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This book-DVD presents a picture and video atlas of organ transplantation that provides a unique and complete presentation of procedures performed by transplant surgeons today. The emphasis is on contemporary procedures, as the field has undergone significant surgical innovation in the last five to ten years. Detailed schematic diagrams and high-quality photographs of the operative procedures provide enhanced visual clarity. Written descriptions, accompanied by a video presentation with detailed narration, present realistic and complete exposure of the operative procedure. A comprehensive compilation of the majority of surgical procedures in transplant surgery, this book details the latest and most innovative procedures in one reference work. Atlas of Organ Transplantation is essential reading for all transplant surgeons, residents and fellows, as well as operating room nurses and transplant nurse coordinators.
Meniscal transplantation has become an attractive option in selected patients with incapacitating knee pain. This book discusses all aspects of meniscal transplantation, covering the use of both allografts and meniscal substitutes, including collagen and polyurethane implants. Acknowledged experts in the field review the basic science, explain indications, and describe surgical techniques and the results achieved to date. All the material is up to date, with information on new implants, new techniques, and new surgical approaches. Future trends in the treatment of meniscal lesions are also discussed as we move towards the application of regenerative strategies to restore meniscus function. "
Clinical lung transplantation has seen an early start within the history of solid organ trans- plantation, marked by the 1963 first lung transplant by James D. Hardy. This was prompted by the seemingly easy way of joining the transplanted organ to the recipient by me ans of a few well-defined anastomoses, i.e. bronchus, pulmonary artery and pulmonary vein carry- ing left atrial cuff. The following decade thus witnessed a number of such mostly unilateral lung transplants in several centres, in Germany represented by the two only lung transplants performed by E. S. Bucherl, then at the Neukoelln City Hospital in Berlin in 1969. As with most other such attempts these two patients suffered early and lethai graft failure. There was only one single lung transplant patient who lived up to ten months after the transplant at Gent, Belgium, having been operated on by Derom in 1969. The alm ost universal failure during this initial phase was attributed to bronchial anasto- motic insufficiency, pulmonary infection of either the transplanted lung or the left-in-place contralateral lung and a far-reaching lack of knowledge how to cope with transplant rejec- tion. In the early 1970s it had become gene rally accepted that lung transplantation could not be performed successfully.
Dr. Kreissig has spent a lifetime refining and teaching the minimalized approach to repairing retinal detachments. In this book, you will get the benefit of her experience -- in an easily accessible, pocket-sized handbook that fits into your lab coat and is also ideal for bedside or office consultation. The book is the first hands-on guide to the art of buckling, i.e., applying a minimum of buckling without vitrectomy for retinal reattachment. The text is excellently illustrated and written in a dialogue style. From completing the preoperative exam to making the diagnosis and choosing the surgical technique, this book provides the facts and guidelines to successfully perform minimal extraocular surgery. It includes instructions on finding the retinal break in phakic, aphakic and pseudophakic detachments the four rules to find the primary break are presented on the back cover for immediate access.Ophthalmologists, fellows in retinal and vitreous surgery, students and residents will find this information-packed manual essential for diagnosing and repairing retinal detachments. Reserve your copy today
Fresh insights into the pathogenic mechanisms by which hyperglycemia induces tissue and organ injurt are the basis for rapidly evolving promising therapies in diabetes. Especially promising as targets for intervention are products of oxidative stress, including kinins and growth factors. Improving results of renal replacement regimes now incorporating pancreatic islet transplants are able to delay and prevent end-organ damage in diabetic individuals. The evolving story of the taming of diabetes is of direct concern to nephrologists, endocrinologists, ophthalmologists, primary care physicians and medical students.
Advances in heart surgical treatment have been impressive in the last 15 years. In end-stage heart disease, procedures are now performed routinely which were only experimental one or two decades ago. Heart transplantation has become a well-established procedure. According to the Gen- eral Registry of the International Society of Heart and Lung Transplantation. 40,738 heart transplantations had been performed through the end of 1997 with survival rates of 78 % at one year, 65 % at five years, and 42 % at ten years. The progress in this field has been due to intense efforts in understanding and modulating immune responses to the trans- planted heart, to elaborate therapeutic strategies to constrain infections, and to improved out-patient care. Accordingly, heart transplantation is integrated into the facilities of the health care systems, the routine of physicians, and the awareness of patients. The resulting increase in potential organ recipients has not been met, however, by an equivalent increase of available donor organs. This increasing discrepancy has forced the technical improvement and clinical evalua- tion of mechanical circulatory support systems as an option for treatment of critically ill patients with a failing heart. Initially, these assist devices were only used to maintain sufficient circulation in post-cardiotomy heart failure until myocardial function had recov- ered. Since the late 1980s, their primary use has been that of bridging patients with heart failure until a suitable organ is available so that heart transplantation can be performed.
This volume is the work product of an international group of authors who are experienced in the field of musculoskeletal allografts. The chapters are written by experts in many differing areas of allografting and represents the current knowledge in this rapidly changing dynamic field. The reconstructive community and their patients owe a significant debt of gratitude to Doctors Czitrom and Winkler for this volume. William F. Enneking, M. D. Preface What follows is the result of a timely project bringing together the newest ideas of top experts worldwide in a rapidly growing technology: Orthopaedic Allograft Surgery. The title of the book reflects a method rather than a speciality. It transgresses well established subspecialities of orthopaedic surgery such as joint replacement, oncology, spine, trauma and sports medicine. The technology encompasses knowledge of tissue banking, biology and biomechanics, both in a research and clinical sense. The common denominator for those interested is the need and ability to provide or use allogeneic tissues in orthopaedic applications. Inherent to a multiauthored text based on chapters written by authors from many parts of the world is a variety in format and style. While we tried to some extent reducing large discrepancies, there was no attempt made to eliminate dissimilar ities. We did not aim for a homogeneous textbook. Rather, we asked for originality, novelty, individuality in the presentation of data and concepts. Consequently, chapters vary in format from that seen in a scientific article to that of a descriptive essay."
This book examines the position of children who provide tissue to potentially save the life of another. It questions whether child donors of all ages have been treated appropriately and whether they are sufficiently protected in acting as tissue donors, and ultimately considers whether a new regulatory response is needed to benefit donor children. The book couples a legal exposition of the donor child's position with the medico-ethical reality of clinical practice. In recent years, a growing body of literature concerning the clinical experiences and outcomes for child donors has emerged. This book adds to this by examining another dimension - the regulatory frameworks at play. It examines the ethical arguments for and against children acting as tissue donors and provides an original analysis of the legal and non-legal regulatory frameworks governing children's participation in the United Kingdom, United States and Australia. It combines these doctrinal and theoretical approaches with insights into clinical practice gained from the results of qualitative research conducted with health professionals. The analysis inevitably explores the more general issues of children's right to make medical decisions, the role of parents in decision-making, the value of the best interests test and alternative (legal and ethical) standards, rights of participation of children before the courts, and the role of law and other forms of regulation in a clinical context.
In the dramatic and rapidly developing field of neural transplantation for CNS repair, the most powerful contributor has been the vital research focusing on stem cells. In Neural Cell Transplantation: Methods and Protocols, leading experts in the field examine tried-and-true laboratory techniques in order to supply scientists with a firm foundation upon which further advancements can be based. Written in the highly successful Methods in Molecular Biology(TM) series format, the chapters of this volume include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and Notes sections, which examine tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and easy to use, Neural Cell Transplantation: Methods and Protocols provides the most thorough and essential protocols that will allow new generations of neuroscientists to enter and contribute to this uniquely inspiring field.
Until a few years ago, eye banks were only considered as centres for collecting and processing units of human donor eyes. However, eye banks in recent years have changed the process of current corneal transplantation. Although the very first corneal transplantation was conceptualised in the late 18th century, it has taken a century to develop methods and understand the role of human corneas in general. This book gives an insight of worldwide associations and their standard regulations in terms of corneal donations, processes and transplantations. The associations mainly include: Eye Bank Association of America, European Eye Bank Association and Eye Bank Association of Australia and New Zealand. This book also refers to some of the early stages of eye banking and current methods of preservation, including cold and organ culture storage. The current eye banking scenario is changing dramatically in terms of tissue processing. Once, tissues were only collected, stored and shipped for transplantation to the surgeons. Now eye banks have advanced in developing techniques in collaboration with surgeons to introduce more reliable methods of transplantation. This includes standardisation of methods such as DSAEK, UT-DSAEK, pre-loaded grafts and DMEK. Furthermore, this compilation describes different techniques of lamellar keratoplasty, such as anterior and posterior lamellar keratoplasties. Retrieving, storing, processing and transplantation of such lenticules are also discussed in this book. Posterior lamellar graft preparation for selective surgeries like DSAEK and Ultra-Thin DSAEK has been included with relevant clinical approaches. DMEK, which is currently taking corneal transplantation to a different level, has been reported with various graft preparation techniques. The role of eye banks in general for such preparation method is also examined. Additionally, the importance of microbiology in day to day care in the field of corneal transplantation and eye banks exists as a topic within these pages. Eye banks are playing a major role and changing the face of corneal transplantation in terms of new research; whether it be graft preparation for surgeries, preservation, surgical tools, ready-to-use tissues or studying cornea in details using available research tissues, these methods are advancing the field. Eye banks play a major role in tissue selection and correct processing methods. Surgeons are provided with a validated tissue so it makes easier for them to follow the transplantation. Therefore, this book highlights the new concepts in the eye banking field with regards to the standards, regulations, retrieval, preservation and transplantation methods. All of these continue to help aid in the research and development of surgical processes and devices.
This volume is a compendium of cutting-edge molecular methods for the successful transplantation of hematopoietic stem cells. The availability of genetic profiles for committed and uncommitted stem cells combined with the determination of molecular steps involved in hematopoietic stem cell activation and self-renewal hold tremendous promise for future success in the clinic. Currently, stem cells can be quantified and sorted successfully, but transduction, labeling, and in vivo tracking of stem cells are difficult techniques with traditionally low efficiency levels. The contributors to this volume describe promising tools for stem cell transplant research models, such as in vivo bioluminescence imaging.
This book is a complete guide to hair transplant surgery for clinicians and trainees. Beginning with an introduction to the history of hair transplantation, anatomy and growth of hair, the following chapters guide clinicians step by step through the procedure, from initial consultation, treatment options and design for the transplant, to anaesthesia, donor and recipient area, and complications. High quality intraoperative photographs present surgical techniques and two interactive DVD-ROMs demonstrate hair transplant procedures. Key points Complete guide to hair transplant surgery for clinicians and trainees Presents step by step process from start to finish Features intraoperative photographs Includes two DVD-ROMs demonstrating procedures
Brought to you by the world s leading transplant clinicians, Textbook of Organ Transplantation provides a complete and comprehensive overview of modern transplantation in all its complexity, from basic science to gold-standard surgical techniques to post-operative care, and from likely outcomes to considerations for transplant program administration, bioethics and health policy. Beautifully produced in full color throughout, and with over 600 high-quality illustrations, it successfully: * Provides a solid overview of what transplant clinicians/surgeons do, and with topics presented in an order that a clinician will encounter them. * Presents a holistic look at transplantation, foregrounding the interrelationships between transplant team members and non-surgical clinicians in the subspecialties relevant to pre- and post-operative patient care, such as gastroenterology, nephrology, and cardiology. * Offers a focused look at pediatric transplantation, and identifies the ways in which it significantly differs from transplantation in adults. * Includes coverage of essential non-clinical topics such as transplant program management and administration; research design and data collection; transplant policy and bioethical issues. Textbook of Organ Transplantation is the market-leading and definitive transplantation reference work, and essential reading for all transplant surgeons, transplant clinicians, program administrators, basic and clinical investigators and any other members of the transplantation team responsible for the clinical management or scientific study of transplant patients.
With the increased prevalence of kidney transplantation, transplant recipients are being treated in a variety of clinical settings - often beyond the transplant center. There is a greater need for clinicians and allied healthcare professionals to have appropriate guidance on managing these patients. Kidney Transplantation offers the latest evidence-based information on the full range of dilemmas in the medical management of kidney transplant recipients before, during and after transplantation. Beginning with the selection of patients who are candidates for transplantation, this authoritative guide covers the care of the patient on the waiting list and evaluation of donors, preoperative care, induction and immunosuppression maintenance. This wealth of new information and guidelines will serve as an important resource for the best possible care for transplant patients.
This book provides a comprehensive guide to successful kidney transplantation in the highly regulated environment of today. It covers the history of kidney transplant to highlight innovations that have made kidney transplantation so successful as well as the new deceased donor kidney allocation strategy and postulates what types of changes might occur with this new policy. The book highlights special areas of nephrology concern in kidney transplantation, especially diseases likely to recur following transplant. It deals with many of the medications used in kidney transplantation including different commonly used antirejection protocols. It also provides a complete reference on the various operations involved in kidney transplantation. The text includes detailed pictures and surgical technique sections on cadaveric kidney transplantation and living kidney transplantation. It includes information on living kidney donation surgery with a chapter dedicated to the minimally invasive techniques that have been popularized in the last fifteen years. Some coverage on open living kidney donation is presented. Included in this section is discussions of how to handle certain operative challenges like severe atherosclerosis, venous sclerosis and various urinary system aberrancies. Comprehensive coverage of common surgical complications is presented including management of urinary strictures, urinary leaks, lymphoceles, vascular probl ems following transplant, and what steps should be taken when an early kidney transplant biopsy is necessary. It also covers in detail what is required for maintenance of health after kidney transplantation including the major risks for graft loss as well as what disease processes kidney transplant patients are particularly vulnerable to.
Organ transplantation is one of the best therapeutic options for patients with end-stage organ failure. Experimental organ transplantation is an important link between basic science and clinical practice. Both editors, Dr Chen and Dr Qian, have been working in this area for over 20 years. Experts from the United States, Canada, China, Japan, Italy, Span, Turkey, Switzerland, Hungary, and Brazil contributed 25 chapters in this book, and provided detailed descriptions of techniques for vascularised organ allografts in mice, rats, pigs, and non-human primates, as well as detailed descriptions of non-vascularised pancreatic islet and spleen allografts. Furthermore, they discussed new advances in transplantation immunology. This book provides numerous important references which were carefully selected by the authors to extend their visions and knowledge. The appropriate readers of this book include medical students, graduate students, residents, surgeons, physicians and immunologists interested in the transplantation area.
Techniques in Revision Hip and Knee Arthroplasty is the one authoritative volume that gives you an efficient, problem-based approach to revision arthroplasty of both the hip and knee. Dr. Giles Scuderi and other leading experts from North America and Western Europe present their favored surgical procedures and post-surgical management strategies in this straightforward, heavily illustrated, video-intensive reference. It's your one-stop, go-to guide for successful revision surgery for a myriad of complications, such as implant loosening, polyethylene wear, osteolysis, or infection of the hip and knee. Get expert guidance on implant choice, management of complications (including infection and wound healing), and failure of mechanisms, as well as step-by-step surgical techniques. Quickly find the exact information you need with a straightforward "just what you need to know" approach, including surgical tips and pearls. Stay up to date with new insights regarding anatomic landmarks, recommended reconstruction options in revision surgery, including management of bone defects and instability. Access the fully searchable contents of the book and an abundance of surgical videos online at Expert Consult.
This book provides an expert view into the current technologies that are revolutionizing the field of solid organ transplantation. This unique book provides insight into progress made in areas spanning robotic surgery to tissue engineering and also gives a glimpse into what may lie ahead for this innovative specialty. Topics covered include nanotherapy, machine perfusion, artificial organ development, robotics in transplant surgery, mobile health technology, stem cell therapy, and ex vivo repair of organs. This is an ideal book for biomedical engineers, physicians and surgeons, general and transplant surgeons, medical students, medical and surgical trainees, and transplant procurement technicians.
This book is designed to fill the need for a contemporary handbook for the practice of renal and pancreatic transplantation that is focussed on a European rather than North American approach. There are significant differences in transplant practice internationally and there is a need for a practical guide to application of the current evidence base.
This book summarizes the latest developments in key areas of the fast moving field of abdominal organ transplantation. It covers such vital topics as living donation (both renal and liver), laparoscopic and robotic techniques, islet and pancreas transplantation, non-heart beating transplantation, blood group incompatible and highly sensitized transplantation, high risk transplants, tolerance, stem cell therapy and novel immunosuppressive techniques. Each chapter offers an overview of the available evidence by a world renowned expert, written in an accessible, easy-to-read manner.
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