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Principles and Methods of Toxicology (Hardcover, 5th Revised edition)
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Discovery Miles 29 040
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Principles and Methods of Toxicology (Hardcover, 5th Revised edition)
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Founded on the paradox that all things are poisons and the
difference between poison and remedy is quantity, the determination
of safe dosage forms the base and focus of modern toxicology. In
order to make a sound determination there must be a working
knowledge of the biologic mechanisms involved and of the methods
employed to define these mechanisms. While the vastness of the
field and the rapid accumulation of data may preclude the
possibility of absorbing and retaining more than a fraction of the
available information, a solid understanding of the underlying
principles is essential. Extensively revised and updated with four
new chapters and an expanded glossary, this fifth edition of the
classic text, Principles and Methods of Toxicology provides
comprehensive coverage in a manageable and accessible format. New
topics include 'toxicopanomics', plant and animal poisons,
information resources, and non-animal testing alternatives.
Emphasizing the cornerstones of toxicology-people differ, dose
matters, and things change, the book begins with a review of the
history of toxicology and followed by an explanation of basic
toxicological principles, agents that cause toxicity, target organ
toxicity, and toxicological testing methods including many of the
test protocols required to meet regulatory needs worldwide. The
book examines each method or procedure from the standpoint of
technique and interpretation of data and discusses problems and
pitfalls that may be associated with each. The addition of several
new authors allow for a broader and more diverse treatment of the
ever-changing and expanding field of toxicology. Maintaining the
high-quality information and organizational framework that made the
previous editions so successful, Principles and Methods of
Toxicology, Fifth Edition continues to be a valuable resource for
the advanced practitioner as well as the new disciple of
toxicology.
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