High Quality Content by WIKIPEDIA articles! Voxel based morphometry
(VBM) is a neuroimaging analysis technique that allows
investigation of focal differences in brain anatomy, using the
statistical approach of so-called statistical parametric mapping.
In traditional morphometry, volume of the whole brain or its
subparts is measured by drawing regions of interest (ROIs) on
images from brain scanning and calculating the volume enclosed.
However, this is time consuming and can only provide measures of
rather large areas. Smaller differences in volume may be
overlooked. VBM registers every brain to a template, which gets rid
of most of the large differences in brain anatomy among people.
Then the brain images are smoothed so that each voxel represents
the average of itself and its neighbors. Finally, the image volume
is compared across brains at every voxel.
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