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Most drugs are analogue drugs. There are no general rules how a new
drug can be discovered, nevertheless, there are some observations
which help to find a new drug, and also an individual story of a
drug discovery can initiate and help new discoveries. Volume III is
a continuation of the successful book series with new examples of
established and recently introduced drugs.
Born out of a project of the IUPAC's committee on Medicinal
Chemistry and Drug Development, this reference addresses past and
current strategies for successful drug analog development,
extending the previously published volume by nine new analog
classes and eight case studies. Like its precursor, this volume
also contains a general section discussing universally applicable
strategies for analog discovery and development. Spanning a wide
range of therapeutic fields and chemical classes, the two volumes
together constitute the first systematic approach to drug analog
The first authoritative overview of past and current strategies for successful drug development by analog generation, this unique resource spans all important drug classes and all major therapeutic fields, including histamine antagonists, ACE inhibitors, beta blockers, opioids, quinolone antibiotics, steroids and anticancer platinum compounds.
Of the 19 analog classes presented in detail, 9 are described by the scientists who discoverd them.
The book includes a table of the most successful drug analogs as based on the IMS ranking and compares them in terms of chemical structure, mode of action and patentability.
"Introduction to Biological and Small Molecule Drug Research and Development "provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the business and management issues of these approaches. The latter part of the book provides carefully selected real-life case studies illustrating how the theory presented in the first part of the book is actually put into practice. Studies include Herceptin/T-DM1, erythropoietin (Epogen/Eprex/NeoRecormon), anti-HIV protease inhibitor Darunavir, and more.
"Introduction to Biological and Small Molecule Drug Research and
Development" is intended for late-stage undergraduates or
postgraduates studying chemistry (at the biology interface),
biochemistry, medicine, pharmacy, medicine, or allied subjects. The
book is also useful in a wide variety of science degree courses, in
post-graduate taught material (Masters and PhD), and as basic
background reading for scientists in the pharmaceutical
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