Diabetes mellitus is a disease in the glucose-insulin endocrine
metabolic regulatory system, in which the pancreas either does not
release insulin or does not properly use insulin to uptake glucose
in the plasma, which is referred as hyperglycemia. Complications of
diabetes mellitus include retinopathy, nephropathy, peripheral
neuropathy and blindness. The purpose of this study is to model the
dynamic of the short-term glucose regulatory system (GRS) in man
and its hormonal regulation by considering all the feedback loops
which are responsible of controlling the glucose metabolism in man.
The model proposed in this work used the system dynamics (SD)
approach which was designed for studying complex systems. This SD
model consists of twenty-three negative (balance) loops and six
compartments. The model was validated during wide range of clinical
test inputs, to be sure that this model accurately represents the
really endocrine system. Understanding the mechanism underlying
glucose-insulin oscillations and determination of the origin of the
glucose-insulin levels oscillations is another purpose of this
model. Other applications for this model also have been explored.
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