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A significant medical event is expected in 1992: the first human
use of a fully implantable, long-term cardiac assist device. This
timely volume reviews the artificial heart program--and in
particular, the National Institutes of Health's major
investment--raising important questions.
In Japan, cadaveric donor liver transplantation is not common even though cadaveric organ transplantation was legally established in 1998. In contrast, the number of living donor liver transplantations is increasing, with more than 1700 cases at 43 Japanese institutes by November 2001. Indications for and have become living donor liver transplantation are widening in Japan similar to those for cadaveric donor liver transplantation in the United States and Europe. At the same time, split liver transplantation from cadaveric donors shares some technical aspects with living donor liver transplantation. Remarkable progress has been reported recently, and thus it was an auspicious time to hold a symposium on "Current issues in liver/small bowel transplantation" in Japan. We were honored to hold a very fruitful symposium sponsored by the Keio University Medical Science Fund and to bring together top-rank transplant surgeons from Japan and other countries. It was a productive and rewarding time for all participants. We were able to share our experience through excellent presentations followed by active discussions and insightful com- ments. At the symposium, we focused on current issues in liver transplanta- tion such as widening indications for viral hepatitis and malignant tumors. We also discussed technical aspects and physiological problems in split/iiving donor liver transplant, novel strategies in immunosuppression, and the current status and future prospects in small bowel transplantation. This book contains the papers from all the distinguished guest speakers, focusing on the topics discussed at the symposium.
Are our identities attached to our faces? If so, what happens when the face connected to the self is gone forever or replaced? In Face/On, Sharrona Pearl investigates the stakes for changing the face and the changing stakes for the face in both contemporary society and the sciences. The first comprehensive cultural study of face transplant surgery, Face/On reveals our true relationships to faces and facelessness, explains the significance we place on facial manipulation, and decodes how we understand loss, reconstruction, and transplantation of the face. To achieve this, Pearl draws on a vast array of sources: bioethical and medical reports, newspaper and television coverage, performances by pop culture icons, hospital records, personal interviews, films, and military files. She argues that we are on the cusp of a new ethics, in an opportune moment for reframing essentialist ideas about appearance in favor of a more expansive form of interpersonal interaction. Accessibly written and respectfully illustrated, Face/On offers a new perspective on face transplant surgery as a way to consider the self and its representation as constantly present and evolving. Highly interdisciplinary, this study will appeal to anyone wishing to know more about critical interventions into recent medicine, makeover culture, and the beauty industry.
The book encompasses Dr Baranski's 20 year experience in the field of abdominal organ donation. It is a step-by-step guide with photographs and drawings with clear explanations highlighting pitfalls. The book quickly and easily guides the reader through the difficult steps during organ procurement. It is mainly illustration-based, without much text, and covers surgical technical mistakes and organ damage.
MICHAEL F.A. WOODRUFF Emeritus Professor of Surgery, University of Edinburgh This book grew out of a very successful conference on Organ Transplantation held in Kuwait in December 1982. The material presented at the conference has been expanded and brought up to date, and the result is a well written and authoritative account of many aspects of organ transplantation by a distinguished team of contributors drawn from many countries. A unique feature of the book is the account it contains of the development of organ transplantation in the Middle East. Although, as yet, it has been virtually impossible in Islamic countries to take organs after death for use as transplants, it is beginning to look as if this situation may change. Meanwhile, using living volunteer donors and a small number of cadaveric organs sent from other countries, transplant teams in Kuwait and Turkey are obtaining results with kidney transplants which are as good, in terms of both transplant survival and patient survival, as those reported from acknowledged centres of excellence in the United States, Europe and other countries where organ transplantation has been established for many years.
Transplantaton meets the needs of surgeons in higher training and practising consultants for a contemporary and evidence-based account of this sub-specialty that is relevant to their general surgical practice. It is a practical reference source incorporating the most current information on recent developments, management issues and operative procedures. The text is thoroughly referenced and supported by evidence-based recommendations wherever possible, distinguishing between strong evidence to support a conclusion, and evidence suggesting that a recommendation can be reached on the balance of probabilities. This is a title in the Companion to Specialist Surgical Practice series whose eight volumes are an established and highly regarded source of information for the specialist general surgeon. The Companion to Specialist Surgical Practice series provides a current and concise summary of the key topics within each major surgical sub-specialty. Each volume highlights evidence-based practice both in the text and within the extensive list of references at the end of every chapter. Purchase of a print book also includes a downloadable version of the eBook. This new Fourth Edition is presented in colour throughout, including colour photographs of operative procedures, investigations and clinical signs throughout. The entire contents have been comprehensively updated with particular reference to the evidence-based content of each chapter. An expanded group of authors provides an increased international dimension to the content of all volumes. Purchase of a print copy includes a downloadable version of the eBook which you can also access on your iPhone, iPod Touch or iPad. In addition the books are available for purchase as a single volume or as part of a set of all eight volumes in an elegant slipcase. Fully updated to reflect the multidisciplinary team approach to transplant medicine.
Techniques of Liver Surgery is a concise, step-by-step guide to a range of techniques used in liver surgery, from standard approaches to transplantation. The book is divided into twelve chapters, beginning with indications for liver resection, and techniques for transection of the liver. Subsequent chapters cover operations for benign lesions, carcinoma of the gall bladder and bile ducts, hepatocellular carcinoma, and colorectal liver metastases. Later chapters focus on liver transplants, covering procurement of the liver, recipient hepatectomy and implantation. The closing chapters cover liver transplant from a living donor. Each chapter assesses indications, contraindications, and preoperative planning, before providing a full step-by-step explanation of the procedure. The book also features a detailed description of the "W" technique, a safer technique for performing the hepatic artery anstomosis in living donor liver transplantation. Enhanced by 240 full colour images and illustrations, Techniques of Liver Surgery is an ideal resource for hepatobilliary and transplant surgeons. Key Points Concise, step-by-step guide to techniques in liver surgery Chapters on transaction, various lesions and cancers, and liver transplant from deceased and living donors 240 full colour images and illustrations
Bone disease, particularly osteoporosis, has emerged as a common
and serious complication of solid organ transplantation. In recent
years there have been real advances in our understanding of the
pathogenesis and pathophysiology of bone loss, however treatment
studies have been relatively sparse and successful strategies to
reduce skeletal morbidity after transplantation remain to be
clearly established. This book provides a unique resource for the
many health professionals involved with transplantation of bone
disease, both in terms of its scientific background and the
management of the disease in clinical practice.
This new edition is a comprehensive guide to the complete field of liver transplantation for practising transplant surgeons. Presented in a step by step format, the book begins with an overview and discussion on different types of liver disease. Pre- and post-transplant considerations and both deceased and live donor evaluation are examined in depth. The following sections describe operative technique, complications, pathology, radiology and much more. Topics have been fully revised to provide the most up to date information, and the atlas is highly illustrated with surgical images and figures. The book is authored by internationally recognised experts in the field of transplant surgery, led by Ernesto Molmenti from North Shore-LIJ Health System and School of Medicine, New York. Previous edition published in 2002. Key Points Second edition of comprehensive guide to liver transplantation Fully revised to provide the most up-to-date information Authored by internationally recognised experts led by Ernesto Molmenti Previous edition (9780721695518) published in 2002
Organ Shortage: The Solutions is the latest subject in the Continuing Education series, organized by Fondation Marcel Merieux and Universite Claude Bernard in Lyon. The annual subject is chosen to reflect the status of the topical issues of the year, as taught by leading international experts. The contribution of transplantation and clinical immunology to advanced medicine is considerable and promising. The annual volumes in this series keep the reader abreast of these developments. "
This is a time ofexcitement and progress in the field ofxenotransplantation. The work described in this book traces the development of the science of cross-spe- cies transplantation, summarizes the current state ofour knowledge, and focuses on approaches directed toward future clinical application. The important question is not whether xenotransplantation will succeed, but rather how and under what circumstances xenografts will provide predictable enough results to warrant clinical application. The fact that the best results to date in clinical xenografting were achieved over three decades ago should not be a matter of discouragement, but rather a stimulus to apply new approaches to this area of work. The shortage of human organs for transplantation is cited frequently as the driving force behind the increased interest in xenotransplantation. This shortage is an undeniable fact, but there are additional potential advantages of xenotrans- plantation, such as the ability to schedule replacement surgery on an elective basis and the modification of animals, organs, and tissues to improve acceptabil- ity in the human host. The advances in the basic science ofxenotransplantation outlined in this book give hope that the immunologic barriers to xenotransplantation will be overcome and that transplanted organs and tissues will succeed consistently in humans. However, if our experience with human allografts provides an analogy, we may anticipate that clinical progress in xenografts will be plagued by failures and rewarded by successes, often without a complete understanding of the mechan- isms involved.
Atlas of Organ Transplantation, Second Edition, provides the reader with a comprehensive and pictorial step-by-step account of abdominal organ transplant procedures performed by contemporary transplant surgeons today. Emphasis is placed on newer procedures or procedures that have undergone significant modifications. It is recognized that there are many well-accepted techniques for the same procedure, with each having potential merit. While it is impossible to present all of these variations, an attempt is made to describe the common variations in surgical technique and common variation in procedure based on anatomical variations. Written by an expert in the field, Atlas of Organ Transplantation, Second Edition, includes schematic diagrams and high-quality intraoperative photographs, allowing readers to clearly visualize the course of the operative procedure. This format provides the reader with a clear visual and written description of all major transplant procedures in one reference book.
Integrated Biomaterials Science provides an intriguing insight into the world of biomaterials. It explores the materials and technology which have brought advances in new biomaterials, highlighting the way in which modern biology and medicine are synergistically linked to other key scientific disciplines-physics, chemistry, and engineering. In doing so, Integrated Biomaterials Science contains chapters on tissue engineering and gene therapy, standards and parameters of biomaterials, applications and interactions within the industrial world, as well as potential aspects of patent regulations. Integrated Biomaterials Science serves as a comprehensive guide to understanding this dynamic field, yet is designed so that chapters may be read and understood independently, depending on the needs of the reader. Integrated Biomaterials Science is attractive to a broad audience interested in a deeper understanding of this evolving field, and serves as a key resource for researchers and students of biomaterials courses, providing all with an opportunity to probe further.
This book covers all topics related to the imaging of organ transplantation. The main part of the book offers in-depth coverage of heart, renal, liver, lung, bone marrow and pancreatic and intestinal transplantation. Each of these topics is discussed firstly in a clinical chapter and then in a radiological chapter. This unique and superbly illustrated volume will be of great assistance to all who work in this field.
In the past few years the transplantation of organs in man has received publicity unprecedented in medical history. The first heart grafts were covered by press, radio, and television on a scal~ equiva- lent to the news of the outbreak of a major war. Unwarranted and extravagant optimism has been followed by bitter criticism. This has undermined public confidence in the medical profession and seriously impeded progress in an important endeavour aimed at reducing human suffering. This unfortunate situation has arisen from widespread ignorance amongst the public and the medical profession of the background, present achievements, and future potential of organ grafting. Short statements by experts, frequently misquoted or cut short by television interviewers, and misinformed derogatory pronouncements by prejudiced medically qualified men, with no knowledge of the field, have produced a sorry state of confusion. It is the purpose of this book to attempt to clarify organ transplantation. The principles of organ transplantation are common to all organs but I will confine most of the discussion to transplantation of four vital organs, namely the kidney, liver, heart, and lung. ROY CALNE Cambridge January 1970 CONTENTS Preface IX List of Illustrations Xlll Acknowledgements XVll I. THE IDEA I II. THE SURGERY 7 III. REJECTION 15 IV. PREVENTION OF REJECTION 23 v. TISSUEMATCHING 39 VI. ORGAN PRESERVATION 47 VII. SUITABLE DONORS 53 VIII. ORGAN TRANSPLANTS 57 IX. ETHICS AND THE LAW 81 X.
The aim of this book is to present a unique compilation of lectures given by international speakers at the Hammersmith Hospital during the recent Meetings in Hepato-Pancreato-Biliary and Transplantation. New therapeutical approaches, advances in oncology and in diagnostic imaging, which reduce the need for invasive techniques and reach an improvement in survival and quality of life in cancer, are considered in this book. Modern literature has been reviewed with special reference to articles of general interest. In the clinical management of patients with liver, bile duct and pancreas diseases, it is important to assess the degree of disturbance and to diagnose the causative insult, and therefore clinical and laboratory methods of assessing each of these pathologies are of high interest. This version is an up-to-date account of diseases of the liver, biliary tract and pancreas, including transplantation, which we trust will be of value for surgeons, physicians and pathologists and also a reference book for medical students.
This book provides an informative update on scientific advances relating to transplant dermatology that may be applicable to clinical practice. Commentary is provided on the emerging role of viruses in transplant dermatology, the management of skin disease secondary to transplant medication, sunscreen use in transplant recipients, the role of revision of immunosuppression, and advances in photodynamic therapy. The latest staging and management criteria for high-risk squamous cell carcinoma and the implications for clinical practice are then analyzed. Finally, the management of other cutaneous malignancies is discussed, covering malignant melanoma, Merkel cell carcinoma, and rarer tumors that also behave aggressively and require special consideration in solid organ transplant patients. Each particular advance is addressed in an individual chapter by leaders in the field. The book both expands current knowledge and complements previous textbooks on the subject.
Over the last century, the world witnessed outstanding advancements in the field of surgery and organ transplantation, with success ratios reaching 80% to 90%. There is, however, a huge difference between the number of organs available for transplantation and the number of people in need of transplantable organs. Over the past few decades, the gap has grown dramatically, and the systems mentioned are insufficient to balance the supply and demand of transplantable organs and, specifically within the scope of this book, the shortage of kidneys. This book primarily aims to calculate the costs of dialysis and/versus transplantation, and to focus on the benefits of increasing the number in donations. The number of donations is further used in a sensitivity analysis of economic gains by increase in donations. Another sensitivity analysis of the effect of monetary incentive by changing the value of statistical life (VSL). The purpose of this study is to make a contribution to health literature by calculating the costs and benefits of kidney transplantation. Although there is a system, there is also a system failure. Current systems are insufficient in terms of reducing prolonged waiting lists. Therefore, this book proposes an alternative system that would help increase kidney donations and transplantations. The proposed system would also heavily suppress the black market that abuses the world's poor. While monetary incentive could be effective for increasing organ donation, every year almost 5 to 10 percent of kidney transplantations are facilitated by organ trafficking.
Developed by the Blood and Marrow Transplant team at Oregon Health & Science University Knight Cancer Institute, this pocket guide provides management guidelines for hematopoietic stem cell transplant patients from the moment of their initial consultation throughout the transplant process. It includes indications for transplant, essential details for patient/donor evaluation, recommendations for management of complications during and after transplant, and guidelines for long-term follow up as well as step-by-step instructions for common procedures and documentation guidelines.
An essential tool for providers, this guide presents a multidisciplinary approach to information you will need to provide quality care for your patients.
Cirrhosis from hepatitis C (HCV) is now the most common indication for liver transplant (LT) in the U.S., but between 2004 and 2013, new LT listings for NASH increased by 170%. Unfortunately, fibrosis progression leading to cirrhosis, liver cancer, and liver decompensation continues to occur after transplantation. Once cirrhosis and decompensation are evident, patient survival is poor and repeat LT is considered to improve outcomes. Therefore, the never-ending thirst for new approaches in the management of patients pre- and post-transplant has led to a very promising future in transplantation, thought there is much to learn to achieve better patient outcomes. This issue of Clinics in Liver Disease addresses the core areas to achieve better patient outcomes, with articles devoted to coagulopathy before liver transplant, challenges in renal failure before LT, LT for acute alcoholic hepatitis, LT in the pregnant patient, bariatric surgery and LT,and MELD Scores in prioritization of LT, to name a few. Readers will place a high value on the current state of liver transplantation in this issue.
Addressing all aspects of brain death and thoroughly detailing how a potential organ donor should be maintained to ensure maximum use of the organs and cells, The Brain-Dead Organ Donor: Pathophysiology and Management is a landmark addition to the literature. This first-of-its-kind, multidisciplinary volume will be of interest to a large section of the medical community. The first section of the book reviews the historical, medical, legal, and ethical aspects of brain death. That is followed by two chapters on the pathophysiology of brain death as investigated in small and large animal models. This includes a review of the many hormonal changes, including the neuroendocrine- adrenergic `storm', that takes place during and following the induction of brain death, and how they impact metabolism. The next section of the book reviews various effects of brain death, namely its impact on thyroid function, the inflammatory response that develops, and those relating to innate immunity. The chapters relating to assessment and management of potential organ donors will be of interest to a very large group of transplant surgeons and physicians as well as critical care and neurocritical care physicians and nurses. Neurologists, endocrinologists, neurosurgeons, and pathologists will also be interested, especially in the more basic science sections on various aspects of brain-death and hormonal therapy. Organ procurement organizations and transplant coordinators worldwide will also be interested in this title. Other chapters will be of interest to medical historians, medico-legal experts, and ethicists.
Although pancreas transplants have been performed for more than 30 years, the last few years have witnessed significant growth in the options available for pancreas transplantation as well as subtantial improvements in outcome. It is therefore appropriate that a new text summarize the recent advances and put forth the standard of future care. Transplantation of the Pancreas, edited by Drs. Gruessner and Sutherland fulfills this mission by providing a state-of-the-art, definitive reference work on pancreas transplantation for transplant surgeons and physicians as well as for endocrinologists, diabetologists, nephrologists, and neurologist. The editors, from the renowned University of Minnesota Transplant Division and the Diabetes Institute, have assembled a group of renowned experts to provide an all inclusive overview of pancreas transplantation. The text features insights on the pathophysiology of diabetes mellitus and the limitations of nontransplant treatments, highlights experimental research and clinical history of pancreas transplantation, and compares and contrasts different surgical procedures. The discussions detail the broad spectrum of posttransplant complications and their treatments, which frequently require skills in general, vascular, and laparoscopic surgery, interventional radiology, critical care, and infectious disease. Chapters on immunosuppression, immunology, pathology, long-term outcome, quality of life, and cost-effectiveness focus on issues unique to pancreas recipients. Evolving areas, such as pretransplant evaluation of pancreas transplant candidates, living donation, and the current status of islet transplantation are discussed. Augmented by more than 280 illustrations, including full color line drawings created exclusively for the text, this book is the standard reference for all transplant professionals as well as all physicians caring for diabetic patients.
Following the great success of Accommodation in ABO-incompatible
Kidney Transplantation published in September 2004, Elsevier is
proud to present the publication of ABO-incompatible Organ
Transplantation from Japan, also edited by Professor Kota
Takahashi. This new publication consists of a collection of invited
papers from the International Meeting at the 41st Annual Meeting of
the Japan Society for Transplantation held in Niigata on 29 October
This issue of "Progress in Brain Research" is split over 2 volumes,
bringing together cutting-edge research on functional neural
transplantation. The 2 volumes review current knowledge and
understanding, provide a starting point for researchers and
practitioners entering the field, and build a platform for further
research and discovery.
Rejection and Tolerance is the latest subject in the Continuing Education series, organized by Fondation Marcel Merieux and Universite Claude Bernard in Lyon. The annual subject is chosen to reflect the status of the topical issues of the year, as taught by leading international experts. The contribution of transplantation and clinical immunology to advanced medicine is considerable and promising. The annual volumes in this series keep the reader abreast of these developments. "
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