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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > Chemotherapy

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History of Research on Tumor Angiogenesis (Hardcover, 2009 ed.) Loot Price: R2,941
Discovery Miles 29 410
You Save: R167 (5%)
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History of Research on Tumor Angiogenesis (Hardcover, 2009 ed.): Domenico Ribatti

History of Research on Tumor Angiogenesis (Hardcover, 2009 ed.)

Domenico Ribatti

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List price R3,108 Loot Price R2,941 Discovery Miles 29 410 | Repayment Terms: R273 pm x 12* You Save R167 (5%)

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In 1971, J. Folkman published in the New England Journal of Medicine a hypothesis that tumor growth is angiogenesis-dependent. Folkman introduced the concept that tumors probably secrete diffusible molecules that could stimulate the growth of new blood vessels toward the tumor and that the resulting tumor neovascularization could conceivably be prevented or interrupted by angiogenesis inhibitors. Solid and haematological tumors consist of an avascular and a subsequent vascular phase. Assuming that this depends on the release of angiogenic factors, acquisition of angiogenic capability can be seen as an expression of progression from neoplastic transformation to tumor growth and metastasis.

Beginning in the 1980 s, the biopharmaceutical industry began exploiting the field of antiangiogenesis for creating new therapeutic compounds for modulating new blood vessels in tumor growth. In 2004, Avastin (Bevacizumab), a humanized anti-VEGF monoclonal antibody, was the first angiogenesis inhibitor approved by the Food and Drug Administration for the treatment of colorectal cancer. At present, it has been estimated that over 20,000 cancer patients worldwide have received experimental form of antiangiogenic therapy.

This book offers a historical account of the relevant literature. It also emphasizes the crucial and paradigmatic role of angiogenesis as a biological process and the significance of antiangiogenic approach for the treatment of tumors."

General

Imprint: Springer-Verlag New York
Country of origin: United States
Release date: 2009
First published: 2009
Authors: Domenico Ribatti
Dimensions: 235 x 156 x 9mm (L x W x T)
Format: Hardcover
Pages: 126
Edition: 2009 ed.
ISBN-13: 978-1-4020-9559-7
Categories: Books > Medicine > Clinical & internal medicine
Books > Medicine > Clinical & internal medicine > Diseases & disorders
Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > Chemotherapy
LSN: 1-4020-9559-7
Barcode: 9781402095597

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