Please note that the content of this book primarily consists of
articles available from Wikipedia or other free sources online. An
oncolytic virus is a virus that preferentially infects and lyses
cancer cells; these have obvious functions for cancer therapy, both
by direct destruction of the tumour cells, and, if modified, as
vectors enabling genes expressing anticancer proteins to be
delivered specifically to the tumor site. Most current oncolytic
viruses are engineered for tumour selectivity, though there are a
few naturally-occurring ones such as the Seneca Valley virus. A
connection between cancer and viruses has long been theorized, and
case reports of cancer regression (cervical cancer, Burkitt
lymphoma, Hodgkin lymphoma) after immunization or infection with an
unrelated virus appeared at the beginning of the 20th century.
Efforts to treat cancer through immunization or deliberate
infection with a virus began in the mid 20th century.
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