Boll (Paperback)

Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Protein boule-like is a protein that in humans is encoded by the BOLL gene.This gene belongs to the DAZ gene family required for germ cell development. It encodes an RNA-binding protein which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ (deleted in azoospermia) or DAZL (deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen (azoospermia). Histological studies demonstrated that the primary defect is at the meiotic G2 / M transition. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.