High Quality Content by WIKIPEDIA articles! Ubiquitin-conjugating
enzyme E2 L3 is a protein that in humans is encoded by the UBE2L3
gene. The modification of proteins with ubiquitin is an important
cellular mechanism for targeting abnormal or short-lived proteins
for degradation. Ubiquitination involves at least three classes of
enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating
enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene
encodes a member of the E2 ubiquitin-conjugating enzyme family.
This enzyme is demonstrated to participate in the ubiquitination of
p53, c-Fos, and the NF-kB precursor p105 in vitro. Two
alternatively spliced transcript variants encoding distinct
isoforms have been found for this gene.
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