Tuberculin in Diagnosis and Treatment (Paperback)

This historic book may have numerous typos and missing text. Purchasers can usually download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1912 edition. Excerpt: ...dilution is used. If this gives no reaction, after an interval of four days, a second test is made with a stronger solution; if too violent a reaction occurs to 1 per cent., a weaker solution is employed for the second test. In this manner one searches for the dilution to which the individual gives a minimal cutaneous reaction. A minimal cutaneous reaction 1White and Graham: A quantitative modification of the von Pirquet tuberculin reaction and its value in diagnosis and prognosis. Jour. Med. Kesearch, 1909, xx, 347. Ibid.: An index to tuberculin treatment in tuberculosis by the minimal cutaneous reaction method. Ibid., 1909, xxi, 255. White and Van Norman: An individual quantitative basis for dosage in tuberculin treatment. Tr. Nat. Assn. for the Study and Prevention of Tuberc., 1910, vi, 224. is defined as a reaction that gives a redness and swelling measuring four to six millimeters in diameter within seventy-two hours. When one is pressed for time two tests, with different strengths of tuberculin, always putting the weaker distal to the stronger, may be performed simultaneously. However, this procedure is inadvisable. White claims the greatest accuracy for this method and states that from the minimal cutaneous reaction he is able to unerringly state the exact dose which, administered subcutaneously. will produce a local reaction and the exact amount necessary to liberate a general reaction. While White has anticipated important diagnostic and prognostic inferences from the determination of the minimal cutaneous reaction by what he terms the volumetric quantitative method, he has not so far published a sufficient number of cases to convincingly demonstrate them. He states specifically only that an absence of reaction to a certain...