Galectin-1 and apoptosis (Paperback)


Galectin-1 (gal-1), a member of the family of beta galactoside binding proteins, participates in several biological processes such as immunomodulation, cell adhesion, regulation of cell growth and apoptosis. The aim of this study was to investigate whether gal-1 the mechanisms of T cell activation on the level of signal transduction induced by galectin-1 (gal-1) having immunosuppressive activity. Gal-1 recognizes and cross-links appropriate glycoepitopes (Gal 1- 4GlcNAc- sequences) on T cell activation markers (CD2, CD3, CD45) and stimulates in parallel several interacting signalling pathways leading to suppression of the expression of Th1 cytokines and to apoptosis in thymocytes, activated T- cells, and in leukemic T cell lines. In cellular models by applying cell- and glycobiological methods we have focused on gal-1 induced or suppressed signalling pathways involved in inhibition of a processive immune response of antigen-stimulated T lymphocytes. In this way, by depletion of activated T cells gal-1 is a negative regulator of the immune response. Therefore, the mechanism of gal-1 induced T cell apoptosis is of special interest.

R1,513

Or split into 4x interest-free payments of 25% on orders over R50
Learn more

Discovery Miles15130
Mobicred@R142pm x 12* Mobicred Info
Free Delivery
Delivery AdviceShips in 10 - 15 working days


Toggle WishListAdd to wish list
Review this Item

Product Description

Galectin-1 (gal-1), a member of the family of beta galactoside binding proteins, participates in several biological processes such as immunomodulation, cell adhesion, regulation of cell growth and apoptosis. The aim of this study was to investigate whether gal-1 the mechanisms of T cell activation on the level of signal transduction induced by galectin-1 (gal-1) having immunosuppressive activity. Gal-1 recognizes and cross-links appropriate glycoepitopes (Gal 1- 4GlcNAc- sequences) on T cell activation markers (CD2, CD3, CD45) and stimulates in parallel several interacting signalling pathways leading to suppression of the expression of Th1 cytokines and to apoptosis in thymocytes, activated T- cells, and in leukemic T cell lines. In cellular models by applying cell- and glycobiological methods we have focused on gal-1 induced or suppressed signalling pathways involved in inhibition of a processive immune response of antigen-stimulated T lymphocytes. In this way, by depletion of activated T cells gal-1 is a negative regulator of the immune response. Therefore, the mechanism of gal-1 induced T cell apoptosis is of special interest.

Customer Reviews

No reviews or ratings yet - be the first to create one!

Product Details

General

Imprint

Lap Lambert Academic Publishing

Country of origin

Germany

Release date

May 2010

Availability

Expected to ship within 10 - 15 working days

First published

May 2010

Authors

Dimensions

229 x 152 x 9mm (L x W x T)

Format

Paperback - Trade

Pages

144

ISBN-13

978-3-8383-3483-7

Barcode

9783838334837

Categories

LSN

3-8383-3483-3



Trending On Loot