A Comparative Study of Tubercle Bacilli from Varied Sources (Paperback)

This historic book may have numerous typos, missing text or index. Purchasers can download a free scanned copy of the original book (without typos) from the publisher. 1907. Not illustrated. Excerpt: ... bounded by any hard and fast lines and that there is no character possessed by any tubercle bacilli in one host that may not be found in tubercle bacilli in another host, under favorable conditions. Is it not therefore reasonable to consider these various types of tubercle bacilli obtained from these different hosts as belonging to the same species of organism and showing in alteration of form the effect of sojourn in the bodies of different animals? May it not also be aasumed in those cases where various types of tubercle bacilli are obtained from one animal that these are transitional forms which have not had time or opportunity during their sojourn to become transformed into the usual type peculiar to this host? It is not an uncommon experience in laboratory work to find that certain characteristics are lost by repeated cultivations, and by the continuation of such conditions certain characteristics become prominent which did not obtain in the original culture. Such organisms may be returnee to their original characteristics by injecting them into animals, and it is therefore generally stated that these changes are due to unfavorable environment. A more complete discussion on this subject will be given in another paper on the transformation of tubercle bacilli. PATHOGENESIS. VIRULENCE FOR RABBITS. In the inoculation of rabbits for purposes of comparative study the subcutaneous method was adopted in all cases except with a series of five rabbits used in the work with culture Girl I. The inoculations were made on the left side of the animal, at a point 20 mm. posterior to the supero-posterior angle of the scapula. The amount of material injected was 0.5 c. c. in practically every instance, and careful endeavor was made to have this quantity represent approxima...