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Medicinal Chemistry Approaches to Personalized Medicine (Hardcover): Karen Lackey, Bruce Roth Medicinal Chemistry Approaches to Personalized Medicine (Hardcover)
Karen Lackey, Bruce Roth; Series edited by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
R3,343 R2,346 Discovery Miles 23 460 Save R997 (30%) Shipped within 7 - 13 working days

Edited by two renowned medicinal chemists who have pioneered the development of personalized therapies in their respective fields, this authoritative analysis of what is already possible is the first of its kind, and the only one to focus on drug development issues. Numerous case studies from the first generation of "personalized drugs" are presented, highlighting the challenges and opportunities for pharmaceutical development. While the majority of these examples are taken from the field of cancer treatment, other key emerging areas, such as neurosciences and inflammation, are also covered. With its careful balance of current and future approaches, this handbook is a prime knowledge source for every drug developer, and one that will remain up to date for some time to come. From the content: * Discovery of Predictive Biomarkers for Anticancer Drugs * Discovery and Development of Vemurafenib * Targeting Basal-Cell Carcinoma * G-Quadruplexes as Therapeutic Targets in Cancer * From Human Genetics to Drug Candidates: An Industrial Perspective on LRRK2 Inhibition as a Treatment for Parkinson's Disease * Therapeutic Potential of Kinases in Asthma * DNA Damage Repair Pathways and Synthetic Lethality * Medicinal Chemistry in the Context of the Human Genome and many more

Stepping Forward - How the Twelve Steps Can Help Anyone (Paperback): Bruce Roth Stepping Forward - How the Twelve Steps Can Help Anyone (Paperback)
Bruce Roth
R341 Discovery Miles 3 410 Shipped within 7 - 11 working days

This book is a compelling story about a man who has made some wrong decisions. He meets some people who take him in and show him how to work the Twelve Steps. As a result of these efforts, he turns his life around and gains a new level of understanding in his life. The steps allow him a new level of success that exceeds anything he has achieved in his life and the benefits extend to all areas of his life. They can help you as well even though you haven't had a problem with addiction. This book is a faxt and easy read that you will love. Bruce Roth is a native Californian and a graduate of Los Angeles City College. He is married to Robyn Gayle Roth and they have 4 children David, Emily, Elizabeth and Sarah. They have a dog named Bear. He is now responsible for his father who needs round the clock care. He has spent the last 25 years in recovery working the 12 steps as well as reading many books about human psychology, spirituality and personal development. He has made a study of Universal Principles as he sees having an understanding of Universal Principles can make each of us more effective in all we do. He has given well over 100 public presentations on various topics such as, "Credit Scoring" "The Greatest Salesman In The World" "How To Find A Job In 14 Days Or Less" along with other recovery related topics. He has now written three books titled, "How To Find A Job In 14 Days Or Less," "Universal Principles For 52 weeks" and "Step Sister." Bruce works as a Real Estate Broker doing property management, rentals and sales transactions. He has been in the Real Estate business since 1986. He has a unique way of serving his clients. He believes in complete honesty with his clients even when they don't want to hear what he has to say. Most people who have used his service really like his style. The few who don't want an honest Broker, should look for a less honest and committed Agent. Bruce's most recent book, "Step Sister" comes out of his experience with the 12 steps, recovery and his study of Universal Principles. In various 12 step meetings, he heard many people who have shared about the strength, healing and power they have gotten by working the steps. He hears many times how someone would say how they had a particular problem because of their addiction and that working the steps created an effective solution for them in their life. When listening to these people share, it occurred to him that the problems they described were not unique to people with an addiction, but rather were common to all human beings. If all humans have similar problems, he thought, could others not also get as much help from the steps as people with and addiction? In this spirit, he wrote a story of a normal man who had some problems in his own life. Like all of us, his problems were of his own making. When he was at his lowest, he found a group of people working the steps and he began his life anew. He made a life that was just as good as it had been before but was based on Universal Principles and the lessons he learned by working the 12 steps. This book is written to introduce people who have not had an addiction to drugs, sex, gambling or some other form of self defeating behavior. It is written in the style of best selling books such as "The One Minute Manager" and "Who Moved My Cheese." This book can make a profound difference in anyone's life. Don't wait to read it.

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