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In about 5% of all organ (kidney, liver) transplant recipients, malignancies occur as a late complication of the massive immunosuppression. The malignancies are mainly skin cancers, lymphomas and renal carcinomas. The present book discusses the possible mechanisms of this type of tumorigenesis and inquires into possibilities of prevention. In particular, the described malignancies might be of viral origin. The book informs about a completely new type of carcinogenesis. Apart from the scientific aspects, it is of great practical value.
Over the last century, the world witnessed outstanding advancements in the field of surgery and organ transplantation, with success ratios reaching 80% to 90%. There is, however, a huge difference between the number of organs available for transplantation and the number of people in need of transplantable organs. Over the past few decades, the gap has grown dramatically, and the systems mentioned are insufficient to balance the supply and demand of transplantable organs and, specifically within the scope of this book, the shortage of kidneys. This book primarily aims to calculate the costs of dialysis and/versus transplantation, and to focus on the benefits of increasing the number in donations. The number of donations is further used in a sensitivity analysis of economic gains by increase in donations. Another sensitivity analysis of the effect of monetary incentive by changing the value of statistical life (VSL). The purpose of this study is to make a contribution to health literature by calculating the costs and benefits of kidney transplantation. Although there is a system, there is also a system failure. Current systems are insufficient in terms of reducing prolonged waiting lists. Therefore, this book proposes an alternative system that would help increase kidney donations and transplantations. The proposed system would also heavily suppress the black market that abuses the world's poor. While monetary incentive could be effective for increasing organ donation, every year almost 5 to 10 percent of kidney transplantations are facilitated by organ trafficking.
Techniques of Liver Surgery is a concise, step-by-step guide to a range of techniques used in liver surgery, from standard approaches to transplantation. The book is divided into twelve chapters, beginning with indications for liver resection, and techniques for transection of the liver. Subsequent chapters cover operations for benign lesions, carcinoma of the gall bladder and bile ducts, hepatocellular carcinoma, and colorectal liver metastases. Later chapters focus on liver transplants, covering procurement of the liver, recipient hepatectomy and implantation. The closing chapters cover liver transplant from a living donor. Each chapter assesses indications, contraindications, and preoperative planning, before providing a full step-by-step explanation of the procedure. The book also features a detailed description of the "W" technique, a safer technique for performing the hepatic artery anstomosis in living donor liver transplantation. Enhanced by 240 full colour images and illustrations, Techniques of Liver Surgery is an ideal resource for hepatobilliary and transplant surgeons. Key Points Concise, step-by-step guide to techniques in liver surgery Chapters on transaction, various lesions and cancers, and liver transplant from deceased and living donors 240 full colour images and illustrations
Bone disease, particularly osteoporosis, has emerged as a common
and serious complication of solid organ transplantation. In recent
years there have been real advances in our understanding of the
pathogenesis and pathophysiology of bone loss, however treatment
studies have been relatively sparse and successful strategies to
reduce skeletal morbidity after transplantation remain to be
clearly established. This book provides a unique resource for the
many health professionals involved with transplantation of bone
disease, both in terms of its scientific background and the
management of the disease in clinical practice.
Post-transplant lymphoproliferative disorders are a group of conditions that straddle the borders between infection and malignancy. They were very rare prior to the mid-1980s but now can be expected to develop in 1-10% of transplant recipients. While some cases are reversible with reduction in immunosuppression, more severe forms are indistinguishable from frank lymphomas. This book sets out to cover in depth every aspect of these disorders, including both basic science and clinical topics. The epidemiology is reviewed, and careful attention is paid to the role of Epstein-Barr virus in their development. Clinical features are documented and clear guidance is provided on diagnosis, with thorough description of pathologic and imaging findings. Further chapters are devoted to treatment, prognosis, preventive and pre-emptive strategies, and organ-specific considerations. The state-of-the-art information contained in this book will aid researchers as well as the many different professionals involved in caring for patients with post-transplant lymphoproliferative disorders. The comprehensive and detailed coverage will appeal to those who already have some expertise in the field, yet the book will also serve as an invaluable resource for beginners in transplantation.
Over the past decade, there has been rapid growth in bioengineering
applications in the field of spine implants. This book explains the
technical foundation for understanding and expanding the field of
spine implants, reviews the major established technologies related
to spine implants, and provides reference material for developing
and commercializing new spine implants. The editors, who have a
track record of collaboration and editing technical books, provide
a unified approach to this topic in the most comprehensive and
useful book to date.
Hair Transplantation is known as the "bible" of hair transplantation and is the most complete resource available on the subject. For the sixth edition, the book has been redesigned in full color, upgrading the artwork, replacing black-and-white photos with color ones and is now sold with a bundled e-book and increased video clips. Multiple new chapters have been added including training the hair restoration team and on new FUE procedures. Multiple new editors have joined Robin Unger MD and Ronald Shapiro MD to lend a full global perspective.
This issue of Progress in Brain Research is split over 2 volumes,
bringing together cutting-edge research on Functional Neural
Transplantation. The 2 volumes review current knowledge and
understanding, provide a starting point for researchers and
practitioners entering the field, and build a platform for further
research and discovery.
The book is laid out in 6 sections: 1. Preclinical Approaches to Face Transplantation 2. Clinical Aspects in Preparation to Face Transplantation in Humans 3. Approval Process of Face Transplantation in Humans 4. Social and Public Relations in Face Transplantation 5. World Experience with Face Transplantation in Humans 6. Future Directions in Face Transplantation This book spans the entire process of a face transplantation, from detailing the anatomy of the face to considering the social and ethical challenges of the procedure. This rigorous presentation of face transplantation also includes the anesthesia involved, the role of Institutional Review Boards in approving the operation, the financial aspects and media response. Since the authorship is international, the book considers the different perspectives, approaches and responses from across the world.
The use of human tissue for transplantation is becoming a billion-dollar business. This book is the first comprehensive exploration of the American tissue transplantation industry. It traces the chain of distribution of musculoskeletal tissue (e.g. bones and ligaments) and skin from the generous donation of grieving families to its transplantation into hundreds of thousands of persons each year. Commodification, commercialization, and the occasional use of tissue for "cosmetic" surgery have raised ethical questions about the acceptability of "markets" in human body parts that have been altruistically donated by families. Inevitably, questions about the informed consent and the need for responsible stewardship by the industry have been raised, often in the Press.
The book provides a comprehensive background to these ethical problems by explaining the historical development, breadth, and organization of the tissue industry, including the technical developments that have made it simultaneously clinically relevant and an attractive market for investment capital. It explores the similarities and differences in how government regulates other tissues and solid organs (such as hearts and kidneys). Contributions to the book come from an interdisciplinary group of scholars, industry representatives, government regulators, and, not least, families who have donated tissue from their dead loved ones.
This series has now established itself as the leading publication on the multi-disciplinary subject of tissue banking. The high quality of the contributors and the broad coverage of the subject have continued in Volume 4. The material given in this volume is not presented anywhere else as systematically or as authoritatively.
The essential feature in establishing confidence in the quality and safety of allografts is the manufacturing quality system utilised. This volume describes the most recent approach to good manufacturing control.
Throughout the world, the old cottage approach to tissue banking is being abandoned, mainly due to the insistence by regulatory authorities that he procedures should be standardised and rigorous infection control applied. The experience in a number of counties is described in this volume, giving the reader quick access to developments in Argentina, Finland, Indonesia, Scotland and France. These represent a geographical and cultural spread of the developments.
A balance needs to be struck between the use of allografts and of bone substitutes, depending on the clinical condition and the availability of grafts in a particular situation. The subject areas -- such as mandibular reconstruction, spinal surgery, surgery and reconstruction of bone tumours and acetabular revision -- covered in this volume demonstrate the universality of this technique. The use of allografts of the repair of knee ligaments has been and remains a controversial subject. The contributions on this subject will surely be and important and positive addition to this debate.
A significant medical event is expected in 1992: the first human
use of a fully implantable, long-term cardiac assist device. This
timely volume reviews the artificial heart program--and in
particular, the National Institutes of Health's major
investment--raising important questions.
In Death, Dying, and Organ Transplantation: Reconstructing Medical
Ethics at the End of Life, Miller and Truog challenge fundamental
doctrines of established medical ethics. They argue that the
routine practice of stopping life support technology in hospitals
causes the death of patients and that donors of vital organs
(hearts, lungs, liver, and both kidneys) are not really dead at the
time that their organs are removed for life-saving transplantation.
These practices are ethically legitimate but are not compatible
with traditional rules of medical ethics that doctors must not
intentionally cause the death of their patients and that vital
organs can be obtained for transplantation only from dead donors.
Transplantaton meets the needs of surgeons in higher training and practising consultants for a contemporary and evidence-based account of this sub-specialty that is relevant to their general surgical practice. It is a practical reference source incorporating the most current information on recent developments, management issues and operative procedures. The text is thoroughly referenced and supported by evidence-based recommendations wherever possible, distinguishing between strong evidence to support a conclusion, and evidence suggesting that a recommendation can be reached on the balance of probabilities. This is a title in the Companion to Specialist Surgical Practice series whose eight volumes are an established and highly regarded source of information for the specialist general surgeon. The Companion to Specialist Surgical Practice series provides a current and concise summary of the key topics within each major surgical sub-specialty. Each volume highlights evidence-based practice both in the text and within the extensive list of references at the end of every chapter. Purchase of a print book also includes a downloadable version of the eBook. This new Fourth Edition is presented in colour throughout, including colour photographs of operative procedures, investigations and clinical signs throughout. The entire contents have been comprehensively updated with particular reference to the evidence-based content of each chapter. An expanded group of authors provides an increased international dimension to the content of all volumes. Purchase of a print copy includes a downloadable version of the eBook which you can also access on your iPhone, iPod Touch or iPad. In addition the books are available for purchase as a single volume or as part of a set of all eight volumes in an elegant slipcase. Fully updated to reflect the multidisciplinary team approach to transplant medicine.
This second edition has been completely updated and greatly expanded to include detailed information on all aspects of autologous and allogeneic haematopoietic stem cell transplantation. The text builds on the strengths of its first edition by maintaining a balance between detailed scientific explanations and practical information on patient care. Thoroughly referenced through 1999, it is divided into 13 sections, ranging from biological background and practical procedures, to clinical results, major transplant-related and organ-specific problems, laboratory services, and developing areas. This new edition provides an increased emphasis on immune cell therapy and contains over 1,200 figures and tables. The author has enlisted an international list of experts to contribute to this authoritative, user-friendly, practical and well-balanced text. Haematologists, oncologists, transplant specialists, and researchers should find it a useful resource.
Cardiac transplantation is a widely accepted therapy for the treatment of end-stage congestive heart failure. Most candidates for cardiac transplantation have not been helped by conventional medical therapy and are excluded from other surgical options because of the poor condition of the heart. About 45 percent of the candidates have ischemic cardiomyopathy; however, this percentage is rising because of the increase in coronary artery disease in younger age groups. Of the candidates, 54 percent have some form of dilated cardiomyopathy, which often has an unclear origin. The remaining one percent of candidates fall into the category of other diseases, including congenital heart disease, that are not amenable to surgical correction. Candidacy determination and evaluation are key components of the process, as is post-operative follow-up care and immunosuppression management. This book presents leading research from around the world.
This book provides up-to-date, clinically relevant information on a range of complex issues relating to supportive care strategies for the recipients of hematopoietic cell transplantation. The topics addressed include the prevention, recognition, and treatment of transplant-related side effects; management of pretransplant comorbidities; supportive care for specific age groups; quality of life issues in patients who experience graft-versus-host disease; mental and spiritual health care; caregiver and healthcare provider support strategies; and important issues related to end of life care. The aim is to supply hematologists, oncologists, transplant specialists, and palliative care physicians with practical knowledge that can be immediately applied in patient care to optimize transplant-related outcomes. The book's format, which offers concise, non-exhaustive coverage of these and other unique topics, is supplemented by a wealth of working tables, algorithms, and figures, ensuring that it will also serve hematology, oncology and transplant trainees as a reliable companion during their daily work. The authors are world-renowned experts in the field of hematopoietic transplantation and palliative care medicine, and present well-reasoned opinions based on their own experiences and draw attention to relevant results from potentially high-impact clinical trials.
One of the most spectacular medical advances of the 20th century, organ transplantation has become a generally effective and routine treatment for patients with organ failure. In this book, a well-known expert in the fields of clinical transplantation and transplantation research traces the evolution of organ transplantation from its initial stirrings in the imaginations of the ancients to its status as accepted treatment for nearly 40,000 patients each year. Drawing often on his own first-hand experience, Dr Nicholas Tilney tells the story of the advances in organ transplantation, discusses how societal forces have driven its development, and reveals how its current success is marred by commercialism and exploitation of the less fortunate. kidney transplant in 1954 between identical twins, the scientific advances for suppressing the immune system, the introduction of the concept of host tolerance, research on donor matching, and the issue of donor brain death. He explores innovations in heart, lung, liver and other abdominal transplants and reflects on the attempts to make transplants between species. Finally he explains how organ transplantation has become a vast business, creating ethical and logistical conflicts about organ donations.
With contributions by D. Albrechtsen, O.H. Bentdal, H. Bondevik, I.B. Brekke, P. Fauchald, J.G. Fjeld, A. Flatmark, A. Foss, A. Hartmann, H. Holdaas, R. Innes, A. Jakobsen, N.E. Klow, B. Lien, O. Oyen, P.F. Pfeffer, K. Rootwelt, G. Sodal and K. Vatne
This book presents international experimental and clinical experience on limb transplantation and other composite tissue allografts, representing the most complete and comprehensive review of this innovative and ground breaking procedure. A DVD with selected videos outlines the function of the transplanted hand in the daily living activities and the professional life of these patients. This book is a milestone in medical literature and an asset for every scientific library.
Management of Heart Failure: Surgical will provide the full spectrum of surgical options, ICU management and rehabilitation, while also referencing heavily the companion volume of Management of Heart Failure: Medical by introducing the medical options in heart failure . The contributing authors are all key opinion leaders in the medical management of heart failure. This volume is designed to integrate with its sister medical title, but also alone be the definitive guide to the surgical management of heart failure.
Optimization of Outcomes for Children After Solid Organ Transplantation is reviewed in this issue of Pediatric Clinics, guest edited by Drs. Vicky Lee Ng and Sandy Feng. Authorities in the field have come together to pen articles addressing Renal, Liver, Heart, Lung, and Small Bowel Transplantation in Children; Immunosuppression Armamentarium in 2010: Mechanistic and Clinical Considerations; Tolerance: Is it achievable in Pediatric Solid Organ Transplantation?; Optimizing Growth, Rehabilitation, and Neurodevelopmental Outcomes in Children after Solid Organ Transplantation; Prevention and Treatment of Infectious Issues after Solid Organ Transplantation in Children; Post-Transplantation Lymphoproliferative Disease; Non-Immune Complications Post-Transplantation?; Health-Related Quality of Life after Pediatric Transplantation; Adolescence and Adherence Issues of the Pediatric Solid Organ Recipient; Transition of Care of the Pediatric Solid Organ Recipient to Adult Care Teams; And Most Commonly Asked Questions from Parents of Transplant Families.
This volume of tissue banking is the second of a series extending the interdisciplinary field. All of the authors of this book have been major contributors of scientific and medical publications in their respective specialities. There are articles covering blood transfusion; bone marrow and stem cell transplantation; immunology and the role of immunology in musculoskeletal transplantation, various aspects of cryopreservation of organs, cartilage and tendons; organ perfusion preservation; the history and long term follow-up of osteochondral allografts, both frozen and fresh; neurosurgical applications; cardiovascular applications; the use of skin and newer biological membranes for wound coverage.The book is of particular importance, in that it has been written in memory of Kenneth W Sell, MD, PhD, a pioneer and promulgator of tissue banking and transplantation. Many of the physicians, surgeons and scientists who trained under his leadership have gone on to distinguish themselves in the various aspects of transplantation. Many of them have contributed to this book, exemplifying the diversity of Dr Sell's contributions to tissue banking and transplantation.
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