Books > Science & Mathematics > Biology, life sciences > Zoology & animal sciences
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Discovery Miles 6 560
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V-type proton ATPase subunit d 1 is an enzyme that in humans is
encoded by the ATP6V0D1 gene.This gene encodes a component of
vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates
acidification of eukaryotic intracellular organelles. V-ATPase
dependent organelle acidification is necessary for such
intracellular processes as protein sorting, zymogen activation,
receptor-mediated endocytosis, and synaptic vesicle proton gradient
generation. V-ATPase is composed of a cytosolic V1 domain and a
transmembrane V0 domain. The V1 domain consists of three A and
three B subunits, two G subunits plus the C, D, E, F, and H
subunits. The V1 domain contains the ATP catalytic site. The V0
domain consists of five different subunits: a, c, c', c, and d.
Additional isoforms of many of the V1 and V0 subunit proteins are
encoded by multiple genes or alternatively spliced transcript
variants. This encoded protein is known as the D subunit and is
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