Books > Science & Mathematics > Biology, life sciences > Zoology & animal sciences
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V-type proton ATPase subunit G 1 is an enzyme that in humans is
encoded by the ATP6V1G1 gene.This gene encodes a component of
vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates
acidification of eukaryotic intracellular organelles. V-ATPase
dependent organelle acidification is necessary for such
intracellular processes as protein sorting, zymogen activation,
receptor-mediated endocytosis, and synaptic vesicle proton gradient
generation. V-ATPase is composed of a cytosolic V1 domain and a
transmembrane V0 domain. The V1 domain consists of three A, three
B, and two G subunits, as well as a C, D, E, F, and H subunit. The
V1 domain contains the ATP catalytic site. The protein encoded by
this gene is one of three V1 domain G subunit proteins. Pseudogenes
of this gene have been characterized.
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