With the increasing interest in the experimental and clinical
application of molecular imaging many institutions create research
groups or interdisciplinary centers focussing on the complex
development process of this new methodology. The aim of this
textbook of molecular imaging is to provide an up to date review of
this rapidly growing field and to discuss basic methodological
aspects necessary for the interpretation of experimental and
clinical results. Emphasis is placed on the interplay of imaging
technology and probe development, since the physical properties of
the imaging approach need to be closely linked with the biologic
application of the probe (i.e. nanoparticles and microbubbles).
Various chemical strategies are discussed and related to the
biologic applications. Reporter-gene imaging is beeing addressed
not only in experimental protocols, but also first clinical
applications are discussed. Finally, strategies of imaging to
characterize apoptosis and angiogenesis are described and discussed
in the context of possible clinical translation.
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