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Protein DEK is a protein that in humans is encoded by the DEK
gene.This gene encodes a protein with one SAP domain. This protein
binds to cruciform and superhelical DNA and induces positive
supercoils into closed circular DNA and is also involved in splice
site selection during mRNA processing. Chromosomal aberrations
involving this region, increased expression of this gene and the
presence of antibodies against this protein are all associated with
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