Selective Immunosuppression: Basic Concepts and Clinical Applications (Hardcover)

Induction of selective immunosuppression is a challenging research topic, and enough is now known about the immune system to permit new ideas on immunoregulation to be applied clinically. This book provides an authoritative update of developments in this fast-moving field from both a basic and clinical perspective. Leading immunologists highlight appropriate targets for selective immunotherapy of autoimmune diseases, allograft rejection and allergies. Strategies based on autoantigen, MHC, TCR, cytokines, coreceptors, adhesion molecules and Th1/Th2 balance are analyzed in detail in order to understand the underlying mechanisms and to explore their possible impact on the formulation of increasingly more selective immunotherapies. Immunologists and immunopharmacologists will find this book of particular interest, and it should also appeal to molecular and cell biologists.