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Books > Professional & Technical > Industrial chemistry & manufacturing technologies > Industrial chemistry > Pharmaceutical technology

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Scaffold Hopping in Medicinal Chemistry (Hardcover) Loot Price: R2,386
Discovery Miles 23 860
You Save: R603 (20%)
Scaffold Hopping in Medicinal Chemistry (Hardcover): Nathan Brown

Scaffold Hopping in Medicinal Chemistry (Hardcover)

Nathan Brown; Series edited by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

Series: Methods and Principles in Medicinal Chemistry

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List price R2,989 Loot Price R2,386 Discovery Miles 23 860 | Repayment Terms: R222 pm x 12* You Save R603 (20%)

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This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader's own projects. The first section serves as an introduction to the topic by describing the concept of scaffolds, their discovery, diversity and representation, and their importance for finding new chemical entities. The following part describes the most common tools and methods for scaffold hopping, whether topological, shape-based or structure-based. Methods such as CATS, Feature Trees, Feature Point Pharmacophores (FEPOPS), and SkelGen are discussed among many others. The final part contains three fully documented real-world examples of successful drug development projects by scaffold hopping that illustrate the benefits of the approach for medicinal chemistry. While most of the case studies are taken from medicinal chemistry, chemical and structural biologists will also benefit greatly from the insights presented here.

General

Imprint: Wiley-VCH Verlag GmbH
Country of origin: Germany
Series: Methods and Principles in Medicinal Chemistry
Release date: December 2013
First published: 2014
Editors: Nathan Brown
Series editors: Raimund Mannhold • Hugo Kubinyi • Gerd Folkers
Dimensions: 246 x 177 x 22mm (L x W x T)
Format: Hardcover
Pages: 328
ISBN-13: 978-3-527-33364-6
Categories: Books > Science & Mathematics > Chemistry
Books > Professional & Technical > Industrial chemistry & manufacturing technologies
Books > Science & Mathematics > Chemistry > General
Books > Professional & Technical > Industrial chemistry & manufacturing technologies > Industrial chemistry
Books > Professional & Technical > Industrial chemistry & manufacturing technologies > Industrial chemistry > Pharmaceutical technology
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LSN: 3-527-33364-9
Barcode: 9783527333646

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