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Analogue-based Drug Discovery III (Hardcover): Janos Fischer, C. Robin Ganellin, David P. Rotella Analogue-based Drug Discovery III (Hardcover)
Janos Fischer, C. Robin Ganellin, David P. Rotella
R3,326 R2,684 Discovery Miles 26 840 Save R642 (19%) Shipped within 7 - 12 working days

Most drugs are analogue drugs. There are no general rules how a new drug can be discovered, nevertheless, there are some observations which help to find a new drug, and also an individual story of a drug discovery can initiate and help new discoveries. Volume III is a continuation of the successful book series with new examples of established and recently introduced drugs.
The major part of the book is written by key inventors either as a case study or a study of an analogue class. With its wide range across a variety of therapeutic fields and chemical classes, this is of interest to virtually every researcher in drug discovery and pharmaceutical chemistry, and -- together with the previous volumes -- constitutes the first systematic approach to drug analogue development.

Analogue-based Drug Discovery II (Hardcover): Janos Fischer, C. Robin Ganellin Analogue-based Drug Discovery II (Hardcover)
Janos Fischer, C. Robin Ganellin
R4,152 R3,367 Discovery Miles 33 670 Save R785 (19%) Shipped within 7 - 12 working days

Born out of a project of the IUPAC's committee on Medicinal Chemistry and Drug Development, this reference addresses past and current strategies for successful drug analog development, extending the previously published volume by nine new analog classes and eight case studies. Like its precursor, this volume also contains a general section discussing universally applicable strategies for analog discovery and development. Spanning a wide range of therapeutic fields and chemical classes, the two volumes together constitute the first systematic approach to drug analog development.
Of interest to virtually every researcher working in drug discovery and pharmaceutical chemistry.

Analogue-based Drug Discovery (Hardcover): IUPAC (International Union of Pure and Applied Chemistry), Janos Fischer, C. Robin... Analogue-based Drug Discovery (Hardcover)
IUPAC (International Union of Pure and Applied Chemistry), Janos Fischer, C. Robin Ganellin
R5,938 R4,139 Discovery Miles 41 390 Save R1,799 (30%) Shipped within 7 - 13 working days

The first authoritative overview of past and current strategies for successful drug development by analog generation, this unique resource spans all important drug classes and all major therapeutic fields, including histamine antagonists, ACE inhibitors, beta blockers, opioids, quinolone antibiotics, steroids and anticancer platinum compounds.

Of the 19 analog classes presented in detail, 9 are described by the scientists who discoverd them.

The book includes a table of the most successful drug analogs as based on the IMS ranking and compares them in terms of chemical structure, mode of action and patentability.

Introduction to Biological and Small Molecule Drug Research and Development - Theory and Case Studies (Hardcover, New): C.... Introduction to Biological and Small Molecule Drug Research and Development - Theory and Case Studies (Hardcover, New)
C. Robin Ganellin, Stanley M Roberts, Roy Jefferies
R1,956 Discovery Miles 19 560 Special order

"Introduction to Biological and Small Molecule Drug Research and Development "provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the business and management issues of these approaches. The latter part of the book provides carefully selected real-life case studies illustrating how the theory presented in the first part of the book is actually put into practice. Studies include Herceptin/T-DM1, erythropoietin (Epogen/Eprex/NeoRecormon), anti-HIV protease inhibitor Darunavir, and more.

"Introduction to Biological and Small Molecule Drug Research and Development" is intended for late-stage undergraduates or postgraduates studying chemistry (at the biology interface), biochemistry, medicine, pharmacy, medicine, or allied subjects. The book is also useful in a wide variety of science degree courses, in post-graduate taught material (Masters and PhD), and as basic background reading for scientists in the pharmaceutical industry.
For the first time, the fundamental scientific principles of biopharmaceuticals and small molecule chemotherapeutics are discussed side-by-side at a basic levelEdited by three senior scientists with over 100 years of experience in drug research who have compiled the best scientific comparison of small molecule and biopharmaceuticals approaches to new drugsIllustrated with key examples of important drugs that exemplify the basic principles of pharmaceutical drug research and development

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