Eps15 (Paperback)

Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Epidermal growth factor receptor substrate 15 is a protein that in humans is encoded by the EPS15 gene.This gene encodes a protein that is part of the EGFR pathway. The protein is present at clathrin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.