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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology

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Protein Kinase C in Cancer Signaling and Therapy (Hardcover, Edition.) Loot Price: R5,969
Discovery Miles 59 690
You Save: R1,509 (20%)
Protein Kinase C in Cancer Signaling and Therapy (Hardcover, Edition.): Marcelo G. Kazanietz

Protein Kinase C in Cancer Signaling and Therapy (Hardcover, Edition.)

Marcelo G. Kazanietz

Series: Current Cancer Research

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List price R7,478 Loot Price R5,969 Discovery Miles 59 690 | Repayment Terms: R546 pm x 12* You Save R1,509 (20%)

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Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980's with its identification as an effector of phorbol esters, natural products with tumor promoting activity. Phorbol esters had long been of interest to the cancer research field due to early studies in the mouse skin carcinogenesis model, which showed that prolonged topical application of phorbol esters promoted the formation of skin tumors on mice previously treated with mutagenic agents. Research in the last years has established key roles for PKC isozymes in the control of cell proliferation, migration, adhesion, and malignant transformation. In addition, there is a large body of evidence linking PKC to invasion and cancer cell metastasis. Moreover, it is now well established that the expression of PKC isozymes is altered in various types of cancers. More importantly, small molecule inhibitors have been developed with significant anti-cancer activity. The relevance of PKC isozymes in cancer signaling is therefore remarkable. This book will have 4 sections. There will be 23 chapters. Each section will have a brief introduction by an expert in the field (~ 1-2 pages).

General

Imprint: HumanaPress
Country of origin: United States
Series: Current Cancer Research
Release date: 2010
First published: 2010
Editors: Marcelo G. Kazanietz
Dimensions: 235 x 155 x 33mm (L x W x T)
Format: Hardcover
Pages: 494
Edition: Edition.
ISBN-13: 978-1-60761-542-2
Categories: Books > Medicine > Clinical & internal medicine
Books > Medicine > Other branches of medicine
Books > Medicine > Clinical & internal medicine > Diseases & disorders
Books > Medicine > Other branches of medicine > Pharmacology
Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
Books > Medicine > Other branches of medicine > Pharmacology > General
Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
LSN: 1-60761-542-8
Barcode: 9781607615422

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