This issue of Hematology/Oncology Clinics, guest edited by Dr.
Elliott Vichinsky, is devoted to Sickle Cell Disease, and focuses
on pathophysiology of hemoglobinopathies, therapeutic targets, and
new approaches to correcting ineffective erythropoiesis and iron
dysregulation. Articles in this issue include Polymerization and
red cell membrane changes; Overview on reperfusion injury in the
pathophysiology of SCD; Regulation of ineffective erythropoiesis in
iron metabolism; Altering oxygen affinity; Cellular adhesion and
the endothelium; Arginine therapy; Role of the hemostatic system on
SCD pathophysiology and potential therapeutics; Adenosine signaling
and novel therapies; New approaches to correcting ineffective
erythropoiesis and iron dysregulation; New approaches to correcting
ineffective erythropoiesis and iron dysregulation; Fetal hemoglobin
induction; Gene therapy for hemoglobinopathies; and Oxidative
injury and the role of antioxidant therapy.
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