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Showing 1 - 11 of 11 matches in All departments

Synthesis of Heterocycles via Cycloadditions II (Hardcover, 2008 ed.): Alfred Hassner Synthesis of Heterocycles via Cycloadditions II (Hardcover, 2008 ed.)
Alfred Hassner
R7,012 R5,829 Discovery Miles 58 290 Save R1,183 (17%) Shipped within 7 - 12 working days

Heterocyclicmoleculesplayasigni?cantroleinlifeprocessesandhaveplayed a major rolein industrial developments of the last century, for instance in the ?eld of dyes, pharmaceuticals, pesticides, polymers etc. They comprise not onlysomeofthemostinterestingandbiologicallyimportantnaturalproducts like alkaloids, carbohydrates, nucleic acids, and antibiotics but include many practical drugs and a large segment of known synthetic organic compounds. Hencescientistshavedevotedagreatamountofeffortto?ndoptimalsynthetic approachesto a variety ofheterocyclic compounds. Amongthemostsuccessfulandselectivesyntheticprocessesarecycload- tionreactions, since theyinvolvesimultaneous orsequential formationoftwo or more bonds often with a high degree of stereoselectivity and regiosel- tivity.Forinstance, 1,3 dipolar cycloadditions, whichare electronicallyequ- alent to Diels-Alder reactions, are among the most-common 5-membered ring-forming systems. In addition they usually proceed with a high degree of stereo-andregio-control.Itistherefore, notsurprising thatsynthesisofmany important classes ofheterocycles, including thoseof useful biologicallyactive molecules, have utilized cycloadditionsteps intheirformation.Furthermore, many heterocycles serve as intermediates in the synthesis of polyfunctional molecules. Volume I of "Synthesis of Heterocycles via Cycloadditions" featured ?ve chapters onthe followingtopics: - Isoxazolines fromNitroCompounds: Synthesis and Applications; - Cycloaddition Reactions of Azides Including Bioconjugation; - Enantioselective Cycloadditions ofAzomethine Ylides; - Heterocyclesby Cycloadditions of CarbonylYlides Generated fromDiazo Ketones; - HeterocyclesfromUnsaturated Phosphorus Ylides. In this volume we present four selected contributions by well-known authors, each an authority in his ?eld. The ?rst chapter is devoted to the use of oximes in cycloadditions which leads to formationof isoxazolines and isoxazolidines and from there to synthesis of macrolides like amphotericin and of other natural products and bioactive molecules. Furthermore, 4+2 cycloadditions of nitrosoalkenes are also included. This chapter complements the one in the X Preface previous volume which discussed access to isoxazolines via nitroalkanes.

Small Ring Heterocycles, Part 1 - Aziridines, Azirines, Thiiranes, Thiirenes (Hardcover, Volume 42): Alfred Hassner Small Ring Heterocycles, Part 1 - Aziridines, Azirines, Thiiranes, Thiirenes (Hardcover, Volume 42)
Alfred Hassner
R10,426 R9,621 Discovery Miles 96 210 Save R805 (8%) Shipped within 7 - 13 working days

The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects - properties, synthesis, reactions, physiological and industrial significance - of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.

Synthesis of Heterocycles via Cycloadditions I (Hardcover, 2008 ed.): Alfred Hassner Synthesis of Heterocycles via Cycloadditions I (Hardcover, 2008 ed.)
Alfred Hassner
R6,160 R5,129 Discovery Miles 51 290 Save R1,031 (17%) Shipped within 7 - 12 working days

Heterocyclicmoleculesplayasigni?cantroleinlifeprocessesandhaveplayed a major rolein industrial developments of the last century, for instance in the ?eld of dyes, pharmaceuticals, pesticides, polymers etc. They comprise not onlysomeofthemostinterestingandbiologicallyimportantnaturalproducts like alkaloids, carbohydrates, nucleic acids, and antibiotics but include many practical drugs and a large segment of known synthetic organic compounds. Hencescientistshavedevotedagreatamountofeffortto?ndoptimalsynthetic approachesto a variety ofheterocyclic compounds. Amongthemostsuccessfulandselectivesyntheticprocessesarecycload- tionreactions, since theyinvolvesimultaneous orsequential formationoftwo ormorebondsoftenwithahighdegreeofstereoselectivityandregioselectivity. Forinstance, 1,3 dipolar cycloadditionsareelectronicallyequivalent to Diels- Alder reactions and are among the most common 5-membered ring-forming systems. In addition they usually proceed with a high degree of stereo- and regio-control.It is therefore, not surprising that synthesis of many important classesofheterocycles, includingthoseofusefulbiologicallyactivemolecules, haveutilized cycloadditionsteps intheir formation.Furthermore, manyhe- rocyclesserve as intermediates in the synthesis of polyfunctional molecules. In this volume we present ?ve selected contributions by well-known - thors, each an authority in his ?eld. The ?rst chapter deals with construction ofisoxazolines(dihydroisoxazoles)via1,3-dipolarcycloadditionsofnitronates or of nitrile oxides generated from nitroalkanes. This includes inter- as well as intramolecular processes. Many of these heterocycles possess important synthetic and biological properties and are shown to lead to stereo- and - gioselectiveintroductionofmultifunctionalmoleculessuchasaminoalcohols, ?-amino acids, aldols, nitriles, and othe

Small Ring Heterocycles, Part 3 (Hardcover, Volume 42): Alfred Hassner Small Ring Heterocycles, Part 3 (Hardcover, Volume 42)
Alfred Hassner
R10,431 R9,626 Discovery Miles 96 260 Save R805 (8%) Shipped within 7 - 13 working days

The chemistry of heterocyclic compounds is one of the most complex branches of organic chemistry. It is equally interesting for its theoretical implications, for the diversity of its synthetic procedures, and for the physiological and industrial significance of heterocyclic compounds. The aim of this series is to offer expert presentations of the various branches of heterocyclic chemistry. The subdivisions have been designed to cover the field in its entirety by monographs which reflect the importance and the interrelations of the various compounds, and accommodate the specific interests of the authors.

Small Ring Heterocycles, Part 2 (Hardcover, Volume 42): Alfred Hassner Small Ring Heterocycles, Part 2 (Hardcover, Volume 42)
Alfred Hassner
R10,876 Discovery Miles 108 760 Shipped within 7 - 11 working days

The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects - properties, synthesis, reactions, physiological and industrial significance - of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.

Advances in Asymmetric Synthesis, Volume 2 (Hardcover): Gerard Meurant Advances in Asymmetric Synthesis, Volume 2 (Hardcover)
Gerard Meurant; Edited by Alfred Hassner
R2,349 Discovery Miles 23 490 Special order

Novel asymmetric synthetic methods are a vital strategem in the armoury of the organic chemist, particularly for those involved in the preparation or application of chiral organic molecules. this series is devoted to presenting the latest advances in the field of asymmetric synthesis, drawing contributions on emerging areas and articles providing authoritative perspectives on more developed synthetic stategies from leading researchers in the field. This volume consists of six contributions on a variety of topical areas, ranging from the preparation and application of chiral cylopentadienes, the synthesis of non-racemic amines, diketones and -keto esters and ferrocenes, to the use of biocatalysis and application of microbial methods for the synthesis of chiral molecules and fine chemicals.

Organic Syntheses Based on Name Reactions, Volume 22 (Paperback, 2nd edition): C. Stumer, Alfred Hassner Organic Syntheses Based on Name Reactions, Volume 22 (Paperback, 2nd edition)
C. Stumer, Alfred Hassner; Series edited by J.E. Baldwin, Robert M. Williams
R900 Discovery Miles 9 000 Special order

Since the publication of "Organic Syntheses Based on Name Reactions and Unnamed Reactions"(Volume 11 in the Tetrahedron Organic Chemistry series), there has been a proliferation of discoveries of name reactions in the field of organic chemistry. Hence, this, the second, revised, edition of the text has focused on the ongoing development in this area of research. The revised title reflects the notion whereby many new reagents and reactions are now being referred to by their names. The inclusion of over 155 new stereoselective and regioselective reagents or reactions including asymmetric syntheses, brings the total to over 540. Features that should be valuable to the reader include over 3000 references, a names index, reagent index, reaction index and a functional group transformation index. The latter of these indexes will allow the reader to search for conversions of one functional group to another and has proved a much utilized tool for the synthetic chemist, searching for pathways to perform synthetic procedures.

Stereoselective Heterocyclic Synthesis III (Paperback, Softcover reprint of the original 1st ed. 2001): Peter Metz Stereoselective Heterocyclic Synthesis III (Paperback, Softcover reprint of the original 1st ed. 2001)
Peter Metz; Contributions by Alfred Hassner, P.Ten Holte, I.N.N. Namboothiri, Udo Nubbemeyer, …
R5,483 R5,166 Discovery Miles 51 660 Save R317 (6%) Special order

Keeping up with the advances in modern heterocyclic chemistry is essential for many of our colleagues in academia and industry. It is the aim of this series on "Stereoselective Heterocyclic Synthesis" to assist the chemical community in this respect by presenting a selection of exciting recent developments. As it was for the first two volumes (1997), the stereoselective synthesis of - or with the aid of - heterocycles is the common motif for all the chapters in this third volume. I am very glad that again leading researchers in this area have contrib- ed highly stimulating accounts with up-to-date coverage. "Stereoselective Heterocyclic Synthesis 111" features chapters on "Stereoselective Intramolecular J,3-Dipolar Cycloadditions" by I. N. N. Nambothiiri and A. Hassner giving an in depth survey of the generation and synthetic application of valuable 1,3-dipoles,"4-Acetoxy- and 4-Cyano-12-dioxanes in Synthesis" by C. J. Sinz and S. D. Rychnovsky presenting a comprehensive summary of the utility of the versatile title compounds in natural products synthesis,"The Synthetic Potential of Three-Membered Ring Aza-Heterocycles" by B. Zwanenburg and l? ten Holte highlighting the fascinating chemistry of aziridine and azirine carboxylic esters, and '(Synthesis of Medium-Sized Ring Lactams" by U. Nubbemeyer discussing a wide range of modern strategies for the stereoselective preparation of these important heterocycles. I wish to express my thanks to all contributors for their dedicated effort and to Mrs. Kollmar-Thoni, Springer-Verlag, for her continuous support. Dresden, March 2001 Peter Metz Contents Stereoselective Intramolecular 1. 3. Dipolar Cycloadditions I. N. N. Namboothiri. A . Hassner . . . . . . . . . . . . . . . . . . . . . . .

Advances in Asymmetric Synthesis, Volume 3 (Hardcover): Alfred Hassner Advances in Asymmetric Synthesis, Volume 3 (Hardcover)
Alfred Hassner
R2,245 Discovery Miles 22 450 Special order

Enantioselective synthetic methods are not only in the forefront of chemical and pharmaceutical research but activity in this area is constantly increasing. It is stimulated by the urgency to obtain drugs or compounds of medicinal interest as single anantiomers, and the keeness to synthesize natural products in nonracemic form. This volume presents seven chapters from pioneers and authorities in this rapidly expanding field.

Synthesis of Heterocycles via Cycloadditions I (Paperback, Softcover reprint of hardcover 1st ed. 2008): Alfred Hassner Synthesis of Heterocycles via Cycloadditions I (Paperback, Softcover reprint of hardcover 1st ed. 2008)
Alfred Hassner
R5,485 R5,169 Discovery Miles 51 690 Save R316 (6%) Special order

Heterocyclicmoleculesplayasigni?cantroleinlifeprocessesandhaveplayed a major rolein industrial developments of the last century, for instance in the ?eld of dyes, pharmaceuticals, pesticides, polymers etc. They comprise not onlysomeofthemostinterestingandbiologicallyimportantnaturalproducts like alkaloids, carbohydrates, nucleic acids, and antibiotics but include many practical drugs and a large segment of known synthetic organic compounds. Hencescientistshavedevotedagreatamountofeffortto?ndoptimalsynthetic approachesto a variety ofheterocyclic compounds. Amongthemostsuccessfulandselectivesyntheticprocessesarecycload- tionreactions, since theyinvolvesimultaneous orsequential formationoftwo ormorebondsoftenwithahighdegreeofstereoselectivityandregioselectivity. Forinstance, 1,3 dipolar cycloadditionsareelectronicallyequivalent to Diels- Alder reactions and are among the most common 5-membered ring-forming systems. In addition they usually proceed with a high degree of stereo- and regio-control.It is therefore, not surprising that synthesis of many important classesofheterocycles, includingthoseofusefulbiologicallyactivemolecules, haveutilized cycloadditionsteps intheir formation.Furthermore, manyhe- rocyclesserve as intermediates in the synthesis of polyfunctional molecules. In this volume we present ?ve selected contributions by well-known - thors, each an authority in his ?eld. The ?rst chapter deals with construction ofisoxazolines(dihydroisoxazoles)via1,3-dipolarcycloadditionsofnitronates or of nitrile oxides generated from nitroalkanes. This includes inter- as well as intramolecular processes. Many of these heterocycles possess important synthetic and biological properties and are shown to lead to stereo- and - gioselectiveintroductionofmultifunctionalmoleculessuchasaminoalcohols, ?-amino acids, aldols, nitriles, and othe

Synthesis of Heterocycles via Cycloadditions II (Paperback, Softcover reprint of hardcover 1st ed. 2008): Alfred Hassner Synthesis of Heterocycles via Cycloadditions II (Paperback, Softcover reprint of hardcover 1st ed. 2008)
Alfred Hassner
R5,484 R5,167 Discovery Miles 51 670 Save R317 (6%) Special order

Heterocyclicmoleculesplayasigni?cantroleinlifeprocessesandhaveplayed a major rolein industrial developments of the last century, for instance in the ?eld of dyes, pharmaceuticals, pesticides, polymers etc. They comprise not onlysomeofthemostinterestingandbiologicallyimportantnaturalproducts like alkaloids, carbohydrates, nucleic acids, and antibiotics but include many practical drugs and a large segment of known synthetic organic compounds. Hencescientistshavedevotedagreatamountofeffortto?ndoptimalsynthetic approachesto a variety ofheterocyclic compounds. Amongthemostsuccessfulandselectivesyntheticprocessesarecycload- tionreactions, since theyinvolvesimultaneous orsequential formationoftwo or more bonds often with a high degree of stereoselectivity and regiosel- tivity.Forinstance, 1,3 dipolar cycloadditions, whichare electronicallyequ- alent to Diels-Alder reactions, are among the most-common 5-membered ring-forming systems. In addition they usually proceed with a high degree of stereo-andregio-control.Itistherefore, notsurprising thatsynthesisofmany important classes ofheterocycles, including thoseof useful biologicallyactive molecules, have utilized cycloadditionsteps intheirformation.Furthermore, many heterocycles serve as intermediates in the synthesis of polyfunctional molecules. Volume I of "Synthesis of Heterocycles via Cycloadditions" featured ?ve chapters onthe followingtopics: - Isoxazolines fromNitroCompounds: Synthesis and Applications; - Cycloaddition Reactions of Azides Including Bioconjugation; - Enantioselective Cycloadditions ofAzomethine Ylides; - Heterocyclesby Cycloadditions of CarbonylYlides Generated fromDiazo Ketones; - HeterocyclesfromUnsaturated Phosphorus Ylides. In this volume we present four selected contributions by well-known authors, each an authority in his ?eld. The ?rst chapter is devoted to the use of oximes in cycloadditions which leads to formationof isoxazolines and isoxazolidines and from there to synthesis of macrolides like amphotericin and of other natural products and bioactive molecules. Furthermore, 4+2 cycloadditions of nitrosoalkenes are also included. This chapter complements the one in the X Preface previous volume which discussed access to isoxazolines via nitroalkanes.

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