High Quality Content by WIKIPEDIA articles! NEDD9 is a protein that
in humans is encoded by the NEDD8 gene. (In Saccharomyces
cerevisiae this protein is known as Rub1.) This ubiquitin-like
protein (ULP), which becomes covalently conjugated to a limited
number of cellular proteins in a manner analogous to
ubiquitination. Human NEDD8 shares 60% amino acid sequence identity
to ubiquitin. The only known substrates of NEDD8 modification are
the cullin subunits of SCF ubiquitin E3 ligases. The NEDDylation of
cullins is critical for the recruitment of E2 to the ligase
complex, thus facilitating ubiquitin conjugation. NEDD8
modification has therefore been implicated in cell cycle
progression and cytoskeletal regulation.
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