Books > Science & Mathematics > Biology, life sciences > Zoology & animal sciences
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Discovery Miles 6 760
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Segment polarity protein dishevelled homolog DVL-1 is a protein
that in humans is encoded by the DVL1 gene.DVL1, the human homolog
of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic
phosphoprotein that regulates cell proliferation, acting as a
transducer molecule for developmental processes, including
segmentation and neuroblast specification. DVL1 is a candidate gene
for neuroblastomatous transformation. The Schwartz-Jampel syndrome
and Charcot-Marie-Tooth disease type 2A have been mapped to the
same region as DVL1. The phenotypes of these diseases may be
consistent with defects which might be expected from aberrant
expression of a DVL gene during development. Three transcript
variants encoding three different isoforms have been found for this
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