Defending Life - The Nature of Host-Parasite Relations (Electronic book text)

"Defending Life" discusses the relationship between hosts and parasites. A major contention of the book is that the immune system depends ontologically on the ecosystem in which it is embedded; it would not have the features it has if it was not related in one way or other to parasitic agents and to the host's own cells and tissues. To sustain the argument, life is investigated at all layers - from molecules up through cells, organisms and ecosystems. Together with the inverse course, which goes from ecological contingencies down to gene-expression profiles, the approach facilitates an advanced understanding of immunocompetence as well as its converse, immunoincompetence. The emphasis on analytical abstractions, coherent patterns and generative mechanisms makes possible the distinction between genuine causality and coincidental associations, and thus increases the understanding of why we observe what we observe. The book contains detailed descriptions of the immune system and the microbial world as well as methodological and conceptual clarifications.; It will be of interest not only to biologists, medical scientists, physicians and philosophers of science, but also microbiologists and immunologists. Many of the discussions are also relevant for students at both the graduate and PhD levels.