High Quality Content by WIKIPEDIA articles! Ubiquitin-conjugating
enzyme E2 D2 is a protein that in humans is encoded by the UBE2D2
gene. The modification of proteins with ubiquitin is an important
cellular mechanism for targeting abnormal or short-lived proteins
for degradation. Ubiquitination involves at least three classes of
enzymes: ubiquitin-activating enzymes, or E1s,
ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein
ligases, or E3s. This gene encodes a member of the E2
ubiquitin-conjugating enzyme family. This enzyme functions in the
ubiquitination of the tumor-suppressor protein p53, which is
induced by an E3 ubiquitin-protein ligase. Two alternatively
spliced transcript variants have been found for this gene and they
encode distinct isoforms.
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