Arachidonate 5-Lipoxygenase (Paperback)

Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Arachidonate 5-lipoxygenase (5-lipoxygenase, 5-LO or Alox5) is a member of the lipoxygenase family of enzymes. It transforms EFAs into leukotrienes and is a current target for pharmaceutical intervention in a number of diseases.Lipoxygenases (EC 1.13.11.-) are a family of iron-containing enzymes that catalyse the dioxygenation of polyunsaturated fatty acids in lipids containing a cis, cis-1,4- pentadiene structure. It catalyses the following reaction: fatty acid + O2 = fatty acid hydroperoxide.Lipoxygenases are found in plants, animals and fungi. Products of lipoxygenases are involved in diverse cell functions