various animal models are given and the regenerative potential of in vivo reprogramming is compared to that of cell transplantation studies. The last chapter discusses current challenges of these preclinical studies and gives suggestions in order to improve the current strategies. Future directions are indicated for the transition of in vivo reprogramming technology to clinical settings. This is among the first books in the literature which specifically focuses on the in vivo reprogramming technology in regenerative medicine and these chapters collectively cover one of the most important and exciting topics of regenerative medicine.
The first textbook of its kind dealing with composite tissue allograft and allograft transplantation, provides an excellent overview on the subject. It provides a clear description of the current status of the transplant of every composite tissue allograft already performed and others which are still at the basic experimental level.The editors of the book, who also contribute chapters in their expertise, are world renowned surgeons. This book opens with an introductory chapter on the history of this type of transplantation and then details the clinical experience in each graft such as hand, larynx, face, uterus and the related histopathology, immunosuppression and immunomodulation.A multidisciplinary and comprehensive presentation of the various aspects of this new area of transplantation will allow the reader to understand the complexity and the challenges of composite tissue transplantation. A number of important topics are analyzed and discussed in detail, such as the ethical, medicolegal, psychological and immunological implications. New rehabilitation techniques and strategies, together with innovative tools for the functional evaluation of the transplanted parts, are highlighted. A section on the experimental work underlines what lies ahead of us.
Given the tensions and demands of medicine, highly successful physicians and surgeons rarely achieve equal success as prose writers. It is truly extraordinary that a major, international pioneer in the controversial field of transplant surgery should have written a spellbinding, and heart-wrenching, autobiography. Thomas Starzl grew up in LeMars, Iowa, the son of a newspaper publisher and a nurse. His father also wrote science fiction and was acquainted with the writer Ray Bradbury. Starzl left the family business to enter Northwestern University Medical School where he earned both and M.D. and a PhD. While he was a student, and later during his surgical internship at the Johns Hopkins Hospital, he began the series of animal experiments that led eventually to the world's first transplantation of the human liver in 1963. Throughout his career, first at the University of Colorado and then at the University of Pittsburgh, he has aroused both worldwide admiration and controversy. His technical innovations and medical genius have revolutionized the field, but Starzl has not hesitated to address the moral and ethical issues raised by transplantation. In this book he clearly states his position on many hotly debated issues including brain death, randomized trials for experimental drugs, the costs of transplant operations, and the system for selecting organ recipients from among scores of desperately ill patients. There are many heroes in the story of transplantation, and many "puzzle people," the patients who, as one journalist suggested, might one day be made entirely of various transplanted parts. They are old and young, obscure and world famous. Some have been taken into the hearts of America, like Stormie Jones, the brave and beautiful child from Texas. Every patient who receives someone else's organ - and Starzl remembers each one - is a puzzle. "It was not just the acquisition of a new part," he writes. "The rest of the body had to change in many ways before the gift could be accepted. It was necessary for the mind to see the world in a different way." The surgeons and physicians who pioneered transplantation were also changed: they too became puzzle people. "Some were corroded or destroyed by the experience, some were sublimated, and none remained the same."
Although the history of organ transplant has its roots in ancient Christian mythology, it is only in the past fifty years that body parts from a dead person have successfully been procured and transplanted into a living person. After fourteen years, the three main issues that Robert Veatch first outlined in his seminal study Transplantation Ethics still remain: deciding when human beings are dead; deciding when it is ethical to procure organs; and deciding how to allocate organs, once procured. However, much has changed. Enormous strides have been made in immunosuppression. Alternatives to the donation model are debated much more openly - living donors are used more widely and hand and face transplants have become more common, raising issues of personal identity. In this second edition of Transplantation Ethics, coauthored by Lainie F Ross, transplant professionals and advocates will find a comprehensive update of this critical work on transplantation policies.
This atlas describes and illustrates the pathology of solid organ transplants and includes chapters covering transplant pathology of the kidney, lung, heart, liver, pancreas, small bowel and limbs. Each of these chapters briefly reviews the latest rejection classifications for each organ system with explanatory notes highlighting diagnostic criteria, and tables listing entities in the differential diagnosis. Included with each chapter are images demonstrating the pathology of the most common and important diseases, especially patterns of organ rejection and related entities or mimickers. Examples of classic disease processes are provided, as well as atypical presentations that may highlight and prevent diagnostic pitfalls. A comprehensive explanation of the immunogenetics of transplant rejection is included, enabling the general pathologist to become familiar with the most important aspects of serologic testing in this patient population. A review of post-transplant lymphoproliferative diseases is also provided. Practical Atlas of Transplant Pathology is aimed at both general and expert pathologists who encounter transplant pathology specimens in their practice.
This book provides clinicians with the most recent developments in anaesthesia for transplant surgery. Beginning with the history and ethics of the procedure, the following chapters discuss anaesthetic techniques for transplant surgery of different organs in the body. The importance of history taking, thorough clinical examination, invention of the artificial respirator and controversies surrounding brain death, are discussed in depth. This useful manual includes more than 110 clinical photographs and illustrations to enhance learning. Key points Provides clinicians with recent developments in anaesthesia for transplant surgery Covers techniques for transplant surgery of different organs in body Emphasis on importance of history taking and thorough clinical examination Includes more than 110 clinical photographs and illustrations
From humble beginnings as a `barefoot boy' in a small town in the heart of South Africa, he learned to mix with presidents and prime ministers, with royalty and popes, and quickly embraced the high-life of the jet-set who surrounded him. Throughout life, he was a serial womanizer, bedding famous European film stars (and their secretaries). He survived three tempestuous marriages and divorces, each wife becoming younger than the last until their age difference reached 40 years. This scientifically-trained surgeon called on the services of a `witchdoctor' (a sangoma)-unsuccessfully-to help punish those who had contributed to the break-up of his second marriage. With no experience himself, he trained his daughter to become the second-ranked water skier in the world, though he was disappointed she never became world champion. Perhaps the immense effort he put into driving her to success accounted for the relative neglect of his oldest son, who, as a young doctor, suffered increasing depression until he died of a drug overdose at an early age. The surgeon pursued his goals in heart surgery despite a lifetime of pain from arthritis and a disability from asthma, which might eventually have killed him. Having established the first major heart surgery programme in Africa, he eventually became distracted by other interests until he was a mere shadow in his own department. Yet he remained in the public eye through his gifts for public speaking and as a writer. He travelled the world, published two autobiographies, wrote popular books on health for the public, particularly relating to heart disease and arthritis, and penned books on such varied subjects as the politics of apartheid in his homeland, and euthanasia. He became a well-regarded and popular columnist for several South African newspapers, and collaborated on the writing of four novels. He branched into the business world and expanded the meagre financial rewards earned from his surgical services to the South African health care system by investing in restaurants in Cape Town, establishing a game reserve in the hinterland of South Africa, and causing controversy by his role in advertising a cream that reputedly prevented wrinkling of the skin. He set up a heart research foundation and a foundation that paid for children from all over the world to travel to Cape Town for corrective open heart surgery. This charismatic and controversial man was Chris Barnard who, by the way, also dared to carry out the world's first human heart transplant in December 1967. Can we summarize Chris Barnard? Not very easily. He was a first-class doctor-skilled, knowledgeable, compassionate, conscientious, concerned, decisive, and wise. He was an inquiring and innovative surgeon-though famously irascible in the operating room-with a vision of the future developments in his chosen field, and the ability, judgment, and courage to play a part in contributing to those developments. He was an informative and highly entertaining speaker and raconteur, a gifted writer, farmer, restaurateur, an unofficial ambassador for his country-and a good friend.
The book includes recommendations for COPD from published guidelines (eg, the GOLD, ATS, and NICE guidelines) and presents them in the context of relevant clinical treatment issues. This is an in-depth guide on the management of COPD, concentrating on the impact of COPD on a patient as well as how healthcare professionals can intervene and educate the patient at an early stage and thereby slow the onset of severe symptoms.
Hepatitis C Virus and Liver Transplantation is designed to provide a comprehensive and state-of-the-art overview of the major issues specific to the field of liver transplantation and hepatitis C virus infection. The sections of the book have been structured to review the overall scope of issues of recurrent hepatitis C in different complex settings, including retransplantation, HIV-coinfected patients or in the setting of suboptimal graft donors. This book provides up-to-date information on the application of new therapies to the field of liver transplantation. It provides the most recent data on their efficacy, the management of side effects, as well as the potential interactions and specific problems associated with their use in the transplant setting. Finally, an appraisal of the risks and benefits of using organs from anti-HCV positive donors is presented. This book provides concise and actual materials for several important topics that are simply not adequately covered by current available literature. Hepatitis C Virus and Liver Transplantation will provide a unique and valuable resource in the field of liver transplantation and will be of great value to Hepatologists, Transplant and Abdominal Surgeons, Oncologists, as well as Fellows and Residents training in these fields.
The research field of biobanks and tissue research is highly promising. Many projects around the globe are involved in the collection of human tissue and health data for research purposes. These initiatives are driven by the perspective of decisive breakthroughs in the knowledge of the genetic pathways involved in widespread diseases. However, there are considerable ethical and legal challenges to be considered as well. These challenges encompass the use of body material for research purposes, the misuse of genetic and other health data by third parties, trust in science and medicine, concerns regarding privacy, use of genetic data for forensic applications by the state and the police, and regulatory issues. This volume is divided into three parts: the inclusion of the public, the rights of donors and patients, examples and recommendations for the future of tissue research. It presents a comprehensive overview of the most important topics in the field by renowned scholars in medical ethics and biolaw.
Neural Stem Cells: Development and Transplantation provides comprehensive, critical and insightful reviews by leading experts in this exciting field of research. This volume will provide the latest data on neural stem cell properties and their therapeutic applications. This volume will be particularly useful for students, basic scientists, and clinicians in the academic or industrial sectors who have an interest in understanding neural development and its application to repairing the nervous system.
After decades of research in clinical transplantation, new techniques have been developed that permit a further understanding of the immune mechanisms underlying immune recognition of allografts and a more accurate and thorough evaluation of compatibility between donors and recipients. The second edition of Transplantation Immunology: Methods and Protocols expands upon the previous edition with current, detailed methods in transplantation immunology. The new methods chapters cover four major areas that are being applied in compatibility evaluations and ongoing transplantation immunology research. Seven overview chapters provide reviews of the molecular basis for alloreactivity, current understanding of humoral and cellular mechanisms, as well as new developments in thoracic organ transplantation, composite tissue transplantation and in the transplantation of sensitized patients. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Transplantation Immunology: Methods and Protocol, Second Edition is devoted to transplantation immunology, both in the practice of compatibility testing and in transplantation research.
Organ transplantation is a much-discussed subject, and the importance of living organ donation is increasing significantly. Yet despite all efforts, too few donor organs are available to help all patients in need. This book analyses whether the national legal regulations are also partly responsible for the organ shortage in the Member States of the European Union. In addition to a detailed analysis of the various national regulations, the main arguments in favour of and against legal restrictions on living organ donation are considered. Furthermore, the European Union's authority is investigated, namely, whether it is entitled to establish statutory provisions for the Member States with respect to a harmonized regulation of living organ donation. Based on the results of the analysis, the author establishes a Best Practice Proposal for living organ donation.
Facing certain death in 1991 from chronic liver disease brought on by Hepatitus B, Kevin Hopf instead began a journey to healing. After a liver transplant and tangling with Western medical establishment, Hopf discovered non-traditional healing techniques, and in Noncompliant List, he offers alternatives that will encourage and enlighten fellow travelers.
Laryngotracheal Reconstruction: From Lab to Clinic lines for using the technique of tracheal autotra- presents the experimental and clinical aspects of plantation in conservation laryngectomy. The tissue reconstruction of the larynx and trachea. shortcomings and complications of tracheal auto- The book reflects the development and implemen- transplantation encountered in the initial patient tation of a research-based clinical program. The series led to a modification of the technique. The experimental work was started in 1989 with the modified autotransplantation technique proved to aim of improving the reconstructive possibilities be reliable from a reconstructive, functional and in the following two clinical situations: (1) extend- oncological viewpoint. ed hemilaryngectomy defects after tumour In a second part (Chap. VI), healing aspects after removal and (2) tracheal stenoses that are impos- repair of laryngotracheal defects are highlighted. sible to repair by segmental tracheal resection. The The healing mechanisms of the cartilage support, two problems differ in localization (larynx, tra- the mucosal lining and the blood supply were chea), etiology (oncology, traumatic), and treat- studied for each tissue component individually.
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