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Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response (Hardcover, 2008 ed.): Hans E. Kaiser Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response (Hardcover, 2008 ed.)
Hans E. Kaiser; Adapted by N.A. Nasir; Edited by Aejaz Nasir
R4,419 R3,344 Discovery Miles 33 440 Save R1,075 (24%) Shipped within 7 - 12 working days

The processes of tumor metastasis, apoptosis and anti-tumor immune response are among the most complex yet rapidly advancing fields in the area of cancer research. This monogaph presents a comprehensive coverage of the recent advances in the various key concepts in these fundamental aspects of human cancer. It would be of particular interest to members of the cancer research community, especially those who are actively involved in the study of basic and translational aspects of human cancer. Specifically, this volume includes authentic subject reviews by leading experts on the following aspects:

  • Control of tumor cell motility
  • Role of tumor-cell adhesion and migration in organ-selective metastasis-formation
  • Tumor heterogeneity in relation to invasion and metastasis and its clinical implications
  • Tumor angiogenesis, angioprevention, anti-angiogenic therapies and response
  • Role of apoptosis in the development, progression and therapy of cancer
  • Role of macrophages in tumor development and metastasis
  • Pathways of macrophage-mediated tumor progression
  • Abnormal variation of immune response against cancer
  • Immunological aspects of Mareka (TM)s disease virus (MDV)-induced lymphoma progression
  • A biodynamical model of human T-cell proliferative disorders
  • Current methodologies for characterization of tumor directed immune response
Comparative Aspects of Tumor Development (Paperback, Softcover reprint of the original 1st ed. 1989): Hans E. Kaiser Comparative Aspects of Tumor Development (Paperback, Softcover reprint of the original 1st ed. 1989)
Hans E. Kaiser
R1,627 Discovery Miles 16 270 Out of stock

of the interaction and relationship of both systems is chal- In this volume, aspects of neoplastic spread, already elu- cidated in Volumes I-IV of this series, are considered lenging indeed. against a broad biological background. The mammalian The volume also reviews environmental oncology and species-specific aspects of environmental chain reactions. It orders constituting the logical framework for man as focal point of a comparative oncology are reviewed. Selected is apparent that the environment plays a significant role in examples of neoplastic progression in various taxonomic the development of neoplasms. Neoplasms among the spe- units are provided, beginning with the opposite pole of ci es have become much more common as a result of man's taxonomic development, the vascular plants, where no impact on the environment. The latter chapters present a metastatis of malignant neoplasms occur. Among in- brief review of geologic and technologic and cuItural vertebrates, vertebrates, and vascular plants, Iining mem- changes, and the implications of species-specific cancer pro- branes (epithelia) exhibit the highest degree of comparabil- gression. The remainder of this section outlines a number of ity. Metastases also occur, but more rarely, in invertebrates; selected chain reactions leading to neoplastic development and are discussed as they are found in the nonmammalian in certain members of these chains. A discussion of the vertebrates: in fish, amphibians, reptiles, and birds. Diseases storage of chemical carcinogens in plants and their interac- ofthe leukemia (Ieucosis)-Iymphoma complex are present in tion with other causes of neoplastic growth is also included.

Molecular Markers of Brain Tumor Cells - Implications for Diagnosis, Prognosis and Anti-Neoplastic Biological Therapy... Molecular Markers of Brain Tumor Cells - Implications for Diagnosis, Prognosis and Anti-Neoplastic Biological Therapy (Paperback, Softcover reprint of hardcover 1st ed. 2004)
Bela Bodey, Stuart E Siegel, Hans E. Kaiser
R2,439 R2,314 Discovery Miles 23 140 Save R125 (5%) Out of stock

I. MOLECULAR BIOLOGY OF TUMORS.

1. Brain Tumors

1. Introduction

2. Medulloblastoma

3. Glial Tumors

2. Immunophenotypic Characterization of Infiltrating Poly- and Mononuclear Cells in Childhood Brain Tumors

1. Introduction

2. The Significance of Immunohistochemistry

3. Original Immunohistochemical Observations

4. Intermediate filaments (IFs)

5. Expression of Homeobox B3, B4, and C6 Gene Products

6. Cell proliferation

7. Epidermal growth factor (EGF) and its receptor (EGFR)

8. p53, the guardian of the integrity of the genome

9. Apoptosis in Brain Tumors

10. Survivin

11. Tumor-related Neoangiogenesis in Childhood Brain Tumors

12. Presence of Matrix Metalloproteinases (MMPs)

13. The MAGE gene family

II. ANTI-NEOPLASTIC BIOLOGICAL THERAPIES

3. Experimental Therapies in Brain Tumors

4. Biologic Anti-Neoplastic Therapies

1. Introduction

2. Active nonspecific immunomodulation of natural immunity

3. Thymic hormones

4. Interferons: basic and preclinical studies

5. Tumor Necrosis Factors

6. The discovery of interleukin-2: basic principles

5. The lymphokine activated killer (LAK) cell phenomenon

1. Administration of rIL-2 and LAK cells: preclinical trials

6. Angiogenesis Inhibition in Anti-Neoplastic Therapy

7. Antigen Presentation by Dendritic Cells and Their Significance in Anti-Neoplastic Immunotherapy

1. Active antigen specific immunotherapy (tumor vaccines)

2. Antigen Presentation within Childhood Brain Tumors

3. Immunosuppression within the Cellular Microenvironment of Childhood Brain Tumors

4. The Dendritic Cell Network

5. Antigen Presentation by DCs

6. The Significance of DCs in Anti-Neoplastic Immunotherapy

8. Genetically Engineered Antibodies for Direct Anti-Neoplastic Treatment and Systematic Delivery of Various Therapeutic Agents to Cancer Cells

1. Introduction

2. Human Cancer Cell Related Antigens

3. Oncogenes and Growth Factors in Neoplastic Cells

4. Antibodies and Neoplastic Cells

5. Anti-neoplastic Immunotherapeutical Regiments Influenced by Immunohistochemistry

6. Human Antibodies

7. Anti-Idiotypic Antibodies

8. Bispecific Antibodies

9. Radiolabeled Antibodies

10. Construction of Immunotoxins

11. Monoclonal Antibodies: Carriers of Drugs, Toxins and Cytotoxic Cells

12. Clinical Trials with Monoclonal Antibodies and their Minimal Toxicity

9. Cancer-Testis Antigens: Promising Targets for Antigen Directed Anti-neoplastic Immunotherapy

1. Introduction

2. Cancer/Testis Antigens

3. Detection of Cancer/Testis Antigens in Various Malignant Neoplasms and their Therapeutic Significance

Prologue

III. APPENDIX

10. Materials and Methods

1. Tissues and Tissue Handling

2. Libraries of Antibodies

3. Antigen Retrieval Technique

4. Immunoalkaline Phosphatase Antigen Detection Technique

5. Immunoperoxidase Antigen Detection Technique

6. Controls in Immunocytochemistry

7. Evaluation of the Immunoreactivity (immunostaining)

8. Tissue Processing for Tissue Culture Experiments

9. Preparation of Thymic, Peripheral Blood and Bone Marrow Cell Suspensions

10. Isolation of Cortical Thymocytes

11. Isolation of Thymic Nurse Cells (TNCs)

12. Thymic Stromal Cell (RE & DC) Cultures

13. Proliferation Assay (PA) for Thymocytes and Peripheral Blood Hematopoietic Cells

14. Transmission Electronmicroscopy (TEM) of Cultured Thymic Medullary Cells (RE, DC, including LC, & IDC) and Macrophages

15. Scanning Electronmicroscopic (SEM) Procedure for Tissue Samples

Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response (Paperback, Softcover reprint of hardcover... Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response (Paperback, Softcover reprint of hardcover 1st ed. 2008)
Hans E. Kaiser; Adapted by N.A. Nasir; Edited by Aejaz Nasir
R3,097 R2,931 Discovery Miles 29 310 Save R166 (5%) Out of stock

The processes of tumor metastasis, apoptosis and anti-tumor immune response are among the most complex yet rapidly advancing fields in the area of cancer research. This monogaph presents a comprehensive coverage of the recent advances in the various key concepts in these fundamental aspects of human cancer. It would be of particular interest to members of the cancer research community, especially those who are actively involved in the study of basic and translational aspects of human cancer. Specifically, this volume includes authentic subject reviews by leading experts on the following aspects:

  • Control of tumor cell motility
  • Role of tumor-cell adhesion and migration in organ-selective metastasis-formation
  • Tumor heterogeneity in relation to invasion and metastasis and its clinical implications
  • Tumor angiogenesis, angioprevention, anti-angiogenic therapies and response
  • Role of apoptosis in the development, progression and therapy of cancer
  • Role of macrophages in tumor development and metastasis
  • Pathways of macrophage-mediated tumor progression
  • Abnormal variation of immune response against cancer
  • Immunological aspects of Marek s disease virus (MDV)-induced lymphoma progression
  • A biodynamical model of human T-cell proliferative disorders
  • Current methodologies for characterization of tumor directed immune response
"
Molecular Markers of Brain Tumor Cells - Implications for Diagnosis, Prognosis and Anti-Neoplastic Biological Therapy... Molecular Markers of Brain Tumor Cells - Implications for Diagnosis, Prognosis and Anti-Neoplastic Biological Therapy (Hardcover, 2004 ed.)
Bela Bodey, Stuart E Siegel, Hans E. Kaiser
R3,326 R3,146 Discovery Miles 31 460 Save R180 (5%) Out of stock

Childhood brain tumors are a diverse group of diseases characterized by the abnormal growth of tissue contained within the skull. Other than leukemia and lymphoma, brain tumors are the most common type of neoplasms that occur in children. The leading cause of death from childhood neoplasms among persons up to 19 years is brain tumors. As such, this book is a review of the most recent molecular biological research concerning brain tumors with references and comparisons to a variety of neoplastic disorders. The book then uses this information to foreshadow the direction that future anti-neoplastic therapies will take. Because of the wide spectrum of the objectives of the book, any individual involved in cancer research will greatly benefit from the work. Histopathologists, neuropathologists, clinical and research oncologists, and medical students will find this book to be an invaluable resource as a reference guide. Patients and their families will also find the book useful as it offers a comprehensive update on new, non-classical therapeutic modality options and contains a detailed description and analysis of brain tumors. Such an endeavor has yet to be undertaken by any other book and may prove to be the most comprehensive book on brain tumors thus far.

Immunological Aspects of Neoplasia - The Role of the Thymus (Hardcover, 2004 ed.): Bela Bodey, Stuart E Siegel, Hans E. Kaiser Immunological Aspects of Neoplasia - The Role of the Thymus (Hardcover, 2004 ed.)
Bela Bodey, Stuart E Siegel, Hans E. Kaiser
R4,016 R3,795 Discovery Miles 37 950 Save R221 (6%) Out of stock

Our work began where the greatest classical morphologists left off; their best work was the start of ours. As our work progressed, the rigidity of basic, previous embryological principles was broken down as scientific knowledge advanced. At the same time, the molecular, biological characterization of the cell surface receptor systems progressed enormously with the invention of numerous monoclonal antibodies. Thus, thymology became once again very important because the thymus is the first and central organ of the human immunological system. Then, the question of immuno-neuroendocrine regulation arose and has only been partially answered. Our book seeks to explore what has not been explored. The topic of thymic epithelial cells is a unique one and has never been explored in any previous book as it is explored in this one.

Only a handful of great thymologists remain in the world today, especially after the great loss the medical community suffered with the passing of Dr. Good, the list includes but is not limited to: Dr. Ritter and Dr. Kendall in England, Dr. Savino in Brazil, Dr. Dardenne in France, Dr. von Gaudecker in Germany, a few others in Belgium and Holland, and it is our hope that Dr. Bodey is among them. Nonetheless, a book on the thymus has not been written in the last five years and a book such as this one has never been. This book is based on a 30-year period of research and includes references from a broad range of sources spanning the globe and all sources, even those that were the beginning of thymic research. The book, thus, is uniquely well rounded, more so that previous works.

Immunological Aspects of Neoplasia - The Role of the Thymus (Paperback, Softcover reprint of the original 1st ed. 2004): Bela... Immunological Aspects of Neoplasia - The Role of the Thymus (Paperback, Softcover reprint of the original 1st ed. 2004)
Bela Bodey, Stuart E Siegel, Hans E. Kaiser
R2,873 R2,721 Discovery Miles 27 210 Save R152 (5%) Out of stock

Our work began where the greatest classical morphologists left off; their best work was the start of ours. As our work progressed, the rigidity of basic, previous embryological principles was broken down as scientific knowledge advanced. At the same time, the molecular, biological characterization of the cell surface receptor systems progressed enormously with the invention of numerous monoclonal antibodies. Thus, thymology became once again very important because the thymus is the first and central organ of the human immunological system. Then, the question of immuno-neuroendocrine regulation arose and has only been partially answered. Our book seeks to explore what has not been explored. The topic of thymic epithelial cells is a unique one and has never been explored in any previous book as it is explored in this one. Only a handful of great thymologists remain in the world today, especially after the great loss the medical community suffered with the passing of Dr. Good, the list includes but is not limited to: Dr. Ritter and Dr. Kendall in England, Dr. Savino in Brazil, Dr. Dardenne in France, Dr. von Gaudecker in Germany, a few others in Belgium and Holland, and it is our hope that Dr. Bodey is among them. Nonetheless, a book on the thymus has not been written in the last five years and a book such as this one has never been. This book is based on a 30-year period of research and includes references from a broad range of sources spanning the globe and all sources, even those that were the beginning of thymic research. The book, thus, is uniquely well rounded, more so that previous works.

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