This practical reference for medicinal and pharmaceutical chemists
combines the theoretical background with modern methods as well as
applications from recent lead finding and optimization projects.
Divided into two parts on the thermodynamics and kinetics of
drug-receptor interaction, the text provides the conceptual and
methodological basis for characterizing binding mechanisms for
drugs and other bioactive molecules. It covers all currently used
methods, from experimental approaches, such as ITC or SPR, right up
to the latest computational methods. Case studies of real-life lead
or drug development projects are also included so readers can apply
the methods learned to their own projects. Finally, the benefits of
a thorough binding mode analysis for any drug development project
are summarized in an outlook chapter written by the editors.
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