Moxifloxacin is a fourth generation fluoroquinolone has potent
activity against Gram-positive bacteria, especially against
pneumococcus and anaerobes, and still retain excellent activity
against aerobic Gram-negative pathogens. I developed different
methods for simultaneous determination of quinolones with different
interacting drugs and performed drug-drug and drug-metals
interactions by using these methods. We have synthesized
derivatives and metal complexes of quinolones and characterized by
physicochemical and spectroscopic methods (FT-IR, 1HNMR and mass
spectrometry). The in-vitro antibacterial and antifungal activities
of resulting complexes and derivatives were also performed and
compared with the parent drug. Enzymatic activities of all
synthesized compounds were carried out against different enzymes
including urease, carbonic anhydrase, and -chymotrypsin."
Lap Lambert Academic Publishing
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||229 x 152 x 22mm (L x W x T)
||Paperback - Trade
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